Browse by UCL people
Group by: Type | Date
Number of items: 55.
2024
Lindeboom, Rik GH;
Worlock, Kaylee B;
Dratva, Lisa M;
Yoshida, Masahiro;
Scobie, David;
Wagstaffe, Helen R;
Richardson, Laura;
... Teichmann, Sarah A; + view all
(2024)
Author Correction: Human SARS-CoV-2 challenge uncovers local and systemic response dynamics.
Nature
, 632
, Article E3. 10.1038/s41586-024-07838-7.
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Lindeboom, Rik GH;
Worlock, Kaylee B;
Dratva, Lisa M;
Yoshida, Masahiro;
Scobie, David;
Wagstaffe, Helen R;
Richardson, Laura;
... Teichmann, Sarah A; + view all
(2024)
Human SARS-CoV-2 challenge uncovers local and systemic response dynamics.
Nature
, 631
pp. 189-198.
10.1038/s41586-024-07575-x.
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Woodall, Maximillian NJ;
Cujba, Ana-Maria;
Worlock, Kaylee B;
Case, Katie-Marie;
Masonou, Tereza;
Yoshida, Masahiro;
Polanski, Krzysztof;
... Smith, Claire M; + view all
(2024)
Author Correction: Age-specific nasal epithelial responses to SARS-CoV-2 infection.
Nature Microbiology
, 9
(11)
, Article 3076. 10.1038/s41564-024-01757-z.
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Woodall, Maximillian NJ;
Cujba, Ana-Maria;
Worlock, Kaylee B;
Case, Katie-Marie;
Masonou, Tereza;
Yoshida, Masahiro;
Polanski, Krzysztof;
... Smith, Claire M; + view all
(2024)
Age-specific nasal epithelial responses to SARS-CoV-2 infection.
Nature Microbiology
10.1038/s41564-024-01658-1.
(In press).
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2023
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Brightling, CE;
Evans, RA;
Singapuri, A;
Smith, N;
Wain, LV;
Brightling, CE;
Evans, RA;
... Barker, RE; + view all
(2023)
Long COVID research: an update from the PHOSP-COVID Scientific Summit.
The Lancet Respiratory Medicine
, 11
(11)
e93-e94.
10.1016/S2213-2600(23)00341-7.
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Mehta, Puja;
Samanta, Romit J;
Wick, Katherine;
Coll, Rebecca C;
Mawhinney, Thea;
McAleavey, Patrick G;
Boyle, Andrew J;
... O'Kane, Cecilia M; + view all
(2023)
Elevated ferritin, mediated by IL-18 is associated with systemic inflammation and mortality in acute respiratory distress syndrome (ARDS).
Thorax
10.1136/thorax-2023-220292.
(In press).
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Selvarajah, Brintha;
Platé, Manuela;
Chambers, Rachel C;
(2023)
Pulmonary fibrosis: Emerging diagnostic and therapeutic strategies.
Molecular Aspects of Medicine
, 94
, Article 101227. 10.1016/j.mam.2023.101227.
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Stewart, Iain;
Jacob, Joseph;
George, Peter M;
Molyneaux, Philip L;
Porter, Joanna C;
Allen, Richard J;
Aslani, Shahab;
... Jenkins, R Gisli; + view all
(2023)
Residual Lung Abnormalities Following COVID-19 Hospitalization: Interim Analysis of the UKILD Post-COVID Study.
American Journal of Respiratory and Critical Care Medicine
, 207
(6)
pp. 693-703.
10.1164/rccm.202203-0564OC.
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2022
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Chambers, RC;
(2022)
Preferential PDE4B Inhibition - A Step toward a New Treatment for Idiopathic Pulmonary Fibrosis.
New England Journal of Medicine
, 386
(23)
pp. 2235-2236.
10.1056/NEJMe2205411.
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2021
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Evans, RA;
McAuley, H;
Harrison, EM;
Shikotra, A;
Singapuri, A;
Sereno, M;
Elneima, O;
... PHOSP-COVID Collaborative Group, .; + view all
(2021)
Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study.
Lancet Respiratory Medicine
10.1016/S2213-2600(21)00383-0.
