Meran, L;
Baulies, A;
Li, VSW;
(2017)
Intestinal Stem Cell Niche: The Extracellular Matrix and Cellular Components.
Stem Cells International
, 2017
, Article 7970385. 10.1155/2017/7970385.
![[thumbnail of 7970385.pdf]](https://discovery.ucl.ac.uk/style/images/fileicons/text.png) |
Text
7970385.pdf - Published Version Download (1MB) |
Abstract
The intestinal epithelium comprises a monolayer of polarised columnar cells organised along the crypt-villus axis. Intestinal stem cells reside at the base of crypts and are constantly nourished by their surrounding niche for maintenance, self-renewal, and differentiation. The cellular microenvironment including the adjacent Paneth cells, stromal cells, smooth muscle cells, and neural cells as well as the extracellular matrix together constitute the intestinal stem cell niche. A dynamic regulatory network exists among the epithelium, stromal cells, and the matrix via complex signal transduction to maintain tissue homeostasis. Dysregulation of these biological or mechanical signals could potentially lead to intestinal injury and disease. In this review, we discuss the role of different intestinal stem cell niche components and dissect the interaction between dynamic matrix factors and regulatory signalling during intestinal stem cell homeostasis.
| Type: | Article |
|---|---|
| Title: | Intestinal Stem Cell Niche: The Extracellular Matrix and Cellular Components |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1155/2017/7970385 |
| Publisher version: | http://doi.org/10.1155/2017/7970385 |
| Language: | English |
| Additional information: | Copyright © 2017 Laween Meran et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10025040 |
Archive Staff Only
 |
View Item |
