2025

Alam, Fairooza; (2025) Petri net Modelling to Assess the Performance of the Protein Folding Machinery for Recombinantly Expressed Proteins in Escherichia coli. Doctoral thesis (Ph.D), UCL (University College London).

Almulla, Fatma Mohamed Ebrahim Alhamer; (2025) Optimisation of an alkaline lysis process to improve plasmid DNA production at scale – challenges and opportunities. Doctoral thesis (Ph.D), UCL (University College London).

Anselmi, Silvia; Ni, Yeke; Tonoli, Alessia; Wu, Jingyue; Wang, Yu; Prout, Luba; Miodownik, Mark; ... Hailes, Helen C; + view all Anselmi, Silvia; Ni, Yeke; Tonoli, Alessia; Wu, Jingyue; Wang, Yu; Prout, Luba; Miodownik, Mark; Jeffries, Jack WE; Hailes, Helen C; - view fewer (2025) The discovery of new metagenomic urethanases utilising a novel colorimetric assay for applications in the biodegradation of polyurethanes. Green Chemistry 10.1039/d5gc03560k. (In press).

Aranda Hernández, Jorge; (2025) Microfluidic Devices as Tools for Cell Therapy Manufacturing. Doctoral thesis (Eng.D), UCL (University College London).

Armstrong, Alexander; (2025) Effect of temperature on the purification of monoclonal antibodies using protein A, cation exchange, and anion exchange chromatography. Doctoral thesis (Ph.D), UCL (University College London).

Ayrton, John-Paul; (2025) Engineering nanobody fusion proteins for nanoparticle stabilisation and application in biosensing. Doctoral thesis (Ph.D), UCL (University College London).

Bradford, HF; Lalaurie, CJ; Gor, J; Gao, X; Pericleous, C; Perkins, SJ; Britt, H; ... McDonnell, TCR; + view all Bradford, HF; Lalaurie, CJ; Gor, J; Gao, X; Pericleous, C; Perkins, SJ; Britt, H; Thalassinos, K; Giles, I; Rahman, A; Delcea, M; Dalby, PA; McDonnell, TCR; - view fewer (2025) Plasmin cleavage of β2-glycoprotein I alters its structure and ability to bind to pathogenic antibodies. Journal of Thrombosis and Haemostasis , 23 (6) pp. 1864-1878. 10.1016/j.jtha.2025.02.015.

Carrillo Sanchez, Braulio; Fernández-García, Raquel; Gerontas, Spyridon; Hales, John E; Aylott, Jonathan W; Dalby, Paul A; (2025) Systematic formulation optimisation to enhance buffer exchange recovery and storage stability for adeno-associated virus (AAV2) vectors. International Journal of Pharmaceutics , 686 , Article 126312. 10.1016/j.ijpharm.2025.126312.

Ceballos Rodríguez-Conde, Fátima; (2025) A Comparative Evaluation of Bacterial Monocultures and a Synthetic Consortia for Plastic Degradation. Doctoral thesis (Ph.D), UCL (University College London).

Chen, Qiantong; Lee, Chae Hyon; Whitfield, Robert; Nesbeth, Darren N; (2025) Chronologically distributed transfection improves AAV2 and AAV2/8 capsid filling and reveals assembly schedule divergence. Molecular Therapy: Methods and Clinical Development , Article 101610. 10.1016/j.omtm.2025.101610. (In press).

Cheung, Thomas Kwun Long; (2025) Evaluation of enzyme addition on sucrose extraction during the sugar beet diffusion process. Doctoral thesis (Ph.D), UCL (University College London).

Colao, Ivano Luigi; Corteling, Randolph L; Bracewell, Daniel G; Wall, Ivan B; (2025) Neural stem cell–derived extracellular vesicles purified by monolith chromatography retain stimulatory effect in in vitro scratch assay. Cytotherapy , 27 (3) pp. 365-377. 10.1016/j.jcyt.2024.11.007.

De Sa Magalhaes, Salome; Keshavarz-Moore, Eli; (2025) Building long-term vaccine manufacturing capacity for the world: a framework for sustainable development in LMICs. Vaccine Insights , 4 (6) pp. 191-208. 10.18609/vac.2025.030. (In press).

De Sá Magalhães, Salomé; Morris, Stephen A; Kusumawardani, Shinta; Wijayadikusumah, Acep Riza; Nurainy, Neni; Keshavarz-Moore, Eli; (2025) Defining a Simplified Process in Yeast for Production of Enveloped VLP Dengue Vaccine. Bioengineering , 12 (9) , Article 956. 10.3390/bioengineering12090956.

Dorn, Marie; Ferng, Christine; Klottrup-Rees, Kerensa; Lee, Kenneth; Micheletti, Martina; (2025) Cell clone selection-impact of operation modes and medium exchange strategies on clone ranking. Frontiers in Bioengineering and Biotechnology , 12 , Article 1479633. 10.3389/fbioe.2024.1479633.

Elgabry, Mariam; Nesbeth, Darren; Ekblom, Paul; Johnson, Shane; (2025) BAKE: a novel framework for iterative security design for identifying criminally-exploitable vulnerabilities in biotechnology products. Crime Science , 14 , Article 16. 10.1186/s40163-025-00256-8.

Faustinelli Barrios, Valentina; (2025) Exploring the role of mass spectrometry analytical methods in nanobody therapeutic development. Doctoral thesis (Ph.D), UCL (University College London).

Gill, Megha; (2025) Investigating an E.coli-based cell-free protein synthesis system as a biological amplification tool for lateral flow immunoassays. Doctoral thesis (Ph.D), UCL (University College London).

Howe, Geoffrey; (2025) Engineering Biology Approaches to Improving Viral Vector Manufacturing. Doctoral thesis (Ph.D), UCL (University College London).

Huang, W; Chen, W; Singh, V; Zhang, J; Wang, Y; Alabdullatif, M; Bele, E; ... Tiwari, MK; + view all Huang, W; Chen, W; Singh, V; Zhang, J; Wang, Y; Alabdullatif, M; Bele, E; Lye, GJ; Hailes, HC; Tiwari, MK; - view fewer (2025) Modulation-enabled healable and stretchable shape-memory polymer composites for digital light processing 4D printing. Additive Manufacturing , 101 , Article 104699. 10.1016/j.addma.2025.104699.

Hussein, Shams Fathy Youssef; (2025) Development of Mucoadhesive Self-Targeted Polymersomes for Bladder Cancer. Doctoral thesis (Ph.D), UCL (University College London).

Jonsson, KG; Nesbeth, D; Keshavarz-Moore, E; (2025) Novel approaches to engineering autolysis: A scalable alternative for recovery of bioproducts. Journal of Biotechnology , 406 pp. 115-126. 10.1016/j.jbiotec.2025.07.007.

Labbe, Roman; (2025) Development of a lentiviral platform for the simultaneous transduction and activation of T lymphocytes for improved CAR T cell function. Doctoral thesis (Ph.D), UCL (University College London).

Lacerda, Luis; Kostas, Emily; (2025) Seaweed and the bioeconomy: enabling growth through aquaculture policy. UCL Policy Impact Unit: London, UK.

Lalaurie, CJ; Kulke, M; Geist, N; Delcea, M; Dalby, PA; McDonnell, TCR; (2025) The J-shape of β2GPI reveals a cryptic discontinuous epitope across domains I and II. Journal of Structural Biology X , 12 , Article 100135. 10.1016/j.yjsbx.2025.100135. (In press).

Lalaurie, CJ; Zloh, M; Higazi, DR; Bunting, KA; Dalby, PA; (2025) Inter-Domain interactions Slow BoNT/A’s onset of action. Journal of Structural Biology , 217 (1) , Article 108171. 10.1016/j.jsb.2025.108171.

Leite, Mara; Dobrijevic, Dragana; Macey, Michael C; Maheshwarappa, Mamatha; Ward, John; Dartnell, Lewis; (2025) Analysis of Microbial Diversity and Evidence of Contamination at a Mars Analogue Habitat. Environmental Microbiology Reports , 17 (4) , Article e70146. 10.1111/1758-2229.70146.

Li, Yiwen; (2025) Protein Engineering for Biotechnology. Doctoral thesis (Ph.D), UCL (University College London).

Llamas Ramírez, Reneé Martha; (2025) Establishing a systematic framework with syntrophy as principle to build a Streptomyces-Saccharomyces interaction in liquid culture using the natural capabilities of the microorganisms. Doctoral thesis (Ph.D), UCL (University College London).

Lucas, Ciara; (2025) Development of scale-down platforms for the continuous production of mammalian cell derived biopharmaceuticals. Doctoral thesis (Eng.D), UCL (University College London).

Mahal, Hanna CK; (2025) Decisional tools to evaluate the business case of end-to-end continuous antibody manufacture: from development to market. Doctoral thesis (Eng.D), UCL (University College London).

Mazlan, Farhaneen A; Wasmuth, Matthew AJ; Nesbeth-Bain, Mahalia EM; Nesbeth, Darren N; (2025) Halal considerations that signpost a cellular agriculture compatible with world religions. Trends in Food Science & Technology , 161 , Article 105015. 10.1016/j.tifs.2025.105015.

Mujahid, Noor; (2025) Characterisation of Membrane Filtration Processes in the Manufacture of Lentiviral Vectors for Cell and Gene Therapy. Doctoral thesis (Ph.D), UCL (University College London).

Nourafkan, E; Yang, Z; Maamra, M; Kis, Z; (2025) Advancing continuous encapsulation and purification of mRNA vaccines and therapeutics. European Journal of Pharmaceutical Sciences , 212 , Article 107183. 10.1016/j.ejps.2025.107183. (In press).

Nweke, Chika; Luk, Lillian; Lazar, Irina; (2025) Addressing Challenges of Teamworking and Communication Skills in International Transdisciplinary Projects Contexts. Transdiciplinarity for a Better World , 76 pp. 221-229. 10.3233/ATDE251094.

Nytko, Kinga; (2025) Manipulation of partner protein expression levels in bacterial cytochrome P450 systems. Doctoral thesis (Ph.D), UCL (University College London).

Redwood-Sawyerr, Chileab; (2025) Applying synthetic biology to improve biologics production by mammalian cell transient transfection. Doctoral thesis (Ph.D), UCL (University College London).

Rizzo, Andrea; (2025) Discovery and characterisation of C-C bond forming enzymes from genomic and metagenomic sources for applications in industrial biocatalysis. Doctoral thesis (Ph.D), UCL (University College London).

Roth, Felix; (2025) Experimentally driven predictive soft sensors and economic models for continuous upstream bioprocesses. Doctoral thesis (Ph.D), UCL (University College London).

Sciscione, Fabiola; Prout, Luba; Jeffries, Jack WE; Karam, Hajar J; Constantinou, Achilleas; Peng, Fei; Al-Salem, SM; ... Miodownik, Mark; + view all Sciscione, Fabiola; Prout, Luba; Jeffries, Jack WE; Karam, Hajar J; Constantinou, Achilleas; Peng, Fei; Al-Salem, SM; Hailes, Helen C; Miodownik, Mark; - view fewer (2025) Comparison of the behaviour of pro-oxidant additive containing plastic degradation in the unmanaged natural environment and in the laboratory. Royal Society Open Science , 12 (3) , Article 241270. 10.1098/rsos.241270.

Shi, Xinyue; (2025) Use of fragment-based drug discovery to identify potential inhibitors targeting SARS-CoV-2 non-structural protein 14 and DENV-3 methyltransferase. Doctoral thesis (Ph.D), UCL (University College London).

Soni, Harshal; Pryshchep, Sergey; Johnson, Thomas F; Cramer, Steven M; (2025) Elucidating the Interplay Between Resin Media, Feed Constituents, and Process Conditions in AAV Affinity Column Fouling With Confocal Microscopy. Biotechnology and Bioengineering , 122 (12) pp. 3339-3354. 10.1002/bit.70060.

Tacu, Anca; Micheletti, Martina; Morris, Stephen A; Parker, Brenda; (2025) Pioneering technological innovation and sustainability in vaccine manufacturing to ensure pandemic preparedness and global access. Vaccine Insights , 4 (6) pp. 175-181. 10.18609/vac.2025.028.

Tonoli, A; Anselmi, S; Ward, JM; Hailes, HC; Jeffries, JWE; (2025) Expanding the Enzymatic Toolbox for Carboligation: Increasing the Diversity of the ‘Split’ Transketolase Sequence Space. ChemBioChem , Article e202401028. 10.1002/cbic.202401028. (In press).

Vicente, Pedro; Meliciano, Ana; Diniz, Claudia; Charalambidou, Artemis; Terrasso, Ana Paula; Freitas, Catarina; Ducci, Andrea; ... Serra, Margarida; + view all Vicente, Pedro; Meliciano, Ana; Diniz, Claudia; Charalambidou, Artemis; Terrasso, Ana Paula; Freitas, Catarina; Ducci, Andrea; Alves, Paula M; Micheletti, Martina; Roldao, Antonio; Serra, Margarida; - view fewer (2025) Engineering Characterization of Small-Scale Bioreactors for Large-Scale hiPSC Production. Biotechnology Journal , 20 (9) , Article e70106. 10.1002/biot.70106.

Von Massow, Georg; (2025) Flaring up the Tumour: Bioprocessing Conditions and Bacterial Outer Membrane Vesicles (OMV) potentiate Gamma Delta T Cell Cancer Cell Cytotoxicity. Doctoral thesis (Ph.D), UCL (University College London).

Wang, Yuhan; (2025) Elucidating protein aggregation and key protein-protein interaction sites with molecular dynamics simulations and predictive model building. Doctoral thesis (Eng.D), UCL (University College London).

Wint, Natalie; Bairaktarova, Diana; Nweke, Mauryn; (2025) Ethics and engineering design foundations. In: Shannon, Chance and Tom, Børsen and Diana Adela, Martin and Roland, Tormey and Thomas Taro, Lennerfors and Gunter, Bombaerts, (eds.) The Routledge International Handbook of Engineering Ethics Education. (pp. 213-229). Routledge: London, UK.

Wyrobnik, Tom A; Miranda, Laia; Lam, Alan; Oh, Steve; Ducci, Andrea; Micheletti, Martina; (2025) Scalable, High-Density Expansion of Human Mesenchymal Stem Cells on Microcarriers Using the Bach Impeller in Stirred-Tank Reactors. Biotechnology and Bioengineering , 122 (10) pp. 2803-2818. 10.1002/bit.70025.

Zhuang, Yibin; (2025) Towards the establishment of an efficient and scalable recovery process for pneumococcal glycoconjugate vaccines produced in Escherichia coli. Doctoral thesis (Ph.D), UCL (University College London).

2024

Alosert, Haneen; (2024) Big data analytics streamlining therapeutic drug development from micro-scale to bench-scale cell culture. Doctoral thesis (Eng.D), UCL (University College London).

Atanasova, Gergana G; Klettner, Christian A; Micheletti, Martina; Ducci, Andrea; (2024) On the fluid dynamics of spin-over in a partially filled cylinder. Physics of Fluids , 36 (12) , Article 124122. 10.1063/5.0239925.

Atanasova, Gergana Georgieva; (2024) Fluid flow, mixing and suspension in an intermittently rotating cylinder bioreactor for CAR-T cell therapy manufacturing. Doctoral thesis (Ph.D), UCL (University College London).

Atanasova, GG; Ducci, A; Micheletti, M; (2024) Fluid dynamics and mixing in a novel intermittently rotating bioreactor for CAR-T cell therapy: Spin-down from incomplete spin-up. Chemical Engineering Research and Design , 205 pp. 486-497. 10.1016/j.cherd.2024.04.016.

Ayrton, John-Paul; Ho, Chapman; Zhang, Haoran; Chudasama, Vijay; Frank, Stefanie; Thomas, Michael R; (2024) Multivalent nanobody engineering for enhanced physisorption and functional display on gold nanoparticles. Nanoscale , 16 pp. 19881-19896. 10.1039/d4nr02762k.

Blanco, Elena; Camps, Carme; Bahal, Sameer; Kerai, Mohit D; Ferla, Matteo P; Rochussen, Adam M; Handel, Adam E; ... Kreins, Alexandra Y; + view all Blanco, Elena; Camps, Carme; Bahal, Sameer; Kerai, Mohit D; Ferla, Matteo P; Rochussen, Adam M; Handel, Adam E; Golwala, Zainab M; Spiridou Goncalves, Helena; Kricke, Susanne; Klein, Fabian; Zhang, Fang; Zinghirino, Federica; Evans, Grace; Keane, Thomas M; Lizot, Sabrina; Kusters, Maaike AA; Iro, Mildred A; Patel, Sanjay V; Morris, Emma C; Burns, Siobhan O; Radcliffe, Ruth; Vasudevan, Pradeep; Price, Arthur; Gillham, Olivia; Valdebenito, Gabriel E; Stewart, Grant S; Worth, Austen; Adams, Stuart P; Duchen, Michael; Andre, Isabelle; Adams, David J; Santili, Giorgia; Gilmour, Kimberly C; Hollaender, Georg A; Davies, E Graham; Taylor, Jenny C; Griffiths, Gillian M; Thrasher, Adrian J; Dhalla, Fatima; Kreins, Alexandra Y; - view fewer (2024) Dominant negative variants in ITPR3 impair T cell Ca2+ dynamics causing combined immunodeficiency. Journal of Experimental Medicine (JEM) , 222 (1) , Article e20220979. 10.1084/jem.20220979.

Borgosz, L; Dikicioglu, D; (2024) Industrial internet of things: What does it mean for the bioprocess industries? Biochemical Engineering Journal , 201 , Article 109122. 10.1016/j.bej.2023.109122. (In press).

Bradford, Hannah F; Lalaurie, Christophe J; God, Jayesh; Gao, Xin; Pericleous, Charis; Perkins, Stephen J; Britt, Hannah; ... McDonnell, Thomas CR; + view all Bradford, Hannah F; Lalaurie, Christophe J; God, Jayesh; Gao, Xin; Pericleous, Charis; Perkins, Stephen J; Britt, Hannah; Thalassinos, Konstantinos; Giles, Ian; Rahman, Anisur; Delcea, Mihaela; Dalby, Paul A; McDonnell, Thomas CR; - view fewer (2024) Plasmin-Clipped Beta-2-Glycoprotein I: Novel Structures Lead to Increased Antibody Binding. Presented at: 7th European Conference of Immunology, Dublin, Ireland.

Chan, Choi Yee; (2024) 3D Biomimetic Scaffolds for In Vitro γδ T Cell Expansion. Doctoral thesis (Ph.D), UCL (University College London).

Charalambidou, Artemis-Danae; Wyrobnik, Tom A; Micheletti, Martina; Ducci, Andrea; (2024) Investigation of the impact of probes and internals on power and flow in stirred tank reactors. Chemical Engineering Science , 286 , Article 119683. 10.1016/j.ces.2023.119683.

Csalane Besenyei, Greta; (2024) Engineering Phaeodactylum for vaccine production. Doctoral thesis (Ph.D), UCL (University College London).

Davidson, Alexander James; (2024) Investigating the optimal expansion platform and bioprocessing parameters for the improved production of autologous chimeric antigen receptor T-cell immunotherapies. Doctoral thesis (Eng.D), UCL (University College London).

Delbridge, Jordan; (2024) A Comprehensive Characterisation of the Allegro™ Stirred Tank Bioreactor Towards Process Optimisation. Doctoral thesis (Eng.D), UCL (University College London).

Deuker, D; Asilonu, E; Bracewell, DG; Frank, S; (2024) Adeno-Associated Virus 5 Protein Particles Produced by E. coli Cell-Free Protein Synthesis. ACS Synthetic Biology 10.1021/acssynbio.4c00403. (In press).

Dorn, Marie; Klottrup-Rees, Kerensa; Lee, Ken; Micheletti, Martina; (2024) Platform development for high-throughput optimization of perfusion processes: Part I: Implementation of cell bleeds in microwell plates. Biotechnology and Bioengineering 10.1002/bit.28682. (In press).

Dorn, Marie; Lucas, Ciara; Klottrup-Rees, Kerensa; Lee, Ken; Micheletti, Martina; (2024) Platform development for high-throughput optimization of perfusion processes—Part II: Variation of perfusion rate strategies in microwell plates. Biotechnology and Bioengineering 10.1002/bit.28685. (In press).

Elia Venanzi, Niccolo Alberto; Basciu, Andrea; Vargiu, Attilio Vittorio; Kiparissides, Alexandros; Dalby, Paul A; Dikicioglu, Duygu; (2024) Machine Learning Integrating Protein Structure, Sequence, and Dynamics to Predict the Enzyme Activity of Bovine Enterokinase Variants. Journal of Chemical Information and Modeling 10.1021/acs.jcim.3c00999. (In press).

Escrich, A; Jonguitud-Borrego, N; Malci, K; Sanchez-Muñoz, R; Palazon, J; Rios-Solis, L; Moyano, E; (2024) A novel step towards the heterologous biosynthesis of paclitaxel: Characterization of T1βOH taxane hydroxylase. Metabolic Engineering , 85 pp. 201-212. 10.1016/j.ymben.2024.08.005.

Fanthom, Thomas Benjamin; (2024) Mechanisms of Therapeutic Protein Aggregation During Peristaltic Pumping. Doctoral thesis (Eng.D), UCL (University College London).

Firth, Jack; (2024) Exploring The Immunogenicity of Bacterial Outer Membrane Vesicles and Their Use in Cancer Immunotherapy. Doctoral thesis (Ph.D), UCL (University College London).

Frost, Sarah Chaney; (2024) Interchain disulfide bond reduction alters the structure and function of therapeutic monoclonal antibodies. Doctoral thesis (Ph.D), UCL (University College London).

Galindo-Rodriguez, Giuseppe Rafael; Sarwar, M Sulaiman; Rios-Solis, Leonardo; Dimartino, Simone; (2024) Development, characterization and application of 3D printed adsorbents for in situ recovery of taxadiene from microbial cultivations. Journal of Chromatography A , 1721 , Article 464815. 10.1016/j.chroma.2024.464815.

Gkoutzioupa, Victoria; (2024) Integrated Experimental Investigation of Upstream and Primary Recovery Operations to Improve Mammalian Cell Based Process Performance. Doctoral thesis (Ph.D), UCL (University College London).

Gulec, Fatih; Williams, Orla; Samson, Abby; Kostas, Emily T; Stevens, Lee A; Lester, Edward; (2024) Exploring the Utilisation of Natural Biosorbents for Effective Methylene Blue Removal. Applied Sciences , 14 (1) , Article 81. 10.3390/app14010081.

Gurgul, SJ; Kollamaram, G; Zhang, C; Williams, GR; (2024) An investigation into the effect of polysorbate 80 grade in biotherapeutic formulations. Journal of Excipients and Food Chemicals , 1 (1) pp. 25-55.

Hailes, Helen C; Wang, Yu; Li, Yiwen; Ni, Yeke; Bucar, Dejan-Kresimir; Dalby, Paul A; Ward, John M; Hailes, Helen C; Wang, Yu; Li, Yiwen; Ni, Yeke; Bucar, Dejan-Kresimir; Dalby, Paul A; Ward, John M; Jeffries, Jack; - view fewer (2024) A transaminase-mediated aldol reaction and applications in cascades to styryl pyridines. Catalysis Science & Technology 10.1039/d3cy01370g. (In press).

Hood, T; Slingsby, F; Sandner, V; Geis, W; Schmidberger, T; Bevan, N; Vicard, Q; ... Rafiq, QA; + view all Hood, T; Slingsby, F; Sandner, V; Geis, W; Schmidberger, T; Bevan, N; Vicard, Q; Hengst, J; Springuel, P; Dianat, N; Rafiq, QA; - view fewer (2024) A quality-by-design approach to improve process understanding and optimise the production and quality of CAR-T cells in automated stirred-tank bioreactors. Frontiers in Immunology , 15 , Article 1335932. 10.3389/fimmu.2024.1335932.

Howe, Geoffrey; Bal, Mehtap; Wasmuth, Matthew; Massaro, G; Rahim, Ahad; Ali, Sadfer; Rivera, Milena; ... Nesbeth, Darren; + view all Howe, Geoffrey; Bal, Mehtap; Wasmuth, Matthew; Massaro, G; Rahim, Ahad; Ali, Sadfer; Rivera, Milena; Schofield, D; Omotosho, Aminat; Ward, john; Keshavarz-Moore, Elaheh; Mason, Chris; Nesbeth, Darren; - view fewer (2024) An autonucleolytic suspension HEK293F host cell line for high-titre serum-free AAV5 and AAV9 production with reduced levels of DNA impurity. Molecular Therapy - Methods and Clinical Development , Article 101317. 10.1016/j.omtm.2024.101317. (In press).

Howe, Geoffrey; Wasmuth, matthew; Emanuelle, Pamela; Massaro, Giulia; Rahim, Ahad; Ali, sadfer; Rivera, Milena; ... Nesbeth, Darren; + view all Howe, Geoffrey; Wasmuth, matthew; Emanuelle, Pamela; Massaro, Giulia; Rahim, Ahad; Ali, sadfer; Rivera, Milena; Ward, john; Keshavarz-Moore, Elaheh; Mason, chris; Nesbeth, Darren; - view fewer (2024) Engineering an autonucleolytic mammalian suspension host cell line to reduce DNA impurity levels in serum-free lentiviral process streams. ACS Synthetic Biology , 13 (2) pp. 408-692. 10.1021/acssynbio.3c00682.

Hu, Heng; (2024) Evaluation of the Performance of Immobilised Enzymes in Batch and Continuous Reactions. Doctoral thesis (Ph.D), UCL (University College London).

Isimite, Joseph Ogochukwu; (2024) Development of a Biorefinery Training Simulator with Automatic Operating Procedure Adaptation. Doctoral thesis (Ph.D), UCL (University College London).

Jiang, W; Cai, Y; Sun, S; Wang, W; Tišma, M; Baganz, F; Hao, J; (2024) Inactivation of hydrogenase-3 leads to enhancement of 1,3-propanediol and 2,3-butanediol production by Klebsiella pneumoniae. Enzyme and Microbial Technology , 177 , Article 110438. 10.1016/j.enzmictec.2024.110438.

Jungbauer, Alois; Satzer, Peter; Duerauer, Astrid; Azevedo, Ana; Aires-Barros, Raquel; Nilsson, Bernt; Farid, Suzy; ... Marcelo Fernandez Lahore, Hector; + view all Jungbauer, Alois; Satzer, Peter; Duerauer, Astrid; Azevedo, Ana; Aires-Barros, Raquel; Nilsson, Bernt; Farid, Suzy; Goldrick, Stephen; Ottens, Marcel; Sponchioni, Mattia; Marcelo Fernandez Lahore, Hector; - view fewer (2024) Continuous downstream processing. Separation and Purification Technology , 338 , Article 126439. 10.1016/j.seppur.2024.126439.

Kashif-Khan, Naail; Savva, Renos; Frank, Stefanie; (2024) Mining metagenomics data for novel bacterial nanocompartments. NAR Genomics and Bioinformatics , 6 (1) , Article lqae025. 10.1093/nargab/lqae025.

Khiawjan, Sansanee; (2024) Intensification of biocatalytic process for the conversion of lignin derivative ferulic acid to high value chemicals. Doctoral thesis (Ph.D), UCL (University College London).

Lacerda, L; Flynn, AO; Pung, W; Heavey, B; Farid, Suzanne S; (2024) Reimagining the Future of Biopharmaceutical Digitalization. BioProcess International , 22 (9) pp. 10-17.

Liu, Shuchang; (2024) Assessment of CV-1 as a Production Cell Line for Large Scale Manufacturing of a Lister Strain Oncolytic Vaccinia Virus. Doctoral thesis (Ph.D), UCL (University College London).

Lyle, Annabel; (2024) Decisional Tools for Optimising Process Economics, Capacity Sourcing and Portfolio Management for Biotherapeutics. Doctoral thesis (Eng.D), UCL (University College London).

Matchett, KP; Wilson-Kanamori, JR; Portman, JR; Kapourani, CA; Fercoq, F; May, S; Zajdel, E; ... Henderson, NC; + view all Matchett, KP; Wilson-Kanamori, JR; Portman, JR; Kapourani, CA; Fercoq, F; May, S; Zajdel, E; Beltran, M; Sutherland, EF; Mackey, JBG; Brice, M; Wilson, GC; Wallace, SJ; Kitto, L; Younger, NT; Dobie, R; Mole, DJ; Oniscu, GC; Wigmore, SJ; Ramachandran, P; Vallejos, CA; Carragher, NO; Saeidinejad, MM; Quaglia, A; Jalan, R; Simpson, KJ; Kendall, TJ; Rule, JA; Lee, WM; Hoare, M; Weston, CJ; Marioni, JC; Teichmann, SA; Bird, TG; Carlin, LM; Henderson, NC; - view fewer (2024) Multimodal decoding of human liver regeneration. Nature 10.1038/s41586-024-07376-2. (In press).

Meng, Ke; (2024) Block copolymer-derived mesoporous membranes for bioprocessing. Doctoral thesis (Ph.D), UCL (University College London).

Moser, Andre; Appl, Christian; Poertner, Ralf; Baganz, Frank; Hass, Volker C; (2024) A New Concept for the Rapid Development of Digital Twin Core Models for Bioprocesses in Various Reactor Designs. Fermentation , 10 (9) , Article 463. 10.3390/fermentation10090463.

Mukhopadhyay, Arka; Karu, Kersti; Dalby, Paul A; (2024) Two-substrate enzyme engineering using small libraries that combine the substrate preferences from two different variant lineages. Scientific Reports , 14 , Article 1287. 10.1038/s41598-024-51831-z.

Neves, Catarina; (2024) Decision-support tool for bioprocess economics and sustainability analysis of end-to-end continuous antibody manufacturing strategies. Doctoral thesis (Ph.D), UCL (University College London).

Neves, Catarina PG; Coffman, Jonathan L; Farid, Suzanne S; (2024) Evaluating end-to-end continuous antibody manufacture with column-free capture alternatives from economic, environmental, and robustness perspectives. Biotechnology Progress , Article e3427. 10.1002/btpr.3427. (In press).

Nowrouzi, Behnaz; Torres-Montero, Pablo; Kerkhoven, Eduard J; Martínez, José L; Rios-Solis, Leonardo; (2024) Rewiring Saccharomyces cerevisiae metabolism for optimised Taxol® precursors production. Metabolic Engineering Communications , 18 , Article e00229. 10.1016/j.mec.2023.e00229.

Nweke, Mauryn C; (2024) An Investigative Review: How Well Does the Higher Engineering Education Curriculum Align With the UK’s Economic and National Goals? In: ECE Official Conference Proceedings. (pp. pp. 805-816). The International Academic Forum(IAFOR)

Nweke, Mauryn C; (2024) Evaluating Professional Skills Development Across the Engineering Undergraduate Degree Programme: An IEP Review. In: The Paris Conference on Education 2024: Official Conference Proceedings. (pp. pp. 469-481). The International Academic Forum (IAFOR)

Nweke, Mauryn C; Florez-Martin, Maria; Ackerley, Samuel; Truscott, Fiona; (2024) Teaching Scientific Writing in the Era of ChatGPT. In: The Paris Conference on Education 2024: Official Conference Proceedings. (pp. pp. 483-496). The International Academic Forum(IAFOR)

Ovari, Gyorgy; Johnson, Thomas F; Foroutan, Farzad; Malmquist, Gunnar; Townsend, Matthew; Bracewell, Daniel G; (2024) Fabrication of electrospun ion exchanger adsorbents with morphologies designed for the separation of proteins and plasmid DNA. Journal of Chromatography A , 1734 , Article 465268. 10.1016/j.chroma.2024.465268.

Pandya, Akash; Zhang, Cheng; Barata, Teresa S; Brocchini, Steve; Howard, Mark J; Zloh, Mire; Dalby, Paul A; (2024) Molecular Dynamics Simulations Reveal How Competing Protein-Surface Interactions for Glycine, Citrate, and Water Modulate Stability in Antibody Fragment Formulations. Molecular Pharmaceutics 10.1021/acs.molpharmaceut.4c00332.

Pannerchelvan, Sangkaran; Rios-Solis, Leonardo; Wasoh, Helmi; Sobri, Mohamad Zulfazli Mohd; Faizal Wong, Fadzlie Wong; Mohamed, Mohd Shamzi; Mohamad, Rosfarizan; Pannerchelvan, Sangkaran; Rios-Solis, Leonardo; Wasoh, Helmi; Sobri, Mohamad Zulfazli Mohd; Faizal Wong, Fadzlie Wong; Mohamed, Mohd Shamzi; Mohamad, Rosfarizan; Halim, Murni; - view fewer (2024) Functional yogurt: a comprehensive review of its nutritional composition and health benefits. Food and Function , 15 (22) pp. 10927-10955. 10.1039/d4fo03671a.

Parker, Brenda; Cruz, Marcos; (2024) Augmented Polycultures: Scaling up Algal Ecosystems and Design of a Biofouling Aesthetic. In: Hendlin, Yogi Hale and Weggelar, Johanna and Derossi, Natalia and Mugnai, Sergio, (eds.) Being Algae: Transformations in Water, Plants. (pp. 234-267). Brill: Leiden, Netherlands.

Prout, Luba; Hailes, Helen C; Ward, John M; (2024) Natural transaminase fusions for biocatalysis. RSC Advances , 14 (6) pp. 4264-4273. 10.1039/d3ra07081f.

Ramin, Elham; Cardillo, Antonio Gaetano; Liebers, Reinhard; Schmölder, Johannes; Von Lieres, Eric; Van Molle, Wim; Niebel, Bastian; ... Gernaey, Krist V; + view all Ramin, Elham; Cardillo, Antonio Gaetano; Liebers, Reinhard; Schmölder, Johannes; Von Lieres, Eric; Van Molle, Wim; Niebel, Bastian; Natalis, Laurent; Meln, Irina; Perea-Vélez, Mónica; Clénet, Didier; Jørgensen, John Bagterp; Nilsson, Bernt; Bracewell, Daniel G; Gernaey, Krist V; - view fewer (2024) Accelerating vaccine manufacturing development through model-based approaches: current advances and future opportunities. Current Opinion in Chemical Engineering , 43 , Article 100998. 10.1016/j.coche.2023.100998.

Redwood-Sawyerr, Chileab; Howe, Geoffrey; Theodore, Andalucia Evans; Nesbeth, Darren N; (2024) Genetically Encoded Trensor Circuits Report HeLa Cell Treatment with Polyplexed Plasmid DNA and Small-Molecule Transfection Modulators. ACS Synthetic Biology , 13 (10) pp. 3163-3172. 10.1021/acssynbio.4c00148.

Ripoll Fiol, Carme; (2024) Development of a scalable and robust upstream process for the chemically-defined production of lentiviral vectors for gene-modified cellular immunotherapies. Doctoral thesis (Eng.D), UCL (University College London).

Rizzo, Andrea; Aranda, Carmen; Galman, James; Alcasabas, Annette; Pandya, Akash; Bornadel, Amin; Costa, Bruna; ... Dominguez, Beatriz; + view all Rizzo, Andrea; Aranda, Carmen; Galman, James; Alcasabas, Annette; Pandya, Akash; Bornadel, Amin; Costa, Bruna; Hailes, Helen C; Ward, John M; Jeffries, Jack WE; Dominguez, Beatriz; - view fewer (2024) Broadening The Substrate Scope of Aldolases Through Metagenomic Enzyme Discovery. ChemBioChem , Article e202400278. 10.1002/cbic.202400278. (In press).

Salinger, Matthew T; Castellano Garrido, Daniel; Lamming, Eleanor D; Ward, John M; Moody, Thomas S; Jeffries, Jack WE; Hailes, Helen C; (2024) An Alternative Cascade for the Selective Methylation of Catechols and Tetrahydroisoquinolines by O-Methyltransferases. ChemCatChem , 16 (7) , Article e202400492. 10.1002/cctc.202400492.

Salinger, Matthew T; Ward, John M; Moody, Thomas S; Jeffries, Jack WE; Hailes, Helen C; (2024) Bioalkylation Strategies to Synthesize Allylated Tetrahydroisoquinolines by Using Norcoclaurine Synthase and O-Methyltransferases. ChemCatChem , Article e202401668. 10.1002/cctc.202401668. (In press).

Sari, Yustika; Sousa Rosa, Sara; Jeffries, Jack; Marques, Marco PC; (2024) Comprehensive evaluation of T7 promoter for enhanced yield and quality in mRNA production. Scientific Reports , 14 (1) , Article 9655. 10.1038/s41598-024-59978-5.

Sawadkar, Prasad; Mandakhbayar, Nandin; Patel, Kapil D; Owji, Nazanin; Rajasekar, Poojitha; Sarama, Roudin; Lee, Jung-Hwan; ... Garcia-Gareta, Elena; + view all Sawadkar, Prasad; Mandakhbayar, Nandin; Patel, Kapil D; Owji, Nazanin; Rajasekar, Poojitha; Sarama, Roudin; Lee, Jung-Hwan; Kim, Hae-Won; Knowles, Jonathan; Garcia-Gareta, Elena; - view fewer (2024) 3D Porous Binary Composites of Collagen, Elastin, and Fibrin Proteins Orchestrate Adipose Tissue Regeneration. Macromolecular Bioscience , Article 2400073. 10.1002/mabi.202400073. (In press).

Sharma, Paras; Robbel, Lars; Schmitt, Michael; Dikicioglu, Duygu; Bracewell, Daniel G; (2024) Integrated micro-scale protein a chromatography and Low pH viral inactivation unit operations on an automated platform. Biotechnology Progress , Article e3476. 10.1002/btpr.3476.

Söderström, Ksheereja; (2024) Scale-down models for increased capacity in egg-based Influenza vaccines manufacturing. Doctoral thesis (Ph.D), UCL (University College London).

Sodhi, GK; Kaur, G; George, N; Walia, HK; Sillu, D; Rath, SK; Saxena, S; ... Dwibedi, V; + view all Sodhi, GK; Kaur, G; George, N; Walia, HK; Sillu, D; Rath, SK; Saxena, S; Rios-Solis, L; Dwibedi, V; - view fewer (2024) Waste to wealth: microbial-based valorization of grape pomace for nutraceutical, cosmetic, and therapeutic applications to promote circular economy. Process Safety and Environmental Protection , 188 pp. 1464-1478. 10.1016/j.psep.2024.06.059.

Spiteri, Valentina A; Doutch, James; Rambo, Robert P; Bhatt, Jayesh S; Gor, Jayesh; Dalby, Paul A; Perkins, Stephen J; (2024) Using atomistic solution scattering modelling to elucidate the role of the Fc glycans in human IgG4. PLoS One , 19 (4) , Article e0300964. 10.1371/journal..

Stibbs, Dale J; Silva Couto, Pedro; Takeuchi, Yasuhiro; Rafiq, Qasim A; Jackson, Nigel B; Rayat, Andrea CME; (2024) Continuous manufacturing of lentiviral vectors using a stable producer cell line in a fixed-bed bioreactor. Molecular Therapy: Methods & Clinical Development , 32 (1) , Article 101209. 10.1016/j.omtm.2024.101209.

Suarez Heredia, Ricardo; (2024) A combined in-vitro and in-silico investigation on the design and optimisation of nutrient supplementation strategies for mammalian cell cultures. Doctoral thesis (Ph.D), UCL (University College London).

Talukdar, Avishek; Kundu, Pritha; Bhattacharya, Sayan; Dutta, Nalok; (2024) Microplastic contamination in wastewater: Sources, distribution, detection and remediation through physical and chemical-biological methods. Science of the Total Environment , 916 , Article 170254. 10.1016/j.scitotenv.2024.170254.

Torres-Acosta, Mario A; Bozeat, Pierce; Ceballos Rodriguez-Conde, Fatima; Kent, Ross; Leitão, Nuno; Lye, Gary J; Dikicioglu, Duygu; (2024) Practical considerations for the high-level automation of a biosciences research laboratory. Biochemical Engineering Journal , 201 , Article 109154. 10.1016/j.bej.2023.109154.

Torres-Acosta, Mario A; Olivares-Molina, Alex; Kent, Ross; Leitão, Nuno; Gershater, Markus; Parker, Brenda; Lye, Gary J; Torres-Acosta, Mario A; Olivares-Molina, Alex; Kent, Ross; Leitão, Nuno; Gershater, Markus; Parker, Brenda; Lye, Gary J; Dikicioglu, Duygu; - view fewer (2024) Practical Deployment of Automation to Expedite Aqueous Two-Phase Extraction. Journal of Biotechnology , 387 pp. 32-43. 10.1016/j.jbiotec.2024.03.013.

Van de Steen, Alexander; Wilkinson, Henry C; Dalby, Paul A; Frank, Stefanie; (2024) Encapsulation of Transketolase into In Vitro-Assembled Protein Nanocompartments Improves Thermal Stability. ACS Applied Biomaterials , 7 (6) pp. 3660-3674. 10.1021/acsabm.3c01153.

Venanzi, Niccolò Alberto Elia; (2024) Machine Learning for Protein Engineering Using Molecular Dynamics Simulation Data. Doctoral thesis (Ph.D), UCL (University College London).

Wang, Q; Jiang, W; Cai, Y; Tišma, M; Baganz, F; Shi, J; Lye, GJ; ... Hao, J; + view all Wang, Q; Jiang, W; Cai, Y; Tišma, M; Baganz, F; Shi, J; Lye, GJ; Xiang, W; Hao, J; - view fewer (2024) 2-Hydroxyisovalerate production by Klebsiella pneumoniae. Enzyme and Microbial Technology , 172 , Article 110330. 10.1016/j.enzmictec.2023.110330.

Wanika, Linda; Egan, Joseph R; Swaminathan, Nivedhitha; Duran-Villalobos, Carlos A; Branke, Juergen; Goldrick, Stephen; Chappell, Mike; (2024) Structural and practical identifiability analysis in bioengineering: a beginner’s guide. Journal of Biological Engineering , 18 , Article 20. 10.1186/s13036-024-00410-x.

Williams-Fegredo, Thomas Edward; (2024) Developing strategies to enhance transfection efficiency and mitigate auto-transduction in transient lentiviral vector bioprocessing. Doctoral thesis (Ph.D), UCL (University College London).

Wood, Victoria E; Kellerman, Mark-Adam; Groves, Kate; Quaglia, Milena; Topp, Elizabeth M; Matejtschuk, Paul; Dalby, Paul A; (2024) Investigation of the Solid-State Interactions in Lyophilized Human G-CSF Using Hydrogen-Deuterium Exchange Mass Spectrometry. Molecular Pharmaceutics , 21 (4) pp. 1965-1976. 10.1021/acs.molpharmaceut.3c01211.

Worsham, Robert D; (2024) Continuous Manufacturing of Liposomal Drug Products. Doctoral thesis (Ph.D), UCL (University College London).

Wyrobnik, Tom A; Oh, Steve; Micheletti, Martina; Ducci, Andrea; (2024) Insights into the fluid dynamics of the Bach impeller. Chemical Engineering Research and Design , 206 pp. 511-523. 10.1016/j.cherd.2024.05.026.

Yamanie, Almir; (2024) Towards Upstream Process Development Using Mixed Induction Strategy and Continuous System in Cultivation of Komagataella phaffii. Doctoral thesis (Ph.D), UCL (University College London).

Yoon, John K; Schindler, Jeffrey W; Loperfido, Mariana; Baricordi, Cristina; DeAndrade, Mark P; Jacobs, Mary E; Treleaven, Christopher; ... van Til, Niek P; + view all Yoon, John K; Schindler, Jeffrey W; Loperfido, Mariana; Baricordi, Cristina; DeAndrade, Mark P; Jacobs, Mary E; Treleaven, Christopher; Plasschaert, Robert N; Yan, Aimin; Barese, Cecilia N; Dogan, Yildirim; Chen, Vicky Ping; Fiorini, Claudia; Hull, Fritz; Barbarossa, Luigi; Unnisa, Zeenath; Ivanov, Daniel; Kutner, Robert H; Guda, Swaroopa; Oborski, Christine; Maiwald, Tim; Michaud, Véronique; Rothe, Michael; Schambach, Axel; Pfeifer, Richard; Mason, Chris; Biasco, Luca; van Til, Niek P; - view fewer (2024) Preclinical lentiviral vector-mediated hematopoietic stem and progenitor cell gene therapy corrects Pompe disease-related muscle and neurological manifestations. Molecular Therapy , 32 (11) pp. 3847-3864. 10.1016/j.ymthe.2024.09.024.