(In press).
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Mehta, P;
Bunker, CB;
Ciurtin, C;
Porter, JC;
Chambers, RC;
Papdopoulou, C;
Garthwaite, H;
... Denton, CP; + view all
(2021)
Chilblain-like acral lesions in long COVID-19: management and implications for understanding microangiopathy.
The Lancet Infectious Diseases
, 21
(7)
p. 912.
10.1016/s1473-3099(21)00133-x.
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Mehta, P;
Chambers, RC;
Dagna, L;
(2021)
Granulocyte-macrophage colony stimulating factor in COVID-19: friend or foe?
The Lancet Rheumatology
10.1016/S2665-9913(21)00078-3.
(In press).
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Mehta, P;
Sanchez, E;
Moraitis, E;
Longley, N;
Lendrem, DW;
Giles, IP;
Chambers, RC;
... Isaacs, JD; + view all
(2021)
Influenza vaccination and interruption of methotrexate in adult patients in the COVID-19 era: an ongoing dilemma.
The Lancet Rheumatology
, 3
(1)
e9-e10.
10.1016/s2665-9913(20)30392-1.
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Selvarajah, B;
Azuelos, I;
Anastasiou, D;
Chambers, RC;
(2021)
Fibrometabolism-An emerging therapeutic frontier in pulmonary fibrosis.
Science Signaling
, 14
(697)
10.1126/scisignal.aay1027.
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Wild, JM;
Porter, JC;
Molyneaux, PL;
George, PM;
Stewart, I;
Allen, RJ;
Aul, R;
... Jenkins, RG; + view all
(2021)
Understanding the burden of interstitial lung disease post-COVID-19: the UK Interstitial Lung Disease-Long COVID Study (UKILD-Long COVID).
BMJ Open Respiratory Research
, 8
(1)
, Article e001049. 10.1136/bmjresp-2021-001049.
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2020
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Guillotin, D;
Taylor, AR;
Platé, M;
Mercer, PF;
Edwards, LM;
Haggart, R;
Miele, G;
... Chambers, RC; + view all
(2020)
Transcriptome analysis of IPF fibroblastic foci identifies key pathways involved in fibrogenesis.
Thorax
, 76
(1)
pp. 73-82.
10.1136/thoraxjnl-2020-214902.
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John, AE;
Graves, RH;
Pun, KT;
Vitulli, G;
Forty, EJ;
Mercer, PF;
Morrell, JL;
... Slack, RJ; + view all
(2020)
Translational pharmacology of an inhaled small
molecule αvβ6 integrin inhibitor for idiopathic
pulmonary fibrosis.
Nature Communications
, 11
(1)
, Article 4659. 10.1038/s41467-020-18397-6.
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José, RJ;
Williams, A;
Manuel, A;
Brown, JS;
Chambers, RC;
(2020)
Targeting coagulation activation in severe COVID-19 pneumonia: lessons from bacterial pneumonia and sepsis.
European Respiratory Review
, 29
(157)
, Article 200240. 10.1183/16000617.0240-2020.
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Lipman, M;
Chambers, RC;
Singer, M;
Brown, JS;
(2020)
SARS-CoV-2 pandemic: clinical picture of COVID-19 and implications for research.
Thorax
10.1136/thoraxjnl-2020-215024.
(In press).
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Mehta, P;
Ciurtin, C;
Scully, M;
Levi, M;
Chambers, RC;
(2020)
JAK inhibitors in COVID-19: need for vigilance regarding increased inherent thrombotic risk.
European Respiratory Journal
, 56
(3)
, Article 2001919. 10.1183/13993003.01919-2020.
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Mehta, P;
Porter, JC;
Chambers, RC;
Isenberg, DA;
Reddy, V;
(2020)
B-cell depletion with rituximab in the COVID-19 pandemic: where do we stand?
The Lancet Rheumatology
, 2
(10)
e589-e590.
10.1016/S2665-9913(20)30270-8.
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Mehta, P;
Porter, JC;
Manson, JJ;
Isaacs, JD;
Openshaw, PJM;
McInnes, IB;
Summers, C;
(2020)
Therapeutic blockade of granulocyte macrophage colony-stimulating factor in COVID-19-associated hyperinflammation: challenges and opportunities.
