Browse by UCL people
Group by: Type | Date
Number of items: 48.
Article
Abeyakoon, O;
Latifoltojar, A;
Gong, F;
Papoutsaki, M-V;
Chowdhury, R;
Glaser, M;
Jeraj, H;
... Punwani, S; + view all
(2019)
Hyperpolarised 13C MRI: a new horizon for non-invasive diagnosis of aggressive breast cancer.
BJR case reports
, 5
(3)
, Article 20190026. 10.1259/bjrcr.20190026.
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Avnet, S;
Baldini, N;
Brisson, L;
De Milito, A;
Otto, AM;
Pastorekova, S;
Porporato, PE;
... Sonveaux, P; + view all
(2018)
Annual Meeting of the International Society of Cancer Metabolism (ISCaM): Cancer Metabolism.
Frontiers in Oncology
, 8
, Article 329. 10.3389/fonc.2018.00329.
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Avnet, S;
Baldini, N;
Brisson, L;
Pedersen, SF;
Porporato, PE;
Sonveaux, P;
Szabadkai, G;
(2019)
Annual Meeting of the International Society of Cancer Metabolism (ISCaM): Metabolic Adaptations and Targets in Cancer.
Frontiers in Oncology
, 9
, Article 1332. 10.3389/fonc.2019.01332.
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Bentham, RB;
Bryson, K;
Szabadkai, G;
(2019)
Biclustering Analysis of Co-regulation Patterns in Nuclear-Encoded Mitochondrial Genes and Metabolic Pathways.
Cancer Metabolism
, 1928
pp. 469-478.
10.1007/978-1-4939-9027-6_24.
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Bentham, RB;
Bryson, K;
Szabadkai, G;
(2017)
MCbiclust: a novel algorithm to discover large-scale functionally related gene sets from massive transcriptomics data collections.
Nucleic Acids Research
, 45
(15)
pp. 8712-8730.
10.1093/nar/gkx590.
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Bhosale, G;
Sharpe, JA;
Koh, A;
Kouli, A;
Szabadkai, G;
Duchen, MR;
(2017)
Pathological consequences of MICU1 mutations on mitochondrial calcium signalling and bioenergetics.
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
, 1864
(6)
pp. 1009-1017.
10.1016/j.bbamcr.2017.01.015.
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Bilanges, B;
Alliouachene, S;
Pearce, W;
Morelli, D;
Szabadkai, G;
Chung, Y-L;
Chicanne, G;
... Vanhaesebroeck, B; + view all
(2017)
Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism.
Nature Communications
, 8
, Article 1804. 10.1038/s41467-017-01969-4.
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Blacker, TS;
Berecz, T;
Duchen, MR;
Szabadkai, G;
(2017)
Assessment of Cellular Redox State Using NAD(P)H Fluorescence Intensity and Lifetime.
Bio Protocol
, 7
(2)
, Article e2105. 10.21769/BioProtoc.2105.
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Blacker, TS;
Mann, ZF;
Gale, JE;
Ziegler, M;
Bain, AJ;
Szabadkai, G;
Duchen, MR;
(2014)
Separating NADH and NADPH fluorescence in live cells and tissues using FLIM.
Nat Commun
, 5
, Article 3936. 10.1038/ncomms4936.
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Briston, T;
Lewis, S;
Koglin, M;
Mistry, K;
Shen, Y;
Hartopp, N;
Katsumata, R;
... Powney, B; + view all
(2016)
Identification of ER-000444793, a Cyclophilin D-independent inhibitor of mitochondrial permeability transition, using a high-throughput screen in cryopreserved mitochondria.
Scientific Reports
, 6
, Article 37798. 10.1038/srep37798.
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Briston, T;
Roberts, M;
Lewis, S;
Powney, B;
M Staddon, J;
Szabadkai, G;
Duchen, MR;
(2017)
Mitochondrial permeability transition pore: sensitivity to opening and mechanistic dependence on substrate availability.
Scientific Reports
, 7
, Article 10492. 10.1038/s41598-017-10673-8.
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Briston, T;
Selwood, DL;
Szabadkai, G;
Duchen, MR;
(2019)
Mitochondrial Permeability Transition: A Molecular Lesion with Multiple Drug Targets.
[Review].
Trends in Pharmacological Sciences
, 40
(1)
pp. 50-70.
10.1016/j.tips.2018.11.004.
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Briston, T;
Stephen, JM;
Thomas, LW;
Esposito, C;
Chung, Y-L;
Syafruddin, SE;
Turmaine, M;
... Ashcroft, M; + view all
(2018)
VHL-Mediated Regulation of CHCHD4 and Mitochondrial Function.