Youngthong, Chalermkiart; (2024) Establishing yeast Komagataella phaffii as an expression platform for prokaryotic nanocompartments and its potential application for antigen display. Doctoral thesis (Ph.D), UCL (University College London).

2023

Abdullah Thaidi, Nur Imanina; Mohamad, Rosfarizan; Wasoh, Helmi; Kapri, Mohammad Rizal; Ghazali, Ahmad Badruddin; Tan, Joo Shun; Rios-Solis, Leonardo; Abdullah Thaidi, Nur Imanina; Mohamad, Rosfarizan; Wasoh, Helmi; Kapri, Mohammad Rizal; Ghazali, Ahmad Badruddin; Tan, Joo Shun; Rios-Solis, Leonardo; Halim, Murni; - view fewer (2023) Development of In Situ Product Recovery (ISPR) System Using Amberlite IRA67 for Enhanced Biosynthesis of Hyaluronic Acid by Streptococcus zooepidemicus. Life , 13 (2) , Article 558. 10.3390/life13020558.

Alhubaysh, Abeer Abdullah; (2023) Investigating the Optimal Storage Conditions for the Manufacture and Delivery of CAR-T cells. Doctoral thesis (Ph.D), UCL (University College London).

Ali, Sadfer; Rivera, Milena; Ward, John; Keshavarz-Moore, Eli; Mason, Chris; Nesbeth, Darren; (2023) Serum-free lentiviral vector production is compatible with medium-resident nuclease activity arising from adherent HEK293T host cells engineered with a nuclease-encoding transgene. Heliyon , 9 (6) , Article e17067. 10.1016/j.heliyon.2023.e17067.

Ambrose-Dempster, Esther; Leipold, Leona; Dobrijevic, Dragana; Bawn, Maria; Carter, Eve M; Stojanovski, Gorjan; Sheppard, Tom D; ... Hailes, Helen C; + view all Ambrose-Dempster, Esther; Leipold, Leona; Dobrijevic, Dragana; Bawn, Maria; Carter, Eve M; Stojanovski, Gorjan; Sheppard, Tom D; Jeffries, Jack WE; Ward, John M; Hailes, Helen C; - view fewer (2023) Mechanoenzymatic reactions for the hydrolysis of PET. RSC Advances , 13 (15) pp. 9954-9962. 10.1039/d3ra01708g.

Appl, Christian Bernhard; (2023) A new digital twin for enzymatic hydrolysis processes applied to model-based process design. Doctoral thesis (Ph.D), UCL (University College London).

Atanasova, GG; Micheletti, M; Ducci, A; (2023) Fluid flow and mixing in a novel intermittently rotating bioreactor for CAR-T cell therapy manufacturing. Chemical Engineering Science , 281 , Article 119175. 10.1016/j.ces.2023.119175.

Bandyopadhyay, Sushobhan; Pavlika, Vasos; Bracewell, Daniel; Nesbeth, Darren; (2023) A biological OR(XNOR) logic gate couples carbon source and transgene expression switching in a Komagatella phaffii (Pichia pastoris) strain co-producing process-enhancing lipase and a virus-like particle (VLP) vaccine. ACS Synthetic Biology , 12 (3) pp. 657-663. 10.1021/acssynbio.2c00342.

Barbieri, Eduardo; Mollica, Gina N; Moore, Brandyn D; Sripada, Sobhana A; Shastry, Shriarjun; Kilgore, Ryan E; Loudermilk, Casee M; ... Menegatti1, Stefano; + view all Barbieri, Eduardo; Mollica, Gina N; Moore, Brandyn D; Sripada, Sobhana A; Shastry, Shriarjun; Kilgore, Ryan E; Loudermilk, Casee M; Whitacre, Zachary H; Kilgour, Katie M; Wuestenhagen, Elena; Aldinger, Annika; Graalfs, Heiner; Rammo, Oliver; Schulte, Michael M; Johnson, Thomas F; Daniele, Michael A; Menegatti1, Stefano; - view fewer (2023) Peptide ligands targeting the vesicular stomatitis virus G (VSV-G) protein for the affinity purification of lentivirus particles. Biotechnology and Bioengineering 10.1002/bit.28594. (In press).

Barnes, Benjamin; (2023) Process Development for Recovery and Purification of Extracellular Vesicles for Biological Products. Doctoral thesis (Eng.D), UCL (University College London).

Bhattacharya, Sayan; Talukdar, Avishek; Sengupta, Shubhalakshmi; Das, Tuyelee; Dey, Abhijit; Gupta, Kaushik; Dutta, Nalok; (2023) Arsenic contaminated water remediation: A state-of-the-art review in synchrony with sustainable development goals. Groundwater for Sustainable Development , 23 , Article 101000. 10.1016/j.gsd.2023.101000.

Bhavsar, Gaurav; (2023) Evaluation of Primary Capture Procedures for Recombinant Antibodies Manufactured in Pichia pastoris: Method, Viability and Economics. Doctoral thesis (Ph.D), UCL (University College London).

Biswas, G; Mukherjee, D; Dutta, N; Ghosh, P; Basu, S; (2023) EnCPdock: a web-interface for direct conjoint comparative analyses of complementarity and binding energetics in inter-protein associations. Journal of Molecular Modeling , 29 , Article 239. 10.1007/s00894-023-05626-0.

Booth, Matthew; (2023) Development of a turbidostat photo-bioreactor to investigate the effects of process parameters on the physiology and growth of micro-algae. Doctoral thesis (Eng.D), UCL (University College London).

Budd, Jobie; Miller, Benjamin S; Weckman, Nicole E; Cherkaoui, Dounia; Huang, Da; Decruz, Alyssa Thomas; Fongwen, Noah; ... McKendry, Rachel A; + view all Budd, Jobie; Miller, Benjamin S; Weckman, Nicole E; Cherkaoui, Dounia; Huang, Da; Decruz, Alyssa Thomas; Fongwen, Noah; Han, Gyeo-Re; Broto, Marta; Estcourt, Claudia S; Gibbs, Jo; Pillay, Deenan; Sonnenberg, Pam; Meurant, Robyn; Thomas, Michael R; Keegan, Neil; Stevens, Molly M; Nastouli, Eleni; Topol, Eric J; Johnson, Anne M; Shahmanesh, Maryam; Ozcan, Aydogan; Collins, James J; Fernandez Suarez, Marta; Rodriguez, Bill; Peeling, Rosanna W; McKendry, Rachel A; - view fewer (2023) Lateral flow test engineering and lessons learned from COVID-19. Nature Reviews Bioengineering , 1 pp. 13-31. 10.1038/s44222-022-00007-3.

Cárdenas‐Fernández, Max; Roddan, Rebecca; Carter, Eve M; Hailes, Helen C; Ward, John M; (2023) The Discovery of Imine Reductases and their Utilisation for the Synthesis of Tetrahydroisoquinolines. ChemCatChem 10.1002/cctc.202201126. (In press).

Couto, Pedro Silva; Stibbs, Dale J; Rotondi, Marco C; Takeuchi, Yasuhiro; Rafiq, Qasim A; (2023) Scalable manufacturing of gene-modified human mesenchymal stromal cells with microcarriers in spinner flasks. Applied Microbiology and Biotechnology 10.1007/s00253-023-12634-w. (In press).

De Sa Magalhaes, Salome; Morris, Stephen; Kusumawardani, Shinta; Riza, Acep Wijayadikusumah; Nurainy, Neni; Keshavarz-Moore, Eli; (2023) Technical transfer of a rapid microbial platform for vaccine production. Vaccine Insights , 2 (4) pp. 133-146. 10.18609/vac.2023.024.

Delbridge, JN; Barrett, TA; Ducci, A; Micheletti, M; (2023) Suspension and flow dynamics of the Allegro™ stirred tank reactor. Chemical Engineering Research and Design , 195 pp. 355-369. 10.1016/j.cherd.2023.05.047.

Delbridge, JN; Barrett, TA; Ducci, A; Micheletti, M; (2023) Power, mixing and flow dynamics of the novel Allegro™ stirred tank reactor. Chemical Engineering Science , 271 , Article 118545. 10.1016/j.ces.2023.118545.

Dutta, Nalok; Kundu, Pritha; Lee, Jonathan Tian En; Bhattacharya, Sayan; (2023) Implementation and Optimization of Algal Biomass in Value-Added Products Recovery: A Step towards Algae-Based Green Economy. Hydrobiology , 2 (2) pp. 326-346. 10.3390/hydrobiology2020021.

Fanthom, Thomas B; Wilson, Christopher; Gruber, David; Bracewell, Daniel G; (2023) Solid-Solid Interfacial Contact of Tubing Walls Drives Therapeutic Protein Aggregation During Peristaltic Pumping. Journal of Pharmaceutical Sciences 10.1016/j.xphs.2023.08.012. (In press).

Farid, Suzanne S; Dikicioglu, Duygu; Goldrick, Stephen; Lye, Gary J; (2023) Delivering the Digital Skills Needs of the Bioprocessing Sector: Realizing the Vision of Industry 4.0 for Your Organization. BioProcess International , 21 (1-2) pp. 20-25.

Fiol, Carme Ripoll; Collignon, Marie-Laure; Welsh, John; Rafiq, Qasim A; (2023) Optimizing and developing a scalable, chemically defined, animal component-free lentiviral vector production process in a fixed-bed bioreactor. Molecular Therapy - Methods & Clinical Development , 30 pp. 221-234. 10.1016/j.omtm.2023.06.011.

Flores Fernández, Carol Nathali; (2023) Novel thermophilic pectinases for recycling sustainable biomass. Doctoral thesis (Ph.D), UCL (University College London).

Flores-Fernández, Carol N; Cárdenas-Fernández, Max; Lye, Gary J; Ward, John M; (2023) Co-expression of thermophilic pectinases in a single host for cost-effective pectin bioconversion into D-galacturonic acid. Frontiers in Catalysis , 3 , Article 1112154. 10.3389/fctls.2023.1112154.

Galindo-Rodriguez, Giuseppe R; Santoyo-Garcia, Jorge H; Rios-Solis, Leonardo; Dimartino, Simone; (2023) In situ recovery of taxadiene using solid adsorption in cultivations with Saccharomyces cerevisiae. Preparative Biochemistry & Biotechnology 10.1080/10826068.2023.2207204. (In press).

Gangadharan, Nishanthi; Cankorur-Cetinkaya, Ayca; Cheeks, Matthew; Routh, Alexander F; Dikicioglu, Duygu; (2023) Online Data Condensation for Digitalised Biopharmaceutical Processes. Computers & Chemical Engineering , 179 , Article 108402. 10.1016/j.compchemeng.2023.108402.

George, Vaques; (2023) The Bioprocessing of T cells and T cell Derived Extracellular Vesicles. Doctoral thesis (Ph.D), UCL (University College London).

Glyn, Veronica Audrey Marie; (2023) Development of predictive, experimentally driven mathematical models for CAR T cell therapy production. Doctoral thesis (Ph.D), UCL (University College London).

Goebel, Sven; Jaen, Karim EE; Dorn, Marie; Neumeyer, Victoria; Jordan, Ingo; Sandig, Volker; Reichl, Udo; ... Genzel, Yvonne; + view all Goebel, Sven; Jaen, Karim EE; Dorn, Marie; Neumeyer, Victoria; Jordan, Ingo; Sandig, Volker; Reichl, Udo; Altomonte, Jennifer; Genzel, Yvonne; - view fewer (2023) Process intensification strategies toward cell culture-based high-yield production of a fusogenic oncolytic virus. Biotechnology and Bioengineering , 120 (9) pp. 2639-2657. 10.1002/bit.28353.

Goldrick, S; Alosert, H; Lovelady, C; Bond, NJ; Senussi, T; Hatton, D; Klein, J; ... Farid, SS; + view all Goldrick, S; Alosert, H; Lovelady, C; Bond, NJ; Senussi, T; Hatton, D; Klein, J; Cheeks, M; Turner, R; Savery, J; Farid, SS; - view fewer (2023) Next-generation cell line selection methodology leveraging data lakes, natural language generation and advanced data analytics. Frontiers in Bioengineering and Biotechnology , 11 , Article 1160223. 10.3389/fbioe.2023.1160223.

Gulec, Fatih; Sudibyo, Hanifrahmawan; Kostas, Emily T; Williams, Orla; Samson, Abby; Meredith, Will; Lester, Edward; (2023) A comprehensive analysis on the synthesis of value-added chemicals via slow pyrolysis: Valorisation of rapeseed residue, whitewood, and seaweed (Laminaria digitata). Journal of Analytical and Applied Pyrolysis , 173 , Article 106093. 10.1016/j.jaap.2023.106093.

Gunn, Rebecca; (2023) Novel Biopolymers for the Activation and Expansion of T-cells: Towards 3D Scaffolds for Cell Therapy. Doctoral thesis (Eng.D), UCL (University College London).

Guo, H; Li, W; Zhu, C; Chen, Y; Dalby, PA; Fan, D; (2023) Enhancement of thermal stability of Bacillus subtilis 168 glycosyltransferase YjiC based on PoPMuSiC algorithm and its catalytic conversion of rare ginsenoside PPD. Process Biochemistry , 132 pp. 1-12. 10.1016/j.procbio.2023.07.005.

Harvey, Joseph Gregory Havelock; (2023) Using a microfluidic approach to test for critical quality attributes of viral vectors for gene therapy applications. Doctoral thesis (Eng.D), UCL (University College London).

Heshmatifar, Shahin; (2023) Towards Extracellular Release of Recombinant Protein from Escherichia coli During Fermentation: Utilisation of Antisense Technology in Bioprocesses. Doctoral thesis (Ph.D), UCL (University College London).

Hood, Tiffany Tamara; (2023) Development of a robust and efficient manufacturing process for improved production of chimeric antigen receptor T cell (CAR-T) immunotherapies. Doctoral thesis (Ph.D), UCL (University College London).

Jennings, MD; Srivastava, P; Kershaw, CJ; Talavera, D; Grant, CM; Pavitt, GD; (2023) Interaction of the La-related protein Slf1 with colliding ribosomes maintains translation of oxidative-stress responsive mRNAs. Nucleic Acids Research , 51 (11) pp. 5755-5773. 10.1093/nar/gkad272.

Jiang, Z; Dalby, PA; (2023) Challenges in scaling up AAV-based gene therapy manufacturing. Trends in Biotechnology , 41 (10) pp. 1268-1281. 10.1016/j.tibtech.2023.04.002.

Johnson, Thomas; Bracewell, Daniel; (2023) Visualization and Characterization of Chromatography Structures: Imaging at Packed-Bed and Individual-Bead Scales. BioProcess International , 21 (10) pp. 30-33.

Johnson, Thomas F; Conti, Mariachiara; Iacoviello, Francesco; Bracewell, Daniel; Shearing, Paul R; Pullen, James; Dimartino, Simone; Johnson, Thomas F; Conti, Mariachiara; Iacoviello, Francesco; Bracewell, Daniel; Shearing, Paul R; Pullen, James; Dimartino, Simone; Bracewell, Daniel G; - view fewer (2023) Evaluating 3D-printed bioseparation structures using multi-length scale tomography. Analytical and Bioanalytical Chemistry 10.1007/s00216-023-04866-6. (In press).

Kalkan, Ali Kerem; Palaz, Fahreddin; Sofija, Semeniuk; Elmousa, Nada; Ledezma, Yuri; Cachat, Elise; Rios-Solis, Leonardo; (2023) Improving recombinant protein production in CHO cells using the CRISPR-Cas system. Biotechnology Advances , 64 , Article 108115. 10.1016/j.biotechadv.2023.108115.

Karagoz, Pinar; Khiawjan, Sansanee; Marques, Marco PC; Santzouk, Samir; Bugg, Timothy DH; Lye, Gary J; (2023) Pharmaceutical applications of lignin-derived chemicals and lignin-based materials: linking lignin source and processing with clinical indication. Biomass Conversion and Biorefinery 10.1007/s13399-023-03745-5. (In press).

Kellerman, Mark-Adam Walter; (2023) Mapping Functionally Important and Stabilising Regions in Biotherapeutic Proteins, using NMR and Mutagenesis. Doctoral thesis (Ph.D), UCL (University College London).

Khalife, Rana; Springer, Pierre; Nweke, Chika; (2023) Investigating the Usage of Labster and Its Future Implications for Industry and Academia. In: The European Conference on Education 2023: Official Conference Proceedings. (pp. pp. 351-360). The International Academic Forum (IAFOR)

Lalaurie, Christophe Jean; (2023) Structural Studies of pH Effects on Botulinum Toxins A & E. Doctoral thesis (Ph.D), UCL (University College London).

Linke, Julia A; Rayat, Andrea; Ward, John M; (2023) Production of indigo by recombinant bacteria. Bioresources and Bioprocessing , 10 , Article 20. 10.1186/s40643-023-00626-7.

Lopes Viana Nunes, Sofia; (2023) Establishing Ultra Scale-Down Tools for the Rational Design of Linked Bioprocesses: Flocculation and Centrifugation. Doctoral thesis (Ph.D), UCL (University College London).

Lyle, Annabel; Stamatis, Christos; Linke, Thomas; Hulley, Martyn; Schmelzer, Albert; Turner, Richard; Farid, Suzanne S; (2023) Process economics evaluation and optimization of adeno-associated virus downstream processing. Biotechnology and Bioengineering 10.1002/bit.28402. (In press).

Malcı, Koray; Santibáñez, Rodrigo; Jonguitud-Borrego, Nestor; Santoyo-Garcia, Jorge H; Kerkhoven, Eduard J; Rios-Solis, Leonardo; (2023) Improved production of Taxol® precursors in S. cerevisiae using combinatorial in silico design and metabolic engineering. Microbial Cell Factories , 22 , Article 243. 10.1186/s12934-023-02251-7.

Marques, MPC; Aranda Hernandez, J; Fernandes, P; (2023) β-Sitosterol Bioconversion in Small-Scale Devices: From Microtiter Plates to Microfluidic Reactors. Methods in Molecular Biology , 2704 pp. 201-219. 10.1007/978-1-0716-3385-4_12.

Melinek, Beatrice Judith; Tuck, Jade; Probert, Philip; Branton, Harvey; Bracewell, Daniel G; (2023) Designing of an extract production protocol for industrial application of cell‐free protein synthesis technology: Building from a current best practice to a quality by design approach. Engineering Biology , 7 (1-4) pp. 1-17. 10.1049/enb2.12029.

Meng, Ke; Johnson, Thomas F; Alvarez-Fernandez, Alberto; Guldin, Stefan; Bracewell, Daniel G; (2023) Opportunities for isoporous membranes in the manufacture of genomic medicines. Journal of Membrane Science Letters , 3 (2) , Article 100052. 10.1016/j.memlet.2023.100052.

Morris, Stephen A; Vaiarelli, Ludovica; De Sa Magalhaes, Salome; Micheletti, Martina; (2023) Increasing understanding of the role of engineering in vaccine development and manufacture: A collaborative project between UCL-Oxford Future Vaccine Manufacturing Research Hub (Vax-Hub) and UK secondary schools. Presented at: 17th Vaccine Congress, Glasgow, UK.

Nettleton, David F; Marí-Buyé, Núria; Marti-Soler, Helena; Egan, Joseph R; Hort, Simon; Horna, David; Costa, Miquel; ... R. Reyes, Aldo; + view all Nettleton, David F; Marí-Buyé, Núria; Marti-Soler, Helena; Egan, Joseph R; Hort, Simon; Horna, David; Costa, Miquel; Vallejo Benítez-Cano, Elia; Goldrick, Stephen; Rafiq, Qasim A; König, Niels; Schmitt, Robert H; R. Reyes, Aldo; - view fewer (2023) Smart Sensor Control and Monitoring of an Automated Cell Expansion Process. Sensors , 23 (24) , Article 9676. 10.3390/s23249676.

Ni, Yeke; Wang, Yu; Tabor, Alethea B; Ward, John M; Hailes, Helen C; (2023) The use of tyrosinases in a chemoenzymatic cascade as a peptide ligation strategy. RSC Chemical Biology 10.1039/d2cb00237j. (In press).

Noppiboon, S; Lapanusorn, N; Ekkpongpaisit, P; Slack, S; Frank, S; Hocharoen, L; (2023) A Simple and Cost-Efficient Platform for a Novel Porcine Circovirus Type 2d (PCV2d) Vaccine Manufacturing. Vaccines , 11 (1) , Article 169. 10.3390/vaccines11010169.

Nunes, Sofia LV; Mannall, Gareth J; Rayat, Andrea CME; (2023) Integrated ultra scale-down and multivariate analysis of flocculation and centrifugation for enhanced primary recovery. Food and Bioproducts Processing , 139 pp. 61-74. 10.1016/j.fbp.2023.02.008.

Nweke, Mauryn C; Banner, Matthew; Chaib, Manal; (2023) An Investigation Into ChatGPT Generated Assessments: Can We Tell the Difference? In: The Barcelona Conference on Education 2023: Official Conference Proceedings. (pp. pp. 1-6). The International Academic Forum(IAFOR)

Nweke, Mauryn C; Chaib, Manal; Banner, Matthew; (2023) Investigating the Challenges of Teamwork for 1st Year Undergraduate Engineering Students. In: The European Conference on Education 2023 Official Conference Proceedings. The International Academic Forum (IAFOR)

Nweke, Mauryn C; Sulu, Michael; (2023) Addressing the Attainment Gap: Investigating Gaps in Personal Tutoring Provision. In: The Barcelona Conference on Education 2023: Official Conference Proceedings. (pp. pp. 1-9). The International Academic Forum(IAFOR)

Otun, Sarah; Escrich, Ainoa; Achilonu, Ikechukwu; Rauwane, Molemi; Lerma-Escalera, Jordy Alexis; Morones-Ramírez, José Rubén; Rios-Solis, Leonardo; (2023) The future of cassava in the era of biotechnology in Southern Africa. Critical Reviews in Biotechnology , 43 (4) pp. 594-612. 10.1080/07388551.2022.2048791.

Pamenter, George; Davies, Lee; Knevelman, Carol; Miskin, James; Mitrophanous, Kyriacos; Dikicioglu, Duygu; Bracewell, Daniel G; (2023) Time-dependent sorption behavior of lentiviral vectors during anion-exchange chromatography. Biotechnology and Bioengineering 10.1002/bit.28483. (In press).

Pannerchelvan, S; Rios-Solis, L; Faizal Wong, FW; Zaidan, UH; Wasoh, H; Mohamed, MS; Tan, JS; ... Halim, M; + view all Pannerchelvan, S; Rios-Solis, L; Faizal Wong, FW; Zaidan, UH; Wasoh, H; Mohamed, MS; Tan, JS; Mohamad, R; Halim, M; - view fewer (2023) Strategies for improvement of gamma-aminobutyric acid (GABA) biosynthesis via lactic acid bacteria (LAB) fermentation. Food and Function , 14 (9) pp. 3929-3948. 10.1039/d2fo03936b.

Parau, Maria; (2023) Process related impurity breakthrough from depth filtration during monoclonal antibody purification. Doctoral thesis (Eng.D), UCL (University College London).

Parau, Maria; Pullen, James; Bracewell, Daniel G; (2023) Depth filter material process interaction in the harvest of mammalian cells. Biotechnol Prog , Article e3329. 10.1002/btpr.3329. (In press).

Patel, Hamza; (2023) Developing a novel feeding strategy for enhanced lentiviral vector production. Doctoral thesis (Eng.D), UCL (University College London).

Paul, Roshni; Silkina, Alla; Melville, Lynsey; Suhartini, Sri; Sulu, Michael; (2023) Optimisation of Ultrasound Pretreatment of Microalgal Biomass for Effective Biogas Production through Anaerobic Digestion Process. Energies , 16 (1) , Article 553. 10.3390/en16010553.

Perry, Christopher; Mujahid, Noor; Takeuchi, Yasu; Rayat, Andrea CME; (2023) Insights into product and process related challenges of lentiviral vector bioprocessing. Biotechnology and Bioengineering 10.1002/bit.28498. (In press).

Platten, Robert H. G.; (2023) Development of a Spectroscopic, Monolithic, Label-Free Probe for Bioprocess Analysis. Doctoral thesis (Eng.D), UCL (University College London).

Rayani, Ekta Yogesh; (2023) Stabilisation of low temperature biocatalysts. Doctoral thesis (Ph.D), UCL (University College London).

Redwood-Sawyerr, Chileab; Nesbeth, Darren N; (2023) Tetracycline-mediated fluorescence correlates with passage number and β-galactosidase activity in HeLa and HEK293T cells. Biology Open , 12 (7) , Article bio059691. 10.1242/bio.059691.

Ripoll, M; Lerma-Escalera, JA; Morones-Ramírez, JR; Rios-Solis, L; Betancor, L; (2023) New perspectives into Gluconobacter-catalysed biotransformations. Biotechnology Advances , 65 , Article 108127. 10.1016/j.biotechadv.2023.108127.

Rodgers, S; Bowler, A; Wells, L; Lee, CS; Hayes, M; Poulston, S; Lester, E; ... Conradie, A; + view all Rodgers, S; Bowler, A; Wells, L; Lee, CS; Hayes, M; Poulston, S; Lester, E; Meng, F; McKechnie, J; Conradie, A; - view fewer (2023) A surrogate model for the economic evaluation of renewable hydrogen production from biomass feedstocks via supercritical water gasification. International Journal of Hydrogen Energy 10.1016/j.ijhydene.2023.08.016. (In press).

Santos, Mariana; (2023) A study of chemoenzymatic and multi-enzymatic microreactor cascades for the synthesis of pharmaceutical compounds in continuous flow. Doctoral thesis (Ph.D), UCL (University College London).

Santos Beato, Patricia; (2023) 3D Bioprinting of an in vitro Osteochondral Model for Osteoarthritis Disease Modelling. Doctoral thesis (Eng.D), UCL (University College London).

Santoyo-Garcia, JH; Valdivia-Cabrera, M; Ochoa-Villarreal, M; Casasola-Zamora, S; Ripoll, M; Escrich, A; Moyano, E; ... Rios-Solis, L; + view all Santoyo-Garcia, JH; Valdivia-Cabrera, M; Ochoa-Villarreal, M; Casasola-Zamora, S; Ripoll, M; Escrich, A; Moyano, E; Betancor, L; Halliday, KJ; Loake, GJ; Rios-Solis, L; - view fewer (2023) Increased paclitaxel recovery from Taxus baccata vascular stem cells using novel in situ product recovery approaches. Bioresources and Bioprocessing , 10 , Article 68. 10.1186/s40643-023-00687-8.

Santoyo-Garcia, JH; Walls, LE; Valdivia-Cabrera, M; Malcı, K; Jonguitud-Borrego, N; Halliday, KJ; Rios-Solis, L; (2023) The synergetic effect from the combination of different adsorption resins in batch and semi-continuous cultivations of S. Cerevisiae cell factories to produce acetylated Taxanes precursors of the anticancer drug Taxol. Biotechnology and Bioengineering , 120 (8) pp. 2160-2174. 10.1002/bit.28487.

Sebastian, Martina; Goldrick, Stephen; Cheeks, Matthew; Turner, Richard; Farid, Suzanne S; (2023) Enhanced harvest performance predictability through advanced multivariate data analysis of mammalian cell culture particle size distribution. Biotechnology and Bioengineering 10.1002/bit.28571. (In press).

Shastry, Shriarjun; Chu, Wenning; Barbieri, Eduardo; Greback‐Clarke, Paul; Smith, William K; Cummings, Christopher; Minzoni, Arianna; ... Menegatti, Stefano; + view all Shastry, Shriarjun; Chu, Wenning; Barbieri, Eduardo; Greback‐Clarke, Paul; Smith, William K; Cummings, Christopher; Minzoni, Arianna; Pancorbo, Jennifer; Gilleskie, Gary; Ritola, Kimberly; Daniele, Michael A; Johnson, Thomas F; Menegatti, Stefano; - view fewer (2023) Rational design and experimental evaluation of peptide ligands for the purification of adeno-associated viruses via affinity chromatography. Biotechnology Journal 10.1002/biot.202300230. (In press).

Shen, Wenfeng; Dalby, Paul A; Guo, Zheng; Li, Weina; Zhu, Chenhui; Fan, Daidi; (2023) Residue Effect-Guided Design: Engineering of S. Solfataricus β-Glycosidase to Enhance Its Thermostability and Bioproduction of Ginsenoside Compound K. Journal of Agricultural and Food Chemistry , 71 (44) pp. 16669-16680. 10.1021/acs.jafc.3c04575.

Silva Couto, P; Molina, SA; O’Sullivan, D; O’Neill, L; Lyness, AM; Rafiq, QA; (2023) Understanding the impact of bioactive coating materials for human mesenchymal stromal cells and implications for manufacturing. Biotechnology Letters 10.1007/s10529-023-03369-9.

Stibbs, Dale John; (2023) Continuous Manufacturing of Lentiviral Vectors for Cell and Gene Therapy Applications. Doctoral thesis (Eng.D), UCL (University College London).

Tang, Jiazhi; Zhang, Cheng; Castillo, Nuria Codina; Lalaurie, Christophe J; Gao, Xin; Dalby, Paul A; Kozielski, Frank; (2023) Crystal structures and molecular dynamics simulations of a humanised antibody fragment at acidic to basic pH. Scientific Reports , 13 , Article 16281. 10.1038/s41598-023-42698-7.

Teneb Lobos, Jaime Camilo; (2023) Towards the Development of a Protein Developability Selection Platform for Directed Evolution Libraries. Doctoral thesis (Ph.D), UCL (University College London).

Tregidgo, Molly; Dorn, Marie; Lucas, Ciara; Micheletti, Martina; (2023) Design and characterization of a novel perfusion reactor for biopharmaceuticals production. Chemical Engineering Research and Design , 194 pp. 344-357. 10.1016/j.cherd.2023.04.066.

Tregidgo, Molly; Lucas, Ciara; Dorn, Marie; Martina, Micheletti; (2023) Development of mL-scale Pseudo-Perfusion Methodologies for High-Throughput Early Phase Development Studies. Biochemical Engineering Journal , Article 108906. 10.1016/j.bej.2023.108906.

Ucan, Deniz; (2023) Optical Deconvolution of Multiple Co-eluting Proteins in Chromatography. Doctoral thesis (Eng.D), UCL (University College London).

Uçan, Deniz; Hales, John E; Aoudjane, Samir; Todd, Nathan; Dalby, Paul A; (2023) Column-free optical deconvolution of intrinsic fluorescence for a monoclonal antibody and its product-related impurities. Journal of Chromatography A , 1711 , Article 464463. 10.1016/j.chroma.2023.464463.

Udugama, Isuru A; Atkins, Martin; Bayer, Christoph; Carson, James; Dikicioglu, Duygu; Gernaey, Krist V; Glassey, Jarka; ... Young, Brent R; + view all Udugama, Isuru A; Atkins, Martin; Bayer, Christoph; Carson, James; Dikicioglu, Duygu; Gernaey, Krist V; Glassey, Jarka; Taylor, Mathew; Young, Brent R; - view fewer (2023) Digital Tools in Chemical Engineering Education: the needs and the desires. Education for Chemical Engineers , 44 pp. 63-70. 10.1016/j.ece.2023.05.002.

Van De Steen, Alexander; (2023) Biochemical and biophysical characterisation of Thermotoga maritima and Myxococcus xanthus encapsulins towards biotechnology applications. Doctoral thesis (Ph.D), UCL (University College London).

Varma, AR; Shrirame, BS; Maity, SK; Agrawal, D; Malys, N; Rios-Solis, L; Kumar, G; Varma, AR; Shrirame, BS; Maity, SK; Agrawal, D; Malys, N; Rios-Solis, L; Kumar, G; Kumar, V; - view fewer (2023) Recent advances in fermentative production of C4 diols and their chemo-catalytic upgrading to high-value chemicals. Chinese Journal of Catalysis , 52 pp. 99-126. 10.1016/S1872-2067(23)64512-7.

Vilatte, Anaëlle; Spencer-Milnes, Xenia; Jackson, Harry Oliver; Purton, Saul; Parker, Brenda; (2023) Spray Drying Is a Viable Technology for the Preservation of Recombinant Proteins in Microalgae. Microorganisms , 11 (2) , Article 512. 10.3390/microorganisms11020512.

Walls, Laura E; Otoupal, Peter; Ledesma-Amaro, Rodrigo; Velasquez-Orta, Sharon B; Gladden, John M; Rios-Solis, Leonardo; (2023) Bioconversion of cellulose into bisabolene using Ruminococcus flavefaciens and Rhodosporidium toruloides. Bioresource Technology , 368 , Article 128216. 10.1016/j.biortech.2022.128216.

Williams, Thomas; Kalinka, Kevin; Sanches, Rui; Blanchard-Emmerson, Greg; Watts, Samuel; Davies, Lee; Knevelman, Carol; ... Dikicioglu, Duygu; + view all Williams, Thomas; Kalinka, Kevin; Sanches, Rui; Blanchard-Emmerson, Greg; Watts, Samuel; Davies, Lee; Knevelman, Carol; McCloskey, Laura; Jones, Peter; Mitrophanous, Kyriacos; Miskin, James; Dikicioglu, Duygu; - view fewer (2023) Machine Learning and Metabolic Modelling Assisted Implementation of a Novel Process Analytical Technology in Cell and Gene Therapy Manufacturing. Scientific Reports , 13 (834) 10.1038/s41598-023-27998-2.

Woods, Ben; Thompson, Katherine C; Szita, Nicolas; Chen, Shu; Milanesi, Lilia; Tomas, Salvador; (2023) Confinement effect on hydrolysis in small lipid vesicles. Chemical Science , 14 (10) pp. 2616-2623. 10.1039/d2sc05747f.

Worsham, Robert D; Thomas, Vaughan; Farid, Suzanne S; (2023) Impact of ethanol on continuous inline diafiltration of liposomal drug products. Biotechnology Journal 10.1002/biot.202300194. (In press).

Wyrobnik, Tom Adam; (2023) Engineering Characterisation of the Bach Impeller and its Application to Mesenchymal Stem Cell Microcarrier Cultures. Doctoral thesis (Ph.D), UCL (University College London).

Zedler, Julie AZ; Schirmacher, Alexandra M; Russo, David A; Hodgson, Lorna; Gundersen, Emil; Matthes, Annemarie; Frank, Stefanie; ... Jensen, Poul Erik; + view all Zedler, Julie AZ; Schirmacher, Alexandra M; Russo, David A; Hodgson, Lorna; Gundersen, Emil; Matthes, Annemarie; Frank, Stefanie; Verkade, Paul; Jensen, Poul Erik; - view fewer (2023) Self-Assembly of Nanofilaments in Cyanobacteria for Protein Co-localization. ACS Nano , 17 (24) pp. 25279-25290. 10.1021/acsnano.3c08600.

Zhang, Cheng; Berg, Adam; Joe, Carina CD; Dalby, Paul A; Douglas, Alexander D; (2023) Lyophilization to enable distribution of ChAdOx1 and ChAdOx2 adenovirus-vectored vaccines without refrigeration. NPJ Vaccines , 8 (1) , Article 85. 10.1038/s41541-023-00674-2.

Zhang, Cheng; Bye, Jordan W; Lui, Lok H; Zhang, Hongyu; Hales, John; Brocchini, Steve; Curtis, Robin A; Zhang, Cheng; Bye, Jordan W; Lui, Lok H; Zhang, Hongyu; Hales, John; Brocchini, Steve; Curtis, Robin A; Dalby, Paul A; - view fewer (2023) Enhanced Thermal Stability and Reduced Aggregation in an Antibody Fab Fragment at Elevated Concentrations. Molecular Pharmaceutics 10.1021/acs.molpharmaceut.3c00081. (In press).

Zhang, Cheng; Dalby, Paul Anthony; (2023) Assessing and Engineering Antibody Stability Using Experimental and Computational Methods. Methods in Molecular Biology , 2552 pp. 165-197. 10.1007/978-1-0716-2609-2_9.

2022

Abdelraheem, Eman; Thair, Benjamin; Varela, Romina Fernández; Jockmann, Emely; Popadić, Désirée; Hailes, Helen C; Ward, John M; ... Hanefeld, Ulf; + view all Abdelraheem, Eman; Thair, Benjamin; Varela, Romina Fernández; Jockmann, Emely; Popadić, Désirée; Hailes, Helen C; Ward, John M; Iribarren, Adolfo M; Lewkowicz, Elizabeth S; Andexer, Jennifer N; Hagedoorn, Peter-Leon; Hanefeld, Ulf; - view fewer (2022) Methyltransferases: Functions and Applications. ChemBioChem , 23 (18) , Article e202200212. 10.1002/cbic.202200212.

Allen, James R; Torres-Acosta, Mario A; Mohan, Naresh; Lye, Gary J; Ward, John M; (2022) Segregationally stabilised plasmids improve production of commodity chemicals in glucose-limited continuous fermentation. Microbial Cell Factories , 21 (1) , Article 229. 10.1186/s12934-022-01958-3.

Alosert, Haneen; Savery, James; Rheaume, Jennifer; Cheeks, Matthew; Turner, Richard; Spencer, Christopher; S Farid, Suzanne; Alosert, Haneen; Savery, James; Rheaume, Jennifer; Cheeks, Matthew; Turner, Richard; Spencer, Christopher; S Farid, Suzanne; Goldrick, Stephen; - view fewer (2022) Data integrity within the biopharmaceutical sector in the era of Industry 4.0. Biotechnology Journal , Article e2100609. 10.1002/biot.202100609. (In press).

Barnes, Benjamin; Caws, Thomas; Thomas, Samantha; Shephard, Alex P; Corteling, Randolph; Hole, Paul; Bracewell, Daniel G; (2022) Investigating heparin affinity chromatography for extracellular vesicle purification and fractionation. Journal of Chromatography A , 1670 , Article 462987. 10.1016/j.chroma.2022.462987.

Besenhard, Maximilian O; Pal, Sayan; Storozhuk, Liudmyla; Dawes, Simon; Thanh, Nguyen Thi Kim; Norfolk, Laura; Staniland, Sarah; Besenhard, Maximilian O; Pal, Sayan; Storozhuk, Liudmyla; Dawes, Simon; Thanh, Nguyen Thi Kim; Norfolk, Laura; Staniland, Sarah; Gavriilidis, Asterios; - view fewer (2022) A versatile non-fouling multi-step flow reactor platform: demonstration for partial oxidation synthesis of iron oxide nanoparticles. Lab on a Chip 10.1039/d2lc00892k.

Borg, Yanika; Alsford, Sam; Pavlika, Vasos; Zaikin, Alexey; Nesbeth, Darren; (2022) Synthetic biology tools for engineering Goodwin oscillation in Trypanosoma brucei brucei. Heliyon , 8 (2) , Article e08891. 10.1016/j.heliyon.2022.e08891.

Carrillo Sanchez, Braulio; (2022) Design and production of engineered extracellular vesicles in Chinese hamster ovary cells. Doctoral thesis (Ph.D), UCL (University College London).

Carrillo Sanchez, Braulio; Hinchliffe, Matthew; Bracewell, Daniel G; (2022) GFP-tagging of extracellular vesicles for rapid process development. Biotechnology Journal , Article e2100583. 10.1002/biot.202100583. (In press).

Charalambidou, AD; Micheletti, M; Ducci, A; (2022) Study of Trailing Vortices and Impeller Jet Instabilities of a Flat Blade Impeller in Small-Scale Reactors. AIChE Journal , Article e17842. 10.1002/aic.17842. (In press).

Chilakwad, Shama; (2022) Automation and analysis of high-dimensionality experiments in biocatalytic reaction screening. Doctoral thesis (Eng.D), UCL (University College London).

Comisel, Ruxandra-Maria; (2022) Decisional Tools for Supply Chain Economics of Cell and Gene Therapy Products. Doctoral thesis (Eng.D), UCL (University College London).

Cui, J; Purton, S; Baganz, F; (2022) Characterisation of a simple 'hanging bag' photobioreactor for low-cost cultivation of microalgae. Journal of Chemical Technology & Biotechnology , 97 (3) pp. 608-619. 10.1002/jctb.6985.

Dogan, Y; Barese, CN; Schindler, JW; Yoon, JK; Unnisa, Z; Guda, S; Jacobs, ME; ... van Til, NP; + view all Dogan, Y; Barese, CN; Schindler, JW; Yoon, JK; Unnisa, Z; Guda, S; Jacobs, ME; Oborski, C; Maiwald, T; Clarke, DL; Schambach, A; Pfeifer, R; Harper, C; Mason, C; van Til, NP; - view fewer (2022) Screening chimeric GAA variants in preclinicalstudy results in hematopoietic stem cell genetherapy candidate vectors for Pompe disease. Molecular Therapy: Methods & Clinical Development , 27 pp. 464-487. 10.1016/j.omtm.2022.10.017.

Durán-Jiménez, Gabriela; Rodriguez, Jose; Kostas, Emily T; Stevens, Lee A; Lozada-Rodríguez, Leticia; Binner, Eleanor; Dodds, Chris; (2022) Simultaneous conventional and microwave heating for the synthesis of adsorbents for CO2 capture: Comparative study to pristine technologies. Chemical Engineering Journal , 438 , Article 135549. 10.1016/j.cej.2022.135549.

Edwards, Elizabeth; Livanos, Maria; Krueger, Anja; Dell, Anne; Haslam, Stuart M; Mark Smales, C; Bracewell, Daniel G; (2022) Strategies to Control Therapeutic Antibody Glycosylation during Bioprocessing: Synthesis and Separation. Biotechnology and Bioengineering , 119 (6) pp. 1343-1358. 10.1002/bit.28066.

Elgabry, Mariam; Nesbeth, Darren; Johnson, Shane; (2022) The Future of Biotechnology Crime: A Parallel Delphi Study with Non-Traditional Experts. Futures , 141 , Article 102970. 10.1016/j.futures.2022.102970.

Flores-Fernández, Carol N; Cárdenas-Fernández, Max; Lye, Gary J; Ward, John M; (2022) Synergistic action of thermophilic pectinases for pectin bioconversion into D-galacturonic acid. Enzyme and Microbial Technology , 160 , Article 110071. 10.1016/j.enzmictec.2022.110071.

Grinsted, Julian; Liddell, John; Bouleghlimat, Emir; Kwok, Ka Yan; Taylor, Georgia; Marques, Marco PC; Bracewell, Daniel G; (2022) Purification of therapeutic & prophylactic mRNA by affinity chromatography. Cell and Gene Therapy Insights , 8 (2) pp. 335-349. 10.18609/cgti.2022.049.

Guelec, Fatih; Samson, Abby; Williams, Orla; Kostas, Emily T; Lester, Edward; (2022) Biofuel characteristics of chars produced from rapeseed, whitewood, and seaweed via thermal conversion technologies-Impacts of feedstocks and process conditions. Fuel Processing Technology , 238 , Article 107492. 10.1016/j.fuproc.2022.107492.

Guelec, Fatih; Williams, Orla; Kostas, Emily T; Samson, Abby; Stevens, Lee A; Lester, Edward; (2022) A comprehensive comparative study on methylene blue removal from aqueous solution using biochars produced from rapeseed, whitewood, and seaweed via different thermal conversion technologies. Fuel , 330 , Article 125428. 10.1016/j.fuel.2022.125428.

Güleç, Fatih; Williams, Orla; Kostas, Emily T; Samson, Abby; Lester, Edward; (2022) A comprehensive comparative study on the energy application of chars produced from different biomass feedstocks via hydrothermal conversion, pyrolysis, and torrefaction. Energy Conversion and Management , 270 , Article 116260. 10.1016/j.enconman.2022.116260.

Hickey, John M; Jacob, Shaleem I; Tait, Andrew S; Vahid, Fatemeh Dastjerdi; Barritt, Joseph; Rouse, Sarah; Douglas, Alexander; ... Bracewell, Daniel G; + view all Hickey, John M; Jacob, Shaleem I; Tait, Andrew S; Vahid, Fatemeh Dastjerdi; Barritt, Joseph; Rouse, Sarah; Douglas, Alexander; Joshi, Sangeeta B; Volkin, David B; Bracewell, Daniel G; - view fewer (2022) Measurement of Adenovirus-Based Vector Heterogeneity. Journal of Pharmaceutical Sciences 10.1016/j.xphs.2022.12.012. (In press).