The Lancet Respiratory Medicine
, 8
(8)
pp. 822-830.
10.1016/S2213-2600(20)30267-8.
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Platé, M;
Guillotin, D;
Chambers, RC;
(2020)
The promise of mTOR as a therapeutic target pathway in idiopathic pulmonary fibrosis.
European Respiratory Review
, 29
(157)
, Article 200269. 10.1183/16000617.0269-2020.
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Woodcock, HV;
Eley, JD;
Guillotin, D;
Platé, M;
Nanthakumar, CB;
Martufi, M;
Peace, S;
... Chambers, RC; + view all
(2020)
Author Correction: The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis.
[Corrigendum].
Nature Communications
, 11
, Article 4680. 10.1038/s41467-020-18621-3.
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2019
Brombal, L;
Kallon, G;
Jiang, J;
Savvidis, S;
De Coppi, P;
Urbani, L;
Forty, E;
... Endrizzi, M; + view all
(2019)
Monochromatic Propagation-Based Phase-Contrast Microscale Computed-Tomography System with a Rotating-Anode Source.
Physical Review Applied
, 11
, Article 034004. 10.1103/PhysRevApplied.11.034004.
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Cunningham, PS;
Meijer, P;
Nazgiewicz, A;
Anderson, SG;
Borthwick, LA;
Bagnall, J;
Kitchen, GB;
... Blaikley, JF; + view all
(2019)
The circadian clock protein REVERBα inhibits pulmonary fibrosis development.
Proceedings of the National Academy of Sciences of the United States of America
10.1073/pnas.1912109117.
(In press).
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Lukey, PT;
Harrison, SA;
Yang, S;
Man, Y;
Holman, BF;
Rashidnasab, A;
Azzopardi, G;
... Maher, TM; + view all
(2019)
A Randomised, Placebo-Controlled Study of Omipalisib (PI3K/mTOR) in Idiopathic Pulmonary Fibrosis.
European Respiratory Journal
, 53
(2)
10.1183/13993003.01992-2018.
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Selvarajah, B;
Azuelos, I;
Platé, M;
Guillotin, D;
Forty, EJ;
Contento, G;
Woodcock, HV;
... Chambers, RC; + view all
(2019)
mTORC1 amplifies the ATF4-dependent de novo serine-glycine pathway to supply glycine during TGF-β1-induced collagen biosynthesis.
Science Signaling
, 12
(582)
10.1126/scisignal.aav3048.
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Teixeira, VH;
Pipinikas, CP;
Pennycuick, A;
Lee-Six, H;
Chandrasekharan, D;
Beane, J;
Morris, TJ;
... Janes, SM; + view all
(2019)
Deciphering the genomic, epigenomic, and transcriptomic landscapes of pre-invasive lung cancer lesions.
Nature Medicine
, 25
pp. 517-525.
10.1038/s41591-018-0323-0.
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Woodcock, HV;
Eley, JD;
Guillotin, D;
Plate, M;
Nanthakumar, CB;
Martufi, M;
Peace, S;
... Chambers, RC; + view all
(2019)
The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis.
Nature Communications
, 10
, Article 6. 10.1038/s41467-018-07858-8.
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2018
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Martinez-Nunez, RT;
Rupani, H;
Platé, M;
Niranjan, M;
Chambers, RC;
Howarth, PH;
Sanchez-Elsner, T;
(2018)
Genome-Wide Posttranscriptional Dysregulation by MicroRNAs in Human Asthma as Revealed by Frac-seq.
The Journal of Immunology
, 201
(1)
pp. 251-263.
10.4049/jimmunol.1701798.
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Meiners, S;
Lloyd, C;
Chambers, RC;
(2018)
Cell-matrix interactions in lung disease and regeneration: ERS Lung Science Conference 2018 report.
European Respiratory Review
, 27
(148)
, Article 180040. 10.1183/16000617.0040-2018.