Frontiers in Oncology
, 8
(388)
10.3389/fonc.2018.00388.
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Cali, T;
Szabadkai, G;
(2018)
Organelles: The Emerging Signalling Chart of Mitochondrial Dynamics.
Current Biology
, 28
(2)
R73-R75.
10.1016/j.cub.2017.11.040.
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Chung, C-Y;
Singh, K;
Kotiadis, VN;
Valdebenito, GE;
Ahn, JH;
Topley, E;
Tan, J;
... Duchen, MR; + view all
(2021)
Constitutive activation of the PI3K-Akt-mTORC1 pathway sustains the m.3243 A > G mtDNA mutation.
Nature Communications
, 12
(1)
, Article 6409. 10.1038/s41467-021-26746-2.
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Chung, Chih-Yao;
Singh, Kritarth;
Sheshadri, Preethi;
Valdebenito, Gabriel E;
Chacko, Anitta R;
Costa Besada, María Alicia;
Liang, Xiao Fei;
... Duchen, Michael R; + view all
(2024)
Inhibition of the PI3K-AKT-MTORC1 axis reduces the burden of the m.3243A>G mtDNA mutation by promoting mitophagy and improving mitochondrial function.
Autophagy
pp. 1-16.
10.1080/15548627.2024.2437908.
(In press).
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Dal Pra, M;
Carta, D;
Szabadkai, G;
Suman, M;
Frion-Herrera, Y;
Paccagnella, N;
Castellani, G;
... Ferlin, MG; + view all
(2018)
Targeting RORs nuclear receptors by novel synthetic steroidal inverse agonists for autoimmune disorders.
Bioorganic & Medicinal Chemistry
, 26
(8)
pp. 1686-1704.
10.1016/j.bmc.2018.02.018.
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Dalton, CM;
Szabadkai, G;
Carroll, J;
(2013)
Measurement of ATP in Single Oocytes: Impact of Maturation and Cumulus Cells on Levels and Consumption.
Journal of Cellular Physiology
, 222
(3)
pp. 353-361.
10.1002/jcp.24457.
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Davidson, SM;
Szabadkai, G;
Duchen, MR;
(2019)
Fantastic beasts and how to find them—Molecular identification of the mitochondrial ATP-sensitive potassium channel.
Cell Calcium
, 84
, Article 102100. 10.1016/j.ceca.2019.102100.
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De Mario, A;
Tosatto, A;
Hill, JM;
Kriston-Vizi, J;
Ketteler, R;
Vecellio Reane, D;
Cortopassi, G;
... Mammucari, C; + view all
(2021)
Identification and functional validation of FDA-approved positive and negative modulators of the mitochondrial calcium uniporter.
Cell Reports
, 35
(12)
, Article 109275. 10.1016/j.celrep.2021.109275.
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Desai, R;
East, DA;
Hardy, L;
Faccenda, D;
Rigon, M;
Crosby, J;
Alvarez, MS;
... Campanella, M; + view all
(2020)
Mitochondria form contact sites with the nucleus to couple prosurvival retrograde response.
Science Advances
, 6
(51)
, Article eabc9955. 10.1126/sciadv.abc9955.
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Dongworth, RK;
Mukherjee, UA;
Hall, AR;
Astin, R;
Ong, SB;
Yao, Z;
Dyson, A;
... Hausenloy, DJ; + view all
(2014)
DJ-1 protects against cell death following acute cardiac ischemia-reperfusion injury.
Cell Death Dis
, 5
, Article e1082. 10.1038/cddis.2014.41.
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Galluzzi, L;
Bravo-San Pedro, JM;
Vitale, I;
Aaronson, SA;
Abrams, JM;
Adam, D;
Alnemri, ES;
... Kroemer, G; + view all
(2015)
Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.
Cell Death and Differentiation
, 22
(1)
pp. 58-73.
10.1038/cdd.2014.137.
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Galluzzi, L;
Vitale, I;
Aaronson, SA;
Abrams, JM;
Adam, D;
Agostinis, P;
Alnemri, ES;
... Kroemer, G; + view all
(2018)
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.
Cell Death & Differentiation
10.1038/s41418-017-0012-4.
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Gaude, E;
Schmidt, C;
Gammage, PA;
Dugourd, A;
Blacker, T;
Chew, SP;
Saez-Rodriguez, J;
... Frezza, C; + view all
(2018)
NADH Shuttling Couples Cytosolic Reductive Carboxylation of Glutamine with Glycolysis in Cells with Mitochondrial Dysfunction.