Johnson, Thomas; Jones, Kyle; Zourna, Kalliopi; Bracewell, Daniel; (2022) Using 3D Imaging To Understand Sterilizing-Grade Filtration of Liposomes. BioProcess international

Jonguitud-Borrego, N; Malcı, K; Anand, M; Baluku, E; Webb, C; Liang, L; Barba-Ostria, C; ... Rios-Solis, L; + view all Jonguitud-Borrego, N; Malcı, K; Anand, M; Baluku, E; Webb, C; Liang, L; Barba-Ostria, C; Guaman, LP; Hui, L; Rios-Solis, L; - view fewer (2022) High—throughput and automated screening for COVID-19. Frontiers in Medical Technology , 4 , Article 969203. 10.3389/fmedt.2022.969203.

Kellerman, Mark-Adam W; Almeida, Teresa; Rudd, Timothy R; Matejtschuk, Paul; Dalby, Paul A; (2022) NMR Reveals Functionally Relevant Thermally Induced Structural Changes within the Native Ensemble of G-CSF. Molecular Pharmaceutics 10.1021/acs.molpharmaceut.2c00398. (In press).

Krishnan, Trishanka; (2022) The Computational and Experimental Study of the Freeze-Drying Process for a Monoclonal Antibody. Doctoral thesis (Ph.D), UCL (University College London).

Kriston-Vizi, Janos; Lenart, Izabela; Iwawaki, Takao; Gould, Keith; Nesbeth, Darren; Powis, Simon J; Antoniou, Antony N; (2022) Salmonella Exhibit Altered Cellular Localization in the Presence of HLA-B27 and Codistribute with Endo-Reticular Membrane. Journal of Immunology Research , 2022 , Article 9493019. 10.1155/2022/9493019.

Lalaurie, Christophe J; Splevins, Andrew; Barata, Teresa S; Bunting, Karen A; Higazi, Daniel R; Zloh, Mire; Spiteri, Valentina A; ... Dalby, Paul A; + view all Lalaurie, Christophe J; Splevins, Andrew; Barata, Teresa S; Bunting, Karen A; Higazi, Daniel R; Zloh, Mire; Spiteri, Valentina A; Perkins, Stephen J; Dalby, Paul A; - view fewer (2022) Elucidation of critical pH-dependent structural changes in Botulinum Neurotoxin E. J Struct Biol , 214 (3) , Article 107876. 10.1016/j.jsb.2022.107876.

Lazaro, Jorge; Jansen, Giorgio; Yang, Yiheng; Torres-Acosta, Mario A; Lye, Gary; Oliver, Stephen G; Julvez, Jorge; (2022) Combination of Genome-Scale Models and Bioreactor Dynamics to Optimize the Production of Commodity Chemicals. Frontiers in Molecular Biosciences , 9 , Article 855735. 10.3389/fmolb.2022.855735.

Lee, Weiluo; Pradhan, Subhas; Zhang, Cheng; Venanzi, Niccolo AE; Li, Weina; Goldrick, Stephen; Dalby, Paul A; (2022) Directed evolution for soluble and active periplasmic expression of bovine enterokinase in Escherichia coli. Scientific Reports , 12 , Article 17721. 10.1038/s41598-022-22574-6.

Lenart, Isabella; Truong, L-H; Nguyen, D; Kumar, P; McHugh, K; Pereira, B; Maan, B; ... Antoniou, Anthony; + view all Lenart, Isabella; Truong, L-H; Nguyen, D; Kumar, P; McHugh, K; Pereira, B; Maan, B; Gartska, M; Bowness, P; Blake, Neil; Powis, Simon; Gould, Keith; Nesbeth, Darren; Antoniou, Anthony; - view fewer (2022) Intrinsic Folding Properties of the HLA-B27 Heavy Chain Revealed by Single Chain Trimer Versions of Peptide-Loaded Class I Major Histocompatibility Complex Molecules. Frontiers in Immunology , 13 , Article 902135. 10.3389/fimmu.2022.902135.

Li, Yiwen; Dalby, Paul A; (2022) Engineering of enzymes using non-natural amino acids. Bioscience Reports , 42 , Article 8. 10.1042/BSR20220168.

Lui, Lok Hin; van der Walle, Christopher F; Brocchini, Steve; Velayudhan, Ajoy; (2022) Discovering Novel Small Molecule Compound for Prevention of Monoclonal Antibody Self-Association. Antibodies , 11 (2) , Article 40. 10.3390/antib11020040.

Lyu, Xiaochen; Zhao, Qichao; Hui, Julia; Wang, Tiffany; Lin, Mengyi; Wang, Keying; Zhang, Jialing; ... Liu, Bo; + view all Lyu, Xiaochen; Zhao, Qichao; Hui, Julia; Wang, Tiffany; Lin, Mengyi; Wang, Keying; Zhang, Jialing; Shentu, Jiaqian; Dalby, Paul A; Zhang, Hongyu; Liu, Bo; - view fewer (2022) The global landscape of approved antibody therapies. Antibody Therapeutics , 5 (4) pp. 233-257. 10.1093/abt/tbac021.

Magalhaes, Salome De Sa; De Santis, Emiliana; Hussein-Gore, Saba; Colomb-Delsuc, Mathieu; Keshavarz-Moore, Eli; (2022) Quality assessment of virus-like particle: A new transmission electron microscopy approach. Frontiers in Molecular Biosciences , 9 , Article 975054. 10.3389/fmolb.2022.975054.

Malcı, K; Walls, LE; Rios-Solis, L; (2022) Rational Design of CRISPR/Cas12a-RPA Based One-Pot COVID-19 Detection with Design of Experiments. ACS Synthetic Biology , 11 (4) pp. 1555-1567. 10.1021/acssynbio.1c00617.

Malcı, K; Watts, E; Roberts, TM; Auxillos, JY; Nowrouzi, B; Boll, HO; Nascimento, CZSD; ... Rios-Solis, L; + view all Malcı, K; Watts, E; Roberts, TM; Auxillos, JY; Nowrouzi, B; Boll, HO; Nascimento, CZSD; Andreou, A; Vegh, P; Donovan, S; Fragkoudis, R; Panke, S; Wallace, E; Elfick, A; Rios-Solis, L; - view fewer (2022) Standardization of Synthetic Biology Tools and Assembly Methods for Saccharomyces cerevisiae and Emerging Yeast Species. ACS Synthetic Biology , 11 (8) pp. 2527-2547. 10.1021/acssynbio.1c00442.

Malcl, K; Jonguitud-Borrego, N; Van Der Straten Waillet, H; Puodžiūnaitė, U; Johnston, EJ; Rosser, SJ; Rios-Solis, L; (2022) ACtivE: Assembly and CRISPR-Targeted in Vivo Editing for Yeast Genome Engineering Using Minimum Reagents and Time. ACS Synthetic Biology , 11 (11) pp. 3629-3643. 10.1021/acssynbio.2c00175.

McDonnell, Thomas; Amarnani, Raj; Spicer, Carina; Jbari, Hajar; Pericleous, Charis; Spiteri, Valentina A; Wincup, Chris; ... Giles, Ian; + view all McDonnell, Thomas; Amarnani, Raj; Spicer, Carina; Jbari, Hajar; Pericleous, Charis; Spiteri, Valentina A; Wincup, Chris; Artim-Esen, Bahar; Mackie, Ian; Botto, Marina; Rahman, Anisur; Giles, Ian; - view fewer (2022) Antibodies to FXa and thrombin in patients with SLE differentially regulate C3 and C5 cleavage. Lupus Science & Medicine , 9 (1) , Article e000738. 10.1136/lupus-2022-000738.

Meng, Jingyuan; Alnaeb, Dali; Salmane, Anete Krista; Devadass, Pradeep; Cruz, Marcos; Parker, Brenda; (2022) A robotically extruded sugar waste composite for a circular biomateriality in architecture. In: Hvejsel, Marie F and Cruz, Paulo JS, (eds.) Structures and Architecture. A Viable Urban Perspective? Proceedings of the Fifth International Conference on Structures and Architecture (ICSA 2022), July 6-8, 2022, Aalborg, Denmark. CRC Press: London, UK.

Moody, Gawain; (2022) Biochemical characterisation of the Glycyl Radical Enzyme Containing Microcompartment (GRM2) from Proteus mirabilis. Doctoral thesis (Ph.D), UCL (University College London).

Nagel, F; Palm, GJ; Geist, N; McDonnell, TCR; Susemihl, A; Girbardt, B; Mayerle, J; ... Delcea, M; + view all Nagel, F; Palm, GJ; Geist, N; McDonnell, TCR; Susemihl, A; Girbardt, B; Mayerle, J; Lerch, MM; Lammers, M; Delcea, M; - view fewer (2022) Structural and Biophysical Insights into SPINK1 Bound to Human Cationic Trypsin. International Journal of Molecular Sciences , 23 (7) p. 3468. 10.3390/ijms23073468.

Nowrouzi, B; Lungang, L; Rios-Solis, L; (2022) Exploring optimal Taxol® CYP725A4 activity in Saccharomyces cerevisiae. Microbial Cell Factories , 21 , Article 197. 10.1186/s12934-022-01922-1.

Nowrouzi, B; Rios-Solis, L; (2022) Redox metabolism for improving whole-cell P450-catalysed terpenoid biosynthesis. Critical Reviews in Biotechnology , 42 (8) pp. 1213-1237. 10.1080/07388551.2021.1990210.

Ochs, J; Hanga, MP; Shaw, G; Duffy, N; Kulik, M; Tissin, N; Reibert, D; ... Murphy, JM; + view all Ochs, J; Hanga, MP; Shaw, G; Duffy, N; Kulik, M; Tissin, N; Reibert, D; Biermann, F; Moutsatsou, P; Ratnayake, S; Nienow, A; Koenig, N; Schmitt, R; Rafiq, Q; Hewitt, CJ; Barry, F; Murphy, JM; - view fewer (2022) Needle to needle robot-assisted manufacture of cell therapy products. Bioengineering & Translational Medicine , Article e10387. 10.1002/btm2.10387. (In press).

Ologhu, William; Stamatis, Christos; Farid, Suzanne; Gruber, David; (2022) Cell-Free Synthesis of Highly Potent Recombinant Neurotoxins: A Process Economic Feasibility Study. BioProcess International , 20 (11-12) pp. 33-39.

Owji, Nazanin; Mandakhbayar, Nandin; Cha, Jae-Ryung; Padalhin, Andrew R; Erdogan, Zalike Keskin; Aldaadaa, Alaa; Shakouri, Taleen; ... Knowles, Jonathan C; + view all Owji, Nazanin; Mandakhbayar, Nandin; Cha, Jae-Ryung; Padalhin, Andrew R; Erdogan, Zalike Keskin; Aldaadaa, Alaa; Shakouri, Taleen; Sawadkar, Prasad; Frost, Oliver; Kim, Hae-Won; García-Gareta, Elena; Knowles, Jonathan C; - view fewer (2022) Inclusion of calcium phosphate does not further improve in vitro and in vivo osteogenesis in a novel, highly biocompatible, mechanically stable and 3D printable polymer. Scientific Reports , 12 , Article 16977. 10.1038/s41598-022-21013-w.

Pandya, Akash Rajnikant; (2022) Mapping the interaction between excipients with proteins in formulations by computational modelling and NMR. Doctoral thesis (Ph.D), UCL (University College London).

Panzella, L; Benning, K; Nesbeth, DN; Setaro, B; D'Errico, G; Napolitano, A; d'Ischia, M; (2022) Identification of black sturgeon caviar pigment as eumelanin. Food Chemistry , 373 (B) , Article 131474. 10.1016/j.foodchem.2021.131474.

Parau, M; Johnson, TF; Pullen, J; Bracewell, DG; (2022) Analysis of fouling and breakthrough of process related impurities during depth filtration using confocal microscopy. Biotechnology Progress , 38 (2) , Article e3233. 10.1002/btpr.3233.

Patel, Neha Naran; (2022) Protein Glycan Coupling Technology as an alternative method for the production of pneumococcal conjugate vaccines: Investigation of the impact of fermentation and technology-specific factors on recombinant vaccine production. Doctoral thesis (Ph.D), UCL (University College London).

Peswani, AR; Narkpuk, J; Krueger, A; Bracewell, DG; Lekcharoensuk, P; Haslam, SM; Dell, A; ... Robinson, C; + view all Peswani, AR; Narkpuk, J; Krueger, A; Bracewell, DG; Lekcharoensuk, P; Haslam, SM; Dell, A; Jaru-Ampornpan, P; Robinson, C; - view fewer (2022) Novel constructs and 1-step chromatography protocols for the production of Porcine Circovirus 2d (PCV2d) and Circovirus 3 (PCV3) subunit vaccine candidates. Food and Bioproducts Processing , 131 pp. 125-135. 10.1016/j.fbp.2021.10.001.

Qin, Li; Lu, Gang; Hossain, Md Moinul; Morris, Andy; Yan, Yong; (2022) A Flame Imaging-Based Online Deep Learning Model for Predicting NOₓ Emissions From an Oxy-Biomass Combustion Process. IEEE Transactions on Instrumentation and Measurement , 71 , Article 2501811. 10.1109/tim.2021.3132998.

Rawat, Deepak; Sharma, Udita; Poria, Pankaj; Finlan, Arran; Parker, Brenda; Sharma, Radhey Shyam; Mishra, Vandana; (2022) Iron-dependent mutualism between Chlorella sorokiniana and Ralstonia pickettii forms the basis for a sustainable bioremediation system. ISME Communications , 2 (1) , Article 83. 10.1038/s43705-022-00161-0.

Rosa, Sara Sousa; Nunes, Davide; Antunes, Luis; Prazeres, Duarte MF; Marques, Marco PC; Azevedo, Ana M; (2022) Maximizing mRNA vaccine production with Bayesian optimization. Biotechnology and Bioengineering 10.1002/bit.28216. (In press).

Samaras, JJ; Micheletti, M; Ding, W; (2022) Transformation of Biopharmaceutical Manufacturing Through Single-Use Technologies: Current State, Remaining Challenges, and Future Development. Annual Review of Chemical and Biomolecular Engineering , 13 (1) pp. 73-97. 10.1146/annurev-chembioeng-092220-030223.

Santoyo-Garcia, JH; Walls, LE; Nowrouzi, B; Galindo-Rodriguez, GR; Ochoa-Villarreal, M; Loake, GJ; Dimartino, S; Santoyo-Garcia, JH; Walls, LE; Nowrouzi, B; Galindo-Rodriguez, GR; Ochoa-Villarreal, M; Loake, GJ; Dimartino, S; Rios-Solis, L; - view fewer (2022) In situ solid-liquid extraction enhances recovery of taxadiene from engineered Saccharomyces cerevisiae cell factories. Separation and Purification Technology , 290 , Article 120880. 10.1016/j.seppur.2022.120880.

Shin, Ji Ho; (2022) Characterisation of the Interaction Between Recombinant Staphylococcal Protein-As and Human Heavy Chain Variable Domains. Doctoral thesis (Ph.D), UCL (University College London).

Shu, L; Wang, Q; Jiang, W; Tišma, M; Oh, B; Shi, J; Lye, GJ; ... Hao, J; + view all Shu, L; Wang, Q; Jiang, W; Tišma, M; Oh, B; Shi, J; Lye, GJ; Baganz, F; Wei, D; Hao, J; - view fewer (2022) The roles of diol dehydratase from pdu operon on glycerol catabolism in Klebsiella pneumoniae. Enzyme and Microbial Technology , 157 , Article 110021. 10.1016/j.enzmictec.2022.110021.

Shu, Lin; Gu, Jinjie; Wang, Qinghui; Sun, Shaoqi; Cui, Youtian; Fell, Jason; Mak, Wai Shun; ... Hao, Jian; + view all Shu, Lin; Gu, Jinjie; Wang, Qinghui; Sun, Shaoqi; Cui, Youtian; Fell, Jason; Mak, Wai Shun; Siegel, Justin B; Shi, Jiping; Lye, Gary J; Baganz, Frank; Hao, Jian; - view fewer (2022) The pyruvate decarboxylase activity of IpdC is a limitation for isobutanol production by Klebsiella pneumoniae. Biotechnology for Biofuels and Bioproducts , 15 (1) , Article 41. 10.1186/s13068-022-02144-8.

Silva Couto, Pedro; (2022) Development of a scalable and consistent manufacturing process for human mesenchymal stromal cells from different sources for therapeutic applications. Doctoral thesis (Ph.D), UCL (University College London).

Slack, Sarah Louise; (2022) A high-throughput approach to vaccine bioprocess development. Doctoral thesis (Eng.D), UCL (University College London).

Stojanovski, Gorjan; Hailes, Helen C; Ward, John M; (2022) Facile and selective N-alkylation of gentamicin antibiotics via chemoenzymatic synthesis. Green Chemistry 10.1039/d2gc03600b. (In press).

Tan, Ruijie; Franzreb, Matthias; (2022) Simulation-based evaluation of single pass continuous diafiltration with alternating permeate flow direction. Separation and Purification Technology , 282 , Article 119987. 10.1016/j.seppur.2021.119987.

Tau, Omri; Henley, Alice; Boichenko, Anton N; Kleshchina, Nadezhda N; Riley, River; Wang, Bingxing; Winning, Danielle; ... Fielding, Helen H; + view all Tau, Omri; Henley, Alice; Boichenko, Anton N; Kleshchina, Nadezhda N; Riley, River; Wang, Bingxing; Winning, Danielle; Lewin, Ross; Parkin, Ivan P; Ward, John M; Hailes, Helen C; Bochenkova, Anastasia V; Fielding, Helen H; - view fewer (2022) Liquid-microjet photoelectron spectroscopy of the green fluorescent protein chromophore. Nature Communications , 13 (1) , Article 507. 10.1038/s41467-022-28155-5.

Teworte, S; Malcı, K; Walls, LE; Halim, M; Rios-Solis, L; (2022) Recent advances in fed-batch microscale bioreactor design. Biotechnology Advances , 55 , Article 107888. 10.1016/j.biotechadv.2021.107888.

Thangsunan, P; Temisak, S; Jaimalai, T; Rios-Solis, L; Suree, N; (2022) Sensitive Detection of Chicken Meat in Commercial Processed Food Products Based on One-Step Colourimetric Loop-Mediated Isothermal Amplification. Food Analytical Methods , 15 (5) pp. 1341-1355. 10.1007/s12161-021-02210-1.

Torres-Acosta, Mario A; Lye, Gary J; Dikicioglu, Duygu; (2022) Automated liquid-handling operations for robust, resilient, and efficient bio-based laboratory practices. Biochemical Engineering Journal , 188 , Article 108713. 10.1016/j.bej.2022.108713.

Torres-Bautista, A; Torres-Acosta, MA; González-Valdez, J; (2022) Characterization and optimization of polymer-polymer aqueous two-phase systems for the isolation and purification of CaCo2 cell-derived exosomes. PLoS ONE , 17 (9) , Article e0273243. 10.1371/journal.pone.0273243.

Tregidgo, Molly Beth; (2022) Scale-down Technologies for Perfusion Culture for Rapid Biopharmaceutical Process Development. Doctoral thesis (Eng.D), UCL (University College London).

Unnisa, Zeenath; Yoon, John K; Schindler, Jeffrey W; Mason, Chris; van Til, Niek P; (2022) Gene Therapy Developments for Pompe Disease. Biomedicines , 10 (2) , Article 302. 10.3390/biomedicines10020302.

Vicente, Filipa A; Ventura, Sonia PM; Passos, Helena; Dias, Ana CRV; Torres-Acosta, Mario A; Novak, Uros; Likozar, Blaz; (2022) Crustacean waste biorefinery as a sustainable cost-effective business model. Chemical Engineering Journal , 442 (2) , Article 135937. 10.1016/j.cej.2022.135937.

Walls, LE; Martinez, JL; Del Rio Chanona, EA; Rios-Solis, L; (2022) Definitive screening accelerates Taxol biosynthetic pathway optimization and scale up in Saccharomyces cerevisiae cell factories. Biotechnology Journal , 17 (1) , Article e2100414. 10.1002/biot.202100414.

Walls, LE; Martinez, JL; Rios-Solis, L; (2022) Enhancing Saccharomyces cerevisiae Taxane Biosynthesis and Overcoming Nutritional Stress-Induced Pseudohyphal Growth. Microorganisms , 10 (1) , Article 163. 10.3390/microorganisms10010163.

Wang, Qinghui; Gu, Jinjie; Shu, Lin; Jiang, Weiyan; Mojovic, Ljiljana; Knezevic-Jugovic, Zorica; Shi, Jiping; ... Hao, Jian; + view all Wang, Qinghui; Gu, Jinjie; Shu, Lin; Jiang, Weiyan; Mojovic, Ljiljana; Knezevic-Jugovic, Zorica; Shi, Jiping; Baganz, Frank; Lye, Gary J; Xiang, Wensheng; Hao, Jian; - view fewer (2022) Blocking the 2,3-butanediol synthesis pathway of Klebsiella pneumoniae resulted in L-valine production. World Journal of Microbiology and Biotechnology , 38 (5) , Article 81. 10.1007/s11274-022-03266-9.

Wang, Yu; Subrizi, Fabiana; Carter, Eve M; Sheppard, Tom D; Ward, John M; Hailes, Helen C; (2022) Enzymatic synthesis of benzylisoquinoline alkaloids using a parallel cascade strategy and tyrosinase variants. Nature Communications , 13 , Article 5436. 10.1038/s41467-022-33122-1.

Wilkinson, Meredyth G Ll; Moulding, Dale; McDonnell, Thomas CR; Orford, Michael; Wincup, Chris; Ting, Joanna YJ; Otto, Georg W; ... Wedderburn, Lucy R; + view all Wilkinson, Meredyth G Ll; Moulding, Dale; McDonnell, Thomas CR; Orford, Michael; Wincup, Chris; Ting, Joanna YJ; Otto, Georg W; Restuadi, Restuadi; Kelberman, Daniel; Papadopoulou, Charalampia; Castellano, Sergi; Eaton, Simon; Deakin, Claire T; Rosser, Elizabeth C; Wedderburn, Lucy R; - view fewer (2022) Role of CD14+ monocyte-derived oxidised mitochondrial DNA in the inflammatory interferon type 1 signature in juvenile dermatomyositis. Annals of the Rheumatic Diseases 10.1136/ard-2022-223469. (In press).

Wood, VE; Groves, K; Wong, LM; Kong, L; Bird, C; Wadhwa, M; Quaglia, M; ... Dalby, PA; + view all Wood, VE; Groves, K; Wong, LM; Kong, L; Bird, C; Wadhwa, M; Quaglia, M; Matejtschuk, P; Dalby, PA; - view fewer (2022) Protein Engineering and HDX Identify Structural Regions of G-CSF Critical to Its Stability and Aggregation. Molecular Pharmaceutics , 19 (2) pp. 616-629. 10.1021/acs.molpharmaceut.1c00754.

Wyrobnik, TA; Oh, S; Ducci, A; Micheletti, M; (2022) Engineering characterization of the novel Bach impeller for bioprocessing applications requiring low power inputs. Chemical Engineering Science , 252 , Article 117263. 10.1016/j.ces.2021.117263.

Yang, Yang; Xu, Li; Sun, Liangdong; Zhang, Peng; Farid, Suzanne S; (2022) Machine learning application in personalised lung cancer recurrence and survivability prediction. Computational and Structural Biotechnology Journal , 20 pp. 1811-1820. 10.1016/j.csbj.2022.03.035.

Yang, Yiheng; (2022) Investigation of plasmid stability in glucose-limited E.coli continuous fermentations for commodity chemicals production. Doctoral thesis (Ph.D), UCL (University College London).

Yu, Haoran; Ma, Shuang; Li, Yiwen; Dalby, Paul A; (2022) Hot spots-making directed evolution easier. Biotechnology Advances , 56 , Article 107926. 10.1016/j.biotechadv.2022.107926.

Zakrzewski, Roman; (2022) Development of a novel scale-down method to study pH and dissolved oxygen heterogeneities in mammalian cell cultures. Doctoral thesis (Eng.D), UCL (University College London).

Zakrzewski, Roman; Lee, Kenneth; Lye, Gary J; (2022) Development of a miniature bioreactor model to study the impact of pH and DOT fluctuations on CHO cell culture performance as a tool to understanding heterogeneity effects at large-scale. Biotechnology Progress , Article e3264. 10.1002/btpr.3264. (In press).

Zhang, Hongyu; Dalby, Paul A; (2022) Stability Convergence in Antibody Coformulations. Molecular Pharmaceutics 10.1021/acs.molpharmaceut.2c00534. (In press).

2021

Abdullah Thaidi, NI; Rios-Solis, L; Halim, M; (2021) Fermented Milk: The Most Famous Probiotic, Prebiotic, and Synbiotic Food Carrier. In: Probiotics and Prebiotics in Foods: Challenges, Innovations, and Advances. (pp. 135-151). Elsevier

Allison, AL; Ambrose-Dempster, E; Bawn, M; Casas Arredondo, M; Chau, C; Chandler, K; Dobrijevic, D; ... Ward, JM; + view all Allison, AL; Ambrose-Dempster, E; Bawn, M; Casas Arredondo, M; Chau, C; Chandler, K; Dobrijevic, D; Domenech Aparisi, T; Hailes, HC; Lettieri, P; Liu, C; Medda, F; Michie, S; Miodownik, M; Munro, B; Purkiss, D; Ward, JM; - view fewer (2021) The impact and effectiveness of the general public wearing masks to reduce the spread of pandemics in the UK: a multidisciplinary comparison of single-use masks versus reusable face masks. UCL Open Environment , 3 , Article 1. 10.14324/111.444/ucloe.000022.

Amini, Arman; (2021) The Role of Metabolites and Bioreactor Operating Conditions on T Cell Manufacturing. Doctoral thesis (Ph.D), UCL (University College London).

Aparicio, E; Rodríguez-Jasso, RM; Pinales-Márquez, CD; Loredo-Treviño, A; Robledo-Olivo, A; Aguilar, CN; Kostas, ET; Aparicio, E; Rodríguez-Jasso, RM; Pinales-Márquez, CD; Loredo-Treviño, A; Robledo-Olivo, A; Aguilar, CN; Kostas, ET; Ruiz, HA; - view fewer (2021) High-pressure technology for Sargassum spp biomass pretreatment and fractionation in the third generation of bioethanol production. Bioresource Technology , 329 , Article 124935. 10.1016/j.biortech.2021.124935.

Appl, C; Baganz, F; Hass, VC; (2021) Development of a digital twin for enzymatic hydrolysis processes. Processes , 9 (10) , Article 1734. 10.3390/pr9101734.

Appl, C; Moser, A; Baganz, F; Hass, VC; (2021) Digital Twins for Bioprocess Control Strategy Development and Realisation. Digital Twins , 177 pp. 63-94. 10.1007/10_2020_151.

Armstrong, A; Horry, K; Cui, T; Hulley, M; Turner, R; Farid, SS; Goldrick, S; Armstrong, A; Horry, K; Cui, T; Hulley, M; Turner, R; Farid, SS; Goldrick, S; Bracewell, DG; - view fewer (2021) Advanced control strategies for bioprocess chromatography: Challenges and opportunities for intensified processes and next generation products. Journal of Chromatography A , 1639 , Article 461914. 10.1016/j.chroma.2021.461914.

Arndt, L; Wiegmann, V; Kuchemüller, KB; Baganz, F; Pörtner, R; Möller, J; (2021) Model-based workflow for scale-up of process strategies developed in miniaturized bioreactor systems. Biotechnology Progress 10.1002/btpr.3122. (In press).

Bandyopadhyay, S; Morris, SA; Nesbeth, DN; Bracewell, DG; (2021) Lipid reduction to improve clarification and filterability during primary recovery of intracellular products in yeast lysates using exogenous lipase. Journal of Chemical Technology & Biotechnology , 96 (11) pp. 3166-3174. 10.1002/jctb.6871.

Banner, M; Alosert, H; Spencer, C; Cheeks, M; Farid, SS; Thomas, M; Goldrick, S; (2021) A decade in review: use of data analytics within the biopharmaceutical sector. Current Opinion in Chemical Engineering , 34 10.1016/j.coche.2021.100758.

Bicudo, E; Brass, I; Carmichael, P; Farid, S; (2021) The UK’s emerging regulatory framework for point-of-care manufacture: insights from a workshop on advanced therapies. Cell and Gene Therapy Insights , 7 (9) pp. 1005-1015. 10.18609/cgti.2021.133.

Bracewell, DG; Smith, V; Delahaye, M; Smales, CM; (2021) Analytics of host cell proteins (HCPs): lessons from biopharmaceutical mAb analysis for Gene therapy products. Current Opinion in Biotechnology , 71 pp. 98-104. 10.1016/j.copbio.2021.06.026.

Buchholz, I; McDonnell, T; Nestler, P; Tharad, S; Kulke, M; Radziszewska, A; Ripoll, VM; ... Delcea, M; + view all Buchholz, I; McDonnell, T; Nestler, P; Tharad, S; Kulke, M; Radziszewska, A; Ripoll, VM; Schmidt, F; Hammer, E; Toca-Herrera, JL; Rahman, A; Delcea, M; - view fewer (2021) Specific domain V reduction of beta-2-glycoprotein I induces protein flexibility and alters pathogenic antibody binding. Scientific Reports , 11 , Article 4542. 10.1038/s41598-021-84021-2.

Cárdenas-Fernández, M; Sinclair, O; Ward, JM; (2021) Novel transaminases from thermophiles: from discovery to application. Microbial Biotechnology 10.1111/1751-7915.13940. (In press).

Cárdenas-Fernández, M; Subrizi, F; Dobrijevic, D; Hailes, HC; Ward, JM; (2021) Characterisation of a hyperthermophilic transketolase from Thermotoga maritima DSM3109 as a biocatalyst for 7-keto-octuronic acid synthesis. Organic & Biomolecular Chemistry 10.1039/d1ob01237a. (In press).

Cardos Elena, Rosalía Paula; (2021) Towards the Development of a Genome Ablation Strategy for Synthetic Biology. Doctoral thesis (Ph.D), UCL (University College London).

Carter, EM; Subrizi, F; Ward, JM; Sheppard, TD; Hailes, HC; (2021) Direct Conversion of Hydrazones to Amines using Transaminases. ChemCatChem 10.1002/cctc.202101008. (In press).

Charria-Girón, E; Amazo, V; De Angulo, D; Hidalgo, E; Villegas-Torres, MF; Baganz, F; Ortega, NHC; (2021) Strategy for managing industrial anaerobic sludge through the heterotrophic cultivation of chlorella sorokiniana: Effect of iron addition on biomass and lipid production. Bioengineering , 8 (6) , Article 82. 10.3390/bioengineering8060082.

Chiocchio, Roberto; (2021) Continuous Sugar Beet Pulp Pretreatment and Bioconversion in a Biorefinery Context. Doctoral thesis (Eng.D), UCL (University College London).

Coelewij, L; Waddington, KE; Robinson, GA; Chocano, E; McDonnell, T; Farinha, F; Peng, J; ... Pineda-Torra, I; + view all Coelewij, L; Waddington, KE; Robinson, GA; Chocano, E; McDonnell, T; Farinha, F; Peng, J; Donnes, P; Smith, E; Croca, S; Bakshi, J; Griffin, M; Nicolaides, A; Rahman, A; Jury, EC; Pineda-Torra, I; - view fewer (2021) Serum Metabolomic Signatures Can Predict Subclinical Atherosclerosis in Patients With Systemic Lupus Erythematosus. Arteriosclerosis, Thrombosis, and Vascular Biology 10.1161/ATVBAHA.120.315321. (In press).

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Colant, N; Melinek, B; Frank, S; Rosenberg, W; Bracewell, DG; (2021) Escherichia Coli-Based Cell-Free Protein Synthesis for Iterative Design of Tandem-Core Virus-Like Particles. Vaccines , 9 (3) , Article 193. 10.3390/vaccines9030193.

Colao, Ivano Luigi; (2021) Development of a Process Step for the High Purity Recovery of Exosome Material from a Regenerative Cell Product. Doctoral thesis (Eng.D), UCL (University College London).

Comisel, R-M; Kara, B; Fiesser, FH; Farid, SS; (2021) Gene therapy process change evaluation framework: Transient transfection and stable producer cell line comparison. Biochemical Engineering Journal , 176 , Article 108202. 10.1016/j.bej.2021.108202.

Comisel, RM; Kara, B; Fiesser, FH; Farid, SS; (2021) Lentiviral vector bioprocess economics for cell and gene therapy commercialization. Biochemical Engineering Journal , 167 , Article 107868. 10.1016/j.bej.2020.107868.

Costariol, Elena; (2021) Establishing a scalable manufacturing process for the clinical scale production of CAR-T cell therapies in stirred-tank bioreactors. Doctoral thesis (Ph.D), UCL (University College London).

Dahl, Maria; Smith, Emma MK; Warsi, Sarah; Rothe, Michael; Ferraz, Maria J; Aerts, Johannes MFG; Golipour, Azadeh; ... Karlsson, Stefan; + view all Dahl, Maria; Smith, Emma MK; Warsi, Sarah; Rothe, Michael; Ferraz, Maria J; Aerts, Johannes MFG; Golipour, Azadeh; Harper, Claudia; Pfeifer, Richard; Pizzurro, Daniella; Schambach, Axel; Mason, Chris; Karlsson, Stefan; - view fewer (2021) Correction of pathology in mice displaying Gaucher disease type 1 by a clinically-applicable lentiviral vector. Molecular Therapy - Methods & Clinical Development , 20 pp. 312-323. 10.1016/j.omtm.2020.11.018.

de Sá Magalhães, S; Keshavarz‐Moore, E; (2021) Pichia pastoris (Komagataella phaffii) as a Cost-Effective Tool for Vaccine Production for Low- and Middle-Income Countries (LMICs). Bioengineering , 8 (9) , Article 119. 10.3390/bioengineering8090119.

Durán-Jiménez, G; Kostas, ET; Stevens, LA; Meredith, W; Erans, M; Hernández-Montoya, V; Buttress, A; ... Binner, E; + view all Durán-Jiménez, G; Kostas, ET; Stevens, LA; Meredith, W; Erans, M; Hernández-Montoya, V; Buttress, A; Uguna, CN; Binner, E; - view fewer (2021) Green and simple approach for low-cost bioproducts preparation and CO2 capture. Chemosphere , 279 , Article 130512. 10.1016/j.chemosphere.2021.130512.

Duran-Villalobos, CA; Ogonah, O; Melinek, B; Bracewell, DG; Hallam, T; Lennox, B; (2021) Multivariate statistical data analysis of cell-free protein synthesis toward monitoring and control. AIChE Journal , Article e17257. 10.1002/aic.17257. (In press).

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Esquivel-Hernandez, Diego A; Pennacchio, Anna; Torres-Acosta, Mario A; Parra-Saldivar, Roberto; de Souza Vandenberghe, Luciana Porto; Faraco, Vincenza; (2021) Multi-product biorefinery from Arthrospira platensis biomass as feedstock for bioethanol and lactic acid production. Scientific Reports , 11 (1) , Article 19309. 10.1038/s41598-021-97803-5.

Esteban, PP; Patel, H; Veraitch, F; Khalife, R; (2021) Optimization of the nutritional environment for differentiation of human‐induced pluripotent stem cells using design of experiments—A proof of concept. Biotechnology Progress , Article e3143. 10.1002/btpr.3143. (In press).

Fedorec, AJH; Karkaria, BD; Sulu, M; Barnes, CP; (2021) Single strain control of microbial consortia. Nature Communications , 12 , Article 1977. 10.1038/s41467-021-22240-x.

Fernández-Castané, A; Li, H; Joseph, S; Ebeler, M; Franzreb, M; Bracewell, DG; Overton, TW; Fernández-Castané, A; Li, H; Joseph, S; Ebeler, M; Franzreb, M; Bracewell, DG; Overton, TW; Thomas, ORT; - view fewer (2021) Nanoparticle tracking analysis as a process analytical tool for characterising magnetosome preparations. Food and Bioproducts Processing , 127 pp. 426-434. 10.1016/j.fbp.2021.03.013.

Flores-Gatica, Miguel; Castaneda-Aponte, Hector; Gil-Garzon, Monica Rebeca; Mora-Galvez, Liliana Monserrath; Banda-Magana, Martin Paul; Jauregui-Jauregui, Jesus Antonio; Torres-Acosta, Mario A; ... Licona-Cassani, Cuauhtemoc; + view all Flores-Gatica, Miguel; Castaneda-Aponte, Hector; Gil-Garzon, Monica Rebeca; Mora-Galvez, Liliana Monserrath; Banda-Magana, Martin Paul; Jauregui-Jauregui, Jesus Antonio; Torres-Acosta, Mario A; Mayolo-Deloisa, Karla; Licona-Cassani, Cuauhtemoc; - view fewer (2021) Primary recovery of hyaluronic acid produced in Streptococcus equi subsp. zooepidemicus using PEG-citrate aqueous two-phase systems. AMB Express , 11 (1) , Article 123. 10.1186/s13568-021-01287-5.

Gali, KK; Reddy Tadi, SR; E.V.R., A; Mohan, N; Swaminathan, N; Katiyar, V; Sivaprakasam, S; (2021) Cost-effective valorization of cassava fibrous waste into enantiomerically pure D-lactic acid: Process engineering and kinetic modeling approach. Environmental Technology & Innovation , 22 , Article 101519. 10.1016/j.eti.2021.101519.

Gangadharan, N; Sewell, D; Turner, R; Field, R; Cheeks, M; Oliver, SG; Slater, NKH; Gangadharan, N; Sewell, D; Turner, R; Field, R; Cheeks, M; Oliver, SG; Slater, NKH; Dikicioglu, D; - view fewer (2021) Data intelligence for process performance prediction in biologics manufacturing. Computers & Chemical Engineering , 146 , Article 107226. 10.1016/j.compchemeng.2021.107226.

Goh, Hai-Yuan; (2021) The Characterisation, Optimisation, Scalability, And Use Of A GS-CHO Cell Line To Improve Bioprocess Productivity. Doctoral thesis (Ph.D), UCL (University College London).

Groves, K; Ashcroft, AE; Cryar, A; Sula, A; Wallace, BA; Stocks, BB; Burns, C; ... Quaglia, M; + view all Groves, K; Ashcroft, AE; Cryar, A; Sula, A; Wallace, BA; Stocks, BB; Burns, C; Cooper-Shepherd, D; De Lorenzi, E; Rodriguez, E; Zhang, H; Ault, JR; Ferguson, J; Phillips, JJ; Pacholarz, K; Thalassinos, K; Luckau, L; Ashton, L; Durrant, O; Barran, P; Dalby, P; Vicedo, P; Colombo, R; Davis, R; Parakra, R; Upton, R; Hill, S; Wood, V; Soloviev, Z; Quaglia, M; - view fewer (2021) Reference Protocol to Assess Analytical Performance of Higher Order Structural Analysis Measurements: Results from an Interlaboratory Comparison. Analytical Chemistry , 93 (26) pp. 9041-9048. 10.1021/acs.analchem.0c04625.

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Güleç, F; Riesco, LMG; Williams, O; Kostas, ET; Samson, A; Lester, E; (2021) Hydrothermal conversion of different lignocellulosic biomass feedstocks – Effect of the process conditions on hydrochar structures. Fuel , 302 , Article 121166. 10.1016/j.fuel.2021.121166.

Hailes, S; Jones, E; Micheletti, M; Mitchell, J; Nyamapfene, A; Roach, K; Tilley, E; ... ., .; + view all Hailes, S; Jones, E; Micheletti, M; Mitchell, J; Nyamapfene, A; Roach, K; Tilley, E; Truscott, F; ., .; - view fewer (2021) The UCL Integrated Engineering Programme. Advances in Engineering Education , 9 (3)

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Hanga, MP; de la Raga, FA; Moutsatsou, P; Hewitt, CJ; Nienow, AW; Wall, I; (2021) Scale-up of an intensified bioprocess for the expansion of bovine adipose-derived stem cells (bASCs) in stirred tank bioreactors. Biotechnology and Bioengineering , 118 (8) pp. 3175-3186. 10.1002/bit.27842.

Hanga, MP; Nienow, AW; Murasiewicz, H; Pacek, AW; Hewitt, CJ; Coopman, K; (2021) Expansion of human mesenchymal stem/stromal cells on temporary liquid microcarriers. Journal of Chemical Technology and Biotechnology , 96 (4) pp. 930-940. 10.1002/jctb.6601.

Hernández López, Roberto Icken; (2021) Development of a high-throughput screening method for transketolase and protein engineering for biotechnology applications. Doctoral thesis (Ph.D), UCL (University College London).

Hirschmann, Roland; (2021) Evaluating the potential of anaerobic production of ethyl(3)hydroxybutyrate for integration in biorefineries. Doctoral thesis (Ph.D), UCL (University College London).

Jacob, SI; Konstantinidis, S; Bracewell, DG; (2021) High-Throughput Process Development for the Chromatographic Purification of Viral Antigens. Vaccine Delivery Technology , 2183 pp. 119-182. 10.1007/978-1-0716-0795-4_9.

Jasulaityte, Greta; (2021) Characterisation of ion exchange chromatography resins for therapeutic protein manufacture. Doctoral thesis (Eng.D), UCL (University College London).

Javanmardi, Y; Colin-York, H; Szita, N; Fritzsche, M; Moeendarbary, E; (2021) Quantifying cell-generated forces: Poisson's ratio matters. Communications Physics , 4 , Article 237. 10.1038/s42005-021-00740-y.

Johnson, T; Jones, K; Iacoviello, F; Turner, S; Jackson, N; Zourna, K; Welsh, J; ... Bracewell, D; + view all Johnson, T; Jones, K; Iacoviello, F; Turner, S; Jackson, N; Zourna, K; Welsh, J; Shearing, P; Hoare, M; Bracewell, D; - view fewer (2021) Liposome Sterile Filtration Characterization via X-ray Computed Tomography and Confocal Microscopy. Membranes , 11 (11) , Article 905. 10.3390/membranes11110905.

Johnson, TF; Iacoviello, F; Welsh, JH; Shearing, PR; Bracewell, DG; (2021) High-resolution imaging of depth filter structures using X-ray computed tomography. Journal of Materials Science 10.1007/s10853-021-06238-w. (In press).

Kostas, ET; Adams, JMM; Ruiz, HA; Durán-Jiménez, G; Lye, GJ; (2021) Macroalgal biorefinery concepts for the circular bioeconomy: A review on biotechnological developments and future perspectives. Renewable and Sustainable Energy Reviews , 151 , Article 111553. 10.1016/j.rser.2021.111553.

Labbé, RP; Vessillier, S; Rafiq, QA; (2021) Lentiviral vectors for t cell engineering: Clinical applications, bioprocessing and future perspectives. Viruses , 13 (8) , Article 1519. 10.3390/v13081519.

Lanphere, C; Arnott, PM; Jones, SF; Korlova, K; Howorka, S; (2021) A Biomimetic DNA‐Based Membrane Gate for Protein‐Controlled Transport of Cytotoxic Drugs. Angewandte Chemie , 133 (4) pp. 1931-1936. 10.1002/ange.202011583.

Lunson, Mary Alice Gallaway; (2021) Establishment of High Cell Density Fed-Batch Microbial Cultures at the Microwell Scale. Doctoral thesis (Eng.D), UCL (University College London).

Macario, Ines PE; Ventura, Sonia PM; Goncalves, Fernando JM; Torres-Acosta, Mario A; Pereira, Joana L; (2021) The "Bright Side" of Cyanobacteria: Revising the Nuisance Potential and Prospecting Innovative Biotechnology-Based Solutions to Integrate Water Management Programs. ACS Sustainable Chemistry & Engineering , 9 (21) pp. 7182-7197. 10.1021/acssuschemeng.1c00458.

Mahal, H; Branton, H; Farid, SS; (2021) End‐to‐end continuous bioprocessing: impact on facility design, cost of goods and cost of development for monoclonal antibodies. Biotechnology and Bioengineering , 118 (9) pp. 3468-3485. 10.1002/bit.27774.

Mandair, Ravneet; Karagoz, Pinar; Bill, Roslyn M; (2021) A Redox-Neutral, Two-Enzyme Cascade for the Production of Malate and Gluconate from Pyruvate and Glucose. Applied Sciences , 11 (11) , Article 4877. 10.3390/app11114877.

Martin Bufajer, Jose Mauricio; (2021) Design of Counter-current Tangential Chromatography to Improve Resin Lifetime and Operational Simplicity. Doctoral thesis (Ph.D), UCL (University College London).

Martinez, Michael; (2021) Scale-up of continuous monoclonal antibody precipitation. Doctoral thesis (Eng.D), UCL (University College London).