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2017
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Artim-Esen, B;
Smoktunowicz, N;
McDonnell, T;
Ripoll, VM;
Pericleous, C;
Mackie, I;
Robinson, E;
... Giles, I; + view all
(2017)
Factor Xa Mediates Calcium Flux in Endothelial Cells and is Potentiated by Igg From Patients With Lupus and/or Antiphospholipid Syndrome.
Scientific Reports
, 7
(1)
, Article 10788. 10.1038/s41598-017-11315-9.
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Gosens, R;
Giangreco, A;
Sahai, E;
Chambers, RC;
(2017)
Mechanistic overlap between chronic lung injury and cancer: ERS Lung Science Conference 2017 report.
European Respiratory Review
, 26
(144)
, Article 170060. 10.1183/16000617.0060-2017.
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Johnston, CJC;
Smyth, DJ;
Kodali, RB;
White, MPJ;
Harcus, Y;
Filbey, KJ;
Hewitson, JP;
... Maizels, RM; + view all
(2017)
A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells.
Nature Communications
, 8
, Article 1741. 10.1038/s41467-017-01886-6.
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Molina-Molina, M;
Agusti, A;
Crestani, B;
Schwartz, DA;
Königshoff, M;
Chambers, RC;
Maher, TM;
... Sellares, J; + view all
(2017)
Towards a global initiative for fibrosis treatment (GIFT).
ERJ Open Research
, 3
(4)
, Article 00106. 10.1183/23120541.00106-2017.
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Thompson, BT;
Chambers, RC;
Liu, KD;
(2017)
Acute Respiratory Distress Syndrome: Response.
[Letter].
The New England Journal of Medicine
, 377
(19)
pp. 1904-1905.
10.1056/NEJMc1711824.
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Thompson, BT;
Chambers, RC;
Liu, KD;
(2017)
Acute Respiratory Distress Syndrome.
The New England Journal of Medicine
, 377
(6)
pp. 562-572.
10.1056/NEJMra1608077.
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Williams, AE;
José, RJ;
Mercer, PF;
Brealey, D;
Parekh, D;
Thickett, DR;
O'Kane, C;
... Chambers, RC; + view all
(2017)
Evidence for chemokine synergy during neutrophil migration in ARDS.
Thorax
, 72
(1)
pp. 66-73.
10.1136/thoraxjnl-2016-208597.
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2016
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Alexander, RE;
(2016)
The regulation of extra-hepatic coagulation factor X production in alveolar and bronchiolar epithelium.
Doctoral thesis , UCL (University College London).
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Crowley, C;
Klanrit, P;
Butler, CR;
Varanou, A;
Platé, M;
Hynds, RE;
Chambers, RC;
... Janes, SM; + view all
(2016)
Surface modification of a POSS-nanocomposite material to enhance cellular integration of a synthetic bioscaffold.
Biomaterials
, 83
pp. 283-293.
10.1016/j.biomaterials.2016.01.005.
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Knight, E;
Robinson, E;
Smoktunowicz, N;
Chambers, RC;
Aliev, AE;
Inglis, GG;
Chudasama, V;
(2016)
Synthesis of novel and potent vorapaxar analogues.
Organic & Biomolecular Chemistry
, 14
(12)
pp. 3264-3274.
10.1039/c5ob02541a.
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Mercer, PF;
Woodcock, HV;
Eley, JD;
Platé, M;
Sulikowski, MG;
Durrenberger, PF;
Franklin, L;
... Chambers, RC; + view all
(2016)
Exploration of a potent PI3 kinase/mTOR inhibitor as a novel anti-fibrotic agent in IPF.
Thorax
, 71
(8)
pp. 701-711.
10.1136/thoraxjnl-2015-207429.
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Robinson, E;
Knight, E;
Smoktunowicz, N;
Chambers, RC;
Inglis, GG;
Chudasama, V;
Caddick, S;
(2016)
Identification of an active metabolite of PAR-1 antagonist RWJ-58259 and synthesis of analogues to enhance its metabolic stability.
Organic & Biomolecular Chemistry
(14)
pp. 3198-3201.
10.1039/c6ob00332j.