Mol Cell
, 69
(4)
581-593.e7.
10.1016/j.molcel.2018.01.034.
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Giorgi, C;
Marchi, S;
Simoes, ICM;
Ren, Z;
Morciano, G;
Perrone, M;
Patalas-Krawczyk, P;
... Wieckowski, MR; + view all
(2018)
Chapter Six - Mitochondria and Reactive Oxygen Species in Aging and Age-Related Diseases.
International Review of Cell and Molecular Biology
, 340
pp. 209-344.
10.1016/bs.ircmb.2018.05.006.
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Jones, AW;
Yao, Z;
Vicencio, JM;
Karkucinska-Wieckowska, A;
Szabadkai, G;
(2012)
PGC-1 family coactivators and cell fate: roles in cancer, neurodegeneration, cardiovascular disease and retrograde mitochondria-nucleus signalling.
Mitochondrion
, 12
(1)
86 - 99.
10.1016/j.mito.2011.09.009.
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Lampada, A;
O'Prey, J;
Szabadkai, G;
Ryan, KM;
Hochhauser, D;
Salomoni, P;
(2017)
mTORC1-independent autophagy regulates receptor tyrosine kinase phosphorylation in colorectal cancer cells via an mTORC2-mediated mechanism.
Cell Death and Differentiation
, 24
(6)
pp. 1045-1062.
10.1038/cdd.2017.41.
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Llorente-Folch, I;
Rueda, CB;
Pardo, B;
Szabadkai, G;
Duchen, MR;
Satrustegui, J;
(2015)
The regulation of neuronal mitochondrial metabolism by calcium.
Journal of Physiology
, 593
(16)
pp. 3447-3462.
10.1113/JP270254.
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Logan, CV;
Szabadkai, G;
Sharpe, JA;
Parry, DA;
Torelli, S;
Childs, AM;
Kriek, M;
... Sheridan, E; + view all
(2014)
Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling.
Nature Genetics
, 46
(2)
pp. 188-193.
10.1038/ng.2851.
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Montague, K;
Malik, B;
Gray, AL;
La Spada, AR;
Hanna, MG;
Szabadkai, G;
Greensmith, L;
(2014)
Endoplasmic reticulum stress in spinal and bulbar muscular atrophy: a potential target for therapy.
Brain
, 137
(7)
pp. 1894-1906.
10.1093/brain/awu114.
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Pingitore, Valeria;
Pancholi, Jessica;
Hornsby, Thomas W;
Warne, Justin;
Pryce, Gareth;
Mccormick, Laura J;
Hill, Julia;
... Selwood, David L; + view all
(2024)
Delocalized quinolinium-macrocyclic peptides, an atypical chemotype for CNS penetration.
Science Advances
, 10
(28)
, Article eado3501. 10.1126/sciadv.ado3501.
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Piston, D;
Alvarez-Erviti, L;
Bansal, V;
Gargano, D;
Yao, Z;
Szabadkai, G;
Odell, M;
... Gegg, ME; + view all
(2017)
DJ-1 is a redox sensitive adapter protein for high molecular weight complexes involved in regulation of catecholamine homeostasis.
Human Molecular Genetics
, 26
(20)
pp. 4028-4041.
10.1093/hmg/ddx294.
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Piston, D;
Alvarez-Erviti, L;
Bansal, V;
Gargano, D;
Yao, Z;
Szabadkai, G;
Odell, M;
... Gegg, ME; + view all
(2017)
DJ-1 is a redox sensitive adapter protein for high molecular weight complexes involved in regulation of catecholamine homeostasis.
[Corrigendum].
Human Molecular Genetics
, Article ddx425. 10.1093/hmg/ddx425.
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Plotegher, N;
Perocheau, D;
Ferrazza, R;
Massaro, G;
Bhosale, G;
Zambon, F;
Rahim, AA;
... Duchen, MR; + view all
(2020)
Impaired cellular bioenergetics caused by GBA1 depletion sensitizes neurons to calcium overload.
Cell Death & Differentiation
, 27
pp. 1588-1603.
10.1038/s41418-019-0442-2.
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Rashid, S;
Freitas, MO;
Cucchi, D;
Bridge, G;
Yao, Z;
Gay, L;
Williams, M;
... Martin, SA; + view all
(2019)
MLH1 deficiency leads to deregulated mitochondrial metabolism.