Martins, M; Soares, BP; Santos, JHPM; Bharmoria, P; Torres Acosta, MA; Dias, ACRV; Coutinho, JAP; Martins, M; Soares, BP; Santos, JHPM; Bharmoria, P; Torres Acosta, MA; Dias, ACRV; Coutinho, JAP; Ventura, SPM; - view fewer (2021) Sustainable Strategy Based on Induced Precipitation for the Purification of Phycobiliproteins. ACS Sustainable Chemistry and Engineering , 9 (10) pp. 3942-3954. 10.1021/acssuschemeng.0c09218.

Martins, Margarida; de Souza Mesquita, Leonardo M; Vaz, Barbara MC; Dias, Ana CR; Torres-Acosta, Mario A; Queguineur, Benoit; Coutinho, Joao AP; Martins, Margarida; de Souza Mesquita, Leonardo M; Vaz, Barbara MC; Dias, Ana CR; Torres-Acosta, Mario A; Queguineur, Benoit; Coutinho, Joao AP; Ventura, Sonia PM; - view fewer (2021) Extraction and Fractionation of Pigments from Saccharina latissima (Linnaeus, 2006) Using an Ionic Liquid plus Oil plus Water System. ACS Sustainable Chemistry & Engineering , 9 (19) pp. 6599-6612. 10.1021/acssuschemeng.0c09110.

Martins, M; Fernandes, APM; Torres-Acosta, MA; Collen, PN; Abreu, MH; Ventura, SPM; (2021) Extraction of chlorophyll from wild and farmed Ulva spp. using aqueous solutions of ionic liquids. Separation and Purification Technology , 254 , Article 117589. 10.1016/j.seppur.2020.117589.

Mendonça da Silva, J; Stamatis, C; Chalmers, S-A; Erro, E; Selden, C; Farid, SS; (2021) Decisional tool for cost of goods analysis of bioartificial liver devices for routine clinical use. Cytotherapy , 23 (8) pp. 683-693. 10.1016/j.jcyt.2021.04.006.

Mital, S; Christie, G; Dikicioglu, D; (2021) Recombinant expression of insoluble enzymes in Escherichia coli: a systematic review of experimental design and its manufacturing implications. Microbial Cell Factories , 20 (1) , Article 208. 10.1186/s12934-021-01698-w.

Montoya, G; Gutierrez, MI; Giraldo, JD; Jaramillo, LD; Ruiz-Sandoval, J; Orozco, S; Orozco, F; ... Villegas-Torres, MF; + view all Montoya, G; Gutierrez, MI; Giraldo, JD; Jaramillo, LD; Ruiz-Sandoval, J; Orozco, S; Orozco, F; Ward, J; Rojas, G; Villegas-Torres, MF; - view fewer (2021) Sustainable sugarcane vinasse biorefinement for trans-aconitic acid-based biopolymer synthesis and bioenergy generation. Bioresource Technology Reports , 15 , Article 100786. 10.1016/j.biteb.2021.100786.

Morris, P; García-Arrazola, R; Rios-Solis, L; Dalby, PA; (2021) Biophysical characterization of the inactivation of E. coli transketolase by aqueous co-solvents. Scientific Reports , 11 , Article 23584. 10.1038/s41598-021-03001-8.

Newgas, Sophie A; Jeffries, Jack WE; Moody, Thomas S; Ward, John M; Hailes, Helen C; (2021) Discovery of New Carbonyl Reductases Using Functional Metagenomics and Applications in Biocatalysis. Advanced Synthesis and Catalysis , 363 (12) pp. 3044-3052. 10.1002/adsc.202100199.

Noaks, E; Peticone, C; Kotsopoulou, E; Bracewell, DG; (2021) Enriching leukapheresis improves T cell activation and transduction efficiency during CAR T processing. Molecular Therapy - Methods and Clinical Development , 20 pp. 675-687. 10.1016/j.omtm.2021.02.002. (In press).

Nweke, MC; (2021) Assessing Skills Development Across The Undergraduate Degree Programme: An IEP Review – Biochemical Engineering. Journal of Engineering Education Transformations , 34 p. 93. 10.16920/jeet/2021/v34i0/157111.

Oberlintner, A; Bajić, M; Kalčíková, G; Likozar, B; Novak, U; (2021) Biodegradability study of active chitosan biopolymer films enriched with Quercus polyphenol extract in different soil types. Environmental Technology & Innovation , 21 , Article 101318. 10.1016/j.eti.2020.101318.

Olivares Molina, Alex; (2021) Building a cascading multi-product biorefinery process for Ascophyllum nodosum: a green chemistry approach. Doctoral thesis (Ph.D), UCL (University College London).

Perry, Christopher; (2021) Lentiviral vector stability and process purification based on modifications to the viral envelope. Doctoral thesis (Eng.D), UCL (University College London).

Perry, C; Rayat, ACME; (2021) Lentiviral Vector Bioprocessing. Viruses , 13 (2) , Article 268. 10.3390/v13020268.

Robinson, JM; Watkins, H; Man, I; Liddicoat, C; Cameron, R; Parker, B; Cruz, M; Robinson, JM; Watkins, H; Man, I; Liddicoat, C; Cameron, R; Parker, B; Cruz, M; Meagher, L; - view fewer (2021) Microbiome-Inspired Green Infrastructure: A bioscience roadmap for urban ecosystem health. arq: Architectural Research Quarterly , 25 (4) pp. 292-303. 10.1017/S1359135522000148.

Robinson, JM; Cameron, R; Parker, B; (2021) The Effects of Anthropogenic Sound and Artificial Light Exposure on Microbiomes: Ecological and Public Health Implications. Frontiers in Ecology and Evolution , 9 , Article 662588. 10.3389/fevo.2021.662588.

Roddan, R; Subrizi, F; Broomfield, J; Ward, JM; Keep, NH; Hailes, HC; (2021) Chemoenzymatic Cascades toward Methylated Tetrahydroprotoberberine and Protoberberine Alkaloids. Organic Letters , 23 (16) pp. 6342-6347. 10.1021/acs.orglett.1c02110.

Rosa, SS; Prazeres, DMF; Azevedo, AM; Marques, MPC; (2021) mRNA vaccines manufacturing: Challenges and bottlenecks. Vaccine , 39 (16) pp. 2190-2200. 10.1016/j.vaccine.2021.03.038.

Rotondi, M; Grace, N; Betts, J; Bargh, N; Costariol, E; Zoro, B; Hewitt, CJ; ... Rafiq, QA; + view all Rotondi, M; Grace, N; Betts, J; Bargh, N; Costariol, E; Zoro, B; Hewitt, CJ; Nienow, AW; Rafiq, QA; - view fewer (2021) Design and development of a new ambr250® bioreactor vessel for improved cell and gene therapy applications. Biotechnology Letters 10.1007/s10529-021-03076-3. (In press).

Samaras, JJ; Mauri, M; Kay, EJ; Wren, BW; Micheletti, M; (2021) Development of an automated platform for the optimal production of glycoconjugate vaccines expressed in Escherichia coli. Microbial Cell Factories , 20 (1) , Article 104. 10.1186/s12934-021-01588-1.

Sanchez Tarre, Victor; (2021) A combined modelling and experimental characterisation of Chlamydomonas reinhardtii under monochromatic LED illumination. Doctoral thesis (Ph.D), UCL (University College London).

Sanchez-Tarre, Victor; Kiparissides, Alexandros; (2021) The effects of illumination and trophic strategy on gene expression in Chlamydomonas reinhardtii. Algal Research , 54 , Article 102186. 10.1016/j.algal.2021.102186.

Santos Beato, P; Kalaskar, D; Torii, R; Lye, G; (2021) Avoiding cell death in 3D biorpinting - computational fluid dynamics (CFD) modelling of extrusion shear stresses. Presented at: 26th Congress of the European Society of Biomechanics, Italy, Milan.

Sibley, M; Ward, JM; (2021) A cell engineering approach to enzyme-based fed-batch fermentation. Microbial Cell Factories , 20 , Article 146. 10.1186/s12934-021-01634-y.

Spiteri, VA; Doutch, J; Rambo, RP; Gor, J; Dalby, PA; Perkins, SJ; (2021) Solution structure of deglycosylated human IgG1 shows the role of CH2 glycans in its conformation. Biophysical Journal , 120 (9) pp. 1814-1834. 10.1016/j.bpj.2021.02.038.

Stamatis, C; Farid, SS; (2021) Process economics evaluation of cell-free synthesis for the commercial manufacture of antibody drug conjugates. Biotechnology Journal , 16 (4) , Article 2000238. 10.1002/biot.202000238.

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Subrizi, F; Wang, Y; Thair, B; Méndez‐Sánchez, D; Roddan, R; Cárdenas‐Fernández, M; Siegrist, J; ... Hailes, HC; + view all Subrizi, F; Wang, Y; Thair, B; Méndez‐Sánchez, D; Roddan, R; Cárdenas‐Fernández, M; Siegrist, J; Richter, M; Andexer, JN; Ward, JM; Hailes, HC; - view fewer (2021) Multienzyme One-Pot Cascades Incorporating Methyltransferases for the Strategic Diversification of Tetrahydroisoquinoline Alkaloids. Angewandte Chemie , 133 (34) pp. 18821-18827. 10.1002/ange.202104476.

Sun, S; Shu, L; Lu, X; Wang, Q; Tisma, M; Zhu, C; Shi, J; ... Hao, J; + view all Sun, S; Shu, L; Lu, X; Wang, Q; Tisma, M; Zhu, C; Shi, J; Baganz, F; Lye, GJ; Hao, J; - view fewer (2021) 1,2-Propanediol production from glycerol via an endogenous pathway of Klebsiella pneumoniae. Applied Microbiology and Biotechnology , 105 (23) pp. 9003-9016. 10.1007/s00253-021-11652-w.

Sun, S; Wang, Y; Shu, L; Lu, X; Wang, Q; Zhu, C; Shi, J; ... Hao, J; + view all Sun, S; Wang, Y; Shu, L; Lu, X; Wang, Q; Zhu, C; Shi, J; Lye, GJ; Baganz, F; Hao, J; - view fewer (2021) Redirection of the central metabolism of Klebsiella pneumoniae towards dihydroxyacetone production. Microbial Cell Factories , 20 , Article 123. 10.1186/s12934-021-01608-0.

Tan, Ruijie; Hezel, Fabian; Franzreb, Matthias; (2021) Continuous single pass diafiltration with alternating permeate flow direction for high efficiency buffer exchange. Journal of Membrane Science , 619 , Article 118695. 10.1016/j.memsci.2020.118695.

Temisak, S; Thangsunan, P; Boonnil, J; Yenchum, W; Hongthong, K; Oss Boll, H; Yata, T; ... Morris, P; + view all Temisak, S; Thangsunan, P; Boonnil, J; Yenchum, W; Hongthong, K; Oss Boll, H; Yata, T; Rios-Solis, L; Morris, P; - view fewer (2021) Accurate determination of meat mass fractions using DNA measurements for quantifying meat adulteration by digital PCR. International Journal of Food Science and Technology , 56 (12) pp. 6345-6358. 10.1111/ijfs.15375.

Thangsunan, P; Temisak, S; Morris, P; Rios-Solis, L; Suree, N; (2021) Combination of Loop-Mediated Isothermal Amplification and AuNP-Oligoprobe Colourimetric Assay for Pork Authentication in Processed Meat Products. Food Analytical Methods , 14 (3) pp. 568-580. 10.1007/s12161-020-01901-5.

Tian, Qingyu; (2021) Towards the development of an energy efficient microalgae biodiesel process. Masters thesis (M.Phil), UCL (University College London).

Torres-Acosta, Mario A; Castaneda-Aponte, Hector M; Mora-Galvez, Liliana M; Gil-Garzon, Monica R; Banda-Magana, Martin P; Marcellin, Esteban; Mayolo-Deloisa, Karla; Torres-Acosta, Mario A; Castaneda-Aponte, Hector M; Mora-Galvez, Liliana M; Gil-Garzon, Monica R; Banda-Magana, Martin P; Marcellin, Esteban; Mayolo-Deloisa, Karla; Licona-Cassani, Cuauhtemoc; - view fewer (2021) Comparative Economic Analysis Between Endogenous and Recombinant Production of Hyaluronic Acid. Frontiers in Bioengineering and Biotechnology , 9 , Article 680278. 10.3389/fbioe.2021.680278.

Torres-Acosta, MA; dos Santos, N; Ventura, SPM; Coutinho, JAP; Rito-Palomares, M; Pereira, JFB; (2021) Economic analysis of the production and recovery of green fluorescent protein using ATPS-based bioprocesses. Separation and Purification Technology , 254 , Article 117595. 10.1016/j.seppur.2020.117595.

Van de Steen, A; Khalife, R; Colant, N; Mustafa Khan, H; Deveikis, M; Charalambous, S; Robinson, CM; ... Frank, S; + view all Van de Steen, A; Khalife, R; Colant, N; Mustafa Khan, H; Deveikis, M; Charalambous, S; Robinson, CM; Dabas, R; Esteban Serna, S; Catana, DA; Pildish, K; Kalinovskiy, V; Gustafsson, K; Frank, S; - view fewer (2021) Bioengineering bacterial encapsulin nanocompartments as targeted drug delivery system. Synthetic and Systems Biotechnology , 6 (3) pp. 231-241. 10.1016/j.synbio.2021.09.001.

Vaud, S; Pearcy, N; Hanževački, M; Van Hagen, AMW; Abdelrazig, S; Safo, L; Ehsaan, M; ... Bryan, SJ; + view all Vaud, S; Pearcy, N; Hanževački, M; Van Hagen, AMW; Abdelrazig, S; Safo, L; Ehsaan, M; Jonczyk, M; Millat, T; Craig, S; Spence, E; Fothergill, J; Bommareddy, RR; Colin, P-Y; Twycross, J; Dalby, P; Minton, N; Jäger, CM; Kim, D-H; Yu, J; Maness, P-C; Lynch, S; Eckert, C; Conradie, A; Bryan, SJ; - view fewer (2021) Engineering improved ethylene production: Leveraging systems Biology and adaptive laboratory evolution. Metabolic Engineering 10.1016/j.ymben.2021.07.001. (In press).

Von Massow, G; Oh, S; Lam, A; Gustafsson, K; (2021) Gamma Delta T Cells and Their Involvement in COVID-19 Virus Infections. Frontiers in Immunology , 12 , Article 741218. 10.3389/fimmu.2021.741218.

Walls, LE; Malcı, K; Nowrouzi, B; Li, RA; d'Espaux, L; Wong, J; Dennis, JA; ... Rios-Solis, L; + view all Walls, LE; Malcı, K; Nowrouzi, B; Li, RA; d'Espaux, L; Wong, J; Dennis, JA; Semião, AJC; Wallace, S; Martinez, JL; Keasling, JD; Rios-Solis, L; - view fewer (2021) Optimizing the biosynthesis of oxygenated and acetylated Taxol precursors in Saccharomyces cerevisiae using advanced bioprocessing strategies. Biotechnology and Bioengineering , 118 (1) pp. 279-293. 10.1002/bit.27569.

Wiegmann, V; Gardner, RA; Spencer, DIR; Baganz, F; (2021) Equal mixing time enables scale-down and optimization of a CHO cell culture process using a shaken microbioreactor system. Biotechnology Journal 10.1002/biot.202100360. (In press).

Wiegmann, Vincent; (2021) Characterisation of a parallel microbioreactor system and its application to accelerate cell culture process development. Doctoral thesis (Eng.D), UCL (University College London).

Wilson, LJ; Lewis, W; Kucia-Tran, R; Bracewell, DG; (2021) Identification and classification of host cell proteins during biopharmaceutical process development. Biotechnology Progress 10.1002/btpr.3224. (In press).

Woodhouse, JL; Henley, A; Lewin, R; Ward, JM; Hailes, HC; Bochenkova, AV; Fielding, HH; (2021) A photoelectron imaging study of the deprotonated GFP chromophore anion and RNA fluorescent tags. Physical Chemistry Chemical Physics 10.1039/d1cp01901e. (In press).

Zainuddin, MF; Fai, CK; Ariff, AB; Rios-Solis, L; Halim, M; (2021) Current pretreatment/cell disruption and extraction methods used to improve intracellular lipid recovery from oleaginous yeasts. Microorganisms , 9 (2) , Article 251. 10.3390/microorganisms9020251.

Zhang, C; Codina, N; Tang, J; Yu, H; Chakroun, N; Kozielski, F; Dalby, PA; (2021) Comparison of the pH- and thermally-induced fluctuations of a therapeutic antibody Fab fragment by molecular dynamics simulation. Computational and Structural Biotechnology Journal , 19 pp. 2726-2741. 10.1016/j.csbj.2021.05.005.

Zhang, H; Yang, Y; Zhang, C; Farid, SS; Dalby, PA; (2021) Machine learning reveals hidden stability code in protein native fluorescence. Computational and Structural Biotechnology Journal , 19 pp. 2750-2760. 10.1016/j.csbj.2021.04.047.

Zhao, J; Méndez-Sánchez, D; Roddan, R; Ward, JM; Hailes, HC; (2021) Norcoclaurine Synthase-Mediated Stereoselective Synthesis of 1,1'-Disubstituted, Spiro- and Bis-Tetrahydroisoquinoline Alkaloids. ACS Catalysis , 11 (1) pp. 131-138. 10.1021/acscatal.0c04704.

2020

Amini, A; Wiegmann, V; Patel, H; Veraitch, F; Baganz, F; (2020) Bioprocess considerations for T cell therapy: Investigating the impact of agitation, dissolved oxygen and pH on T cell expansion and differentiation. Biotechnology and Bioengineering , 117 (10) pp. 3018-3028. 10.1002/bit.27468.

Arnott, Patrick Marthijn; (2020) Development of DNA Nanopores for New Biotherapeutic Applications. Doctoral thesis (Eng.D), UCL (University College London).

Bajić, M; Oberlintner, A; Kõrge, K; Likozar, B; Novak, U; (2020) Formulation of active food packaging by design: Linking composition of the film-forming solution to properties of the chitosan-based film by response surface methodology (RSM) modelling. International Journal of Biological Macromolecules , 160 pp. 971-978. 10.1016/j.ijbiomac.2020.05.186.

Beal, J; Farny, NG; Haddock-Angelli, T; Selvarajah, V; Baldwin, GS; Buckley-Taylor, R; Gershater, M; ... Simona, MF; + view all Beal, J; Farny, NG; Haddock-Angelli, T; Selvarajah, V; Baldwin, GS; Buckley-Taylor, R; Gershater, M; Kiga, D; Marken, J; Sanchania, V; Sison, A; Workman, CT; Pehlivan, M; Roige, BB; Aarnio, T; Kivisto, S; Koski, J; Lehtonen, L; Pezzutto, D; Rautanen, P; Bian, W; Hu, Z; Liu, Z; Liu, Z; Ma, L; Pan, L; Qin, Z; Wang, H; Wang, X; Xu, H; Xu, X; El Moubayed, Y; Dong, S; Fang, C; He, H; He, H; Huang, F; Shi, R; Tang, C; Tang, C; Xu, S; Yan, C; Bartzoka, N; Kanata, E; Kapsokefalou, M; Katopodi, XL; Kostadima, E; Kostopoulos, IV; Kotzastratis, S; Koutelidakis, AE; Krokos, V; Litsa, M; Ntekas, I; Spatharas, P; Tsitsilonis, OE; Zerva, A; Annem, V; Cone, E; Elias, N; Gupta, S; Lam, K; Tutuianu, A; Mishler, DM; Toro, B; Akinfenwa, A; Burns, F; Herbert, H; Jones, M; Laun, S; Morrison, S; Smith, Z; Peng, Z; Ziwei, Z; Deng, R; Huang, Y; Li, T; Ma, Y; Shen, Z; Wang, C; Wang, Y; Zhao, T; Lang, Y; Liang, Y; Wang, X; Wu, Y; Aizik, D; Angel, S; Farhi, E; Keidar, N; Oser, E; Pasi, M; Kalinowski, J; Otto, M; Ruhnau, J; Cubukcu, H; Hoskan, MA; Senyuz, I; Chi, J; Sauter, AP; Simona, MF; - view fewer (2020) Robust estimation of bacterial cell count from optical density. Communications Biology , 3 , Article 512. 10.1038/s42003-020-01127-5.

Beal, J; Goñi-Moreno, A; Myers, C; Hecht, A; De Vicente, MDC; Parco, M; Schmidt, M; ... Porcar, M; + view all Beal, J; Goñi-Moreno, A; Myers, C; Hecht, A; De Vicente, MDC; Parco, M; Schmidt, M; Timmis, K; Baldwin, G; Friedrichs, S; Freemont, P; Kiga, D; Ordozgoiti, E; Rennig, M; Rios, L; Tanner, K; De Lorenzo, V; Porcar, M; - view fewer (2020) The long journey towards standards for engineering biosystems: Are the Molecular Biology and the Biotech communities ready to standardise? EMBO Reports , 21 (5) , Article e50521. 10.15252/embr.202050521.

Bhatta, Mihir; Dutta, Nalok; Nandi, Srijita; Dutta, Shanta; Saha, Malay Kumar; (2020) Mother-to-child HIV transmission and its correlates in India: systematic review and meta-analysis. BMC Pregnancy Childbirth , 20 (1) , Article 509. 10.1186/s12884-020-03193-3.

Chauhan, VM; Zhang, H; Dalby, PA; Aylott, JW; (2020) Advancements in the co-formulation of biologic therapeutics. Journal of Controlled Release , 327 pp. 397-405. 10.1016/j.jconrel.2020.08.013.

Clark, Colleen E.; (2020) Characterization and Scalability Assessment of a Parallel Single-Use Bioreactor System for Mammalian Cell Culture. Doctoral thesis (Ph.D), UCL (University College London).

Colant, N; Melinek, B; Teneb, J; Goldrick, S; Rosenberg, W; Frank, S; Bracewell, DG; (2020) A rational approach to improving titer in Escherichia coli‐based cell‐free protein synthesis reactions. Biotechnology Progress , Article e3062. 10.1002/btpr.3062. (In press).

Colin, P-Y; Dalby, PA; (2020) Functional and computational identification of a rescue mutation near the active site of an mRNA methyltransferase. Scientific Reports , 10 , Article 21841. 10.1038/s41598-020-79026-2.

Colombo, B; Pereira, J; Martins, M; Torres-Acosta, MA; Dias, ACR; Lemos, PC; Ventura, SPM; ... Serafim, LS; + view all Colombo, B; Pereira, J; Martins, M; Torres-Acosta, MA; Dias, ACR; Lemos, PC; Ventura, SPM; Eisele, G; Alekseeva, A; Adani, F; Serafim, LS; - view fewer (2020) Recovering PHA from mixed microbial biomass: Using non-ionic surfactants as a pretreatment step. Separation and Purification Technology , 253 , Article 117521. 10.1016/j.seppur.2020.117521.

Cornish, E; Filipovic, I; Åsenius, F; Williams, D; McDonnell, T; (2020) Innate immune responses to acute viral infection during pregnancy. Frontiers in Immunology 10.3389/fimmu.2020.572567.

Costariol, E; Rotondi, MC; Amini, A; Hewitt, CJ; Nienow, AW; Heathman, TRJ; Rafiq, QA; (2020) Demonstrating the Manufacture of Human CAR-T Cells in an Automated Stirred-Tank Bioreactor. Biotechnology Journal , 15 (9) , Article 2000177. 10.1002/biot.202000177.

Dobrijevic, D; Nematollahi, LA; Hailes, HC; Ward, JM; (2020) pET expression vector customized for efficient seamless cloning. Biotechniques 10.2144/btn-2020-0101.

Durán-Jiménez, G; Stevens, LA; Kostas, ET; Hernández-Montoya, V; Robinson, JP; Binner, ER; (2020) Rapid, simple and sustainable synthesis of ultra-microporous carbons with high performance for CO2 uptake, via microwave heating. Chemical Engineering Journal , 388 , Article 124309. 10.1016/j.cej.2020.124309.

Duran-Villalobos, CA; Goldrick, S; Lennox, B; (2020) Multivariate statistical process control of an industrial-scale fed-batch simulator. Computers and Chemical Engineering , 132 , Article 106620. 10.1016/j.compchemeng.2019.106620.

Elgabry, M; Nesbeth, D; Johnson, SD; (2020) A Systematic Review of the Criminogenic Potential of Synthetic Biology and Routes to Future Crime Prevention. Frontiers in Bioengineering and Biotechnology , 8 , Article 571672. 10.3389/fbioe.2020.571672.

Elgabry, M; Nesbeth, D; Johnson, SD; (2020) A systematic review protocol for crime trends facilitated by synthetic biology. Systematic Reviews , 9 , Article 22. 10.1186/s13643-020-1284-1.

Farid, SS; Baron, M; Stamatis, C; Nie, W; Coffman, J; (2020) Benchmarking biopharmaceutical process development and manufacturing cost contributions to R&D. mAbs , 12 (1) , Article 1754999. 10.1080/19420862.2020.1754999.

Farinha, F; Pepper, RJ; Oliveira, DG; McDonnell, T; Isenberg, DA; Rahman, A; (2020) Outcomes of membranous and proliferative lupus nephritis – analysis of a single-centre cohort with more than 30 years of follow-up. Rheumatology 10.1093/rheumatology/keaa103. (In press).

Fernadez-Cerezo, L; Rayat, A; Chatel, A; Pollard, J; Lye, G; Hoare, M; (2020) The prediction of the operating conditions on the permeate flux and on protein aggregation during membrane processing of monoclonal antibodies. Journal of Membrane Science , 596 , Article 117606. 10.1016/j.memsci.2019.117606.

Fischer, Vivien; (2020) Rapid optimisation of preparative chromatography for monoclonal antibody purification using high-throughput methodology. Doctoral thesis (Eng.D), UCL (University College London).

Goldrick, S; Sandner, V; Cheeks, M; Turner, R; Farid, SS; McCreath, G; Glassey, J; (2020) Multivariate Data Analysis Methodology to Solve Data Challenges Related to Scale-up Model Validation and Missing Data on a Micro-Bioreactor System. Biotechnology Journal , 15 (3) , Article e1800684. 10.1002/biot.201800684.

Goldrick, S; Umprecht, A; Tang, A; Zakrzewski, R; Cheeks, M; Turner, R; Charles, A; ... Farid, SS; + view all Goldrick, S; Umprecht, A; Tang, A; Zakrzewski, R; Cheeks, M; Turner, R; Charles, A; Les, K; Hulley, M; Spencer, C; Farid, SS; - view fewer (2020) High-Throughput Raman Spectroscopy Combined with Innovate Data Analysis Workflow to Enhance Biopharmaceutical Process Development. Processes , 8 (9) , Article 1179. 10.3390/pr8091179.

Gustafsson, K; Herrmann, T; Dieli, F; (2020) Editorial: Understanding Gamma Delta T Cell Multifunctionality - Towards Immunotherapeutic Applications. Frontiers in Immunology , 11 , Article 921. 10.3389/fimmu.2020.00921.

Hanga, Mariana P; Ali, Junaid; Moutsatsou, Panagiota; de la Raga, Fritz A; Hewitt, Christopher J; Nienow, Alvin; Wall, Ivan; (2020) Bioprocess development for scalable production of cultivated meat. Biotechnology and Bioengineering , 117 (10) pp. 3029-3039. 10.1002/bit.27469.

Henríquez, M-J; Braun-Galleani, S; Nesbeth, D; (2020) Whole cell biosynthetic activity of Komagataella phaffii (Pichia pastoris) GS115 strains engineered with transgenes encoding Chromobacterium violaceum ω-transaminase alone or combined with native transketolase. Biotechnology Progress , 36 (1) , Article e2893. 10.1002/btpr.2893.

Henríquez, MJ; Cardós-Elena, RP; Nesbeth, D; (2020) Genomic data mining reveals the transaminase repertoire of Komagataella phaffii (Pichia pastoris) strain GS115 and supports a systematic nomenclature. Journal of Genetics , 99 , Article 49. 10.1007/s12041-020-01201-1.

Hickman, Thomas William Paul; (2020) The development of a novel, CoA-dependent, organic acid modification system as a link to a biosynthetic pathway for the nylon 6 monomer, 6-aminocaproic acid. Doctoral thesis (Ph.D), UCL (University College London).

Hickman, TWP; Baud, D; Benhamou, L; Hailes, HC; Ward, JM; (2020) Characterisation of four hotdog-fold thioesterases for their implementation in a novel organic acid production system. Applied Microbiology and Biotechnology , 104 pp. 4397-4406. 10.1007/s00253-020-10519-w.

Johnson, TF; Iacoviello, F; Hayden, DJ; Welsh, JH; Levison, PR; Shearing, PR; Bracewell, DG; (2020) Packed bed compression visualisation and flow simulation using an erosion-dilation approach. Journal of Chromatography A , 1611 , Article 460601. 10.1016/j.chroma.2019.460601.

Joshi, Jay Ketan Kong; (2020) The development of next-generation small volume biophysical screening for the early assessment of monoclonal antibody manufacturability. Doctoral thesis (Ph.D), UCL (University College London).

Juodeikis, R; Lee, MJ; Mayer, M; Mantell, J; Brown, IR; Verkade, P; Woolfson, DN; ... Warren, MJ; + view all Juodeikis, R; Lee, MJ; Mayer, M; Mantell, J; Brown, IR; Verkade, P; Woolfson, DN; Prentice, MB; Frank, S; Warren, MJ; - view fewer (2020) Effect of metabolosome encapsulation peptides on enzyme activity, coaggregation, incorporation, and bacterial microcompartment formation. MicrobiologyOpen , 9 (5) , Article e1010. 10.1002/mbo3.1010.

Kamrad, S; Grossbach, J; Rodríguez-López, M; Mülleder, M; Townsend, S; Cappelletti, V; Stojanovski, G; ... Bähler, J; + view all Kamrad, S; Grossbach, J; Rodríguez-López, M; Mülleder, M; Townsend, S; Cappelletti, V; Stojanovski, G; Correia-Melo, C; Picotti, P; Beyer, A; Ralser, M; Bähler, J; - view fewer (2020) Pyruvate kinase variant of fission yeast tunes carbon metabolism, cell regulation, growth and stress resistance. Molecular Systems Biology , 16 (4) , Article e9270. 10.15252/msb.20199270.

Kina-Ysa, M; Flores-Fernández, CN; Flores-Santos, JC; Zavaleta, AI; (2020) Obtención de hidrolizados proteicos de leguminosas usando una proteasa recombinante de Pseudomonas aeruginosa M211 = Obtaining protein hydrolysates from leguminous using a recombinant protease from Pseudomonas aeruginosa M211. Revista chilena de nutrición , 47 (3) pp. 381-389. 10.4067/S0717-75182020000300381.

Kõrge, K; Bajić, M; Likozar, B; Novak, U; (2020) Active chitosan–chestnut extract films used for packaging and storage of fresh pasta. International Journal of Food Science & Technology , 55 (8) pp. 3043-3052. 10.1111/ijfs.14569.

Kõrge, K; Šeme, H; Bajić, M; Likozar, B; Novak, U; (2020) Reduction in Spoilage Microbiota and Cyclopiazonic Acid Mycotoxin with Chestnut Extract Enriched Chitosan Packaging: Stability of Inoculated Gouda Cheese. Foods , 9 (11) , Article 1645. 10.3390/foods9111645.

Kostas, ET; Durán-Jiménez, G; Shepherd, BJ; Meredith, W; Stevens, LA; Williams, OSA; Lye, GJ; Kostas, ET; Durán-Jiménez, G; Shepherd, BJ; Meredith, W; Stevens, LA; Williams, OSA; Lye, GJ; Robinson, JP; - view fewer (2020) Microwave pyrolysis of olive pomace for bio-oil and bio-char production. Chemical Engineering Journal , 387 , Article 123404. 10.1016/j.cej.2019.123404.

Kostas, ET; White, DA; Cook, DJ; (2020) Bioethanol Production from UK Seaweeds: Investigating Variable Pre-treatment and Enzyme Hydrolysis Parameters. BioEnergy Research , 13 pp. 271-285. 10.1007/s12155-019-10054-1.

Lanphere, C; Arnott, PM; Jones, SF; Korlova, K; Howorka, S; (2020) A Biomimetic DNA-Based Membrane Gate for Protein-Controlled Transport of Cytotoxic Drugs. Angewandte Chemie International Edition 10.1002/anie.202011583. (In press).

Li, Y; Ducci, A; Micheletti, M; (2020) Study on mixing characteristics in shaken microwell systems. Biochemical Engineering Journal , 153 , Article 107392. 10.1016/j.bej.2019.107392.

Li, Yi; (2020) Free surface, flow and mixing characterisation in orbitally shaken reactors. Doctoral thesis (Ph.D), UCL (University College London).

Lu, X; Yao, Y; Yang, Y; Zhang, Z; Gu, J; Mojovic, L; Knezevic-Jugovic, Z; ... Hao, J; + view all Lu, X; Yao, Y; Yang, Y; Zhang, Z; Gu, J; Mojovic, L; Knezevic-Jugovic, Z; Baganz, F; Lye, G; Shi, J; Hao, J; - view fewer (2020) Ethylene glycol and glycolic acid production by wild-type Escherichia coli. Biotechnology and Applied Biochemistry , 68 (4) pp. 744-755. 10.1002/bab.1987.

Lu, Yang; (2020) Design and optimisation of operon constructs for expression and characterisation of Class I cytochrome P450s from actinomycetes. Doctoral thesis (Ph.D), UCL (University College London).

Lularevic, Maximilian; (2020) A combined mathematical and experimental investigation of lactate metabolism in industrial CHO cell cultures. Doctoral thesis (Eng.D), UCL (University College London).

Malcı, K; Walls, LE; Rios-Solis, L; (2020) Multiplex Genome Engineering Methods for Yeast Cell Factory Development. Frontiers in Bioengineering and Biotechnology , 8 , Article 589468. 10.3389/fbioe.2020.589468.

Martinez, M; Mannall, G; Spitali, M; Norrant, EL; Bracewell, DG; (2020) Reactor Design for Continuous Monoclonal Antibody Precipitation Based Upon Micro‐mixing. Journal of Chemical Technology & Biotechnology 10.1002/jctb.6652. (In press).

Mota Pacheco, Luis Erick; (2020) Biocatalytic conversion of renewable feedstocks for production of value-added chemicals. Doctoral thesis (Ph.D), UCL (University College London).

Novak, U; Bajić, M; Kõrge, K; Oberlintner, A; Murn, J; Lokar, K; Triler, KV; Novak, U; Bajić, M; Kõrge, K; Oberlintner, A; Murn, J; Lokar, K; Triler, KV; Likozar, B; - view fewer (2020) From waste/residual marine biomass to active biopolymer-based packaging film materials for food industry applications- A review. Physical Sciences Reviews , 5 (3) , Article 20190099. 10.1515/psr-2019-0099.

Nowrouzi, B; Li, RA; Walls, LE; D'Espaux, L; Malcı, K; Liang, L; Jonguitud-Borrego, N; ... Rios-Solis, L; + view all Nowrouzi, B; Li, RA; Walls, LE; D'Espaux, L; Malcı, K; Liang, L; Jonguitud-Borrego, N; Lerma-Escalera, AI; Morones-Ramirez, JR; Keasling, JD; Rios-Solis, L; - view fewer (2020) Enhanced production of taxadiene in Saccharomyces cerevisiae. Microbial Cell Factories , 19 , Article 200. 10.1186/s12934-020-01458-2.

Papachristodoulou, M; Doutch, J; Leung, HSB; Church, A; Charleston, T; Clifton, LA; Butler, PD; ... Bracewell, DG; + view all Papachristodoulou, M; Doutch, J; Leung, HSB; Church, A; Charleston, T; Clifton, LA; Butler, PD; Roberts, CJ; Bracewell, DG; - view fewer (2020) In situ neutron scattering of antibody adsorption during protein A chromatography. Journal of Chromatography A , 1617 , Article 460842. 10.1016/j.chroma.2019.460842.

Papachristodoulou, Maria; (2020) Neutron scattering to characterise protein interactions with solid-liquid interfaces in bioprocessing. Doctoral thesis (Ph.D), UCL (University College London).

Papathanasiou, MM; Stamatis, C; Lakelin, M; Farid, S; Titchener-Hooker, N; Shah, N; (2020) Autologous CAR T-cell therapies supply chain: challenges and opportunities? Cancer Gene Therapy 10.1038/s41417-019-0157-z. (In press).

Patel, N; Farid, S; Morris, S; (2020) How should we evaluate the cost-effectiveness of CAR T-cell therapies? Health Policy and Technology 10.1016/j.hlpt.2020.03.002. (In press).

Pereira Chilima, TD; Moncaubeig, F; Farid, SS; (2020) Estimating capital investment and facility footprint in cell therapy facilities. Biochemical Engineering Journal , 155 , Article 107439. 10.1016/j.bej.2019.107439.

Peticone, C; Thompson, DDS; Dimov, N; Jevans, B; Glass, N; Micheletti, M; Knowles, JC; ... Wall, IB; + view all Peticone, C; Thompson, DDS; Dimov, N; Jevans, B; Glass, N; Micheletti, M; Knowles, JC; Kim, HW; Cooper-White, JJ; Wall, IB; - view fewer (2020) Characterisation of osteogenic and vascular responses of hMSCs to Ti-Co doped phosphate glass microspheres using a microfluidic perfusion platform. Journal of Tissue Engineering , 11 pp. 1-19. 10.1177/2041731420954712.

Roddan, R; Sula, A; Méndez-Sánchez, D; Subrizi, F; Lichman, BR; Broomfield, J; Richter, M; ... Hailes, HC; + view all Roddan, R; Sula, A; Méndez-Sánchez, D; Subrizi, F; Lichman, BR; Broomfield, J; Richter, M; Andexer, JN; Ward, JM; Keep, NH; Hailes, HC; - view fewer (2020) Single step syntheses of (1S)-aryl-tetrahydroisoquinolines by norcoclaurine synthases. Communications Chemistry , 3 (1) 10.1038/s42004-020-00416-8. (In press).

Roddan, R; Ward, JM; Keep, NH; Hailes, HC; (2020) Pictet–Spenglerases in alkaloid biosynthesis: Future applications in biocatalysis. Current Opinion in Chemical Biology , 55 pp. 69-76. 10.1016/j.cbpa.2019.12.003.

Samaras, JJ; Ducci, A; Micheletti, M; (2020) Flow, suspension and mixing dynamics in DASGIP bioreactors, Part 2. AIChE Journal , 66 (11) , Article e16999. 10.1002/aic.16999.

Samaras, JJ; Micheletti, M; Ducci, A; (2020) Flow, suspension, and mixing dynamics in DASGIP bioreactors: Part 1. AIChE Journal 10.1002/aic.17014. (In press).

Santos, M; O'Sullivan, B; Müller, S; Bunescu, A; Baganz, F; Marques, MPC; Hailes, H; ... Wohlgemuth, R; + view all Santos, M; O'Sullivan, B; Müller, S; Bunescu, A; Baganz, F; Marques, MPC; Hailes, H; Szita, N; Wohlgemuth, R; - view fewer (2020) Chemoenzymatic microfluidic cascade reaction: Coupling of a diels-alder reaction with a transketolase-catalyzed reaction. In: MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences. (pp. pp. 693-694). CBMS: Online conference.

Sawant, N; Kaur, K; Holland, DA; Hickey, JM; Agarwal, S; Brady, JR; Dalvie, NC; ... Volkin, DB; + view all Sawant, N; Kaur, K; Holland, DA; Hickey, JM; Agarwal, S; Brady, JR; Dalvie, NC; Tracey, MK; Velez-Suberbie, ML; Morris, SA; Jacob, SI; Bracewell, DG; Mukhopadhyay, TK; Love, KR; Love, JC; Joshi, SB; Volkin, DB; - view fewer (2020) Rapid Developability Assessments to Formulate Recombinant Protein Antigens as Stable, Low-Cost, Multi-Dose Vaccine Candidates: Case-Study With Non-Replicating Rotavirus (NRRV) Vaccine Antigens. Journal of Pharmaceutical Sciences 10.1016/j.xphs.2020.11.039. (In press).

Segura, BT; Bernstein, BS; McDonnell, T; Wincup, C; Ripoll, V; Giles, I; Isenberg, D; Segura, BT; Bernstein, BS; McDonnell, T; Wincup, C; Ripoll, V; Giles, I; Isenberg, D; Rahman, A; - view fewer (2020) Damage accrual and mortality over long-term follow-up in 300 patients with systemic lupus erythematosus in a multi-ethnic British cohort. Rheumatology , 59 (3) pp. 524-533. 10.1093/rheumatology/kez292.

Silva Couto, P; Rotondi, MC; Bersenev, A; Hewitt, CJ; Nienow, AW; Verter, F; Rafiq, QA; (2020) Expansion of human mesenchymal stem/stromal cells (hMSCs) in bioreactors using microcarriers: lessons learnt and what the future holds. Biotechnology Advances , 45 , Article 107636. 10.1016/j.biotechadv.2020.107636.

Song, Zhongdi; (2020) Optimisation of Phaeodactylum tricornutum as a microalgal expression host for industrial biotechnology. Doctoral thesis (Ph.D), UCL (University College London).

Song, Z; Lye, GJ; Parker, BM; (2020) Morphological and biochemical changes in Phaeodactylum tricornutum triggered by culture media: Implications for industrial exploitation. Algal Research , 47 , Article 101822. 10.1016/j.algal.2020.101822.

Spice, AJ; Aw, R; Bracewell, DG; Polizzi, KM; (2020) Improving the reaction mix of a Pichia pastoris cell-free system using a design of experiments approach to minimise experimental effort. Synthetic and Systems Biotechnology , 5 (3) pp. 137-144. 10.1016/j.synbio.2020.06.003.

Spice, AJ; Aw, R; Bracewell, DG; Polizzi, KM; (2020) Synthesis and Assembly of Hepatitis B Virus-Like Particles in a Pichia pastoris Cell-Free System. Frontiers in Bioengineering and Biotechnology , 8 , Article 72. 10.3389/fbioe.2020.00072.

Stojanovski, G; Dobrijevic, D; Hailes, HC; Ward, JM; (2020) Identification and catalytic properties of new epoxide hydrolases from the genomic data of soil bacteria. Enzyme and Microbial Technology , 139 , Article 109592. 10.1016/j.enzmictec.2020.109592.

Tan, R; Franzreb, M; (2020) Continuous ultrafiltration/diafiltration using a 3D‐printed two membrane single pass module. Biotechnology and Bioengineering , 117 (3) pp. 654-661. 10.1002/bit.27233.

Torres‐Acosta, MA; González‐Mora, A; Ruiz‐Ruiz, F; Rito‐Palomares, M; Benavides, J; (2020) Economic Evaluation of M13 Bacteriophage Production at Large‐Scale for Therapeutic Applications using Aqueous Two‐Phase Systems. Journal of Chemical Technology & Biotechnology , 95 (11) pp. 2822-2833. 10.1002/jctb.6526.

Velez-Suberbie, ML; Morris, SA; Kaur, K; Hickey, JM; Joshi, SB; Volkin, DB; Bracewell, DG; Velez-Suberbie, ML; Morris, SA; Kaur, K; Hickey, JM; Joshi, SB; Volkin, DB; Bracewell, DG; Mukhopadhyay, TK; - view fewer (2020) Holistic process development to mitigate proteolysis of a subunit rotavirus vaccine candidate produced in Pichia pastoris by means of an acid pH pulse during fed‐batch fermentation. Biotechnology Progress , 36 (3) , Article e2966. 10.1002/btpr.2966.

Walls, LE; Rios-Solis, L; (2020) Sustainable Production of Microbial Isoprenoid Derived Advanced Biojet Fuels Using Different Generation Feedstocks: A Review. Frontiers in Bioengineering and Biotechnology , 8 , Article 599560. 10.3389/fbioe.2020.599560.

Wang, Y; Gu, J; Lu, X; Zhang, Z; Yang, Y; Sun, S; Kostas, ET; ... Hao, J; + view all Wang, Y; Gu, J; Lu, X; Zhang, Z; Yang, Y; Sun, S; Kostas, ET; Shi, J; Gao, M; Baganz, F; Lye, GJ; Hao, J; - view fewer (2020) 2,3-Dihydroxyisovalerate production by Klebsiella pneumoniae. Applied Microbiology and Biotechnology , 104 pp. 6601-6613. 10.1007/s00253-020-10711-y.

Watkins, H; Robinson, JM; Breed, MF; Parker, B; Weinstein, P; (2020) Microbiome-Inspired Green Infrastructure: A Toolkit for Multidisciplinary Landscape Design. Trends in Biotechnology , 38 (12) pp. 1305-1308. 10.1016/j.tibtech.2020.04.009.