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Smoktunowicz, N;
Platé, M;
Ortiz-Stern, A;
D'Antongiovanni, V;
Robinson, E;
Chudasama, V;
Caddick, S;
... Chambers, RC; + view all
(2016)
TGFβ upregulates PAR-1 expression and signalling responses in A549 lung adenocarcinoma cells.
Oncotarget
, 7
(40)
pp. 65471-65484.
10.18632/oncotarget.11472.
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Williams, AE;
Chambers, RC;
(2016)
Neutrophils and tissue damage: is hypoxia the key to excessive degranulation?
Thorax
, 71
(11)
pp. 977-978.
10.1136/thoraxjnl-2016-208879.
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2015
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José, RJ;
Williams, AE;
Mercer, PF;
Sulikowski, MG;
Brown, JS;
Chambers, RC;
(2015)
Regulation of neutrophilic inflammation by proteinase-activated receptor 1 during bacterial pulmonary infection.
Journal of Immunology
, 194
(12)
pp. 6024-6034.
10.4049/jimmunol.1500124.
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Paixao Jose, RJ;
(2015)
Regulation of pulmonary neutrophilic inflammation in community-acquired pneumonia.
Doctoral thesis , UCL (University College London).
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Platé, M;
Lawson, PJ;
Hill, MR;
Marshall, RP;
Booth, HL;
Kumari, M;
Laurent, GJ;
... Chambers, RC; + view all
(2015)
Role of a functional polymorphism in the F2R gene promoter in sarcoidosis.
[Letter].
Respirology
, 20
(8)
pp. 1285-1287.
10.1111/resp.12608.
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Smoktunowicz, N;
Alexander, RE;
Franklin, L;
Williams, AE;
Holman, B;
Mercer, PF;
Jarai, G;
... Chambers, RC; + view all
(2015)
The anti-fibrotic effect of inhibition of TGFβ-ALK5 signalling in experimental pulmonary fibrosis in mice is attenuated in the presence of concurrent γ-herpesvirus infection.
Disease Models & Mechanisms
, 8
(9)
pp. 1129-1139.
10.1242/dmm.019984.
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2014
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Chakraborty, M;
McGreal, EP;
Williams, A;
Davies, PL;
Powell, W;
Abdulla, S;
Voitenok, NN;
... Kotecha, S; + view all
(2014)
Role of Serine Proteases in the Regulation of Interleukin-8(77) during the Development of Bronchopulmonary Dysplasia in Preterm Ventilated Infants.
PLOS ONE
, 9
(12)
10.1371/journal.pone.0114524.
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Mercer, PF;
Williams, AE;
Scotton, CJ;
José, RJ;
Sulikowski, M;
Moffatt, JD;
Murray, LA;
(2014)
Proteinase-Activated Receptor-1, CCL2 and CCL7 Regulate Acute Neutrophilic Lung Inflammation.
American Journal of Respiratory Cell and Molecular Biology
, 50
(1)
pp. 144-157.
10.1165/rcmb.2013-0142OC.
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Platé, M;
Lawson, PJ;
Hill, MR;
Quint, JK;
Kumari, M;
Laurent, GJ;
Wedzicha, JA;
... Hurst, JR; + view all
(2014)
Impact of a functional polymorphism in the PAR-1 gene promoter in COPD and COPD exacerbations.
American Journal of Physiology - Lung Cellular and Molecular Physiology
, 307
(4)
L311-L316.
10.1152/ajplung.00128.2014.
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2013
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Scotton, CJ;
Hayes, B;
Alexander, R;
Datta, A;
Forty, EJ;
Mercer, PF;
Blanchard, A;
(2013)
Ex vivo micro-computed tomography analysis of bleomycin-induced lung fibrosis for preclinical drug evaluation.
Eur Respir J
, 42
(6)
1633 - 1645.
10.1183/09031936.00182412.
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2006
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Jenkins, RG;
Su, X;
Su, G;
Scotton, CJ;
Camerer, E;
Laurent, GJ;
Davis, GE;
... Sheppard, D; + view all
(2006)
Ligation of protease-activated receptor 1 enhances alpha(v)beta(6) integrin-dependent TGF-beta activation and promotes acute lung injury.
J CLIN INVEST
, 116
(6)
1606 - 1614.
10.1172/JCI27183.
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