Cell Death & Disease
, 10
, Article 795. 10.1038/s41419-019-2018-y.
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Suman, M;
Sharpe, JA;
Bentham, RB;
Kotiadis, VN;
Menegollo, M;
Pignataro, V;
Molgó, J;
... Szabadkai, G; + view all
(2018)
Inositol Trisphosphate Receptor Mediated Ca2+ Signalling Stimulates Mitochondrial Function and Gene Expression in Core Myopathy Patients.
Human Molecular Genetics
, 27
(13)
pp. 2367-2382.
10.1093/hmg/ddy149.
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Thomas, LW;
Esposito, C;
Stephen, JM;
Costa, ASH;
Frezza, C;
Blacker, TS;
Szabadkai, G;
(2019)
CHCHD4 regulates tumour proliferation and EMT-related phenotypes, through respiratory chain-mediated metabolism.
Cancer & Metabolism
, 7
, Article 7. 10.1186/s40170-019-0200-4.
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Tosatto, A;
Sommaggio, R;
Kummerow, C;
Bentham, RB;
Blacker, TS;
Berecz, T;
Duchen, MR;
... Mammucari, C; + view all
(2016)
The mitochondrial calcium uniporter regulates breast cancer progression via HIF-1α.
EMBO Molecular Medicine
, 8
(5)
pp. 569-585.
10.15252/emmm.201606255.
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Tsuchiya, Y;
Peak-Chew, S;
Newell, C;
Miller-Aidoo, S;
Mangal, S;
Zhyvoloup, A;
Baković, J;
... Gout, I; + view all
(2017)
Protein CoAlation: a redox-regulated protein modification by coenzyme A in mammalian cells.
Biochemical Journal
, 474
(14)
pp. 2489-2508.
10.1042/BCJ20170129.
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Warne, J;
Pryce, G;
Hill, JM;
Shi, X;
Lennerås, F;
Puentes, F;
Kip, M;
... Selwood, DL; + view all
(2016)
Selective Inhibition of the Mitochondrial Permeability Transition Pore Protects against Neurodegeneration in Experimental Multiple Sclerosis.
The Journal of Biological Chemistry
, 291
(9)
pp. 4356-4373.
10.1074/jbc.M115.700385.
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Wilcz-Villega, E;
Carter, E;
Ironside, A;
Xu, R;
Mataloni, I;
Holdsworth, J;
Jones, W;
... Bianchi, K; + view all
(2020)
Macrophages induce malignant traits in mammary epithelium via IKKε/TBK1 kinases and the serine biosynthesis pathway.
EMBO Molecular Medicine
, Article e10491. 10.15252/emmm.201910491.
(In press).
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Xu, R;
Jones, W;
Wilcz-Villega, E;
Costa, AS;
Rajeeve, V;
Bentham, RB;
Bryson, K;
... Bianchi, K; + view all
(2020)
The breast cancer oncogene IKKε coordinates mitochondrial function and serine metabolism.
EMBO Reports
, Article e48260. 10.15252/embr.201948260.
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Yu, Y;
Niccoli, T;
Ren, Z;
Woodling, NS;
Aleyakpo, B;
Szabadkai, G;
Partridge, L;
(2020)
PICALM rescues glutamatergic neurotransmission, behavioural function, and survival in a Drosophila model of Aβ42 toxicity.
Human Molecular Genetics
10.1093/hmg/ddaa125.
(In press).
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Book chapter
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Blacker, TS;
Sewell, MDE;
Szabadkai, G;
Duchen, MR;
(2019)
Metabolic Profiling of Live Cancer Tissues Using NAD(P)H Fluorescence Lifetime Imaging.
In: Haznadar, M, (ed.)
Cancer Metabolism.
(pp. 365-387).
Springer Nature: New York (NY), USA.
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Menegollo, M;
Tessari, I;
Bubacco, L;
Szabadkai, G;
(2019)
Determination of ATP, ADP, and AMP Levels by Reversed-Phase High-Performance Liquid Chromatography in Cultured Cells.
In: Raffaello, A and Vecellio Reane, D, (eds.)
Calcium Signalling: Methods and Protocols.
(pp. 223-232).
Springer Nature: New York (NY), USA.
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Thesis
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Bentham, RB;
(2016)
A bioinfomatic analysis of the role of mitochondrial biogenesis in human pathologies.
Doctoral thesis , UCL (University College London).
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Hill, JM;
(2016)
Mitochondrial calcium uptake pathways as a potential therapeutic target.
Doctoral thesis , UCL (University College London).
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