Wei, X; Hellier, P; Baganz, F; (2020) Impact on performance and emissions of the aspiration of algal biomass suspensions in the intake air of a direct injection diesel engine. Energy Conversion and Management , 205 , Article 112347. 10.1016/j.enconman.2019.112347.

Wei, Xinyu; (2020) Evaluating alternative routes of using algal biomass for energy production. Doctoral thesis (Ph.D), UCL (University College London).

Wiegmann, V; Martinez, CB; Baganz, F; (2020) Using a Parallel Micro-Cultivation System (Micro-Matrix) as a Process Development Tool for Cell Culture Applications. Animal Cell Biotechnology , 2095 pp. 69-81. 10.1007/978-1-0716-0191-4_5.

Wilkinson, HC; Dalby, PA; (2020) Fine-tuning the activity and stability of an evolved enzyme active-site through non-canonical amino-acids. The FEBS Journal 10.1111/febs.15560. (In press).

Wilkinson, HC; Dalby, PA; (2020) The Two-Species Model of transketolase explains donor substrate-binding, inhibition and heat-activation. Scientific Reports , 10 , Article 4148. 10.1038/s41598-020-61175-z.

Wilson, Louisa Jane; (2020) Integrating upstream and downstream process development strategies for mammalian cell derived therapeutic antibodies. Doctoral thesis (Ph.D), UCL (University College London).

Wood, VE; Groves, K; Cryar, A; Quaglia, M; Matejtschuk, P; Dalby, PA; (2020) HDX and In Silico Docking Reveal that Excipients Stabilize G-CSF via a Combination of Preferential Exclusion and Specific Hotspot Interactions. Molecular Pharmaceutics , 17 (12) pp. 4637-4651. 10.1021/acs.molpharmaceut.0c00877.

Wyrobnik, TA; Ducci, A; Micheletti, M; (2020) Advances in human mesenchymal stromal cell-based therapies – Towards an integrated biological and engineering approach. Stem Cell Research , 47 , Article 101888. 10.1016/j.scr.2020.101888.

Yang, M; Ward, J; Choy, K-L; (2020) Nature‐Inspired Bacterial Cellulose/Methylglyoxal (BC/MGO) Nanocomposite for Broad‐Spectrum Antimicrobial Wound Dressing. Macromolecular Bioscience , Article 2000070. 10.1002/mabi.202000070. (In press).

Yang, Y; Zhang, Z; Lu, X; Gu, J; Wang, Y; Yao, Y; Liao, X; ... Hao, J; + view all Yang, Y; Zhang, Z; Lu, X; Gu, J; Wang, Y; Yao, Y; Liao, X; Shi, J; Lye, G; Baganz, F; Hao, J; - view fewer (2020) Production of 2,3-dihydroxyisovalerate by Enterobacter cloacae. Enzyme and Microbial Technology , 140 , Article 109650. 10.1016/j.enzmictec.2020.109650.

Yu, H; Dalby, PA; (2020) A beginner's guide to molecular dynamics simulations and the identification of cross-correlation networks for enzyme engineering. In: Tawfik, DS, (ed.) Enzyme Engineering and Evolution: General Methods. (pp. 15-49). Academic Press

Yu, H; López, RIH; Steadman, D; Méndez-Sánchez, D; Higson, S; Cázares-Körner, A; Sheppard, TD; ... Dalby, PA; + view all Yu, H; López, RIH; Steadman, D; Méndez-Sánchez, D; Higson, S; Cázares-Körner, A; Sheppard, TD; Ward, JM; Hailes, HC; Dalby, PA; - view fewer (2020) Engineering transketolase to accept both unnatural donor and acceptor substrates and produce α‐hydroxyketones. The FEBS Journal , 287 (9) pp. 1758-1776. 10.1111/febs.15108.

Zhang, H; Dalby, PA; (2020) Stability enhancement in a mAb and Fab coformulation. Scientific Reports , 10 , Article 21129. 10.1038/s41598-020-77989-w.

Zhang, Z; Yang, Y; Wang, Y; Gu, J; Lu, X; Liao, X; Shi, J; ... Hao, J; + view all Zhang, Z; Yang, Y; Wang, Y; Gu, J; Lu, X; Liao, X; Shi, J; Kim, CH; Lye, G; Baganz, F; Hao, J; - view fewer (2020) Ethylene glycol and glycolic acid production from xylonic acid by Enterobacter cloacae. Microbial Cell Factories , 19 (1) , Article 89. 10.1186/s12934-020-01347-8.

2019

Agbebi, TV; (2019) Design and characterization of a miniature photobioreactor for microalgae culture. Masters thesis (M.Phil), UCL (University College London).

Albay, A; Artim-Esen, B; Pericleous, C; Wincup, C; Giles, I; Rahman, A; McDonnell, T; (2019) Domain I of β2GPI is capable of blocking serum IgA antiphospholipid antibodies binding in vitro: an effect enhanced by PEGylation. Lupus 10.1177/0961203319851571. (In press).

Ali, Sadfer; (2019) Synthetic Biology Approaches to Lentiviral Packaging Cell Engineering. Doctoral thesis (Eng.D), UCL (University College London).

Ali, J; Rafiq, Q; Ratcliffe, E; (2019) A scaled down model for the translation of bacteriophage culture to manufacturing scale. Biotechnology and Bioengineering , 116 (5) pp. 972-984. 10.1002/bit.26911.

Ammoury, C; Younes, M; El Khoury, M; Hodroj, MH; Haykal, T; Nasr, P; Sily, M; ... Rizk, S; + view all Ammoury, C; Younes, M; El Khoury, M; Hodroj, MH; Haykal, T; Nasr, P; Sily, M; Taleb, RI; Sarkis, R; Khalife, R; Rizk, S; - view fewer (2019) The pro-apoptotic effect of a Terpene-rich Annona cherimola leaf extract on leukemic cell lines. BMC Complementary and Alternative Medicine , 19 (1) , Article 365. 10.1186/s12906-019-2768-1.

Antoniou, A; Lenart, I; Kriston-Vizi, J; Takao, I; Turmaine, M; McHugh, K; Ali, S; ... Powis, S; + view all Antoniou, A; Lenart, I; Kriston-Vizi, J; Takao, I; Turmaine, M; McHugh, K; Ali, S; Blake, N; Bajaj-Elliott, M; Gould, K; Nesbeth, DN; Powis, S; - view fewer (2019) Salmonella exploits HLA-B27 and host Unfolded Protein Responses to promote intracellular replication. Annals of the Rheumatic Diseases , 78 (1) pp. 74-82. 10.1136/ annrheumdis-2018-213532.

Arnott, PM; Howorka, S; (2019) A Temperature-Gated Nanovalve Self-Assembled from DNA to Control Molecular Transport across Membranes. ACS Nano , 13 (3) pp. 3334-3340. 10.1021/acsnano.8b09200.

Asra, Aisha Mariam; (2019) Novel chassis for engineered pathways and automating biological experiments in the biotechnology industry. Doctoral thesis (Eng.D), UCL (University College London).

Bains, S; (2019) Teaching Technical Communication to Engineering Students at Scale. In: 2019 IEEE International Professional Communication Conference (ProComm). (pp. pp. 83-89). IEEE: Aachen, Germany, Germany.

Bains, S; (2019) Workshop: Making a Technical Argument –Teaching Technical Analysis and Communication Together. In: 2019 IEEE International Professional Communication Conference (ProComm). (pp. pp. 273-274). IEEE: Aachen, Germany, Germany.

Bajić, Marijan; Ročnik, Tina; Oberlintner, Ana; Scognamiglio, Francesca; Novak, Uroš; Likozar, Blaž; (2019) Natural plant extracts as active components in chitosan-based films: A comparative study. Food Packaging and Shelf Life , 21 , Article 100365. 10.1016/j.fpsl.2019.100365.

Bajić, M; Novak, U; Likozar, B; (2019) Development of bio-based chitosan films with incorporated chestnut extract. In: Proceedings of the 5th World Congress on Mechanical, Chemical, and Material Engineering (MCM'19). Avestia Publishing: Lisbon, Portugal.

Bandyopadhyay, Sushobhan Kalyankumar; (2019) Addressing lipid impurities in Pichia pastoris cells producing virus like particles: genetic and bioprocess studies. Doctoral thesis (Ph.D), UCL (University College London).

Braun-Galleani, S; Henríquez, M-J; Nesbeth, D; (2019) Whole cell biosynthesis of 1-methyl-3-phenylpropylamine and 2-amino-1,3,4-butanetriol using Komagataella phaffii (Pichia pastoris) strain BG-10 engineered with a transgene encoding Chromobacterium violaceum ω- transaminase. Heliyon , 5 (8) , Article e02338. 10.1016/j.heliyon.2019.e02338.

Codina, N; Zhang, C; Chakroun, N; Dalby, PA; (2019) Insights into the stability of a therapeutic antibody Fab fragment by molecular dynamics and its stabilization by computational design. BioRxiv: Cold Spring Harbor, NY, USA.

Codina, N; Hilton, D; Zhang, C; Chakroun, N; Ahmad, SS; Perkins, SJ; Dalby, PA; (2019) An Expanded Conformation of an Antibody Fab Region by X-Ray Scattering, Molecular Dynamics and smFRET Identifies an Aggregation Mechanism. Journal of Molecular Biology 10.1016/j.jmb.2019.02.009. (In press).

Costariol, E; Rotondi, M; Amini, A; Hewitt, CJ; Nienow, AW; Heathman, TRJ; Micheletti, M; Costariol, E; Rotondi, M; Amini, A; Hewitt, CJ; Nienow, AW; Heathman, TRJ; Micheletti, M; Rafiq, QA; - view fewer (2019) Establishing the scalable manufacture of primary human T-cells in an automated stirred-tank bioreactor. Biotechnology and Bioengineering , 116 (10) pp. 2488-2510. 10.1002/bit.27088.

De Silva Thompson, D; Peticone, C; Burova, I; Shipley, RJ; Knowles, JC; Kim, H-W; Micheletti, M; De Silva Thompson, D; Peticone, C; Burova, I; Shipley, RJ; Knowles, JC; Kim, H-W; Micheletti, M; Wall, IB; - view fewer (2019) Assessing behaviour of osteoblastic cells in dynamic culture conditions using titanium-doped phosphate glass microcarriers. Journal of Tissue Engineering , 10 pp. 1-13. 10.1177/2041731419825772.

Deng, J; Wang, X; Zhang, B-Z; Gao, P; Lin, Q; Kao, RY-T; Gustafsson, K; ... Huang, J-D; + view all Deng, J; Wang, X; Zhang, B-Z; Gao, P; Lin, Q; Kao, RY-T; Gustafsson, K; Yuen, K-Y; Huang, J-D; - view fewer (2019) Broad and Effective Protection against Staphylococcus aureus Is Elicited by a Multivalent Vaccine Formulated with Novel Antigens. mSphere , 4 , Article e00362-19. 10.1128/mSphere.00362-19.

Dikicioglu, D; Oliver, SG; (2019) Extension of the yeast metabolic model to include iron metabolism and its use to estimate global levels of iron-recruiting enzyme abundance from cofactor requirements. Biotechnology and Bioengineering , 116 (3) pp. 610-621. 10.1002/bit.26905.

Dobrijevic, D; Benhamou, L; Aliev, AE; Méndez-Sánchez, D; Dawson, N; Baud, D; Tappertzhofen, N; ... Ward, JM; + view all Dobrijevic, D; Benhamou, L; Aliev, AE; Méndez-Sánchez, D; Dawson, N; Baud, D; Tappertzhofen, N; Moody, TS; Orengo, CA; Hailes, HC; Ward, JM; - view fewer (2019) Metagenomic ene-reductases for the bioreduction of sterically challenging enones. RSC Advances , 9 (63) pp. 36608-36614. 10.1039/c9ra06088j.

Dorward, A; O'Kennedy, RD; Folarin, O; Ward, JM; Keshavarz-Moore, E; (2019) The role of amino acids in the amplification and quality of DNA vectors for industrial applications. Biotechnology Progress , 35 (6) , Article e2883. 10.1002/btpr.2883.

Edelblum, K; Gustafsson, K; Pennington, DJ; Willcox, BE; Ribot, JC; (2019) Bordeaux 2018: Wine, Cheese, and γδ T Cells. Frontiers in Immunology , 10 , Article 2544. 10.3389/fimmu.2019.02544.

Farid, SS; (2019) Integrated Continuous Biomanufacturing: Industrialization on the Horizon. Biotechnology Journal , 14 (2) , Article 1800722. 10.1002/biot.201800722.

Fernandez-Cerezo, L; Rayat, ACME; Chatel, A; Pollard, JM; Lye, GJ; Hoare, M; (2019) An ultra scale-down method to investigate monoclonal antibody processing during tangential flow filtration (TFF) using ultrafiltration membranes. Biotechnology and Bioengineering , 116 pp. 581-590. 10.1002/bit.26859.

Fischer, V; Kucia-Tran, R; Lewis, W; Velayudhan, A; (2019) Hybrid optimization of preparative chromatography for a ternary monoclonal antibody mixture. Biotechnology Progress , 35 (5) , Article e2849. 10.1002/btpr.2849.

Flores-Fernández, CN; Cárdenas-Fernández, M; Dobrijevic, D; Jurlewicz, K; Zavaleta, AI; Ward, JM; Lye, GJ; (2019) Novel extremophilic proteases from Pseudomonas aeruginosa M211 and their application in the hydrolysis of dried distiller's grain with solubles. Biotechnology Progress , 35 (1) , Article e2728. 10.1002/btpr.2728.

Folarin, O; Nesbeth, D; Ward, JM; Keshavarz-Moore, E; (2019) Application of Plasmid Engineering to Enhance Yield and Quality of Plasmid for Vaccine and Gene Therapy. Bioengineering , 6 (2) , Article 54. 10.3390/bioengineering6020054.

Gangadharan, N; Turner, R; Field, R; Oliver, SG; Slater, N; Dikicioglu, D; (2019) Metaheuristic approaches in biopharmaceutical process development data analysis. Bioprocess and Biosystems Engineering , 42 (9) pp. 1399-1408. 10.1007/s00449-019-02147-0.

Goh, H-Y; Sulu, M; Alosert, H; Lewis, GL; Josland, GD; Merriman, DE; (2019) Applications of off-gas mass spectrometry in fed-batch mammalian cell culture. Bioprocess and Biosystems Engineering 10.1007/s00449-019-02242-2. (In press).

Goldrick, S; Duran-Villalobos, CA; Jankauskas, K; Lovett, D; Farid, SS; Lennox, B; (2019) Modern day monitoring and control challenges outlined on an industrial-scale benchmark fermentation process. Computers and Chemical Engineering , 130 , Article 106471. 10.1016/j.compchemeng.2019.05.037.

Gruber, Pia; (2019) Challenges of Chemoenzymatic and Biocatalytic Reaction Cascades and Online Monitoring at a Microscale. Doctoral thesis (Ph.D), UCL (University College London).

Hailes, H; Ward, J; Wang, Y; Tappertzhofen, N; Mendez-Sanchez, D; Bawn, M; Lyu, B; (2019) Design and use of de novo cascades for new benzylisoquinoline alkaloid biosynthesis. Angewandte Chemie , 58 (30) pp. 10120-10125. 10.1002/anie.201902761.

Hailes, HC; Subrizi, F; Benhamou, L; Ward, J; Sheppard, T; (2019) Aminopolyols from carbohydrates: the amination of sugars and sugar‐derived tetrahydrofurans with transaminases. Angewandte Chemie International Edition , 58 (12) pp. 3854-3858. 10.1002/anie.201813712.

Hales, JE; Matmon, G; Dalby, PA; Ward, JM; Aeppli, G; (2019) Virus lasers for biological detection. Nature Communications , 10 (1) , Article 3594. 10.1038/s41467-019-11604-z.

Heathman, TRJ; Nienow, AW; Rafiq, QA; Coopman, K; Kara, B; Hewitt, CJ; (2019) Development of a process control strategy for the serum-free microcarrier expansion of human mesenchymal stem cells towards cost-effective and commercially viable manufacturing. Biochemical Engineering Journal , 141 pp. 200-209. 10.1016/j.bej.2018.10.018.

Isimite, J; Baganz, F; Hass, V; (2019) A systems engineering framework for the design of bioprocess operator training simulators. In: Wang, Y, (ed.) Proceedings of the 2018 International Seminar on Food Safety and Environmental Engineering (FSEE 2018). EDP Sciences: Guangzhou, China.

Jankauskas, K; Farid, SS; (2019) Multi-objective biopharma capacity planning under uncertainty using a flexible genetic algorithm approach. Computers & Chemical Engineering , 128 pp. 35-52. 10.1016/j.compchemeng.2019.05.023.

Jankauskas, K; Papageorgiou, LG; Farid, SS; (2019) Fast genetic algorithm approaches to solving discrete-time mixed integer linear programming problems of capacity planning and scheduling of biopharmaceutical manufacture. Computers and Chemical Engineering , 121 pp. 212-223. 10.1016/j.compchemeng.2018.09.019.

Jankauskas, Karolis; (2019) Biopharmaceutical Scheduling Using a Flexible Genetic Algorithm Approach. Doctoral thesis (Ph.D), UCL (University College London).

Jasulaityte, G; Johansson, HJ; Bracewell, DG; (2019) Chromatography process development aided by a dye‐based assay. Journal of Chemical Technology & Biotechnology , 95 (1) pp. 132-141. 10.1002/jctb.6214.

Johnson, Thomas Francis; (2019) Three dimensional representation and analysis of individual bead and packed bed scale chromatography using X-ray computed tomography and focused ion beam microscopy. Doctoral thesis (Eng.D), UCL (University College London).

Jury, E; Manson, J; Ciurtin, C; Bradford, C; McDonnell, T; Isenberg, D; Robinson, G; (2019) Characterization of a subset of patients with rheumatoid arthritis for whom current management strategies are inadequate. ACR Open Rheumatology , 1 (3) pp. 145-155. 10.1002/acr2.1021.

Kolmar, JF; Thum, O; Baganz, F; (2019) Improving product specificity of whole-cell alkane oxidation in non-conventional media: a multivariate analysis approach. Biotechnology Journal , 14 (10) , Article 1800581. 10.1002/biot.201800581.

Kostas, ET; Cooper, M; Shepherd, BJ; Robinson, JP; (2019) Identification of Bio-oil Compound Utilizing Yeasts Through Phenotypic Microarray Screening. Waste and Biomass Valorization 10.1007/s12649-019-00636-7.

Kostas, ET; Williams, OSA; Duran-Jimenez, G; Tapper, AJ; Cooper, M; Meehan, R; Robinson, JP; (2019) Microwave pyrolysis of Laminaria digitata to produce unique seaweed-derived bio-oils. Biomass and Bioenergy , 125 pp. 41-49. 10.1016/j.biombioe.2019.04.006.

Lara, AR; Jaen, KE; Folarin, O; Keshavarz-Moore, E; Buechs, J; (2019) Effect of the oxygen transfer rate on oxygen-limited production of plasmid DNA by Escherichia coli. Biochemical Engineering Journal , 150 , Article 107303. 10.1016/j.bej.2019.107303.

Li, Y; Ducci, A; Micheletti, M; (2019) Mixing Time in Intermediate-Sized Orbitally Shaken Reactors with Small Orbital Diameters. Chemical Engineering & Technology , 42 (8) pp. 1611-1617. 10.1002/ceat.201900063.

Livanos, Maria; (2019) Production of DARPins in the Yeast Pichia pastoris. Doctoral thesis (Ph.D), UCL (University College London).

Lularevic, M; Racher, AJ; Jaques, C; Kiparissides, A; (2019) Improving the accuracy of flux balance analysis through the implementation of carbon availability constraints for intracellular reactions. Biotechnology and Bioengineering , 116 (9) pp. 2339-2352. 10.1002/bit.27025.

Maldonado, SL; Krull, J; Rasch, D; Panjan, P; Sesay, AM; Marques, MPC; Szita, N; Maldonado, SL; Krull, J; Rasch, D; Panjan, P; Sesay, AM; Marques, MPC; Szita, N; Krull, R; - view fewer (2019) Application of a multiphase microreactor chemostat for the determination of reaction kinetics of Staphylococcus carnosus. Bioprocess and Biosystems Engineering , 42 pp. 953-961. 10.1007/s00449-019-02095-9.

Malik, S; Hagopian, J; Mohite, S; Cao, L; Els, LS; Giannakopoulos, S; Beckett, R; ... Parker, B; + view all Malik, S; Hagopian, J; Mohite, S; Cao, L; Els, LS; Giannakopoulos, S; Beckett, R; Leung, C; Ruiz, J; Cruz, M; Parker, B; - view fewer (2019) Robotic Extrusion of Algae-Laden Hydrogels for Large-Scale Applications. Global Challenges , Article 1900064. 10.1002/gch2.201900064.

Mante, J; Gangadharan, N; Sewell, DJ; Turner, R; Field, R; Oliver, SG; Slater, N; Mante, J; Gangadharan, N; Sewell, DJ; Turner, R; Field, R; Oliver, SG; Slater, N; Dikicioglu, D; - view fewer (2019) A heuristic approach to handling missing data in biologics manufacturing databases. Bioprocess and Biosystems Engineering , 42 (4) pp. 657-663. 10.1007/s00449-018-02059-5.

Marques, MP; Boyd, A; Polizzi, K; Szita, N; (2019) Microfluidic devices towards personalized health and wellbeing. Journal of Chemical Technology and Biotechnology , 94 (8) pp. 2412-2415. 10.1002/jctb.6009.

Martin-Gutierrez, L; Wilton, J; Robinson, G; McDonnell, T; Isenberg, D; Wincup, C; Kalea, A; ... Ciurtin, C; + view all Martin-Gutierrez, L; Wilton, J; Robinson, G; McDonnell, T; Isenberg, D; Wincup, C; Kalea, A; Pineda Torra, I; Jury, E; Ciurtin, C; - view fewer (2019) Designing a diet interventional study for autoimmune rheumatic disease: asking patients what they think. Presented at: EULAR: Annual European Congress of Rheumatology, Madrid, Spain.

Martinez, M; Spitali, M; Norrant, EL; Bracewell, DG; (2019) Precipitation as an Enabling Technology for the Intensification of Biopharmaceutical Manufacture. Trends in Biotechnology , 37 (3) pp. 237-241. 10.1016/j.tibtech.2018.09.001.

McDonnell, T; Wincup, C; Buchholz, I; Pericleous, C; Giles, I; Ripoll, V; Cohen, H; ... Rahman, A; + view all McDonnell, T; Wincup, C; Buchholz, I; Pericleous, C; Giles, I; Ripoll, V; Cohen, H; Delcea, M; Rahman, A; - view fewer (2019) The role of beta-2-glycoprotein I in health and disease associating structure with function: More than just APS. Blood Reviews , Article 100610. 10.1016/j.blre.2019.100610.

Mohammed, Reema; (2019) Defining The Role Of Oxygen Tension In Human Pluripotent Stem Cell Fate Decisions. Doctoral thesis (Ph.D), UCL (University College London).

Morris, Christopher W; (2019) Protein Precipitation for the Purification of Therapeutic Protein. Doctoral thesis (Eng.D), UCL (University College London).

Neves Dos Reis, Joana; (2019) Development of strategies for isolation and functional testing of cell lines for neuronal regeneration. Doctoral thesis (Ph.D), UCL (University College London).

Oh, G; Sirunyan, AM; Tumasyan, A; Adam, W; Ambrogi, F; Asilar, E; Bergauer, T; ... 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Santiago-Toledo, G; Georgiou, M; Dos Reis, J; Roberton, VH; Valinhas, A; Wood, RC; Phillips, JB; ... Wall, IB; + view all Santiago-Toledo, G; Georgiou, M; Dos Reis, J; Roberton, VH; Valinhas, A; Wood, RC; Phillips, JB; Mason, C; Li, D; Li, Y; Sinden, JD; Choi, D; Jat, PS; Wall, IB; - view fewer (2019) Generation of c-MycERTAM-transduced human late-adherent olfactory mucosa cells for potential regenerative applications. Scientific Reports , 9 (1) , Article 13190. 10.1038/s41598-019-49315-6.

Segura, BT; Bernstein, BS; McDonnell, T; Wincup, C; M Ripoll, V; Giles, I; Isenberg, D; Segura, BT; Bernstein, BS; McDonnell, T; Wincup, C; M Ripoll, V; Giles, I; Isenberg, D; Rahman, A; - view fewer (2019) Damage accrual and mortality over long-term follow-up in 300 patients with systemic lupus erythematosus in a multi-ethnic British cohort. [Corrigendum]. Rheumatology , Article kez516. 10.1093/rheumatology/kez516.

Sharma, A; Bracewell, DG; (2019) Characterisation of porous anodic alumina membranes for ultrafiltration of protein nanoparticles as a size mimic of virus particles. Journal of Membrane Science , 580 pp. 77-91. 10.1016/j.memsci.2019.02.071.

Sheppard, T; Hailes, H; Benhamou, L; Ward, D; Bucar, D-K; Lye, G; Foster, R; ... Sloan, L; + view all Sheppard, T; Hailes, H; Benhamou, L; Ward, D; Bucar, D-K; Lye, G; Foster, R; Tame, C; Wheelhouse, K; Sloan, L; - view fewer (2019) Functionalised tetrahydrofuran fragments from carbohydrates or sugar beet pulp biomass. Green Chemistry , 21 (8) pp. 2035-2042. 10.1039/C9GC00448C.

Shi, Y; Thompson, J; Walker, A; PATON, NI; Cheung, YB; (2019) Mapping the Medical Outcomes Study HIV Health Survey (MOS-HIV) to the EuroQoL 5 Dimension (EQ-5D-3L) utility index. Health and Quality of Life Outcomes , 17 , Article 83. 10.1186/s12955-019-1135-8.

Smith, F; Velayudhan, A; Voulgarelis, D; (2019) Stability of two competing populations in chemostat where one of the population changes its average mass of division in response to changes of its population. PLoS ONE , 14 (3) , Article e0213518. 10.1371/journal.pone.0213518.

Spencer-Milnes, Xenia; (2019) Towards engineering the microalga Chlorella sorokiniana for the production of tailored high-value oils. Doctoral thesis (Ph.D), UCL (University College London).

Stamatis, Christos; (2019) Integrating high-throughput experimentation with advanced decision-support tools for chromatography process development. Doctoral thesis (Eng.D), UCL (University College London).

Stoffels, L; Finlan, A; Mannall, G; Purton, S; Parker, B; (2019) Downstream Processing of Chlamydomonas reinhardtii TN72 for Recombinant Protein Recovery. Frontiers in Bioengineering and Biotechnology , 7 , Article 383. 10.3389/fbioe.2019.00383.

Suhaili, N; Cárdenas-Fernández, M; Ward, JM; Lye, GJ; (2019) Potential of sugar beet vinasse as a feedstock for biocatalyst production within an integrated biorefinery context. Journal of Chemical Technology and Biotechnology , 94 (3) pp. 739-751. 10.1002/jctb.5819.

Sulu, M; (2019) Communicating cutting-edge science. Environmental Scientist , 28 (2) pp. 14-17.

Tee, Qing Xin; (2019) Multiple Intelligent Agents for Manufacturing Intensification (MIAMI): A Platform for Ranking Clonal Variation in Upstream Bioprocess Development. Doctoral thesis (Ph.D), UCL (University College London).

Traustason, B; Cheeks, M; Dikicioglu, D; (2019) Computer-Aided Strategies for Determining the Amino Acid Composition of Medium for Chinese Hamster Ovary Cell-Based Biomanufacturing Platforms. International Journal of Molecular Sciences , 20 (21) , Article 5464. 10.3390/ijms20215464.

Turnbull, J; Wright, B; Green, NK; Tarrant, R; Roberts, I; Hardick, O; Bracewell, DG; (2019) Adenovirus 5 recovery using nanofiber ion exchange adsorbents. Biotechnology and Bioengineering , 116 (7) pp. 1698-1709. 10.1002/bit.26972.

Valinhas, Ana Teresa de Sousa; (2019) Microscale processing tools as screening strategies for cell therapy manufacture. Doctoral thesis (Ph.D), UCL (University College London).

Vasiliadou, R; Dimov, N; Szita, N; Jordan, SF; Lane, N; (2019) Possible mechanisms of CO₂ reduction by H₂ via prebiotic vectorial electrochemistry. Interface Focus , 9 (6) 10.1098/rsfs.2019.0073.

Wang, B; Nesbeth, D; Keshavarz-Moore, E; (2019) Sorbitol/methanol mixed induction reduces process impurities and improves centrifugal dewatering in Pichia pastoris culture. Enzyme and Microbial Technology , 130 , Article 109366. 10.1016/j.enzmictec.2019.109366.

Wang, Y; Tappertzhofen, N; Méndez‐Sánchez, D; Bawn, M; Lyu, B; Ward, JM; Hailes, HC; (2019) Design and Use of de novo Cascades for the Biosynthesis of New Benzylisoquinoline Alkaloids. Angewandte Chemie , 131 (30) pp. 10226-10231. 10.1002/ange.201902761.

Wayne, Chris J.; (2019) Theoretical Analysis and Experimental Investigation of Simulated Moving Bed Chromatography for the Purification of Protein Mixtures. Doctoral thesis (Ph.D), UCL (University College London).

Wiegmann, V; Giaka, M; Martinez, CB; Baganz, F; (2019) Towards the development of automated fed-batch cell culture processes at microscale. Biotechniques , 67 (5) pp. 238-241. 10.2144/btn-2019-0063.

Wilkinson, HC; Dalby, PA; (2019) Novel insights into transketolase activation by cofactor binding identifies two native species subpopulations. Scientific Reports , 9 , Article 16116. 10.1038/s41598-019-52647-y.

Wilson, LJ; Lewis, W; Kucia-Tran, R; Bracewell, DG; (2019) Identification of Upstream Culture Conditions and Harvest Time Parameters That Affect Host Cell Protein Clearance. Biotechnology Progress , 35 (3) , Article e2805. 10.1002/btpr.2805.

Wincup, C; McDonnell, TCR; Rahman, A; (2019) Menorrhagia: an underappreciated problem in pre-menopausal women with systemic lupus erythematosus. Lupus 10.1177/0961203319851868. (In press).

Wood, Victoria Elizabeth; (2019) Use of in silico and biophysical techniques to predict protein stability. Doctoral thesis (Ph.D), UCL (University College London).

Zhang, H; Deng, M; Pei, F; Wang, S; Ho, M; (2019) Next-Generation Antibody Therapeutics: Discovery, Development and Beyond: highlights of the third annual conference of the Chinese Antibody Society. Antibody Therapeutics , 2 (4) pp. 99-107. 10.1093/abt/tbz012.

Zhao, J; Méndez-Sánchez, D; Ward, JM; Hailes, HC; (2019) Biomimetic Phosphate-Catalyzed Pictet–Spengler Reaction for the Synthesis of 1,1′-Disubstituted and Spiro-Tetrahydroisoquinoline Alkaloids. The Journal of Organic Chemistry , 84 (12) pp. 7702-7710. 10.1021/acs.joc.9b00527.

2018

Abdolvand, N; Tostoes, R; Raimes, W; Kumar, V; Szita, N; Veraitch, F; (2018) Long‐Term Retinal Differentiation of Human Induced Pluripotent Stem Cells in a Continuously Perfused Microfluidic Culture Device. Biotechnology Journal , Article 1800323. 10.1002/biot.201800323. (In press).

Ahmad, Asma; (2018) Design and Characterisation of a Scale-Down Platform for the Recovery of Periplasmic Fab’ From E.coli. Doctoral thesis (Eng.D), UCL (University College London).

Ali, J; Rafiq, QA; Ratcliffe, E; (2018) Antimicrobial resistance mechanisms and potential synthetic treatments. Future Science OA , 4 (4) , Article FSO290. 10.4155/fsoa-2017-0109.

Alkassem, Hasan; (2018) Imaging Antimicrobial Peptides in Action by Atomic Force Microscopy. Doctoral thesis (Eng.D), UCL (University College London).

Arnott, PM; Joshi, H; Aksimentiev, A; Howorka, S; (2018) Dynamic Interactions between Lipid-Tethered DNA and Phospholipid Membranes. Langmuir , 34 (39) pp. 15084-15092. 10.1021/acs.langmuir.8b02271.

Bateson, P; Fleet, JEH; Riseley, AS; Janeva, E; Marcella, AS; Farinea, C; Kuptsova, M; ... Parker, BM; + view all Bateson, P; Fleet, JEH; Riseley, AS; Janeva, E; Marcella, AS; Farinea, C; Kuptsova, M; Conde Pueyo, N; Howe, CJ; Bombelli, P; Parker, BM; - view fewer (2018) Electrochemical Characterisation of Bio-Bottle-Voltaic (BBV) Systems Operated with Algae and Built with Recycled Materials. Biology , 7 (2) , Article 26. 10.3390/biology7020026.

Bawn, M; Subrizi, F; Lye, GJ; Sheppard, TD; Hailes, HC; Ward, JM; (2018) One-pot, two-step transaminase and transketolase synthesis of L-gluco-heptulose from L-arabinose. Enzyme and Microbial Technology , 116 pp. 16-22. 10.1016/j.enzmictec.2018.05.006.

Bawn, M; Subrizi, F; Lye, GJ; Sheppard, TD; Hailes, HC; Ward, JM; (2018) Data on a thermostable enzymatic one-pot reaction for the production of a high-value compound from L-arabinose. Data in Brief , 19 pp. 1341-1354. 10.1016/j.dib.2018.05.140.

Bláha, BAF; Morris, SA; Ogonah, OW; Crescente, V; Rosenberg, W; Maucourant, S; Mukhopadhyay, TK; (2018) Development of a high-throughput microscale cell disruption platform for Pichia pastoris in rapid bioprocess design. Biotechnology Progress , 34 (1) pp. 130-140. 10.1002/btpr.2555.

Bláha, Benjamin A. F.; (2018) Platform processes for vaccine production: Development of a universal influenza vaccine using Pichia pastoris. Doctoral thesis (Ph.D), UCL (University College London).

Blas, P; Tolner, B; Ward, J; Chester, K; Hoare, M; (2018) The use of a surface active agent in the protection of a fusion protein during bioprocessing. Biotechnology and Bioengineering , 115 (11) pp. 2760-2770. 10.1002/bit.26817.

Boeing, P; Leon, M; Nesbeth, DN; Finkelstein, A; Barnes, C; (2018) Towards an Aspect-Oriented Design and Modelling Framework for Synthetic Biology. Processes , 6 (9) , Article 167. 10.3390/pr6090167.

Cárdenas-Fernández, M; Hamley-Bennett, C; Leak, DJ; Lye, GJ; (2018) Continuous enzymatic hydrolysis of sugar beet pectin and l-arabinose recovery within an integrated biorefinery. Bioresour Technol , 269 pp. 195-202. 10.1016/j.biortech.2018.08.069.

Chilima, TDP; Moncaubeig, F; Farid, SS; (2018) Impact of allogeneic stem cell manufacturing decisions on cost of goods, process robustness and reimbursement. Biochemical Engineering Journal , 137 pp. 132-151. 10.1016/j.bej.2018.04.017.

Colao, IL; Corteling, R; Bracewell, D; Wall, I; (2018) Manufacturing Exosomes: A Promising Therapeutic Platform. Trends in Molecular Medicine , 24 (3) pp. 242-256. 10.1016/j.molmed.2018.01.006.

Cossu, G; Birchall, M; Brown, T; De Coppi, P; Culme-Seymour, E; Gibbon, S; Hitchcock, J; ... Wilson, JGS; + view all Cossu, G; Birchall, M; Brown, T; De Coppi, P; Culme-Seymour, E; Gibbon, S; Hitchcock, J; Mason, C; Montgomery, J; Morris, S; Muntoni, F; Napier, D; Owji, N; Prasad, A; Round, J; Saprai, P; Stilgoe, J; Thrasher, A; Wilson, JGS; - view fewer (2018) Lancet Commission: Stem Cells and Regenerative Medicine. The Lancet , 391 (10123) pp. 883-910. 10.1016/S0140-6736(17)31366-1.

Cuff, S; Lewis, RD; Chinje, E; Jaffar, M; Knox, R; Weeks, I; (2018) An improved cell-permeable fluorogenic substrate as the basis for a highly sensitive test for NAD(P)H quinone oxidoreductase 1 (NQO1) in living cells. Free Radical Biology and Medicine , 116 pp. 141-148. 10.1016/j.freeradbiomed.2018.01.009.

de Lamotte, A; Delafosse, A; Calvo, S; Toye, D; (2018) Identifying dominant spatial and time characteristics of flow dynamics within free-surface baffled stirred-tanks from CFD simulations. Chemical Engineering Science , 192 pp. 128-142. 10.1016/j.ces.2018.07.024.

de lamotte, A; Delafosse, A; Calvo, S; Toye, D; (2018) Analysis of PIV measurements using modal decomposition techniques, POD and DMD, to study flow structures and their dynamics within a stirred-tank reactor. Chemical Engineering Science , 178 pp. 348-366. 10.1016/j.ces.2017.12.047.

De Villiers, Ann-Marie; (2018) High cell density purification strategies for application to antibody and virus-vectored biopharmaceutical products. Doctoral thesis (Ph.D), UCL (University College London).

Detela, G; Bain, OW; Kim, H-W; Williams, DJ; Mason, C; Mathur, A; Wall, IB; (2018) Donor Variability in Growth Kinetics of Healthy hMSCs Using Manual Processing: Considerations for Manufacture of Cell Therapies. Biotechnology Journal , 13 (2) , Article 1700085. 10.1002/biot.201700085.

Dimov, N; Kastner, E; Hussain, M; Perrie, Y; Szita, N; (2018) Author Correction: Formation and purification of tailored liposomes for drug delivery using a module-based micro continuous-flow system. Scientific Reports , 8 (1) , Article 6762. 10.1038/s41598-018-25217-x.

Efthymiou, M; Arachchillage, DRJ; Lane, PJ; O'Keeffe, AG; McDonnell, T; Cohen, H; Mackie, IJ; (2018) Antibodies against TFPI and protein C are associated with a severe thrombotic phenotype in patients with and without antiphospholipid syndrome. Thrombosis Research , 170 pp. 60-68. 10.1016/j.thromres.2018.08.003.

El-Sabbahy, H; Ward, D; Ogonah, O; Deakin, L; Jellum, GM; Bracewell, DG; (2018) The effect of feed quality due to clarification strategy on the design and performance of protein A periodic counter-current chromatography. Biotechnology Progress , 34 (6) pp. 1380-1392. 10.1002/btpr.2709.

Farid, S; (2018) Technologies for large-scale umbilical cord-derived MSC expansion: Experimental performance and cost of goods analysis. Biochemical Engineering Journal , 135 pp. 36-48. 10.1016/j.bej.2018.02.018.

Farid, SS; Jenkins, MJ; (2018) Bioprocesses for Cell Therapies. In: Jagschies, G and Lindskog, E and Galliher, P, (eds.) Biopharmaceutical Processing: Development, Design, and Implementation of Manufacturing Processes. (pp. 899-930). Elsevier: Amsterdam, Netherlands.

Fazilah, Nurul Farhana; Ariff, Arbakariya B; Khayat, Mohd Ezuan; Rios-Solis, Leonardo; Halim, Murni; (2018) Influence of probiotics, prebiotics, synbiotics and bioactive phytochemicals on the formulation of functional yogurt. Journal of Functional Foods , 48 pp. 387-399. 10.1016/j.jff.2018.07.039.

Field, Nicholas John; (2018) Investigation of multicomponent adsorption isotherms in chromatography using high-throughput formats. Doctoral thesis (Ph.D), UCL (University College London).

Forbes, N; Hussain, MT; Briuglia, ML; Edwards, DP; Horst, JHT; Szita, N; Perrie, Y; (2018) Rapid and scale-independent microfluidic manufacture of liposomes entrapping protein incorporating in-line purification and at-line size monitoring. International Journal of Pharmaceutics , 556 pp. 68-81. 10.1016/j.ijpharm.2018.11.060.

Forte, N; Livanos, M; Miranda, E; Morais, M; Yang, X; Rajkumar, VS; Chester, KA; ... Baker, JR; + view all Forte, N; Livanos, M; Miranda, E; Morais, M; Yang, X; Rajkumar, VS; Chester, KA; Chudasama, V; Baker, JR; - view fewer (2018) Tuning the Hydrolytic Stability of Next Generation Maleimide Cross-Linkers Enables Access to Albumin-Antibody Fragment Conjugates and tri-scFvs. Bioconjugate Chemistry , 29 (2) pp. 486-492. 10.1021/acs.bioconjchem.7b00795.

Fuldauer, L; Parker, B; Yaman, R; Borrion, A; (2018) Managing anaerobic digestate from food waste in the urban environment: Evaluating the feasibility from an interdisciplinary perspective. Journal of Cleaner Production , 185 pp. 929-940. 10.1016/j.jclepro.2018.03.045.

Georgiou, M; Reis, JND; Wood, R; Esteban, PP; Roberton, V; Mason, C; Li, D; ... Wall, I; + view all Georgiou, M; Reis, JND; Wood, R; Esteban, PP; Roberton, V; Mason, C; Li, D; Li, Y; Choi, D; Wall, I; - view fewer (2018) Bioprocessing strategies to enhance the challenging isolation of neuro-regenerative cells from olfactory mucosa. Scientific Reports , 8 , Article 14440. 10.1038/s41598-018-32748-w.

Goldrick, S; Lee, K; Spencer, C; Holmes, W; Kuiper, M; Turner, R; Farid, SS; (2018) On-line control of glucose concentration in high-yielding mammalian cell cultures enabled through oxygen transfer rate measurements. Biotechnology Journal , 13 (4) , Article 1700607. 10.1002/biot.201700607.

Goldrick, S; Lovett, D; Montague, G; Lennox, B; (2018) Influence of Incident Wavelength and Detector Material Selection on Fluorescence in the Application of Raman Spectroscopy to a Fungal Fermentation Process. Bioengineering , 5 (4) , Article 79. 10.3390/bioengineering5040079.

Gruber, P; Carvalho, F; Marques, MPC; O'Sullivan, B; Subrizi, F; Dobrijevic, D; Ward, J; ... Szita, N; + view all Gruber, P; Carvalho, F; Marques, MPC; O'Sullivan, B; Subrizi, F; Dobrijevic, D; Ward, J; Hailes, HC; Fernandes, P; Wohlgemuth, R; Baganz, F; Szita, N; - view fewer (2018) Enzymatic synthesis of chiral amino-alcohols by coupling transketolase and transaminase-catalyzed reactions in a cascading continuous-flow microreactor system. Biotechnology and Bioengineering , 115 pp. 586-596. 10.1002/bit.26470.

Harrison, RP; Medcalf, N; Rafiq, QA; (2018) Cell therapy-processing economics: Small-scale microfactories as a stepping stone toward large-scale macrofactories. Regenerative Medicine , 13 (2) pp. 159-173. 10.2217/rme-2017-0103.

Harrison, RP; Rafiq, QA; Medcalf, N; (2018) Centralised versus decentralised manufacturing and the delivery of healthcare products: A United Kingdom exemplar. Cytotherapy , 20 (6) pp. 873-890. 10.1016/j.jcyt.2018.05.003.

Harrison, RP; Ruck, S; Rafiq, QA; Medcalf, N; (2018) Decentralised manufacturing of cell and gene therapy products: Learning from other healthcare sectors. Biotechnology Advances , 36 (2) pp. 345-357. 10.1016/j.biotechadv.2017.12.013.

Hauck, NC; Kirpach, J; Kiefer, C; Farinelle, S; Maucourant, S; Morris, SA; Rosenberg, W; ... Lu, I-N; + view all Hauck, NC; Kirpach, J; Kiefer, C; Farinelle, S; Maucourant, S; Morris, SA; Rosenberg, W; He, FQ; Muller, CP; Lu, I-N; - view fewer (2018) Applying Unique Molecular Identifiers in Next Generation Sequencing Reveals a Constrained Viral Quasispecies Evolution under Cross-Reactive Antibody Pressure Targeting Long Alpha Helix of Hemagglutinin. Viruses , 10 (4) , Article 148. 10.3390/v10040148.

Heathman, TRJ; Nienow, AW; Rafiq, QA; Coopman, K; Kara, B; Hewitt, CJ; (2018) Agitation and aeration of stirred-bioreactors for the microcarrier culture of human mesenchymal stem cells and potential implications for large-scale bioprocess development. Biochemical Engineering Journal , 136 pp. 9-17. 10.1016/j.bej.2018.04.011.

Henriquez Morales, Maria-Jose; (2018) Synthetic Biology Routes To Production Of Chiral Amino-alcohols In Pichia Pastoris. Doctoral thesis (Ph.D), UCL (University College London).

Hirschmann, R; Borodkin, N; Baganz, F; Hass, VC; (2018) Towards the integration of the anaerobic ethyl (S)-3-hydroxybutyrate production process into a biorefinery concept. Chemical Engineering Transactions , 70 pp. 559-564. 10.3303/CET1870094.

Isimite, J; Baganz, F; Hass, VC; (2018) Operator training simulators for biorefineries: current position and future directions. Journal of Chemical Technology and Biotechnology , 93 (6) pp. 1529-1541. 10.1002/jctb.5583.

Jackson, David Shaun Frederick; (2018) Building a Synthetic Pathway For Nylon precursor Biosynthesis. Doctoral thesis (Ph.D), UCL (University College London).

Jenkins, Michael Joseph; (2018) Decisional tools for cost-effective bioprocess design for cell therapies and patient-specific drug discovery tools. Doctoral thesis (Eng.D), UCL (University College London).

Jenkins, MJ; Farid, SS; (2018) Cost-effective bioprocess design for the manufacture of allogeneic CAR-T cell therapies using a decisional tool with multi-attribute decision-making analysis. Biochemical Engineering Journal , 137 pp. 192-204. 10.1016/j.bej.2018.05.014.

Johnson, TF; Bailey, JJ; Iacoviello, F; Welsh, JH; Levison, PR; Shearing, PR; Bracewell, DG; (2018) Three dimensional characterisation of chromatography bead internal structure using X-ray computed tomography and focused ion beam microscopy. Journal of Chromatography A , 1566 pp. 79-88. 10.1016/j.chroma.2018.06.054.

Jurlewicz, Kosma Michal; (2018) Use of high-throughput tools to optimise polishing-chromatography sequences for complex feed mixtures. Doctoral thesis (Ph.D), UCL (University College London).

Khalife, Rana; (2018) The Effect of the nutritional microenvironment on stem cell differentiation. Doctoral thesis (Ph.D), UCL (University College London).

Khan, Haroon Dawood Sadullah; (2018) Towards development of a platform process for novel Lantiobic production. Doctoral thesis (Eng.D), UCL (University College London).

Khan, Muazzam Ali; (2018) Increasing the efficiency of antibody purification process by high throughput technology and intelligent design of experiment. Doctoral thesis (Eng.D), UCL (University College London).

Kilic, T; Valinhas, ATDS; Wall, I; Renaud, P; Carrara, S; (2018) Label-free detection of hypoxia-induced extracellular vesicle secretion from MCF-7 cells. Scientific Reports , 8 , Article 9402. 10.1038/s41598-018-27203-9.

Konstantinidis, S; Welsh, JP; Titchener-Hooker, NJ; Roush, DJ; Velayudhan, A; (2018) Data‐driven multi‐objective optimization via grid compatible simplex technique and desirability approach for challenging high throughput chromatography applications. Biotechnology Progress , 34 (6) 10.1002/btpr.2673.

Kühlbach, C; da Luz, S; Baganz, F; Hass, VC; Mueller, MM; (2018) A microfluidic system for the investigation of tumor cell extravasation. Bioengineering , 5 (2) , Article 40. 10.3390/bioengineering5020040.

Lee, MJ; Mantell, J; Brown, IR; Fletcher, JM; Verkade, P; Pickersgill, RW; Woolfson, DN; ... Warren, MJ; + view all Lee, MJ; Mantell, J; Brown, IR; Fletcher, JM; Verkade, P; Pickersgill, RW; Woolfson, DN; Frank, S; Warren, MJ; - view fewer (2018) De novo targeting to the cytoplasmic and luminal side of bacterial microcompartments. Nature Communications , 9 , Article 3413. 10.1038/s41467-018-05922-x.

Lee, MJ; Mantell, J; Hodgson, L; Alibhai, D; Fletcher, JM; Brown, IR; Frank, S; ... Warren, MJ; + view all Lee, MJ; Mantell, J; Hodgson, L; Alibhai, D; Fletcher, JM; Brown, IR; Frank, S; Xue, WF; Verkade, P; Woolfson, DN; Warren, MJ; - view fewer (2018) Engineered synthetic scaffolds for organizing proteins within the bacterial cytoplasm. Nature Chemical Biology , 14 (2) pp. 142-147. 10.1038/nchembio.2535.

Leipold, L; Dobrijevic, D; Jeffries, J; Bawn, M; Moody, T; Ward, J; Hailes, HC; (2018) The identification and use of robust transaminases from a domestic drain metagenome. RSC Green Chemistry , 1 pp. 75-86. 10.1039/c8gc02986e.

McDonnell, T; Artim-Esen, B; Wincup, C; Ripoll, VM; Isenberg, D; Giles, IP; Rahman, A; McDonnell, T; Artim-Esen, B; Wincup, C; Ripoll, VM; Isenberg, D; Giles, IP; Rahman, A; Pericleous, C; - view fewer (2018) Antiphospholipid Antibodies to Domain I of Beta-2-Glycoprotein I Show Different Subclass Predominance in Comparison to Antibodies to Whole Beta-2-glycoprotein I. Frontiers in Immunology , 9 (2224) 10.3389/fimmu.2018.02244.

McDonnell, T; Bradford, C; Raj, D; Ciurtin, C; Jury, E; Manson, J; (2018) Differential activation of complement in rheumatoid arthritis. Presented at: Annual European Congress of Rheumatology - European League Against Rheumatism (EULAR) - 2018, Amsterdam, Netherlands.

McDonnell, TCR; Willis, R; Pericleous, C; Ripoll, VM; Giles, IP; Isenberg, DA; Brasier, AR; ... Rahman, A; + view all McDonnell, TCR; Willis, R; Pericleous, C; Ripoll, VM; Giles, IP; Isenberg, DA; Brasier, AR; Gonzalez, EB; Papalardo, E; Romay-Penabad, Z; Jamaluddin, M; Ioannou, V; Rahman, A; - view fewer (2018) PEGylated Domain I of Beta-2-Glycoprotein I Inhibits the Binding, Coagulopathic, and Thrombogenic Properties of IgG From Patients With the Antiphospholipid Syndrome. Frontiers in Immunology , 9 , Article 2413. 10.3389/fimmu.2018.02413.

McDonnell, TCR; Wincup, C; Rahman, A; Giles, I; (2018) Going viral in rheumatology: Using social media to show that mechanistic research is relevant to patients with lupus and antiphospholipid syndrome. Rheumatology Advances in Practice , 2 (1) , Article rky003. 10.1093/rap/rky003.

Melinek, Beatrice; (2018) Scale Down Mimics for Viral Vaccine Harvest and Early Purification. Doctoral thesis (Eng.D), UCL (University College London).

Melinek, BJ; Dessoy, S; Wright, B; Bracewell, DG; Mukhopadhyay, TK; (2018) Ultra scale-down approaches to study the centrifugal harvest for viral vaccine production. Biotechnology and Bioengineering , 115 (5) pp. 1226-1238. 10.1002/bit.26546.

Micheletti, M; Rodriguez, G; Ducci, A; (2018) Macro- and micro-scale mixing in a shaken bioreactor for fluids of high viscosity. Chemical Engineering Research and Design , 132 pp. 890-901. 10.1016/j.cherd.2018.01.018.

Mitchell, SA; Truscott, F; Dickman, R; Ward, J; Tabor, AB; (2018) Simplified lipid II-binding antimicrobial peptides: Design, synthesis and antimicrobial activity of bioconjugates of nisin rings A and B with pore-forming peptides. Bioorganic & Medicinal Chemistry , 26 (21) pp. 5691-5700. 10.1016/j.bmc.2018.10.015.

Mukhopadhyay, A; Basu, S; Sinha, S; Patra, H; (2018) Inner-View of Nanomaterial Incited Protein Conformational Changes: Insights into Designable Interaction. [Review]. Research , 2018 , Article 9712832. 10.1155/2018/9712832.

Newton, Joesph Matthew; (2018) Understanding cell lysis in fermentation and its impact on primary recovery using viscosity monitoring. Doctoral thesis (Eng.D), UCL (University College London).

Nweke, MC; (2018) Chromatography resin characterisation to analyse lifetime and performance during biopharmaceutical manufacture. Doctoral thesis (Ph.D), UCL (University College London).

Nweke, MC; Rathore, AS; Bracewell, DG; (2018) Lifetime and Aging of Chromatography Resins during Biopharmaceutical Manufacture. [Editorial comment]. Trends in Biotechnology , 36 (10) pp. 992-995. 10.1016/j.tibtech.2018.01.001.

Oshinbolu, S; Shah, R; Finka, G; Molloy, M; Uden, M; Bracewell, DG; (2018) Evaluation of fluorescent dyes to measure protein aggregation within mammalian cell culture supernatants. Journal of Chemical Technology and Biotechnology , 93 (3) pp. 909-917. 10.1002/jctb.5519.

Oshinbolu, S; Wilson, LJ; Lewis, W; Shah, R; Bracewell, DG; (2018) Measurement of impurities to support process development and manufacture of biopharmaceuticals. TrAC Trends in Analytical Chemistry , 101 pp. 120-128. 10.1016/j.trac.2017.10.026.

Othman, M; Ariff, AB; Kapri, MR; Rios-Solis, L; Halim, M; (2018) Growth Enhancement of Probiotic Pediococcus acidilactici by Extractive Fermentation of Lactic Acid Exploiting Anion-Exchange Resin. Frontiers in Microbiology , 9 , Article 2554. 10.3389/fmicb.2018.02554.

Pallipurath Radhakrishnan, AN; Marques, MPC; Davies, MJ; O'Sullivan, B; Bracewell, DG; Szita, N; (2018) Flocculation on a chip: a novel screening approach to determine floc growth rates and select flocculating agents. Lab on a Chip 10.1039/C7LC00793K. (In press).

Pandya, A; Howard, MJ; Zloh, M; Dalby, PA; (2018) An Evaluation of the Potential of NMR Spectroscopy and Computational Modelling Methods to Inform Biopharmaceutical Formulations. Pharmaceutics , 10 (4) , Article 165. 10.3390/pharmaceutics10040165.

Patel, N; Bracewell, DG; Sorensen, E; (2018) Dynamic modelling of aqueous two-phase systems to quantify the impact of bioprocess design, operation and variability. Food and Bioproducts Processing , 107 pp. 10-24. 10.1016/j.fbp.2017.10.005.

Patel, Nehal; (2018) Development of aqueous two-phase separations by combining high-throughput screening and process modelling. Doctoral thesis (Eng.D), UCL (University College London).

Pathak, M; Rathore, AS; Lintern, K; Bracewell, DG; (2018) Protein A chromatography resin lifetime—impact of feed composition. Biotechnology Progress , 34 (2) pp. 412-419. 10.1002/btpr.2608.

Rafiq, QA; Ruck, S; Hanga, MP; Heathman, TRJ; Coopman, K; Nienow, AW; Williams, DJ; Rafiq, QA; Ruck, S; Hanga, MP; Heathman, TRJ; Coopman, K; Nienow, AW; Williams, DJ; Hewitt, CJ; - view fewer (2018) Qualitative and quantitative demonstration of bead-to-bead transfer with bone marrow-derived human mesenchymal stem cells on microcarriers: Utilising the phenomenon to improve culture performance. Biochemical Engineering Journal , 135 pp. 11-21. 10.1016/j.bej.2017.11.005.

Ramirez, A; Morris, S; Maucourant, S; D'Ascanio, I; Crescente, V; Lu, I-N; Farinelle, S; ... Rosenberg, W; + view all Ramirez, A; Morris, S; Maucourant, S; D'Ascanio, I; Crescente, V; Lu, I-N; Farinelle, S; Muller, CP; Whelan, M; Rosenberg, W; - view fewer (2018) A virus-like particle vaccine candidate for influenza A virus based on multiple conserved antigens presented on hepatitis B tandem core particles. Vaccine , 36 (6) pp. 873-880. 10.1016/j.vaccine.2017.12.053.

Ridley, CJA; Parker, BM; Norman, L; Schlarb-Ridley, B; Dennis, R; Jamieson, AE; Clark, D; ... Davey, MP; + view all Ridley, CJA; Parker, BM; Norman, L; Schlarb-Ridley, B; Dennis, R; Jamieson, AE; Clark, D; Skill, SC; Smith, AG; Davey, MP; - view fewer (2018) Growth of microalgae using nitrate-rich brine wash from the water industry. Algal Research , 33 pp. 91-98. 10.1016/j.algal.2018.04.018.

Ripoll, VM; Pregnolato, F; Mazza, S; Bodio, C; Grossi, C; McDonnell, T; Pericleous, C; ... Giles, IP; + view all Ripoll, VM; Pregnolato, F; Mazza, S; Bodio, C; Grossi, C; McDonnell, T; Pericleous, C; Meroni, PL; Isenberg, DA; Rahman, A; Giles, IP; - view fewer (2018) Gene expression profiling identifies distinct molecular signatures in thrombotic and obstetric antiphospholipid syndrome. Journal of Autoimmunity 10.1016/j.jaut.2018.07.002. (In press).

Salih, O; He, S; Planamente, S; Stach, L; MacDonald, JT; Manoli, E; Scheres, SHW; ... Freemont, PS; + view all Salih, O; He, S; Planamente, S; Stach, L; MacDonald, JT; Manoli, E; Scheres, SHW; Filloux, A; Freemont, PS; - view fewer (2018) Atomic Structure of Type VI Contractile Sheath from Pseudomonas aeruginosa. Structure , 26 (2) pp. 329-336. 10.1016/j.str.2017.12.005.

Samaras, JJ; Abecasis, B; Serra, M; Ducci, A; Micheletti, M; (2018) Impact of hydrodynamics on iPSC-derived cardiomyocyte differentiation processes. Journal of Biotechnology , 287 pp. 18-27. 10.1016/j.jbiotec.2018.07.028.

Sibley, Michael; (2018) A Cell Engineering Approach to Enzyme-Based Fed-Batch Fermentation. Doctoral thesis (Ph.D), UCL (University College London).

Smith, DM; Culme-Seymour, EJ; Mason, C; (2018) Evolving Industry Partnerships and Investments in Cell and Gene Therapies. Cell Stem Cell , 22 (5) pp. 623-626. 10.1016/j.stem.2018.03.004.

Smith, F; Velayudhan, A; Voulgarelis, D; (2018) Stochastic analysis of a full system of two competing populations in a chemostat. Chemical Engineering Science , 175 pp. 424-444. 10.1016/j.ces.2017.10.052.

Strnisa, F; Bajic, M; Panjan, P; Plazl, I; Sesay, AM; Znidarsic-Plazl, P; (2018) Characterization of an enzymatic packed-bed microreactor: Experiments and modeling. Chemical Engineering Journal , 350 pp. 541-550. 10.1016/j.cej.2018.05.028.

Tang, Zuming; (2018) Size and Location Controlled Microwell Screening Technologies for Stem Cell Differentiation. Doctoral thesis (Ph.D), UCL (University College London).

Torres-Acosta, MA; Pereira, JFB; Freire, MG; Aguilar-Yanez, JM; Coutinho, JAP; Titchener-Hooker, NJ; Rito-Palomares, M; (2018) Economic evaluation of the primary recovery of tetracycline with traditional and novel aqueous two-phase systems. Separation and Purification Technology , 203 pp. 178-184. 10.1016/j.seppur.2018.04.041.

Tsuchiya, Y; Zhyvoloup, A; Bakovic, J; Thomas, N; Yi Kun Yu, B; Das, S; Orengo, C; ... Gout, I; + view all Tsuchiya, Y; Zhyvoloup, A; Bakovic, J; Thomas, N; Yi Kun Yu, B; Das, S; Orengo, C; Newell, C; Ward, J; Saladino, G; Comitani, F; Gervasio, FL; Malanchuk, OM; Khoruzhenko, AI; Filonenko, V; Peak-Chew, SY; Skehel, M; Gout, I; - view fewer (2018) Protein CoAlation and antioxidant function of Coenzyme A in prokaryotic cells. Biochemical Journal , 475 (11) pp. 1909-1937. 10.1042/BCJ20180043.

Uddin, I; Frank, S; Warren, MJ; Pickersgill, RW; (2018) A Generic Self-Assembly Process in Microcompartments and Synthetic Protein Nanotubes. Small , 14 (19) , Article 1704020. 10.1002/smll.201704020.

Vazquez-Villegas, P; Espitia-Saloma, E; Torres-Acosta, MA; Ruiz-Ruiz, F; Rito-Palomares, M; Aguilar, O; (2018) Factorial and Economic Evaluation of an Aqueous Two-Phase Partitioning Pilot Plant for Invertase Recovery From Spent Brewery Yeast. Frontiers in Chemistry , 6 , Article 454. 10.3389/fchem.2018.00454.

Velez-Suberbie, ML; Betts, JPJ; Walker, KL; Robinson, C; Zoro, B; Keshavarz-Moore, E; (2018) High throughput automated microbial bioreactor system used for clone selection and rapid scale-down process optimization. Biotechnology Progress , 34 (1) pp. 58-68. 10.1002/btpr.2534.

Villegas-Torres, MF; Ward, JM; Baganz, F; (2018) Optimisation of enzyme cascades for chiral amino alcohol synthesis in aid of host cell integration using a statistical experimental design approach. Journal of Biotechnology , 281 pp. 150-160. 10.1016/j.jbiotec.2018.07.014.

Vormittag, P; Gunn, R; Ghorashian, S; Veraitch, FS; (2018) A guide to manufacturing CAR T cell therapies. Current Opinion in Biotechnology , 53 pp. 164-181. 10.1016/j.copbio.2018.01.025.

Ward, David; (2018) Scalable separation methods for the isolation of monosaccharides in a biorefinery context. Doctoral thesis (Ph.D), UCL (University College London).

Wayne, CJ; Velayudhan, A; (2018) Modulator Dynamics Shape the Design Space for Stepwise-Elution Simulated Moving Bed Chromatographic Separations. Biotechnology Journal , 13 (8) , Article 1700664. 10.1002/biot.201700664.

Weheliye, HW; Cagney, N; Rodriguez, G; Micheletti, M; Ducci, A; (2018) Mode decomposition and Lagrangian structures of the flow dynamics in orbitally shaken bioreactors. Physics of Fluids , 30 , Article 033603. 10.1063/1.5016305.

Wei, Y-C; Braun-Galleani, S; Henriquez, M-J; Bandara, S; Nesbeth, DN; (2018) Biotransformation of β-Hydroxypyruvate and Glycolaldehyde to L-Erythrulose by Pichia pastoris strain GS115 overexpressing native Transketolase. Biotechnology Progress , 34 (1) pp. 99-106. 10.1002/btpr.2577.

Wiegmann, V; Martinez, CB; Baganz, F; (2018) A simple method to determine evaporation and compensate for liquid losses in small-scale cell culture systems. Biotechnology Letters , 40 (7) pp. 1029-1036. 10.1007/s10529-018-2556-x.

Wong, Jeff; de Rond, Tristan; d'Espaux, Leo; van der Horst, Cas; Dev, Ishaan; Rios-Solis, Leo; Kirby, James; ... Keasling, Jay; + view all Wong, Jeff; de Rond, Tristan; d'Espaux, Leo; van der Horst, Cas; Dev, Ishaan; Rios-Solis, Leo; Kirby, James; Scheller, Henrik; Keasling, Jay; - view fewer (2018) High-titer production of lathyrane diterpenoids from sugar by engineered Saccharomyces cerevisiae. Metabolic Engineering , 45 pp. 142-148. 10.1016/j.ymben.2017.12.007.

Worsham, RD; Thomas, V; Farid, SS; (2018) Potential of Continuous Manufacturing for Liposomal Drug Products. Biotechnology Journal , Article e1700740. 10.1002/biot.201700740.

Yu, H; Dalby, P; (2018) Exploiting correlated molecular-dynamics networks to counteract enzyme activity–stability trade-off. Proceedings of the National Academy of Sciences of the United States of America , 115 (52) E12192-E12200. 10.1073/pnas.1812204115.

Yu, H; Dalby, PA; (2018) Coupled molecular dynamics mediate long- and short-range epistasis between mutations that affect stability and aggregation kinetics. Proceedings of the National Academy of Sciences of the United States of America , 115 (47) E11043-E11052. 10.1073/pnas.1810324115.

Zhang, C; Samad, M; Yu, H; Chakroun, N; Hilton, D; Dalby, PA; (2018) Computational Design To Reduce Conformational Flexibility and Aggregation Rates of an Antibody Fab Fragment. Molecular Pharmaceutics , 15 (8) pp. 3079-3092. 10.1021/acs.molpharmaceut.8b00186.

Zhang, H; Deng, M; Lin, P; Liu, J; Liu, C; Strohl, WR; Wang, S; Zhang, H; Deng, M; Lin, P; Liu, J; Liu, C; Strohl, WR; Wang, S; Ho, M; - view fewer (2018) Frontiers and Opportunities: Highlights of the 2nd Annual Conference of the Chinese Antibody Society. Antibody Therapeutics , 1 (2) pp. 65-74. 10.1093/abt/tby009.

Zhao, J; Lichman, BR; Ward, JM; Hailes, HC; (2018) One-pot chemoenzymatic synthesis of trolline and tetrahydroisoquinoline analogues. Chemical Communications , 54 (11) pp. 1323-1326. 10.1039/c7cc08024g.

2017

Abdolvand, Nima; (2017) Retinal Differentiation of Human Induced Pluripotent Stem Cells in a Continuously Perfused Microfluidic Culture Device. Doctoral thesis (Ph.D), UCL (University College London).

Affaticati, PE; (2017) Engineering Transketolase for Industrial Biotechnology. Doctoral thesis , UCL (University College London).

Artim-Esen, B; Smoktunowicz, N; McDonnell, T; Ripoll, VM; Pericleous, C; Mackie, I; Robinson, E; ... Giles, I; + view all Artim-Esen, B; Smoktunowicz, N; McDonnell, T; Ripoll, VM; Pericleous, C; Mackie, I; Robinson, E; Isenberg, D; Rahman, A; Ioannou, Y; Chambers, RC; Giles, I; - view fewer (2017) Factor Xa Mediates Calcium Flux in Endothelial Cells and is Potentiated by Igg From Patients With Lupus and/or Antiphospholipid Syndrome. Scientific Reports , 7 (1) , Article 10788. 10.1038/s41598-017-11315-9.

Auta, HA; (2017) Ultra scale-down process synthesis of microalgae primary recovery operations. Doctoral thesis , UCL (University College London).

Barisa, M; Kramer, AM; Majani, Y; Moulding, D; Saraiva, L; Bajaj-Elliott, M; Anderson, J; Barisa, M; Kramer, AM; Majani, Y; Moulding, D; Saraiva, L; Bajaj-Elliott, M; Anderson, J; Gustafsson, K; - view fewer (2017) E. coli promotes human Vγ9Vδ2 T cell transition from cytokine-producing bactericidal effectors to professional phagocytic killers in a TCR-dependent manner. Science Reports , 7 (1) , Article 2805. 10.1038/s41598-017-02886-8.

Barisa, Marta; (2017) Human peripheral γδT cell phenotypic and functional shift in response to stimulation with E.coli. Doctoral thesis (Ph.D), UCL (University College London).

Baud, D; Jeffries, JWE; Moody, TS; Ward, JM; Hailes, HC; (2017) A metagenomics approach for new biocatalyst discovery: application to transaminases and the synthesis of allylic amines. Green Chemistry , 19 (4) pp. 1134-1143. 10.1039/c6gc02769e.

Bayir, N; (2017) Modelling of integrated de-novo pathways for amino alcohol synthesis. Doctoral thesis , UCL (University College London).

Beneroso, D; Monti, T; Kostas, ET; Robinson, J; (2017) Microwave pyrolysis of biomass for bio-oil production: Scalable processing concepts. [Review]. Chemical Engineering Journal , 316 pp. 481-498. 10.1016/j.cej.2017.01.130.

Binti Suhaili, Nurashikin; (2017) Characterisation of biocatalyst production within an integrated biorefinery context. Doctoral thesis (Ph.D), UCL (University College London).

Bochenkova, AV; Mooney, CRS; Parkes, MA; Woodhouse, JL; Zhang, L; Lewin, R; Ward, JM; ... Fielding, HH; + view all Bochenkova, AV; Mooney, CRS; Parkes, MA; Woodhouse, JL; Zhang, L; Lewin, R; Ward, JM; Hailes, HC; Andersen, LH; Fielding, HH; - view fewer (2017) Mechanism of resonant electron emission from the deprotonated GFP chromophore and its biomimetics. Chemical Science , 8 (4) pp. 3154-3163. 10.1039/C6SC05529J.

Bourke, LT; McDonnell, T; McCormick, J; Pericleous, C; Ripoll, VM; Giles, I; Rahman, A; ... Ioannou, Y; + view all Bourke, LT; McDonnell, T; McCormick, J; Pericleous, C; Ripoll, VM; Giles, I; Rahman, A; Stephanou, A; Ioannou, Y; - view fewer (2017) Antiphospholipid antibodies enhance rat neonatal cardiomyocyte apoptosis in an in vitro hypoxia/reoxygenation injury model via p38 MAPK. Cell Death & Disease , 8 (1) , Article e2549. 10.1038/cddis.2016.235.

Caplan, AI; Mason, C; Reeve, B; (2017) The 3Rs of Cell Therapy. Stem Cells Translational Medicine , 6 (1) pp. 17-21. 10.5966/sctm.2016-0180.

Capsomidis, A; Benthall, G; Van Acker, HH; Fisher, J; Kramer, AM; Abeln, Z; Majani, Y; ... Anderson, J; + view all Capsomidis, A; Benthall, G; Van Acker, HH; Fisher, J; Kramer, AM; Abeln, Z; Majani, Y; Gileadi, T; Wallace, R; Gustafsson, K; Flutter, B; Anderson, J; - view fewer (2017) Chimeric Antigen Receptor-Engineered Human Gamma Delta T Cells: Enhanced Cytotoxicity with Retention of Cross Presentation. Molecular Therapy 10.1016/j.ymthe.2017.12.001. (In press).

Cárdenas-Fernández, M; Bawn, M; Hamley-Bennett, C; Bharat, PKV; Subrizi, F; Suhaili, N; Ward, DP; ... Lye, GJ; + view all Cárdenas-Fernández, M; Bawn, M; Hamley-Bennett, C; Bharat, PKV; Subrizi, F; Suhaili, N; Ward, DP; Bourdin, S; Dalby, PA; Hailes, HC; Hewitson, P; Ignatova, S; Kontoravdi, C; Leak, DJ; Shah, N; Sheppard, TD; Ward, JM; Lye, GJ; - view fewer (2017) An integrated biorefinery concept for conversion of sugar beet pulp into value-added chemicals and pharmaceutical intermediates. Faraday Discuss , 202 pp. 415-431. 10.1039/c7fd00094d.

Carvalho, F; Marques, M; Fernandes, P; (2017) Sucrose Hydrolysis in a Bespoke Capillary Wall-Coated Microreactor. Catalysts , 7 (2) , Article 42. 10.3390/catal7020042.

de Lamotte, A; Delafosse, A; Calvo, S; Delvigne, F; Toye, D; (2017) Investigating the effects of hydrodynamics and mixing on mass transfer through the free-surface in stirred tank bioreactors. Chemical Engineering Science , 172 pp. 125-142. 10.1016/j.ces.2017.06.028.

Dimov, N; Kastner, E; Hussain, M; Perrie, Y; Szita, N; (2017) Formation and purification of tailored liposomes for drug delivery using a module-based micro continuous-flow system. Scientific Reports , 7 (1) , Article 12045. 10.1038/s41598-017-11533-1.

Dunbabin, A; Subrizi, F; Ward, JM; Sheppard, TD; Hailes, HC; (2017) Furfurylamines from biomass: Transaminase catalysed upgrading of furfurals. Green Chemistry , 19 (2) pp. 397-404. 10.1039/c6gc02241c.

Eastwood, TA; Baker, K; Brooker, HR; Frank, S; Mulvihill, DP; (2017) An enhanced recombinant amino-terminal acetylation system and novel in vivo high-throughput screen for molecules affecting α-synuclein oligomerisation. FEBS Letters , 591 (6) pp. 833-841. 10.1002/1873-3468.12597.

Erdmann, V; Lichmann, BR; Zhao, J; Simon, RC; Kroutil, W; Ward, JM; Hailes, HC; Erdmann, V; Lichmann, BR; Zhao, J; Simon, RC; Kroutil, W; Ward, JM; Hailes, HC; Rother, D; - view fewer (2017) Enzymatic and chemoenzymatic 3-step cascades for the synthesis of stereochemically complementary trisubstituted tetrahydroisoquinolines. Angewandte Chemie International Edition , 56 (41) pp. 12503-12507. 10.1002/anie.201705855.

Eva Fritzsche, E; Gruber, P; Schutting, S; Fischer, JP; Strobl, M; Müller, JD; Borisov, SM; Eva Fritzsche, E; Gruber, P; Schutting, S; Fischer, JP; Strobl, M; Müller, JD; Borisov, SM; Klimant, I; - view fewer (2017) Highly Sensitive Poisoning-Resistant Optical Carbon Dioxide Sensors for Environmental Monitoring. Analytical Methods , 9 (1) pp. 55-65. 10.1039/C6AY02949C.

Fisher, J; Abramowski, P; Wisidagamage Don, ND; Flutter, B; Capsomidis, A; Cheung, GW-K; Gustafsson, K; Fisher, J; Abramowski, P; Wisidagamage Don, ND; Flutter, B; Capsomidis, A; Cheung, GW-K; Gustafsson, K; Anderson, J; - view fewer (2017) Avoidance of On-Target Off-Tumor Activation Using a Co-stimulation-Only Chimeric Antigen Receptor. Molecular Therapy , 25 (3) pp. 1234-1247. 10.1016/j.ymthe.2017.03.002.

Gaciarz, A; Khatri, NK; Velez-Suberbie, ML; Saaranen, MJ; Uchida, Y; Keshavarz-Moore, E; Ruddock, LW; (2017) Efficient soluble expression of disulfide bonded proteins in the cytoplasm of Escherichia coli in fed-batch fermentations on chemically defined minimal media. Microbial Cell Factories , 16 , Article 108. 10.1186/s12934-017-0721-x.

Goldrick, S; Holmes, W; Bond, N; Lewis, G; Kuiper, M; Turner, R; Farid, SS; (2017) Advanced multivariate data analysis to determine the root cause of trisulfide bond formation in a novel antibody-peptide fusion. Biotechnology and Bioengineering , 144 (10) pp. 2222-2234. 10.1002/bit.26339.

Goldrick, S; Joseph, A; Mollet, M; Turner, R; Gruber, D; Farid, SS; Titchener-Hooker, NJ; (2017) Predicting performance of constant flow depth filtration using constant pressure filtration data. Journal of Membrane Science , 531 pp. 138-147. 10.1016/j.memsci.2017.03.002.

Gruber, P; Marques, M; Szita, N; Mayr, T; (2017) Integration and Application of Optical Chemical Sensors in Microbioreactors. Lab on a Chip , 17 (16) pp. 2693-2712. 10.1039/C7LC00538E.

Gruber, P; Marques, MP; Sulzer, P; Wohlgemuth, R; Mayr, T; Baganz, F; Szita, N; (2017) Real-time pH monitoring of industrially relevant enzymatic reactions in a microfluidic side-entry reactor (μSER) shows potential for pH control. Biotechnology Journal , 12 (6) , Article 1600475. 10.1002/biot.201600475.

Gruber, P; Marques, MPC; O'Sullivan, B; Baganz, F; Wohlgemuth, R; Szita, N; (2017) Conscious coupling: The challenges and opportunities of cascading enzymatic microreactors. Biotechnology Journal 10.1002/biot.201700030.

Guitart, AV; Panagopoulou, TI; Villacreces, A; Vukovic, M; Sepulveda, C; Allen, L; Carter, RN; ... Kranc, KR; + view all Guitart, AV; Panagopoulou, TI; Villacreces, A; Vukovic, M; Sepulveda, C; Allen, L; Carter, RN; van de Lagemaat, LN; Morgan, M; Giles, P; Sas, Z; Gonzalez, MV; Lawson, H; Paris, J; Edwards-Hicks, J; Schaak, K; Subramani, C; Gezer, D; Armesilla-Diaz, A; Wills, J; Easterbrook, A; Coman, D; So, CWE; O'Carroll, D; Vernimmen, D; Rodrigues, NP; Pollard, PJ; Morton, NM; Finch, A; Kranc, KR; - view fewer (2017) Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions. Journal of Experimental Medicine , 214 (3) pp. 719-735. 10.1084/jem.20161087.

Harrison, RP; Ruck, S; Medcalf, N; Rafiq, QA; (2017) Decentralized manufacturing of cell and gene therapies: Overcoming challenges and identifying opportunities. Cytotherapy , 19 (10) pp. 1140-1151. 10.1016/j.jcyt.2017.07.005.

Hooker, A; Splevins, A; Horrocks, P; Dalby, P; Farid, SS; (2017) An evaluation of the cGMP manufacturing process economics and high-throughput characterisation of Targeted Secretion Inhibitors. Presented at: TOXINS 2017, Madrid, Spain.

Husson, G; Delangle, A; O'Hara, J; Cianférani, S; Gervais, A; Van Dorsselaer, A; Bracewell, DG; Husson, G; Delangle, A; O'Hara, J; Cianférani, S; Gervais, A; Van Dorsselaer, A; Bracewell, DG; Carapito, C; - view fewer (2017) Dual Data-Independent Acquisition Approach Combining Global HCP Profiling and Absolute Quantification of Key Impurities during Bioprocess Development. Analytical Chemistry , 90 (2) pp. 1241-1247. 10.1021/acs.analchem.7b03965.

Jaccard, N; Szita, N; Griffin, LD; (2017) Segmentation of phase contrast microscopy images based on multi-scale local Basic Image Features histograms. Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization , 5 (5) pp. 359-367. 10.1080/21681163.2015.1016243.

Jacob, SI; Khogeer, B; Bampos, N; Sheppard, T; Schwartz, R; Lowe, CR; (2017) Development and Application of Synthetic Affinity Ligands for the Purification of Ferritin-Based Influenza Antigens. Bioconjugate Chemistry , 28 (7) pp. 1931-1943. 10.1021/acs.bioconjchem.7b00253.

Jeffries, JWE; (2017) Functional metagenomics: metagenome mining for industrial biocatalysis. Doctoral thesis , UCL (University College London).

Jenkins, MJ; Fedechko, RW; Ho, SV; Farid, S; (2017) Decision-support tools for cost-effective bioprocess design in the cell therapy sector. Presented at: ECI Scale-up and manufacturing of cell-based therapies V, San Diego, USA.

Johnson, TF; Levison, PR; Shearing, PR; Bracewell, DG; (2017) X-ray computed tomography of packed bed chromatography columns for three dimensional imaging and analysis. Journal of Chromatography A , 1487 pp. 108-115. 10.1016/j.chroma.2017.01.013.

Joseph, A; Goldrick, S; Mollet, M; Turner, R; Bender, J; Gruber, D; Farid, SS; Joseph, A; Goldrick, S; Mollet, M; Turner, R; Bender, J; Gruber, D; Farid, SS; Titchener-Hooker, N; - view fewer (2017) An automated laboratory-scale methodology for the generation of sheared mammalian cell culture samples. Biotechnology Journal , 12 (5) 10.1002/biot.201600730.

Joseph, AVA; (2017) Scale-down characterisation and modelling of harvest operations in mammalian cell culture processes. Doctoral thesis , UCL (University College London).

Kinna, AW; (2017) Improved production and purification of recombinant proteins from mammalian expression systems. Doctoral thesis , UCL (University College London).

Kiparissides, A; Hatzimanikatis, V; (2017) Thermodynamics-based Metabolite Sensitivity Analysis in metabolic networks. Metabolic Engineering , 39 pp. 117-127. 10.1016/j.ymben.2016.11.006.

Kolmar, JF; (2017) Microscale tools for rapid evaluation of two-liquid phase bio-oxidations of volatile alkanes. Doctoral thesis , UCL (University College London).

Kolmar, JF; Thum, O; Baganz, F; (2017) Customized microscale approach for optimizing two-phase bio-oxidations of alkanes with high reproducibility. Microbial Cell Factories , 16 , Article 174. 10.1186/s12934-017-0788-4.

Konstantinidis, S; Titchener-Hooker, N; Velayudhan, A; (2017) Simplex-based optimization of numerical and categorical inputs in early bioprocess development: Case studies in HT chromatography. Biotechnology Journal , 12 (8) 10.1002/biot.201700174.

Kostas, ET; Beneroso, D; Robinson, JP; (2017) The application of microwave heating in bioenergy: A review on the microwave pre-treatment and upgrading technologies for biomass. Renewable and Sustainable Energy Reviews , 77 pp. 12-27. 10.1016/j.rser.2017.03.135.

Kostas, ET; White, DA; Cook, DJ; (2017) Development of a bio-refinery process for the production of speciality chemical, biofuel and bioactive compounds from Laminaria digitata. Algal Research , 28 pp. 211-219. 10.1016/j.algal.2017.10.022.

Kostas, ET; Wilkinson, SJ; White, DA; Cook, DJ; (2017) Complete Acid-Based Hydrolysis Assay for Carbohydrate Quantification in Seaweed: A Species-Specific Optimized Approach. Methods in Molecular Biology , 1980 pp. 181-190. 10.1007/7651_2017_105.

Kulsharova, G; Dimov, N; Marques, MPC; Szita, N; Baganz, F; (2017) Simplified immobilisation method for histidine-tagged enzymes in poly(methyl methacrylate) microfluidic devices. New Biotechnology 10.1016/j.nbt.2017.12.004.

Lambert, AB; Smith, FT; Velayudhan, A; (2017) A Simplified Model of Glycoprotein Production within Cell Culture. European Journal of Applied Mathematics , 28 (4) pp. 535-561. 10.1017/S0956792516000437.

Lanna, A; Gomes, DC; Muller-Durovic, B; McDonnell, T; Escors, D; Gilroy, DW; Lee, JH; ... Akbar, AN; + view all Lanna, A; Gomes, DC; Muller-Durovic, B; McDonnell, T; Escors, D; Gilroy, DW; Lee, JH; Karin, M; Akbar, AN; - view fewer (2017) A sestrin-dependent Erk-Jnk-p38 MAPK activation complex inhibits immunity during aging. Nature Immunology , 18 (3) pp. 354-363. 10.1038/ni.3665.

Lechner, H; Soriano, P; Poschner, R; Hailes, HC; Ward, JM; Kroutil, W; (2017) Library of norcoclaurine synthases and their immobilization for biocatalytic transformations. Biotechnology Journal 10.1002/biot.201700542. (In press).

Liang, M; Frank, S; Lünsdorf, H; Warren, MJ; Prentice, MB; (2017) Bacterial microcompartment-directed polyphosphate kinase promotes stable polyphosphate accumulation in E. coli. Biotechnology Journal , 12 (3) , Article 1600415. 10.1002/biot.201600415.

Lichman, BR; Sula, A; Pesnot, T; Hailes, HC; Ward, JM; Keep, NH; (2017) Structural Evidence for the Dopamine-First Mechanism of Norcoclaurine Synthase. Biochemistry , 56 (40) pp. 5274-5277. 10.1021/acs.biochem.7b00769.

Lichman, BR; Zhao, J; Hailes, HC; Ward, JM; (2017) Enzyme catalysed Pictet-Spengler formation of chiral 1,1 '-disubstituted- and spiro-tetrahydroisoquinolines. Nature Communications , 8 , Article 14883. 10.1038/ncomms14883.

Lipsitz, YY; Milligan, WD; Fitzpatrick, I; Stalmeijer, E; Farid, SS; Tan, KY; Smith, D; ... Fink, J; + view all Lipsitz, YY; Milligan, WD; Fitzpatrick, I; Stalmeijer, E; Farid, SS; Tan, KY; Smith, D; Perry, R; Carmen, J; Chen, A; Mooney, C; Fink, J; - view fewer (2017) A roadmap for cost-of-goods planning to guide economic production of cell therapy products. Cytotherapy , 19 (12) pp. 1383-1391. 10.1016/j.jcyt.2017.06.009.

Liu, S; Ruban, L; Zhou, Y; Wang, Y; Nesbeth, DN; (2017) Establishing elements of a synthetic biology platform for Vaccinia virus production: BioBrickTM design, serum-free virus production and microcarrier-based cultivation of CV-1 cells. Heliyon , 3 (2) , Article e00238. 10.1016/j.heliyon.2017.e00238.

Marques, MPC; Szita, N; (2017) Bioprocess microfluidics: applying microfluidic devices for bioprocessing. [Review]. Current Opinion in Chemical Engineering , 18 pp. 61-68. 10.1016/j.coche.2017.09.004.

Marsh, DTJ; (2017) Engineering Characterisation of a Rocked Bag Bioreactor for Improved Process Development and Scale-Up. Doctoral thesis , UCL (University College London).

Marsh, DTJ; Odeleye, AOO; Ducci, A; Osborne, MD; Lye, GJ; Micheletti, M; (2017) Fluid Dynamic Characterization of a Laboratory Scale Rocked Bag Bioreactor. AIChE Journal , 63 (9) pp. 4177-4187. 10.1002/aic.15734.

Masri, MF; Lawrence, K; Wall, I; Hoare, M; (2017) An ultra scale-down methodology to characterize aspects of the response of human cells to processing by membrane separation operations. Biotechnology and Bioengineering , 114 (6) pp. 1241-1251. 10.1002/bit.26257.

Mazzer, AR; Clifton, LA; Perevozchikova, T; Butler, PD; Roberts, CJ; Bracewell, DG; (2017) Neutron reflectivity measurement of protein A-antibody complex at the solid-liquid interface. Journal of Chromatography A , 1499 pp. 118-131. 10.1016/j.chroma.2017.03.084.

McInally, AD; (2017) Investigating the use of fusion partners to enhance the expression and recovery of a domain antibody from Escherichia coli. Doctoral thesis , UCL (University College London).

Migani, D; (2017) Proteomics Based Process And Cell Line Development Applied To A Mammalian Therapeutic Enzyme. Doctoral thesis , UCL (University College London).

Migani, D; Smales, CM; Bracewell, DG; (2017) Effects of lysosomal biotherapeutic recombinant protein expression on cell stress and protease and general host cell protein (HCP) release in Chinese hamster ovary cells. Biotechnology Progress , 33 (3) pp. 666-676. 10.1002/btpr.2455.

Miller, KE; (2017) Design and Characterisation of a Novel Internally Illuminating Photobioreactor. Doctoral thesis , UCL (University College London).

Newton, JM; Vlahopoulou, J; Zhou, Y; (2017) Investigating and modelling the effects of cell lysis on the rheological properties of fermentation broths. Biochemical Engineering Journal , 121 pp. 38-48. 10.1016/j.bej.2017.01.009.

Nweke, MC; McCartney, RG; Bracewell, DG; (2017) Mechanical characterisation of agarose-based chromatography resins for biopharmaceutical manufacture. Journal of Chromatography A , 1530 pp. 129-137. 10.1016/j.chroma.2017.11.038.

Ogonah, OW; Polizzi, KM; Bracewell, DG; (2017) Cell free protein synthesis: a viable option for stratified medicines manufacturing? Current Opinion in Chemical Engineering , 18 pp. 77-83. 10.1016/j.coche.2017.10.003.

Othman, M; Ariff, AB; Rios-Solis, L; Halim, M; (2017) Extractive fermentation of lactic acid in lactic acid bacteria cultivation: A review. Frontiers in Microbiology , 8 p. 2285. 10.3389/fmicb.2017.02285.

Oyebolu, FB; van Lidth de Jeude, J; Siganporia, C; Farid, SS; Allmendinger, R; Branke, J; (2017) A new lot sizing and scheduling heuristic for multi-site biopharmaceutical production. Journal of Heuristics , 23 (4) pp. 231-256. 10.1007/s10732-017-9338-9.

Paredes, LA; Flores Fernández, CN; Zavaleta, AI; (2017) OPTIMIZACIÓN DEL MEDIO PARA LA PRODUCCIÓN DE PROTEASAS EXTRACELULARES POR Pseudomonas sp. M211 EN FERMENTACIÓN SUMERGIDA. Revista de la Sociedad Química del Perú , 83 (4) pp. 449-462. 10.37761/rsqp.v83i4.217.

Parker, L; Mansfield, S; Sneddon, K; Charles, B; Rafiq, Q; (2017) Advances and challenges in umbilical cord blood and tissue bioprocessing: procurement and storage. Cell and Gene Therapy Insights , 3 (6) pp. 489-508. 10.18609/cgti.2017.042.

Pathak, M; Lintern, K; Chopda, V; Bracewell, DG; Rathore, AS; (2017) Fluorescence based real time monitoring of fouling in process chromatography. SCIENTIFIC REPORTS , 7 (ARTN 456) 10.1038/srep45640.

Pesnot, T; Gershater, MC; Edwards, M; Ward, JM; Hailes, HC; (2017) One-Pot Phosphate-Mediated Synthesis of Novel 1,3,5-Trisubstituted Pyridinium Salts: A New Family of S. aureus Inhibitors. Molecules , 22 (4) , Article 626. 10.3390/molecules22040626.

Peticone, C; Thompson, DDS; Owens, GJ; Kim, H-W; Micheletti, M; Knowles, JC; Wall, I; (2017) Towards modular bone tissue engineering using Ti-Co-doped phosphate glass microspheres: cytocompatibility and dynamic culture studies. Journal of Biomaterials Applications , 32 (3) pp. 295-310. 10.1177/0885328217720812.

Pollock, J; Coffman, J; Ho, SV; Farid, SS; (2017) Integrated continuous bioprocessing: Economic, operational, and environmental feasibility for clinical and commercial antibody manufacture. Biotechnology Progress , 33 (4) pp. 854-866. 10.1002/btpr.2492.

Rafiq, QA; Davies, OG; (2017) Considerations for the bioprocessing, manufacture and translation of extracellular vesicles for therapeutic applications. Cell and Gene Therapy Insights , 3 (6) pp. 683-694. 10.18609/cgti.2017.066.

Rafiq, QA; Hanga, MP; Heathman, TRJ; Coopman, K; Nienow, AW; Williams, DJ; Hewitt, CJ; (2017) Process development of human multipotent stromal cell microcarrier culture using an automated high-throughput microbioreactor. Biotechnology and Engineering , 114 (10) pp. 2253-2266. 10.1002/bit.26359.

Rafiq, QA; Masri, F; (2017) Downstream Processing for Cell-Based Therapies. BioPharm International , 30 (4) pp. 22-26.

Rafiq, QA; Nienow, AW; Hewitt, CJ; Coopman, K; (2017) The role of biopreservation in cell and gene therapy bioprocessing. Cell and Gene Therapy Insights , 3 (5) pp. 335-344. 10.18609/cgti.2017.037.

Robinson, MJ; Matejtschuk, P; Bristow, AF; Dalby, PA; (2017) Tm-values and unfolded fraction can predict aggregation rates for GCSF variant formulations, but not under predominantly native conditions. Mol Pharm 10.1021/acs.molpharmaceut.7b00876. (In press).

Rodriguez, G; (2017) An engineering characterisation of shaken bioreactors: flow, mixing and suspension dynamics. Doctoral thesis , UCL (University College London).

Schofield, DM; Nesbeth, DN; (2017) A high performance bench scale process for isolation from inclusion bodies, refolding and dimerisation of a thiol-engineered recombinant therapeutic protein. Biotechnology and Bioprocess Engineering , 22 (4) pp. 423-430. 10.1007/s12257-016-0385-0.

Schofield, DM; Sirka, E; Keshavarz-Moore, E; Ward, JM; Nesbeth, DN; (2017) Improving Fab’ fragment retention in an autonucleolytic Escherichia coli strain by swapping periplasmic nuclease translocation signal from OmpA to DsbA. Biotechnology Letters , 39 (12) pp. 1865-1873. 10.1007/s10529-017-2425-z.

Senaratne, Jayan Chathurika; (2017) Alternative approaches for the characterisation of chromatographic separations from scale down experiments. Doctoral thesis (Eng.D), UCL (University College London).

Sharma, V; Kohli, N; Moulding, D; Afolabi, H; Hook, L; Mason, C; Garcia-Gareta, E; (2017) Design of a Novel Two-Component Hybrid Dermal Scaffold for the Treatment of Pressure Sores. Macromolecular Bioscience , 17 (11) , Article 1700185. 10.1002/mabi.201700185.

Sharma, Vaibhav; (2017) Bioengineering of a novel fibrinalginate scaffold for tissue engineering applications. Doctoral thesis (Ph.D), UCL (University College London).

Sharma, VS; Khalife, R; Tostoes, R; Leung, L; Kinsella, R; Ruban, L; Veraitch, FS; (2017) Early retinal differentiation of human pluripotent stem cells in microwell suspension cultures. Biotechnology Letters , 39 (2) pp. 339-350. 10.1007/s10529-016-2244-7.

Sulu, M; Paul, R; Melville, L; (2017) Feasibility of seaweed and agricultural crop waste residues as co-digestion feedstock. In: Proceedings of the 15th IWA World Conference on Anaerobic Digestion. IWA World Conference on Anaerobic Digestion: Beijing, China.

Tapia Orozco,, N; Santiago Toledo, G; Barrón,, V; Espinosa-García,, AM; García-García,, JA; García-Arrazola,, R; (2017) Environmental epigenomics: Current approaches to assess epigenetic effects of endocrine disrupting compounds (EDC's) on human health. Environmental Toxicology and Pharmacology , 51 pp. 94-99. 10.1016/j.etap.2017.02.004.

Templar, A; (2017) Industrially Robust Synthetic Biology Standards for the Polymerase Chain Reaction. Doctoral thesis , UCL (University College London).

Templar, A; Schofield, DM; Nesbeth, DN; (2017) Measuring E. coli and bacteriophage DNA in cell sonicates to evaluate the CAL1 reaction as a synthetic biology standard for qPCR. Biomolecular Detection and Quantification , 11 pp. 21-30. 10.1016/j.bdq.2016.12.001.

Tostoes, R; Dodgson, J; Weil, B; Gerontas, S; Mason, C; Veraitch, FS; (2017) A novel filtration system for point of care washing of cellular therapy products. Journal of Tissue Engineering and Regenerative Medicine , 11 (11) pp. 3157-3167. 10.1002/term.2225.

Vincent, David Isaac William; (2017) Purification of Recombinant Vaccinia Virus for Oncolytic and Immunotherapeutic Applications using Monolithic Column Technology. Doctoral thesis (Eng.D), UCL (University College London).

Voulgarelis, D; Velayudhan, A; Smith, F; (2017) Derivation of Continuum Models from An Agent-based Cancer Model: Optimization and Sensitivity Analysis. Current Pharmaceutical Biotechnology , 18 (15) pp. 1249-1263. 10.2174/1389201019666180329111909.

Ward, DP; Hewitson, P; Cardenas-Fernandez, M; Hamley-Bennett, C; Diaz-Rodriguez, A; Douillet, N; Adams, JP; ... Lye, GJ; + view all Ward, DP; Hewitson, P; Cardenas-Fernandez, M; Hamley-Bennett, C; Diaz-Rodriguez, A; Douillet, N; Adams, JP; Leak, DJ; Ignatova, S; Lye, GJ; - view fewer (2017) Centrifugal partition chromatography in a biorefinery context: Optimisation and scale-up of monosaccharide fractionation from hydrolysed sugar beet pulp. Journal of Chromatography A , 1497 pp. 56-63. 10.1016/j.chroma.2017.03.003.

Weil, BD; Jenkins, MJ; Uddin, S; Bracewell, DG; Wellings, D; Farid, SS; Veraitch, F; (2017) An integrated experimental and economic evaluation of cell therapy affinity purification technologies. Regenerative Medicine , 12 (4) pp. 397-417. 10.2217/rme-2016-0156.

Yang, Y; Velayudhan, A; Thornhill, NF; Farid, SS; (2017) Multi-criteria manufacturability indices for ranking high-concentration monoclonal antibody formulations. Biotechnology and Bioengineering , 114 (9) pp. 2043-2056. 10.1002/bit.26329.

Yu, H; Yan, Y; Zhang, C; Dalby, PA; (2017) Two strategies to engineer flexible loops for improved enzyme thermostability. Scientific Reports , 7 , Article 41212. 10.1038/srep41212.

Zajkoska, P; Cardenas-Fernandez, M; Lye, GJ; Rosenberg, M; Turner, NJ; Rebros, M; (2017) Chemo-biocatalytic one-pot two-step conversion of cyclic amine to lactam using whole cell monoamine oxidase. Journal of Chemical Technology and Biotechnology , 92 (7) pp. 1558-1565. 10.1002/jctb.5146.

Zhang, C; (2017) Freeze-drying of engineered proteins using protein modelling tools and experimental validation. Doctoral thesis , UCL (University College London).

2016

Affaticati, PE; Dai, SB; Payongsri, P; Hailes, HC; Tittmann, K; Dalby, PA; (2016) Structural Analysis of an Evolved Transketolase Reveals Divergent Binding Modes. Scientific Reports , 6 , Article 35716. 10.1038/srep35716.

Andersson, SEM; Eneljung, T; Tengvall, S; Jirholt, P; Stern, A; Henningsson, L; Liang, B; ... Gjertsson, I; + view all Andersson, SEM; Eneljung, T; Tengvall, S; Jirholt, P; Stern, A; Henningsson, L; Liang, B; Thorarinsdottir, K; Kihlberg, J; Holmdahl, R; Martensson, I-L; Gustafsson, K; Gjertsson, I; - view fewer (2016) Collagen epitope expression on B cells is sufficient to confer tolerance to collagen-induced arthritis. Arthritis Research & Therapy , 18 , Article 140. 10.1186/s13075-016-1037-7.

Antemie, AM; (2016) Linking high throughput cell culture, multivariate analysis and economics for more effective process integration. Doctoral thesis , UCL (University College London).

Aoudjane, S; (2016) Bio-analytics - from current clinical practice to all-optical microfluidic technology. Doctoral thesis , UCL (University College London).

Baert, J; Delepierre, A; Telek, S; Fickers, P; Toye, D; Delamotte, A; Lara, AR; ... Delvigne, F; + view all Baert, J; Delepierre, A; Telek, S; Fickers, P; Toye, D; Delamotte, A; Lara, AR; Jaen, KE; Gosset, G; Jensen, PR; Delvigne, F; - view fewer (2016) Microbial population heterogeneity versus bioreactor heterogeneity: Evaluation of Redox Sensor Green as an exogenous metabolic biosensor. Engineering in Life Sciences , 16 (7) pp. 643-651. 10.1002/elsc.201500149.

Barata, TS; Zhang, C; Dalby, PA; Brocchini, S; Zloh, M; (2016) Identification of Protein-Excipient Interaction Hotspots Using Computational Approaches. International Journal of Molecular Sciences , 17(6) (853) 10.3390/ijms17060853.

Borg, Y; Grigonyte, AM; Boeing, P; Wolfenden, B; Smith, P; Beaufoy, W; Rose, S; ... Nesbeth, DN; + view all Borg, Y; Grigonyte, AM; Boeing, P; Wolfenden, B; Smith, P; Beaufoy, W; Rose, S; Ratisai, T; Zaikin, A; Nesbeth, DN; - view fewer (2016) Open source approaches to establishing Roseobacter Glade bacteria as synthetic biology chassis for biogeoengineering. PeerJ , 4 , Article e2031. 10.7717/peerj.2031.

Branke, J; Farid, SS; Shah, N; (2016) Industry 4.0: a vision for personalized medicine supply chains? Cell and Gene Therapy Insights , 2 (2) pp. 263-270. 10.18609/cgti.2016.027.

Call, TP; Akhtar, MK; Baganz, F; Grant, C; (2016) Modulating the import of medium-chain alkanes in E. coli through tuned expression of FadL. Journal of Biological Engineering , 10 , Article 5. 10.1186/s13036-016-0026-3.

Chakroun, N; Hilton, D; Ahmad, SS; Platt, GW; Dalby, PA; (2016) Mapping the Aggregation Kinetics of a Therapeutic Antibody Fragment. Molecular Pharmaceutics , 13 (2) pp. 307-319. 10.1021/acs.molpharmaceut.5b00387.

Dalby, P; (2016) Conformational protein structure shifts in aggregation prone conditions for MAb and Fab. Presented at: UNSPECIFIED.

Dobrijevic, D; Abraham, A-L; Jamet, A; Maguin, E; van de Guchte, M; (2016) Functional Comparison of Bacteria from the Human Gut and Closely Related Non-Gut Bacteria Reveals the Importance of Conjugation and a Paucity of Motility and Chemotaxis Functions in the Gut Environment. PLoS ONE , 11 (7) , Article e0159030. 10.1371/journal.pone.0159030.

Espuny Garcia del Real, G; (2016) Scale-Down Characterisation of Post-Centrifuge Flocculation Processes and the Study of its Impact upon Downstream Processing during Mammalian Cell Antibody Production. Doctoral thesis , UCL (University College London).

Farid, SS; (2016) Allogeneic cell therapy process economics for successful development, manufacture and commercialisation. Presented at: World Stem Cells & Regenerative Medicine Congress, London, UK.

Goldrick, S; Mercer, E; Montague, G; Lovett, D; Lennox, B; (2016) Control of an Industrial Scale Bioreactor using a PAT Analyser. In: IFAC Proceedings Volumes. (pp. pp. 6222-6227). ELSEVIER

Hamley-Bennett, C; Lye, GJ; Leak, DJ; (2016) Selective fractionation of sugar beet pulp for release of fermentation and chemical feedstocks: optimisation of thermo-chemical pre-treatment. Bioresource Technology , 209 pp. 259-264. 10.1016/j.biortech.2016.02.131.

Hassan, S; Huang, H; Warren, K; Mahdavi, B; Smith, D; Jong, S; Farid, SS; (2016) Process change evaluation framework for allogeneic cell therapies: impact on drug development and commercialization. Regenerative Medicine , 11 (3) pp. 287-305. 10.2217/rme-2015-0034.

Hassan, S; Keshavarz-Moore, E; Ward, J; (2016) A cell engineering strategy to enhance supercoiled plasmid DNA production for gene therapy. Biotechnology and Bioengineering , 113 (9) pp. 2064-2071. 10.1002/bit.25971.

Heathman, TRJ; Rafiq, QA; Chan, AKC; Coopman, K; Nienow, AW; Kara, B; Hewitt, CJ; (2016) Characterization of human mesenchymal stem cells from multiple donors and the implications for large scale bioprocess development. Biochemical Engineering Journal , 108 pp. 14-23. 10.1016/j.bej.2015.06.018.

Heathman, TRJ; Stolzing, A; Fabian, C; Rafiq, QA; Coopman, K; Nienow, AW; Kara, B; Heathman, TRJ; Stolzing, A; Fabian, C; Rafiq, QA; Coopman, K; Nienow, AW; Kara, B; Hewitt, CJ; - view fewer (2016) Scalability and process transfer of mesenchymal stromal cell production from monolayer to microcarrier culture using human platelet lysate. Cytotherapy , 18 (4) pp. 523-535. 10.1016/j.jcyt.2016.01.007.

Hilton, DW; (2016) Elucidating the aggregation mechanisms of antibody fragments through biophysical analysis. Doctoral thesis , UCL (University College London).

Hussain, MS; Ma, GJ; Zhou, Y; (2016) Predicting Flux And Pressure Relationships of Large Scale Filtration with USD Model Inputs: Method and application. Presented at: 13th Annual bioProcessUK Conference – Processing priorities for the future, Newcastle, United Kingdom.

Jeffries, JWE; Dawson, N; Orengo, C; Moody, TS; Quinn, DJ; Hailes, HC; Ward, JM; (2016) Metagenome Mining: A Sequence Directed Strategy for the Retrieval of Enzymes for Biocatalysis. ChemistrySelect , 1 (10) pp. 2217-2220. 10.1002/slct.201600515.

Jenkins, M; Bilsland, J; Allsopp, TE; Ho, SV; Farid, SS; (2016) Patient-specific hiPSC bioprocessing for drug screening: Bioprocess economics and optimisation. Biochemical Engineering Journal , 108 pp. 84-97. 10.1016/j.bej.2015.09.024.

Joseph, A; Kenty, B; Mollet, M; Hwang, K; Rose, S; Goldrick, S; Bender, J; ... Titchener-Hooker, N; + view all Joseph, A; Kenty, B; Mollet, M; Hwang, K; Rose, S; Goldrick, S; Bender, J; Farid, SS; Titchener-Hooker, N; - view fewer (2016) A scale-down mimic for mapping the process performance of centrifugation, depth and sterile filtration. Biotechnology and Bioengineering , 113 (9) pp. 1934-1941. 10.1002/bit.25967.

Kinna, A; Tolner, B; Rota, EM; Titchener-Hooker, N; Nesbeth, D; Chester, K; (2016) IMAC capture of recombinant protein from unclarified mammalian cell feed streams. Biotechnology and Bioengineering , 113 (1) pp. 130-140. 10.1002/bit.25705.

Kirk, TV; Marques, MPC; Radhakrishnan, ANP; Szita, N; (2016) Quantification of the oxygen uptake rate in a dissolved oxygen controlled oscillating jet-driven microbioreactor. Journal of Chemical Technology and Biotechnology , 91 (3) pp. 823-831. 10.1002/jctb.4833.

Kloetzer, L; Petrila-Cocuz, I-B; Galaction, A-I; Szita, N; Blaga, A-C; Cascaval, D; (2016) Eco-friendly Production of Chemicals 1. Improvement of Enzymatic Production of Acetophenone by Direct Extraction. Environmental Engineering and Management Journal , 15 (8) pp. 1849-1854.

Kostas, E; Stuart, W; Daniel, W; David, C; (2016) Optimization of a total acid hydrolysis based protocol for the quantification of carbohydrate in macroalgae. Journal of Algal Biomass Utilization , 7 (1) pp. 21-36.

Lee, D; Das, S; Dawson, NL; Dobrijevic, D; Ward, J; Orengo, C; (2016) Novel computational protocols for functionally classifying and characterising serine beta-lactamases. PLoS Computational Biology , 12 (6) , Article e1004926. 10.1371/journal.pcbi.1004926.

Lee, W; (2016) Directed evolution of bovine enterokinase for high functional expression in E.coli. Doctoral thesis , UCL (University College London).

Lichman, BR; (2016) Norcoclaurine synthase: the mechanism and biocatalytic potential of a Pictet-Spenglerase. Doctoral thesis , UCL (University College London).

Lintern, K; Pathak, M; Smales, CM; Howland, K; Rathore, A; Bracewell, DG; (2016) Residual on column host cell protein analysis during lifetime studies of protein A chromatography. Journal of Chromatography A , 1461 pp. 70-77. 10.1016/j.chroma.2016.07.055.

Liu, S; Farid, SS; Papageorgiou, LG; (2016) Integrated Optimization of Upstream and Downstream Processing in Biopharmaceutical Manufacturing under Uncertainty: A Chance Constrained Programming Approach. Industrial & Engineering Chemistry Research , 55 (16) pp. 4599-4612. 10.1021/acs.iecr.5b04403.

Liu, S; Ruban, L; Wang, Y; Zhou, Y; Nesbeth, DN; (2016) Establishing elements of a synthetic biology platform for Vaccinia virus production: BioBrickTM design, serum-free virus production and microcarrier-based cultivation of CV-1 cells. BioRxiv

Lizzul, AM; (2016) Integrated production of algal biomass. Doctoral thesis , UCL (University College London).

Lou, S-C; Wetzel, S; Zhang, H; Crone, EW; Lee, Y-T; Jackson, SE; Hsu, S-TD; (2016) The Knotted Protein UCH-L1 Exhibits Partially Unfolded Forms under Native Conditions that Share Common Structural Features with Its Kinetic Folding Intermediates. Journal of Molecular Biology , 428 (11) pp. 2507-2520. 10.1016/j.jmb.2016.04.002.

Ma, G; Zhou, Y; (2016) Ultra Scale-down Tools to Accelerate Process Development. Presented at: BioTalk 2016: Biological Manufacturing Excellence, Berlin, Germany.

Mahajan, E; Lye, G; (2016) Bridging polymer science and biotechnology applications with single-use technologies. BioProcess International , 14 (6) pp. 22-27.

Markosova, K; Dolejs, I; Stloukal, R; Rios-Solis, L; Rosenberg, M; Micheletti, M; Lye, GJ; ... Rebros, M; + view all Markosova, K; Dolejs, I; Stloukal, R; Rios-Solis, L; Rosenberg, M; Micheletti, M; Lye, GJ; Turner, NJ; Rebros, M; - view fewer (2016) Immobilisation and kinetics of monoamine oxidase (MAO-N-D5) enzyme in polyvinyl alcohol gels. Journal of Molecular Catalysis B: Enzymatic , 129 pp. 69-74. 10.1016/j.molcatb.2016.04.009.

Mayer, MJ; Juodeikis, R; Brown, IR; Frank, S; Palmer, DJ; Deery, E; Beal, DM; ... Warren, MJ; + view all Mayer, MJ; Juodeikis, R; Brown, IR; Frank, S; Palmer, DJ; Deery, E; Beal, DM; Xue, W-F; Warren, MJ; - view fewer (2016) Effect of bio-engineering on size, shape, composition and rigidity of bacterial microcompartments. Scientific Reports , 6 , Article 36899. 10.1038/srep36899.

Mazzer, A; (2016) Understanding the Influence of Adsorption-Mediated Processes on Antibody Aggregation in Bioprocessing. Doctoral thesis , UCL (University College London).

McDonnell, TCR; (2016) Does PEGylated DI have the potential to be an effective therapeutic for Antiphospholipid Syndrome? Doctoral thesis , UCL (University College London).

Mohtasham, P; Keshavarz-Moore, E; Kale, I; Keshavarz, T; (2016) Application of Magnetic Field for Improvement of Microbial Productivity. 5TH INTERNATIONAL SYMPOSIUM ON INDUSTRIAL BIOTECHNOLOGY (IBIC 2016) , 49 pp. 43-48. 10.3303/CET1649008.

Morris, P; Rios-Solis, L; García-Arrazola, R; Lye, GJ; Dalby, PA; (2016) Impact of cofactor-binding loop mutations on thermotolerance and activity of E. coli transketolase. Enzyme and Microbial Technology , 89 pp. 85-91. 10.1016/j.enzmictec.2016.04.003.

Nesbeth, DN; Zaikin, A; Saka, Y; Romano, MC; Giuraniuc, CV; Kanakov, O; Laptyeva, T; (2016) Synthetic biology routes to bio-artificial intelligence. Essays in Biochemistry , 60 (4) pp. 381-391. 10.1042/EBC20160014.

Newton, JM; Schofield, D; Vlahopoulou, J; Zhou, Y; (2016) Detecting cell lysis using viscosity monitoring in E. coli fermentation to prevent product loss. Biotechnology Progress , 32 (4) pp. 1069-1076. 10.1002/btpr.2292.

Newton, JM; Vlahopoulou, J; Zhou, Y; (2016) Rheological Monitoring of Cell Lysis in E. coli Fermentation using acoustic sensors. Presented at: BioProNet 3rd Annual Scientific Symposium, Nottingham, United Kingdom.

Nienow, AW; Hewitt, CJ; Heathman, TRJ; Glyn, VAM; Fonte, GN; Hanga, MP; Coopman, K; Nienow, AW; Hewitt, CJ; Heathman, TRJ; Glyn, VAM; Fonte, GN; Hanga, MP; Coopman, K; Rafiq, QA; - view fewer (2016) Agitation conditions for the culture and detachment of hMSCs from microcarriers in multiple bioreactor platforms. Biochemical Engineering Journal , 108 pp. 24-29. 10.1016/j.bej.2015.08.003.

Nilsson, SM; (2016) Process development of lentiviral vector expression, purification and formulation for gene therapy applications. Doctoral thesis , UCL (University College London).

Nweke, MC; Turmaine, M; McCartney, RG; Bracewell, DG; (2016) Drying techniques for the visualisation of agarose-based chromatography media by scanning electron microscopy. Biotechnology Journal , 12 (3) , Article 1600583. 10.1002/biot.201600583.

Pallipurath Radhakrishnan, AN; (2016) Elucidation of Flocculation Growth Kinetics Using a Microfluidic Approach. Doctoral thesis , UCL (University College London).

Pericleous, C; Ferreira, I; Borghi, O; Pregnolato, F; McDonnell, T; Garza-Garcia, A; Driscoll, P; ... Rahman, A; + view all Pericleous, C; Ferreira, I; Borghi, O; Pregnolato, F; McDonnell, T; Garza-Garcia, A; Driscoll, P; Pierangeli, S; Isenberg, D; Ioannou, Y; Giles, I; Meroni, PL; Rahman, A; - view fewer (2016) Measuring IgA anti-β2-glycoprotein I and IgG/IgA anti-domain I antibodies adds value to current serological assays for the antiphospholipid syndrome. PLoS One , 11 (6) , Article e0156407. 10.1371/journal.pone.0156407.

Pieralisi, I; Rodriguez, G; Micheletti, M; Paglianti, A; Ducci, A; (2016) Microcarriers' suspension and flow dynamics in orbitally shaken bioreactors. Chemical Engineering Research and Design , 108 pp. 198-209. 10.1016/j.cherd.2015.11.020.

Planamente, S; Salih, O; Manoli, E; Albesa-Jove, D; Freemont, PS; Filloux, A; (2016) TssA forms a gp6-like ring attached to the type VI secretion sheath. EMBO Journal , 35 (15) pp. 1613-1627. 10.15252/embj.201694024.

Popova, D; (2016) Robust strategy development for primary recovery of high cell density mammalian cell cultures using ultra scale-down models. Doctoral thesis , UCL (University College London).

Popova, D; Stonier, A; Pain, D; Titchener-Hooker, NJ; Farid, SS; (2016) Integrated economic and experimental framework for screening of primary recovery technologies for high cell density CHO cultures. Biotechnology Journal , 11 (7) pp. 899-909. 10.1002/biot.201500336.

Rafiq, QA; Thomas, RJ; (2016) The evolving role of automation in process development & manufacture of cell & gene-based therapies. Cell and Gene Therapy Insights , 2 (4) pp. 473-479. 10.18609/cgti.2016.058.

Rafiq, QA; Twomey, K; Kulik, M; Leschke, C; O'Dea, J; Callens, S; Gentili, C; ... Murphy, M; + view all Rafiq, QA; Twomey, K; Kulik, M; Leschke, C; O'Dea, J; Callens, S; Gentili, C; Barry, FP; Murphy, M; - view fewer (2016) Developing an automated robotic factory for novel stem cell therapy production. Regenerative Medicine , 11 (4) pp. 351-354. 10.2217/rme-2016-0040.

Raimes, W; Rubi, M; Super, ASM; Marques, M; Veraitch, F; Szita, N; (2016) Transfection in perfused microfluidic cell culture devices: a case study. Process Biochemistry 10.1016/j.procbio.2016.09.006. (In press).

Rayat, ACME; Chatel, A; Hoare, M; Lye, GJ; (2016) Ultra scale-down approaches to enhance the creation of bioprocesses at scale: impacts of process shear stress and early recovery stages. Current Opinion in Chemical Engineering , 14 pp. 150-157. 10.1016/j.coche.2016.09.012.

Robinson, MJ; (2016) Investigating the relationship between forced degradation and long-term shelf life for biotherapeutics. Doctoral thesis , UCL (University College London).

Rodriguez, G; Pieralisi, I; Anderlei, T; Ducci, A; Micheletti, M; (2016) Appraisal of fluid flow in a shaken bioreactor with conical bottom at different operating conditions. Chemical Engineering Research and Design , 108 pp. 186-197. 10.1016/j.cherd.2015.12.012.

Routledge, SJ; Mikaliunaite, L; Patel, A; Clare, M; Cartwright, SP; Bawa, Z; Wilks, MDB; ... Bill, RM; + view all Routledge, SJ; Mikaliunaite, L; Patel, A; Clare, M; Cartwright, SP; Bawa, Z; Wilks, MDB; Low, F; Hardy, D; Rothnie, AJ; Bill, RM; - view fewer (2016) The synthesis of recombinant membrane proteins in yeast for structural studies. Methods , 95 pp. 26-37. 10.1016/j.ymeth.2015.09.027.

Schofield, DM; (2016) Synthetic biology approaches to bioprocess intensification in bacterial and mammalian production platforms. Doctoral thesis , UCL (University College London).

Schofield, DM; Templar, A; Newton, J; Nesbeth, DN; (2016) Promoter engineering to optimise recombinant periplasmic Fab' fragment production in Escherichia coli. Biotechnology Progress , 32 (4) pp. 840-847. 10.1002/btpr.2273.

Subrizi, F; Cárdenas-Fernández, M; Lye, GJ; Ward, JM; Dalby, PA; Sheppard, TD; Hailes, HC; (2016) Transketolase catalysed upgrading of l -arabinose: the one-step stereoselective synthesis of l -gluco-heptulose. Green Chemistry , 18 (10) pp. 3158-3165. 10.1039/C5GC02660A.

Super, A; Jaccard, N; Cardoso Marques, MP; Macown, RJ; Griffin, LD; Veraitch, FS; Szita, N; (2016) Real-time monitoring of specific oxygen uptake rates of embryonic stem cells in a microfluidic cell culture device. Biotechnology Journal , 11 (9) pp. 1179-1189. 10.1002/biot.201500479.

Templar, A; Marsh, D; Nesbeth, DN; (2016) A synthetic biology standard for Chinese Hamster Ovary cell genome monitoring and contaminant detection by polymerase chain reaction. SpringerPlus , 5 , Article 1510. 10.1186/s40064-016-3074-8.

Templar, A; Woodhouse, S; Keshavarz-Moore, E; Nesbeth, DN; (2016) Influence of Pichia pastoris cellular material on polymerase chain reaction performance as a synthetic biology standard for genome monitoring. Journal of Microbiological Methods , 127 pp. 111-122. 10.1016/j.mimet.2016.05.013.

Tengvall, S; Eneljung, T; Jirholt, P; Turesson, O; Wing, K; Holmdahl, R; Kihlberg, J; ... Gjertsson, I; + view all Tengvall, S; Eneljung, T; Jirholt, P; Turesson, O; Wing, K; Holmdahl, R; Kihlberg, J; Stern, A; Martensson, I-L; Henningsson, L; Gustafsson, K; Gjertsson, I; - view fewer (2016) Gene Therapy Induces Antigen-Specific Tolerance in Experimental Collagen-Induced Arthritis. PLoS ONE , 11 (5) , Article e0154630. 10.1371/journal.pone.0154630.

Thomas, S; Straathof, K; Himoudi, N; Anderson, J; Pule, M; (2016) An Optimized GD2-Targeting Retroviral Cassette for More Potent and Safer Cellular Therapy of Neuroblastoma and Other Cancers. PLoS One , 11 (3) , Article e0152196. 10.1371/journal.pone.0152196.

Torres-Acosta, MA; Aguilar-Yáñez, JM; Rito-Palomares, M; Titchener-Hooker, NJ; (2016) Economic analysis of Uricase production under uncertainty: Contrast of chromatographic purification and aqueous two-phase extraction (with and without PEG recycle). Biotechnology Progress , 32 (1) pp. 126-133. 10.1002/btpr.2200.

Vahid Dastjerdi, F; (2016) Novel Recombinant Antibodies to EGFRvIII. Doctoral thesis , UCL (University College London).

Voulgaris, I; Chatel, A; Finka, G; Uden, M; Hoare, M; (2016) Evaluation of options for harvest of a recombinant E. coli fermentation producing a domain antibody using ultra scale-down techniques and pilot-scale verification. Biotechnology Progress , 32 (2) pp. 382-392. 10.1002/btpr.2220.

Wall, IB; Toledo, GS; Jat, PS; (2016) Recent advances in conditional cell immortalization technology. Cell & Gene Therapy Insights , 2 (3) pp. 391-396. 10.18609/cgti.2016.041.

Widner, FJ; Lawrence, AD; Deery, E; Heldt, D; Frank, S; Gruber, K; Wurst, K; ... Kraeutler, B; + view all Widner, FJ; Lawrence, AD; Deery, E; Heldt, D; Frank, S; Gruber, K; Wurst, K; Warren, MJ; Kraeutler, B; - view fewer (2016) Total Synthesis, Structure, and Biological Activity of Adenosylrhodibalamin, the Non-Natural Rhodium Homologue of Coenzyme B-12. In: (Proceedings) 6th EuCheMS Chemistry Congress. (pp. pp. 11281-11286). WILEY-V C H VERLAG GMBH

Woodhouse, SA; (2016) An upstream platform for the production of high grade heterologous proteins in the yeast Pichia pastoris. Doctoral thesis , UCL (University College London).

Wu, T; (2016) An intelligent automation platform for bioprocess development. Doctoral thesis , UCL (University College London).

Xu, Y; Hellier, P; Purton, S; Baganz, F; Ladommatos, N; (2016) Algal biomass and diesel emulsions: An alternative approach for utilizing the energy content of microalgal biomass in diesel engines. Applied Energy , 172 pp. 80-95. 10.1016/j.apenergy.2016.03.019.

Zhou, Y; Torres-Acosta, MA; Rito-Palomares, M; Aguilar-Yáñez, JM; Titchener-Hooker, NJ; (2016) Economic Evaluation of ATPS-based Bioprocesses. Presented at: 2nd BioSolve User Group Forum: Harmonizing the community through innovation, London, United Kingdom.

2015

Al-Ramadhani, O; (2015) Design and characterisation of a parallel miniaturised bioreactor system for mammalian cell culture. Doctoral thesis , UCL (University College London).

Ali, S; Wall, IB; Mason, C; Pelling, AE; Veraitch, FS; (2015) The effect of Young's modulus on the neuronal differentiation of mouse embryonic stem cells. Acta Biomaterialia , 25 pp. 253-267. 10.1016/j.actbio.2015.07.008.

Baud, D; Ladkau, N; Moody, TS; Ward, JM; Hailes, HC; (2015) A rapid, sensitive colorimetric assay for the high-throughput screening of transaminases in liquid or solid-phase. Chemical Communications , 51 (97) pp. 17225-17228. 10.1039/c5cc06817g.

Betts, JPJ; (2015) Incorporation of Developability into Cell Line Selection. Doctoral thesis , UNSPECIFIED.

Borg, Y; (2015) Design, Mathematical Modelling, Construction and Testing of Synthetic Gene Network Oscillators to Establish Roseobacter Clade Bacteria and the Protozoan Trypanosoma brucei as Synthetic Biology Chassis. Doctoral thesis , UCL (University College London).

Bracewell, DG; Francis, R; Smales, CM; (2015) The future of host cell protein (HCP) identification during process development and manufacturing linked to a risk-based management for their control. Biotechnology and Bioengineering , 112 (9) pp. 1727-1737. 10.1002/bit.25628.

Braun-Galleani, S; Baganz, F; Purton, S; (2015) Improving recombinant protein production in the Chlamydomonas reinhardtii chloroplast using vivid Verde Fluorescent Protein as a reporter. Biotechnology Journal , 10 (8) pp. 1289-1297. 10.1002/biot.201400566.

Close, EJ; (2015) The derivation of bioprocess understanding from mechanistic models of chromatography. Doctoral thesis , UCL (University College London).

Conroy, N; Tebble, I; Lye, GJ; (2015) Creation of an ultra scale-down bioreactor mimic for rapid development of lignocellulosic enzymatic hydrolysis processes. Journal of Chemical Technology & Biotechnology , 90 (11) pp. 1983-1990. 10.1002/jctb.4801.

Das, S; Sillitoe, I; Lee, D; Lees, JG; Dawson, NL; Ward, J; Orengo, CA; (2015) CATH FunFHMMer web server: protein functional annotations using functional family assignments. Nucleic Acids Res , 43 (W1) W148-W153. 10.1093/nar/gkv488.

Delahaye, M; Lawrence, K; Ward, SJ; Hoare, M; (2015) An ultra scale-down analysis of the recovery by dead-end centrifugation of human cells for therapy. Biotechnol Bioeng , 112 (5) 997 - 1011. 10.1002/bit.25519.

Deszcz, D; Affaticati, P; Ladkau, N; Gegel, A; Ward, JM; Hailes, HC; Dalby, PA; (2015) Single active-site mutants are sufficient to enhance serine:pyruvate α-transaminase activity in an ω-transaminase. The FEBS Journal , 282 (13) pp. 2512-2526. 10.1111/febs.13293.

Detela, G; (2015) Enhancing Functional Responses of MSCs for Ischemic Injury Using Ex Vivo Pre-conditioning Strategies. Doctoral thesis , UCL (University College London).

Dods, SR; Hardick, O; Stevens, B; Bracewell, DG; (2015) Fabricating electrospun cellulose nanofibre adsorbents for ion-exchange chromatography. J Chromatogr A , 1376 74 - 83. 10.1016/j.chroma.2014.12.010.

Fisher, J; Kramer, AM; Gustafsson, K; Anderson, J; (2015) Non-V delta 2 gamma delta T lymphocytes as effectors of cancer immunotherapy. Oncoimmunology , 4 (3) , Article e973808. 10.4161/2162402X.2014.973808.

Goldstein, R; Sosabowski, J; Livanos, M; Leyton, J; Vigor, K; Bhavsar, G; Nagy-Davidescu, G; ... Chester, K; + view all Goldstein, R; Sosabowski, J; Livanos, M; Leyton, J; Vigor, K; Bhavsar, G; Nagy-Davidescu, G; Rashid, M; Miranda, E; Yeung, J; Tolner, B; Plückthun, A; Mather, S; Meyer, T; Chester, K; - view fewer (2015) Development of the designed ankyrin repeat protein (DARPin) G3 for HER2 molecular imaging. Eur J Nucl Med Mol Imaging , 42 (2) 288 - 301. 10.1007/s00259-014-2940-2.

Guy, HM; (2015) Microscale characterisation of a manufacturing route for lentiviral vectors. Doctoral thesis , UCL (University College London).

Guzman, JD; Pesnot, T; Barrera, DA; Davies, HM; McMahon, E; Evangelopoulos, D; Mortazavi, PN; ... Bhakta, S; + view all Guzman, JD; Pesnot, T; Barrera, DA; Davies, HM; McMahon, E; Evangelopoulos, D; Mortazavi, PN; Munshi, T; Maitra, A; Lamming, ED; Angell, R; Gershater, MC; Redmond, JM; Needham, D; Ward, JM; Cuca, LE; Hailes, HC; Bhakta, S; - view fewer (2015) Tetrahydroisoquinolines affect the whole-cell phenotype of Mycobacterium tuberculosis by inhibiting the ATP-dependent MurE ligase. J Antimicrob Chemother , 70 (6) pp. 1691-1703. 10.1093/jac/dkv010.

Haakuria, VM; (2015) An Integrated Approach to Studying the Regulation of Erythromycin Biosynthesis in Saccharopolyspora erythraea. Doctoral thesis , UCL (University College London).

Hamilton, NJ; Kanani, M; Roebuck, DJ; Hewitt, RJ; Cetto, R; Culme-Seymour, EJ; Toll, E; ... Birchall, MA; + view all Hamilton, NJ; Kanani, M; Roebuck, DJ; Hewitt, RJ; Cetto, R; Culme-Seymour, EJ; Toll, E; Bates, AJ; Comerford, AP; McLaren, CA; Butler, CR; Crowley, C; McIntyre, D; Sebire, NJ; Janes, SM; O'Callaghan, C; Mason, C; De Coppi, P; Lowdell, MW; Elliott, MJ; Birchall, MA; - view fewer (2015) Tissue-engineered tracheal replacement in a child: a 4-year follow-up study. Am J Transplant , 15 (10) pp. 2750-2757. 10.1111/ajt.13318.

Hardick, O; Dods, S; Stevens, B; Bracewell, DG; (2015) Nanofiber adsorbents for high productivity continuous downstream processing. Journal of Biotechnology , 213 pp. 74-82. 10.1016/j.jbiotec.2015.01.031.

Hassan, S; Simaria, AS; Varadaraju, H; Gupta, S; Warren, K; Farid, SS; (2015) Allogeneic cell therapy bioprocess economics and optimization: downstream processing decisions. Regenerative Medicine , 10 (5) pp. 591-609. 10.2217/rme.15.29.

Jaccard, N; (2015) Development of an image processing method for automated, non-invasive and scale-independent monitoring of adherent cell cultures. Doctoral thesis , UCL (University College London).

Jenkins, MJ; Farid, SS; (2015) Human pluripotent stem cell-derived products: Advances towards robust, scalable and cost-effective manufacturing strategies. Biotechnol J , 10 (1) 83 - 95. 10.1002/biot.201400348.

Lau, EC; (2015) A micro-scale study of primary clarification options for the processing of a Fc-fusion protein. Doctoral thesis , UCL (University College London).

Lawrence, JP; (2015) Microfluidic Tangential Flow Filter and Continuous-Flow Reactor for Bioprocess Development. Doctoral thesis , UCL (University College London).

Lichman, BR; Gershater, MC; Lamming, ED; Pesnot, T; Sula, A; Keep, NH; Hailes, HC; Lichman, BR; Gershater, MC; Lamming, ED; Pesnot, T; Sula, A; Keep, NH; Hailes, HC; Ward, JM; - view fewer (2015) 'Dopamine-first' mechanism enables the rational engineering of the norcoclaurine synthase aldehyde activity profile. FEBS J , 282 (6) 1137 - 1151. 10.1111/febs.13208.

Lichman, BR; Lamming, ED; Pesnot, T; Smith, JM; Hailes, HC; Ward, JM; (2015) One-pot triangular chemoenzymatic cascades for the syntheses of chiral alkaloids from dopamine. Green Chemistry , 17 (2) pp. 852-855. 10.1039/c4gc02325k.

Mazzer, AR; Perraud, X; Halley, J; O'Hara, J; Bracewell, DG; (2015) Protein A chromatography increases monoclonal antibody aggregation rate during subsequent low pH virus inactivation hold. Journal of Chromatography A , 1415 pp. 83-90. 10.1016/j.chroma.2015.08.068.

McDonnell, T; Pericleous, C; Laurine, E; Tommasi, R; Garza-Garcia, A; Giles, I; Ioannou, Y; McDonnell, T; Pericleous, C; Laurine, E; Tommasi, R; Garza-Garcia, A; Giles, I; Ioannou, Y; Rahman, A; - view fewer (2015) Development of a high yield expression and purification system for Domain I of Beta-2-glycoprotein I for the treatment of APS. BMC Biotechnology , 15 , Article 104. 10.1186/s12896-015-0222-0.

Nesbeth, DN; (2015) Hyaluronan treatment of biotinylated packaging cells increases titre of progeny retrovirus affinity-captured onto paramagnetic particles. The Winnower , 6 10.15200/winn.145086.69504.

Nie, W; (2015) Cost Evaluation and Portfolio Management Optimization for Biopharmaceutical Product Development. Doctoral thesis , UCL (University College London).

Odeleye, AOO; (2015) Engineering characterisation of single-use bioreactor technology for mammalian cell culture applications. Doctoral thesis , UCL (University College London).

Ojo, EO; (2015) Photobioreactor Technologies for High-throughput Microalgae Cultivation. Doctoral thesis , UCL (University College London).

Ojo, EO; Auta, H; Baganz, F; Lye, GJ; (2015) Design and parallelisation of a miniature photobioreactor platform for microalgal culture evaluation and optimisation. Biochemical Engineering Journal , 103 pp. 93-102. 10.1016/j.bej.2015.07.006.

Payongsri, P; Steadman, D; Hailes, HC; Dalby, PA; (2015) Second generation engineering of transketolase for polar aromatic aldehyde substrates. Enzyme and Microbial Technology , 71 pp. 45-52. 10.1016/j.enzmictec.2015.01.008.

Popova, D; Stonier, A; Pain, D; Titchener-Hooker, NJ; Farid, SS; (2015) Representative mammalian cell culture test materials for assessment of primary recovery technologies: A rapid method with industrial applicability. Biotechnol J , 10 (1) 162 - 170. 10.1002/biot.201400294.

Rayner, LE; Hui, GK; Gor, J; Heenan, RK; Dalby, PA; Perkins, SJ; (2015) The Solution Structures of Two Human IgG1 Antibodies Show Conformational Stability and Accommodate Their C1q and FcγR Ligands. J Biol Chem , 290 (13) 8420 - 8438. 10.1074/jbc.M114.631002.

Richter, N; Simon, RC; Lechner, H; Kroutil, W; Ward, JM; Hailes, HC; (2015) ω-Transaminases for the amination of functionalised cyclic ketones. Organic & Biomolecular Chemistry , 13 (33) pp. 8843-8851. 10.1039/c5ob01204j.

Rios-Solis, L; Morris, P; Grant, C; Odeleye, AOO; Hailes, HC; Ward, JM; Dalby, PA; ... Lye, GJ; + view all Rios-Solis, L; Morris, P; Grant, C; Odeleye, AOO; Hailes, HC; Ward, JM; Dalby, PA; Baganz, F; Lye, GJ; - view fewer (2015) Modelling and optimisation of the one-pot, multi-enzymatic synthesis of chiral amino-alcohols based on microscale kinetic parameter determination. CHEMICAL ENGINEERING SCIENCE , 122 360 - 372. 10.1016/j.ces.2014.09.046.

Rios-Solis, L; Mothia, B; Yi, S; Zhou, Y; Micheletti, M; Lye, GJ; (2015) High throughput screening of monoamine oxidase (MAO-N-D5) substrate selectivity and rapid kinetic model generation. Journal of Molecular Catalysis B: Enzymatic , 120 pp. 100-110. 10.1016/j.molcatb.2015.07.001.

Roberts, IT; (2015) Scale-­up of human pluripotent stem cell-­based therapies for age-­related macular degeneration. Doctoral thesis , UCL (University College London).

Sani, MHB; (2015) Evaluation of microwell based systems and miniature bioreactors for rapid cell culture bioprocess development and scale-up. Doctoral thesis , UCL (University College London).

Tan, CKL; Davies, MJ; McCluskey, DK; Munro, IR; Nweke, MC; Tracey, MC; Szita, N; (2015) Electromagnetic stirring in a microbioreactor with non-conventional chamber morphology and implementation of multiplexed mixing. Journal of Chemical Technology and Biotechnology , 90 (10) pp. 1927-1936. 10.1002/jctb.4762.

Thwaites, JW; (2015) Methods affecting neuronal differentiation of human adult and pluripotent stem cells. Doctoral thesis , UCL (University College London).

Torres-Acosta, MA; Aguilar-Yañez, JM; Rito-Palomares, M; Titchener-Hooker, NJ; (2015) Economic analysis of royalactin production under uncertainty: Evaluating the effect of parameter optimization. Biotechnology Progress , 31 (3) pp. 744-749. 10.1002/btpr.2073.

Villegas-Torres, MF; Martinez-Torres, RJ; Cázares-Körner, A; Hailes, H; Baganz, F; Ward, J; (2015) Multi-step biocatalytic strategies for chiral amino alcohol synthesis. Enzyme and Microbial Technology , 81 pp. 23-30. 10.1016/j.enzmictec.2015.07.003.

Voulgaris, I; Finka, G; Uden, M; Hoare, M; (2015) Enhancing the selective extracellular location of a recombinant E. coli domain antibody by management of fermentation conditions. Applied Microbiology and Biotechnology , 99 (20) pp. 8441-8453. 10.1007/s00253-015-6799-3.

Ward, DP; Cárdenas-Fernández, M; Hewitson, P; Ignatova, S; Lye, GJ; (2015) Centrifugal partition chromatography in a biorefinery context: Separation of monosaccharides from hydrolysed sugar beet pulp. Journal of Chromatography A , 1411 pp. 84-91. 10.1016/j.chroma.2015.08.006.

2014

Abdul Halim, AB; (2014) In vitro metabolic pathway construction in an immobilised enzyme microreactor (IEMR). Doctoral thesis (PhD), UCL (University College London).

Allmendinger, R; Simaria, AS; Turner, R; Farid, SS; (2014) Closed-loop optimization of chromatography column sizing strategies in biopharmaceutical manufacture. J Chem Technol Biotechnol , 89 (10) 1481 - 1490. 10.1002/jctb.4267.

Betts, JPJ; Warr, SRC; Finka, GB; Uden, M; Town, M; Janda, JM; Baganz, F; Betts, JPJ; Warr, SRC; Finka, GB; Uden, M; Town, M; Janda, JM; Baganz, F; Lye, GJ; - view fewer (2014) Impact of aeration strategies on fed-batch cell culture kinetics in a single-use 24-well miniature bioreactor. BIOCHEMICAL ENGINEERING JOURNAL , 82 105 - 116. 10.1016/j.bej.2013.11.010.

Borg, Y; Ullner, E; Alagha, A; Alsaedi, A; Nesbeth, D; Zaikin, A; (2014) Complex and unexpected dynamics in simple genetic regulatory networks. INTERNATIONAL JOURNAL OF MODERN PHYSICS B , 28 (14) , Article ARTN 1430006. 10.1142/S0217979214300060.

Braun Galleani, SC; (2014) Exploring the potential for recombinant protein production in microalgae. Doctoral thesis , UCL (University College London).

Chatel, A; (2014) Development and use of ultra scale-down methodologies to improve rate and quality of bioprocess discoveries. Doctoral thesis , UCL (University College London).

Chatel, A; Kumpalume, P; Hoare, M; (2014) Ultra Scale-Down Characterization of the Impact of Conditioning Methods for Harvested Cell Broths on Clarification by Continuous Centrifugation-Recovery of Domain Antibodies from rec E. coli. BIOTECHNOLOGY AND BIOENGINEERING , 111 (5) 913 - 924. 10.1002/bit.25164.

Close, EJ; Salm, JR; Bracewell, DG; Sorensen, E; (2014) A model based approach for identifying robust operating conditions for industrial chromatography with process variability. CHEMICAL ENGINEERING SCIENCE , 116 284 - 295. 10.1016/j.ces.2014.03.010.

Close, EJ; Salm, JR; Bracewell, DG; Sorensen, E; (2014) Modelling of industrial biopharmaceutical multicomponent chromatography. CHEMICAL ENGINEERING RESEARCH & DESIGN , 92 (7) 1304 - 1314. 10.1016/j.cherd.2013.10.022.

Dimitriadou, E; (2014) Redesign of calcium-regulated protein aequorin towards the development of a novel ion bioreporter. Doctoral thesis , UCL (University College London).

Du, CJ; Rios-Solis, L; Ward, JM; Dalby, PA; Lye, GJ; (2014) Evaluation of CV2025 ω-transaminase for the bioconversion of lignin breakdown products into value-added chemicals: synthesis of vanillylamine from vanillin. Biocatalysis and Biotransformation , 32 (5-6) pp. 302-313. 10.3109/10242422.2014.976632.

Du, C; (2014) Bioconversion of lignin degradation products into value-added chemicals. Doctoral thesis , UCL (University College London).

Espuny Garcia Del Real, G; Davies, J; Bracewell, DG; (2014) Scale-down characterization of post-centrifuge flocculation processes for high-throughput process development. Biotechnol Bioeng , 111 (12) 2486 - 2498. 10.1002/bit.25313.

Farid, SS; Thompson, B; Davidson, A; (2014) Continuous bioprocessing: the real thing this time? 10(th) Annual bioProcessUK Conference, December 3-4, 2013, London, UK. MAbs , 6 (6) 1357 - 1361. 10.4161/mabs.36151.

Grant, C; Deszcz, D; Wei, YC; Martínez-Torres, RJ; Morris, P; Folliard, T; Sreenivasan, R; ... Baganz, F; + view all Grant, C; Deszcz, D; Wei, YC; Martínez-Torres, RJ; Morris, P; Folliard, T; Sreenivasan, R; Ward, J; Dalby, P; Woodley, JM; Baganz, F; - view fewer (2014) Identification and use of an alkane transporter plug-in for applications in biocatalysis and whole-cell biosensing of alkanes. Sci Rep , 4 , Article 5844. 10.1038/srep05844.

Halim, Murni; Rios-Solis, Leonardo; Micheletti, Martina; Ward, John M; Lye, Gary J; (2014) Microscale methods to rapidly evaluate bioprocess options for increasing bioconversion yields: application to the ω-transaminase synthesis of chiral amines. Bioprocess and Biosystems Engineering , 37 (5) pp. 931-941. 10.1007/s00449-013-1065-5.

Hassan, S; Keshavarz-Moore, E; Ma, J; Thomas, C; (2014) Breakage of transgenic tobacco roots for monoclonal antibody release in an ultra-scale down shearing device. Biotechnology and Bioengineering , 111 (1) pp. 196-201. 10.1002/bit.25006.

Hassan, S; Keshavarz-Moore, E; Ma, J; Thomas, C; (2014) Breakage of transgenic tobacco roots for monoclonal antibody release in an ultra-scale down shearing device. Biotechnology and Bioengineering , 111 (1) 196 - 201. 10.1002/bit.25006.

Hemsley, AL; (2014) The effect of mechanical and shear forces on embryonic stem cells. Doctoral thesis , UCL (University College London).

Herschy, B; Whicher, A; Camprubi, E; Watson, C; Dartnell, L; Ward, J; Evans, JR; Herschy, B; Whicher, A; Camprubi, E; Watson, C; Dartnell, L; Ward, J; Evans, JR; Lane, N; - view fewer (2014) An origin-of-life reactor to simulate alkaline hydrothermal vents. J Mol Evol , 79 (5-6) 213 - 227. 10.1007/s00239-014-9658-4.

Hughson, MD; (2014) Micro-scale vaccine bioprocessing of a Japanese Encephalitis Virus vaccine. Doctoral thesis , UCL (University College London).

Hull, EA; Livanos, M; Miranda, E; Smith, ME; Chester, KA; Baker, JR; (2014) Homogeneous Bispecifics by Disulfide Bridging. Bioconjug Chem , 25 (8) pp. 1395-1401. 10.1021/bc5002467.

Jaccard, N; Griffin, LD; Keser, A; Macown, RJ; Super, A; Veraitch, FS; Szita, N; (2014) Automated method for the rapid and precise estimation of adherent cell culture characteristics from phase contrast microscopy images. Biotechnology and Bioengineering , 111 (3) pp. 504-517. 10.1002/bit.25115.

Jaccard, N; Macown, RJ; Super, A; Griffin, LD; Veraitch, FS; Szita, N; (2014) Automated and online characterization of adherent cell culture growth in a microfabricated bioreactor. J Lab Autom , 19 (5) 437 - 443. 10.1177/2211068214529288.

Lebre, PHB; (2014) Evaluation of Staphylococcus carnosus as an Alternative Host Organism for Whole-Cell Biocatalysis. Doctoral thesis , UCL (University College London).

Lichman, BR; Lamming, ED; Pesnot, T; Smith, JM; Hailes, HC; Ward, JM; (2014) One-pot triangular chemoenzymatic cascades for the syntheses of chiral alkaloids from dopamine. Green Chemistry , 17 (2) pp. 852-855. 10.1039/c4gc02325k.

Liu, S; Papageorgiou, LG; Simaria, AS; Farid, SS; (2014) Optimising chromatography strategies of antibody purification processes by mixed integer fractional programming techniques. Computers and Chemical Engineering , 68 151 - 164. 10.1016/j.compchemeng.2014.05.005.

Lizzul, AM; Hellier, P; Purton, S; Baganz, F; Ladommatos, N; Campos, L; (2014) Combined remediation and lipid production using Chlorella sorokiniana grown on wastewater and exhaust gases. Bioresource Technology , 151 pp. 12-18. 10.1016/j.biortech.2013.10.040.

Macown, RJ; Veraitch, FS; Szita, N; (2014) Robust, microfabricated culture devices with improved control over the soluble microenvironment for the culture of embryonic stem cells. Biotechnol J , 9 (6) pp. 805-813. 10.1002/biot.201300245.

McDonnell, T; Ioannou, Y; Rahman, A; (2014) PEGylated drugs in rheumatology--why develop them and do they work? Rheumatology , 53 (3) pp. 391-396. 10.1093/rheumatology/ket278.

Moens, NCH; (2014) Expansion and differentiation of human embryonic stem cells on an automated microwell platform. Doctoral thesis , UCL (University College London).

Ng, CKS; (2014) Optimal design, operation and control of sequential multi-column chromatography for separation of biomolecules. Doctoral thesis , UCL (University College London).

Odeleye, AO; Marsh, DT; Osborne, MD; Lye, GJ; Micheletti, M; (2014) On the fluid dynamics of a laboratory scale single-use stirred bioreactor. Chem Eng Sci , 111 (100) 299 - 312. 10.1016/j.ces.2014.02.032.

Ojo, EO; Auta, H; Baganz, F; Lye, GJ; (2014) Engineering characterisation of a shaken, single-use photobioreactor for early stage microalgae cultivation using Chlorella sorokiniana. Bioresour Technol , 173 367 - 375. 10.1016/j.biortech.2014.09.060.

Payongsri, P; (2014) Synthetic biology approaches for the production of chiral aminoalcohols in engineered E. coli strains. Doctoral thesis (PhD), UCL (University College London).

Perez Pardo, MA; (2014) Characterisation of a biosensor surface for use with scale-down technologies in the process monitoring of Escherichia coli antibody fragment production. Doctoral thesis , UCL (University College London).

Pollock, JE; (2014) Evaluating the Potential of Continuous Processes for Monoclonal Antibodies: Economic, Environmental and Operational Feasibility. Doctoral thesis , UCL (University College London).

Rahimi Fard Jahromi, R; (2014) Evolutionary and Mutagenesis Studies Of E.coli Transketolase To Guide Further Protein Engineering. Doctoral thesis , UCL (University College London).

Randone, P; (2014) Bioprocess Studies of Biomass and Recombinant Protein Production by the Methylotrophic Yeast Pichia Pastoris. Doctoral thesis , UCL (University College London).

Rayner, LE; Hui, GK; Gor, J; Heenan, RK; Dalby, PA; Perkins, SJ; (2014) The Fab conformations in the solution structure of human IgG4 restricts access to its Fc region: implications for functional activity. J Biol Chem , 289 (30) pp. 20740-20756. 10.1074/jbc.M114.572404.

Richter, N; Simon, RC; Kroutil, W; Ward, JM; Hailes, HC; (2014) Synthesis of pharmaceutically relevant 17-α-amino steroids using an ω-transaminase. Chem Commun (Camb) , 50 pp. 6098-6100. 10.1039/c3cc49080g.

Rodriguez, G; Anderlei, T; Micheletti, M; Yianneskis, M; Ducci, A; (2014) On the measurement and scaling of mixing time in orbitally shaken bioreactors. Biochemical Engineering Journal , 82 pp. 10-21. 10.1016/j.bej.2013.10.021.

Sayer, C; Martinez-Torres, RJ; Richter, N; Isupov, MN; Hailes, HC; Littlechild, JA; Ward, JM; (2014) The substrate specificity, enantioselectivity and structure of the (R)-selective amine : pyruvate transaminase from Nectria haematococca. FEBS JOURNAL , 281 (9) 2240 - 2253. 10.1111/febs.12778.

Sehl, T; Hailes, HC; Ward, JM; Menyes, U; Pohl, M; Rother, D; (2014) Efficient 2-step biocatalytic strategies for the synthesis of all nor(pseudo) ephedrine isomers. Green Chemistry , 16 (6) pp. 3341-3348. 10.1039/c4gc00100a.

Sexton, NJ; Cooper, RP; (2014) An architecturally constrained model of random number generation and its application to modeling the effect of generation rate. Frontiers in Psychology , 5 , Article 670. 10.3389/fpsyg.2014.00670.

Siganporia, CC; Ghosh, S; Daszkowski, T; Papageorgiou, LG; Farid, SS; (2014) Capacity planning for batch and perfusion bioprocesses across multiple biopharmaceutical facilities. Biotechnology Progress , 30 (3) pp. 594-606. 10.1002/btpr.1860.

Silk, NJ; (2014) High throughput approaches to mammalian cell culture process development. Doctoral thesis , UCL (University College London).

Simaria, AS; Hassan, S; Varadaraju, H; Rowley, J; Warren, K; Vanek, P; Farid, SS; (2014) Allogeneic cell therapy bioprocess economics and optimisation: Single-use cell expansion technologies. Biotechnol Bioeng , 111 (1) pp. 69-83. 10.1002/bit.25008.

Super, ASM; (2014) Oxygen monitoring in a microfluidic culture device for stem cell bioprocess development. Doctoral thesis , UCL (University College London).

Tagalakis, AD; Lee, DH; Bienemann, AS; Zhou, H; Munye, MM; Saraiva, L; McCarthy, D; ... Hart, SL; + view all Tagalakis, AD; Lee, DH; Bienemann, AS; Zhou, H; Munye, MM; Saraiva, L; McCarthy, D; Du, Z; Vink, CA; Maeshima, R; White, EA; Gustafsson, K; Hart, SL; - view fewer (2014) Multifunctional, self-assembling anionic peptide-lipid nanocomplexes for targeted siRNA delivery. Biomaterials , 35 (29) pp. 8406-8415. 10.1016/j.biomaterials.2014.06.003.

Tarrant, RDR; (2014) Host Cell Protein Characterisation during the Downstream Processing of Monoclonal Antibodies from Mammalian Cells. Doctoral thesis , UCL (University College London).

Tavakoli-Keshe, R; Phillips, JJ; Turner, R; Bracewell, DG; (2014) Understanding the Relationship Between Biotherapeutic Protein Stability and Solid-Liquid Interfacial Shear in Constant Region Mutants of IgG1 and IgG4. J Pharm Sci , 103 (2) pp. 437-444. 10.1002/jps.23822.

Villegas Torres, MF; (2014) Design and characterization of novel biocatalytic cascades for chiral amino alcohol synthesis. Doctoral thesis , UCL (University College London).

Wu, T; Zhou, Y; (2014) An Intelligent Automation Platform for Rapid Bioprocess Design. J Lab Autom , 19 (4) pp. 381-393. 10.1177/2211068213499756.

Xu, Y; (2014) Exploring the potential of microalgae as a source for bioenergy production. Doctoral thesis , UCL (University College London).

Yang, Y; Farid, SS; Thornhill, NF; (2014) Data mining for rapid prediction of facility fit and debottlenecking of biomanufacturing facilities. J Biotechnol , 179 pp. 17-25. 10.1016/j.jbiotec.2014.03.004.

2013

Abdul Halim, A; Szita, N; Baganz, F; (2013) Characterization and multi-step transketolase-ω-transaminase bioconversions in an immobilized enzyme microreactor (IEMR) with packed tube. J Biotechnol , 168 (4) pp. 567-575. 10.1016/j.jbiotec.2013.09.001.

Affandy, A; (2013) Fundamental studies of the sterile filtration of large plasmid DNA. Doctoral thesis , UCL (University College London).

Badger, JL; (2013) The effect of hypoxia on the differentiation of dopaminergic neurons from human pluripotent stem cells. Doctoral thesis , UCL (University College London).

Burden, CS; (2013) Monolith absorbants as a capture step for virus-like particles. Doctoral thesis (PhD), UCL (University College London).

Close, EJ; Salm, JR; Iskra, T; Sørensen, E; Bracewell, DG; (2013) Fouling of an anion exchange chromatography operation in a monoclonal antibody process: Visualization and kinetic studies. Biotechnology and Bioengineering , 110 (9) pp. 2425-2435. 10.1002/bit.24898.

Dartnell, LR; Roberts, TA; Moore, G; Ward, JM; Muller, JP; (2013) Fluorescence characterization of clinically-important bacteria. PLoS One , 8 (9) , Article e75270. 10.1371/journal.pone.0075270.

Delahaye, MT; (2013) An ultra scale-down study of recovery by centrifugation of human cells for therapy. Doctoral thesis (PhD), UCL (University College London).

Dhanoya, A; Wang, T; Keshavarz-Moore, E; Fassati, A; Chain, BM; (2013) Importin-7 mediates nuclear trafficking of DNA in mammalian cells. Traffic , 14 (2) 165 - 175. 10.1111/tra.12021.

Dobrijevic, D; Di Liberto, G; Tanaka, K; de Wouters, T; Dervyn, R; Boudebbouze, S; Binesse, J; ... van de Guchte, M; + view all Dobrijevic, D; Di Liberto, G; Tanaka, K; de Wouters, T; Dervyn, R; Boudebbouze, S; Binesse, J; Blottière, HM; Jamet, A; Maguin, E; van de Guchte, M; - view fewer (2013) High-Throughput System for the Presentation of Secreted and Surface-Exposed Proteins from Gram-Positive Bacteria in Functional Metagenomics Studies. PLOS One , 8 (6) , Article e65956. 10.1371/journal.pone.0065956.

El-Sabbahy, H; (2013) Development of Preparative Microfluidic Techniques for Lysis of Microbial Cells and Affinity Purification of Proteins. Doctoral thesis (PhD), UCL (University College London).

Esbati, E; (2013) An Engineering Study of Solid-liquid Suspension in Shaken and Stirred Bioreactors. Doctoral thesis (PhD), UCL (University College London).

Hardick, OJF; (2013) Fabrication of Nanofibres for High Productivity Downstream Processing. Doctoral thesis , UCL (University College London).

Hussain, W; Moens, N; Veraitch, FS; Hernandez, D; Mason, C; Lye, GJ; (2013) Reproducible culture and differentiation of mouse embryonic stem cells using an automated microwell platform. Biochem Eng J , 77 (100) 246 - 257. 10.1016/j.bej.2013.05.008.

Kirk, TV; (2013) Microfluidic microbioreactor for eukaryote culture with dissolved oxygen control. Doctoral thesis , UCL (University College London).

Kirk, TV; Szita, N; (2013) Oxygen transfer characteristics of miniaturized bioreactor systems. Biotechnol Bioeng , 110 (4) 1005 - 1019. 10.1002/bit.24824.

Konstantinidis, S; (2013) Selection and deployment methods to assist high throughput activities in bioprocess development. Doctoral thesis , UCL (University College London).

Lan, T; (2013) An experimental and simulation study of the influence made by inserts on chromatographic packed bed hydrodynamics. Doctoral thesis (PhD), UCL (University College London).

Lawrence, J; O'Sullivan, B; Lye, GJ; Wohlgemuth, R; Szita, N; (2013) Microfluidic multi-input reactor for biocatalytic synthesis using transketolase. Journal of Molecular Catalysis B: Enzymatic , 95 111 - 117. 10.1016/j.molcatb.2013.05.016.

Lawrence, J; O'Sullivan, B; Lye, GJ; Wohlgemuth, R; Szita, N; (2013) Microfluidic multi-input reactor for biocatalytic synthesis using transketolase. J Mol Catal B Enzym , 95 (100) 111 - 117. 10.1016/j.molcatb.2013.05.016.

Lintern, KB; (2013) Immobilisation of Lactate Oxidase and Deoxyribonuclease I for use within a Bio-Artificial Liver Assist Device for the Treatment of Acute Liver Failure. Doctoral thesis , UCL (University College London).

Liu, S; Simaria, AS; Farid, SS; Papageorgiou, LG; (2013) Designing cost-effective biopharmaceutical facilities using mixed-integer optimization. Biotechnol Prog , 29 (6) 1472 - 1483. 10.1002/btpr.1795.

Lopes, AG; (2013) Development of ultra scale-down methodologies for the prediction of centrifugal dewatering of high cell density yeast cultures. Doctoral thesis , UCL (University College London).

Mondragon-Teran, P; Tostoes, R; Mason, C; Lye, GJ; Veraitch, FS; (2013) Oxygen-controlled automated neural differentiation of mouse embryonic stem cells. Regen Med , 8 (2) 171 - 182. 10.2217/rme.13.12.

Morris, P; (2013) What Cause an Enzyme to degrade during biocatalysis? Doctoral thesis , UCL (University College London).

Ordidge, GC; (2013) Rapid microscale evaluation of the impact of fermentation conditions on inclusion body formation, solubilisation and protein refolding yields. Doctoral thesis , UCL (University College London).

Pradhan, S; (2013) Rational Design of Enterokinase for the Development of Enhanced Biopharmaceutical Proteins. Doctoral thesis , UCL (University College London).

Rayner, LE; Kadkhodayi-Kholghi, N; Heenan, RK; Gor, J; Dalby, PA; Perkins, SJ; (2013) The solution structure of rabbit IgG accounts for its interactions with the Fc receptor and complement C1q and its conformational stability. Journal of Molecular Biology , 425 (3) 506 - 523. 10.1016/j.jmb.2012.11.019.

Reichen, M; Veraitch, FS; Szita, N; (2013) Development of a Multiplexed Microfluidic Platform for the Automated Cultivation of Embryonic Stem Cells. J Lab Autom , 18 (6) pp. 519-529. 10.1177/2211068213499917.

Rios-Solis, L; Bayir, N; Halim, M; Du, C; Ward, JM; Baganz, F; Lye, GJ; (2013) Non-linear kinetic modelling of reversible bioconversions: Application to the transaminase catalyzed synthesis of chiral amino-alcohols. Biochemical Engineering Journal , 73 pp. 38-48. 10.1016/j.bej.2013.01.010.

Sagar, DM; Aoudjane, S; Gaudet, M; Aeppli, G; Dalby, PA; (2013) Optically Induced Thermal Gradients for Protein Characterization in Nanolitre-scale Samples in Microfluidic Devices. Scientific Reports , 3 , Article 2130. 10.1038/srep02130.

Schumacher, FF; Sanchania, VA; Tolner, B; Wright, ZV; Ryan, CP; Smith, ME; Ward, JM; ... Baker, JR; + view all Schumacher, FF; Sanchania, VA; Tolner, B; Wright, ZV; Ryan, CP; Smith, ME; Ward, JM; Caddick, S; Kay, CW; Aeppli, G; Chester, KA; Baker, JR; - view fewer (2013) Homogeneous antibody fragment conjugation by disulfide bridging introduces 'spinostics'. [Magazine_article]. Scientific Reports , 3 , Article 1525. 10.1038/srep01525.

Stonier, A; (2013) A Dynamic Decision Support Tool for Use in the Design of Bio-Manufacturing Facilities and Processes. Doctoral thesis , UCL (University College London).

Tait, AS; Tarrant, RD; Velez-Suberbie, ML; Spencer, DI; Bracewell, DG; (2013) Differential response in downstream processing of CHO cells grown under mild hypothermic conditions. Biotechnology Progress , 29 (3) pp. 688-696. 10.1002/btpr.1726.

Velez Suberbie, L; (2013) Characterisation of the Bioreactor Environment and its Effect on Mammalian Cell Performance in Suspension Culture during Antibody Production. Doctoral thesis , UCL (University College London).

Zhang, J; (2013) A computational framework for harnessing data and knowledge for bioprocess design. Doctoral thesis , UCL (University College London).

Zhou, Y; Ji, Y; (2013) Mathematical modelling of protein precipitation based on the phase equilibrium for an antibody fragment from E. coli Lysis. Journal of Bioprocessing & Biotechniques , 3 (2) , Article 129. 10.4172/2155-9821.1000129.

2012

Ali, S; (2012) Establishment and evaluation of high cell density fermentation processes using a miniature bioreactor in conjunction with ultra-scale cell recovery tools. Doctoral thesis , UCL (University College London).

Anderson, J; Gustafsson, K; Himoudi, N; Yan, M; Heuijerjans, J; (2012) Licensing of γδT cells for professional antigen presentation: A new role for antibodies in regulation of antitumor immune responses. Oncoimmunology , 1 (9) 1652 -1654. 10.4161/onci.21971.

Baboo, JZ; (2012) Automated high-throughput approaches for the development and investigation of novel oxidative biocatalytic processes. Doctoral thesis , UCL (University College London).

Burden, CS; Jin, J; Podgornik, A; Bracewell, DG; (2012) A monolith purification process for virus-like particles from yeast homogenate. Journal of Chromatography B , 880 (1) 82 - 89. 10.1016/j.jchromb.2011.10.044.

CORTES QUIROZ, CA; (2012) Design, analysis and multi-criteria optimization of micromixers. Doctoral thesis , UCL (University College London).

Coward, LG; (2012) Chemoenzymatic synthesis of novel, structurally diverse compounds. Doctoral thesis , UCL (University College London).

Dhanoya, A; Chain, BM; Keshavarz-Moore, E; (2012) Role of DNA topology in uptake of polyplex molecules by dendritic cells. Vaccine , 30 (9) 1675 - 1681. 10.1016/j.vaccine.2011.12.102.

Dhanoya, AS; (2012) Characterisation of plasmid DNA complexes for application in genetic immunisation. Doctoral thesis , UCL (University College London).

Gibbons, D; (2012) Towards complete release from the E. coli periplasm for improved manufacturing. Doctoral thesis , UCL (University College London).

Grant, CR; (2012) Evaluation of the Bio-oxidation of Alkanes. Doctoral thesis , UCL (University College London).

Halim, MB; (2012) Microscale Approaches to the Design and Optimisation of Equilibrium Controlled Bioconversions. Doctoral thesis , UCL (University College London).

Hassan, I; (2012) A Techno-Economic Framework for Assessing Manufacturing Process Changes in the Biopharmaceutical Industry. Doctoral thesis , UCL (University College London).

Ji, Y.; (2012) Model based process design for bioprocess optimisation: case studies on precipitation with its applications in antibody purification. Doctoral thesis , UCL (University College London).

Konstantinidis, S; Chhatre, S; Velayudhan, A; Heldin, E; Titchener-Hooker, N; (2012) The hybrid experimental simplex algorithm – An alternative method for ‘sweet spot’ identification in early bioprocess development: Case studies in ion exchange chromatography. Analytica Chimica Acta , 743 19 - 32. 10.1016/j.aca.2012.06.039.

Lewis, S.M.; (2012) Localisation of mTOR complex proteins in embryonic stem cells: relationship with cell division and survival. Doctoral thesis , UCL (University College London).

Mothia, B; (2012) Hybrid Lantibiotics: Combining Synthesis and Biosynthesis. Doctoral thesis , UCL (University College London).

Ng, CK; Osuna-Sanchez, H; Valéry, E; Sørensen, E; Bracewell, DG; (2012) Design of high productivity antibody capture by protein A chromatography using an integrated experimental and modeling approach. Journal of Chromatography B , 899 116 - 126. 10.1016/j.jchromb.2012.05.010.

Patterson, R; Nerren, J; Kogut, M; Court, P; Villarreal-Ramos, B; Seyfert, HM; Dalby, P; Patterson, R; Nerren, J; Kogut, M; Court, P; Villarreal-Ramos, B; Seyfert, HM; Dalby, P; Werling, D; - view fewer (2012) Yeast-surface expressed BVDV E2 protein induces a Th1/Th2 response in naïve T cells. Developmental & Comparative Immunology , 37 (1) 107 - 114. 10.1016/j.dci.2011.10.009.

Payongsri, P; Steadman, D; Strafford, J; MacMurray, A; Hailes, HC; Dalby, PA; (2012) Rational substrate and enzyme engineering of transketolase for aromatics. Organic & Biomolecular Chemistry , 10 (45) 9021 - 9029. 10.1039/c2ob25751c.

Polykarpou, EM; Dalby, PA; Papageorgiou, LG; (2012) An MILP formulation for the synthesis of protein purification processes. Chemical Engineering Research and Design , 90 (9) 1262 - 1270. 10.1016/j.cherd.2011.11.021.

Reichen, M; (2012) Multiplexed microfabricated cell culture device for stem cell process development. Doctoral thesis , UCL (University College London).

Reichen, M; Macown, RJ; Jaccard, N; Super, A; Ruban, L; Griffin, LD; Veraitch, FS; Reichen, M; Macown, RJ; Jaccard, N; Super, A; Ruban, L; Griffin, LD; Veraitch, FS; Szita, N; - view fewer (2012) Microfabricated modular scale-down device for regenerative medicine process development. PLOS One , 7 (12) , Article e52246. 10.1371/journal.pone.0052246.

Rios, L; (2012) Microscale evaluation of de novo engineered whole cell biocatalysts. Doctoral thesis , UCL (University College London).

Strafford, J; Payongsri, P; Hibbert, EG; Morris, P; Batth, SS; Steadman, D; Smith, ME; ... Dalby, PA; + view all Strafford, J; Payongsri, P; Hibbert, EG; Morris, P; Batth, SS; Steadman, D; Smith, ME; Ward, JM; Hailes, HC; Dalby, PA; - view fewer (2012) Directed evolution to re-adapt a co-evolved network within an enzyme. Journal of Biotechnology , 157 (1) 237 - 245. 10.1016/j.jbiotec.2011.11.017.

Strafford, J.; (2012) Docking and bioinformatics tools to guide enzyme engineering. Doctoral thesis , UCL (University College London).

Tang, A.; (2012) A novel USD-modelling tool for chromatography design - specification of resin properties. Doctoral thesis , UCL (University College London).

Virk, B; Correia, G; Dixon, DP; Feyst, I; Jia, J; Oberleitner, N; Briggs, Z; ... Weinkove, D; + view all Virk, B; Correia, G; Dixon, DP; Feyst, I; Jia, J; Oberleitner, N; Briggs, Z; Hodge, E; Edwards, R; Ward, J; Gems, D; Weinkove, D; - view fewer (2012) Excessive folate synthesis limits lifespan in the C. elegans: E. coli aging model. BMC Biology , 10 (67) 10.1186/1741-7007-10-67.

2011

Abe, Y.; (2011) The molecular basis for antibody stability in the bioprocess environment. Doctoral thesis , UCL (University College London).

Ahmad, S.; (2011) Analysis of the precipitation and aggregation of engineered proteins. Doctoral thesis , UCL (University College London).

Bae, D.-K.; (2011) Developing an efficient process for the production of retinal progenitor cells (RPCs) from human pluripotent stem cells using lowered oxygen tension. Doctoral thesis , UCL (University College London).

Beckett, P.J.; (2011) Ultra scale-down of elution chromatography. Doctoral thesis , UCL (University College London).

Blas, P.; (2011) Ultra scale-down analysis and bioprocessing of fusion proteins. Doctoral thesis , UCL (University College London).

Brown, A.I.; (2011) An ultra scale-down approach to the rapid evaluation of pleated membrane cartridge filter performance. Doctoral thesis , UCL (University College London).

Chang, M.-W.; (2011) Forming of novel drug carriers for stimulated encapsulation, storage and release. Doctoral thesis , UCL (University College London).

Chang, Y.-C.; (2011) Practical investigation on the hydrodynamic behaviour of chromatographic columns packed with compressible media. Doctoral thesis , UCL (University College London).

Chhatre, S; Konstantinidis, S; Ji, Y; Edwards-Parton, S; Zhou, Y; Titchener-Hooker, NJ; (2011) The Simplex Algorithm for the Rapid Identification of Operating Conditions During Early Bioprocess Development: Case Studies in FAb' Precipitation and Multimodal Chromatography. Biotechnology and Bioengineering , 108 (9) pp. 2162-2170. 10.1002/bit.23151.

Dosanjh, J.K.S.; (2011) Protein damage during purification: understanding the effects of size exclusion chromatography on the structure of biosynthetic human insulin (BHI). Doctoral thesis , UCL (University College London).

Grant, Y.G.; (2011) Engineering the rational design and optimisation of lyophilization processes for biological materials. Doctoral thesis , UCL (University College London).

Hudman, P.A.; (2011) Investigation of recombinant protein production by Escherichia coli : expression of Green fluorescent protein and a co-factor dependent flavinated enzyme. Doctoral thesis , UCL (University College London).

Jackson, N.B.; (2011) Microscale approaches to the rapid evaluation and specification of microfiltration processes. Doctoral thesis , UCL (University College London).

Knevelman, C.A.; (2011) An evaluation of bioprocess development approaches for the precipitation-based purification of IgG monoclonal antibodies. Doctoral thesis , UCL (University College London).

Lilley, R.E.; (2011) Fundamental studies to design novel enzyme technologies for home and personal care applications. Doctoral thesis , UCL (University College London).

Paoli, T.Z.; (2011) An investigation into the culturing of lactate re-utilising CHO cells. Doctoral thesis , UCL (University College London).

Polykarpou, E.; (2011) Optimisation of chromatography for downstream protein processing. Doctoral thesis , UCL (University College London).

Rayat, Andrea Chielou May Elumbaring; (2011) Microscale bioprocessing platform for the evaluation of membrane filtration processes for primary recovery. Doctoral thesis (Ph.D), UCL (University College London).

Rayat, Andrea Chielou May Elumbaring; (2011) Microscale bioprocessing platform for the evaluation of membrane filtration processes for primary recovery. Doctoral thesis (Ph.D), UCL (University College London).

Rios-Solis, L; Halim, M; Cazares, A; Morris, P; Ward, JM; Hailes, HC; Dalby, PA; ... Lye, GJ; + view all Rios-Solis, L; Halim, M; Cazares, A; Morris, P; Ward, JM; Hailes, HC; Dalby, PA; Baganz, F; Lye, GJ; - view fewer (2011) A toolbox approach for the rapid evaluation of multi-step enzymatic syntheses comprising a 'mix and match' E. coli expression system with microscale experimentation. Biocatalysis and Biotransformation , 29 (5) pp. 192-203. 10.3109/10242422.2011.609589.

Scutcher, M.; (2011) Modelling and development of process control for a vascular tissue engineering bioreactor. Doctoral thesis , UCL (University College London).

Tran, R.; (2011) Evaluation of challenges to the ubiquitous nature of chromatography. Doctoral thesis , UCL (University College London).

Warburton, PJ; Allan, E; Hunter, S; Ward, J; Booth, V; Wade, WG; Mullany, P; (2011) Isolation of bacterial extrachromosomal DNA from human dental plaque associated with periodontal disease, using transposon-aided capture (TRACA). FEMS Microbiology Ecology , 78 (2) 349 - 354. 10.1111/j.1574-6941.2011.01166.x.

2010

Branston, S.D.; (2010) An investigation of the properties of bacteriophage M13 and the implications for its large-scale bioprocessing. Doctoral thesis , UCL (University College London).

Bryant, W.A.; (2010) Functional genomics, analysis of adaptation in and applications of models to the metabolism of engineered Escherichia coli. Doctoral thesis , UCL (University College London).

Dartnell, LR; Fallaize, DR; Whiting, SJ; Ward, JM; (2010) Desiccation resistance of Antarctic Dry Valley bacteria isolated from contrasting locations. Antarctic Science , 22 (2) 171 - 172. 10.1017/S0954102009990745.

Galman, JL; Steadman, D; Bacon, S; Morris, P; Smith, MEB; Ward, JM; Dalby, PA; Galman, JL; Steadman, D; Bacon, S; Morris, P; Smith, MEB; Ward, JM; Dalby, PA; Hailes, HC; - view fewer (2010) alpha,alpha '-Dihydroxyketone formation using aromatic and heteroaromatic aldehydes with evolved transketolase enzymes. Chemical Communications , 46 (40) 7608 - 7610. 10.1039/c0cc02911d.

Gillett, M.L.; (2010) The effect of in vitro culture on the stability, expansion and neuronal differentiation of human pluripotent cell lines. Doctoral thesis , UCL (University College London).

Harris, Anna Rachael; (2010) Optimisation and characterisation of the culture of limbal epithelial stem cells. Doctoral thesis (Eng.D), UCL (University College London).

Ma, G.; (2010) Development of ultra scale-down shear filtration system and modelling of large scale diafiltration system. Doctoral thesis , UCL (University College London).

Plews, JR; Li, JL; Jones, M; Moore, HD; Mason, C; Andrews, PW; Na, J; (2010) Activation of Pluripotency Genes in Human Fibroblast Cells by a Novel mRNA Based Approach. PLOS ONE , 5 (12) , Article e14397. 10.1371/journal.pone.0014397.

Remtulla, N.; (2010) Feasibility of microfluidic routes to monitor protein stability as a tool for bioprocessing. Doctoral thesis , UCL (University College London).

Wenger, M.D.; (2010) Micro-tip chromatography; a route to an integrated strategy for high throughput bioprocess development. Doctoral thesis , UCL (University College London).

2009

Berrill, A.; (2009) Protein mass spectrometry for bioprocess development & monitoring. Doctoral thesis , UCL (University College London).

Biddlecombe, J.G.; (2009) Antibody stability in bioprocessing focusing on shear effects at solid-liquid interfaces. Doctoral thesis , UCL (University College London).

Bryant, WA; Krabben, P; Baganz, F; Zhou, YH; Ward, JM; (2009) The Analysis of Multiple Genome Comparisons in Genus Escherichia and Its Application to the Discovery of Uncharacterised Metabolic Genes in Uropathogenic Escherichia coli CFT073. International Journal of Genomics , 2009 , Article 782924. 10.1155/2009/782924.

Chau, G.K.; (2009) Tube-forming device design for the creation of cell-integrated alginate tubes. Doctoral thesis , University of London.

Chu, P.K.C.; (2009) The bioprocessing of stem cells for use in regenerative medicine. Doctoral thesis , UCL (University College London).

Hassan, S.Y.; (2009) Prediction of transgenic tobacco plant processing properties by ultra scale down and physical property measurement for monoclonal antibody production. Doctoral thesis , UCL (University College London).

Kee, G.K.; (2009) A rational approach to the development of future generation processes for lipoprotein VLP vaccine candidates. Doctoral thesis , UCL (University College London).

Martínez Torres, R.J.; (2009) Characterisation of the structural stability of transketolase under biocatalytically relevant conditions. Doctoral thesis , UCL (University College London).

Matosevic, S.; (2009) Design and characterisation of a prototype immobilised enzyme microreactor for the quantification of multi−step enzyme kinetics. Doctoral thesis , UCL (University College London).

Parker, B.M.; (2009) Directed evolution of an L-aminoacylase biocatalyst. Doctoral thesis , UCL (University College London).

Scott, R.; (2009) Growth of mesenchymal stromal cells in automated microwell cultures: influence of the engineering environment on cell growth kinetics and non-directed differentiation. Doctoral thesis , UCL (University College London).

Shapiro, M.; (2009) Design and characterisation of microlitre scale chromatography for the comparison with preparative scale chromatography. Doctoral thesis , UCL (University College London).

Sheth, B.; (2009) Characterisation of chromatography adsorbents for antibody bioprocessing. Doctoral thesis , UCL (University College London).

Stephenson, E.; (2009) Derivation of human embryonic stem cells to study early development and genetic disease. Doctoral thesis , UCL (University College London).

Wong, J.W.; (2009) Centrifugal recovery of embryonic stem cells for regenerative medicine bioprocessing. Doctoral thesis , UCL (University College London).

2008

Buranawatanachoke, B.; (2008) Bioprocess analysis using computational fluid dynamics and ultra scale-down. Doctoral thesis , University of London.

Chau, G.K.; (2008) Tube-forming device design for the creation of cell-integrated alginate tubes. Doctoral thesis , University of London.

Chhatre, S.; (2008) Evaluation of the financial and technical impacts of changing commercial-scale pharmaceutical manufacturing processes. Doctoral thesis , University of London.

Costelloe, S.J.; Ward, J.M.; Dalby, P.A.; (2008) Evolutionary analysis of the TPP-dependent enzyme family. Journal of Molecular Evolution , 66 (1) pp. 36-49. 10.1007/s00239-007-9056-2.

Eardley-Patel, R.; (2008) Development of engineering methods for the rapid evaluation of membrane filtration within bioprocesses. Doctoral thesis , University of London.

Ferreria-Torres, C.; (2008) Microscale process characterisation of oxidative bioconversions. Doctoral thesis , University of London.

George, E.D.; (2008) Decision-support algorithms for biopharmaceutical portfolio & capacity management. Doctoral thesis , UCL (University College London).

George, E.D.; (2008) Decision-support algorithms for biopharmaceutical portfolio & capacity management. Doctoral thesis , University of London.

Gill, N.K.; (2008) Design and characterisation of parallel miniature bioreactors for bioprocess optimisation and scale-up. Doctoral thesis , University of London.

Lin, B.; (2008) Evaluation of advanced wound healing products from an operational and financial perspective. Doctoral thesis , University of London.

Mukhopadhyay, Tarit K; (2008) Rapid vaccine development using a micro-scale platform. Doctoral thesis , UCL (University College London).

Mullen, LM; Bosse, JT; Nair, SP; Ward, JM; Rycroft, AN; Robertson, G; Langford, PR; Mullen, LM; Bosse, JT; Nair, SP; Ward, JM; Rycroft, AN; Robertson, G; Langford, PR; Henderson, B; - view fewer (2008) Pasteurellaceae ComE1 Proteins Combine the Properties of Fibronectin Adhesins and DNA Binding Competence Proteins. PLOS ONE , 3 (12) , Article e3991. 10.1371/journal.pone.0003991.

O'Malley, C.J.; (2008) Information extraction for enhanced bioprocess development. Doctoral thesis , UCL (University College London).

Paramesvaran, J; (2008) Enzyme engineering of bovine trypsin. Doctoral thesis , UCL (University College London).

Pittarello, L.; (2008) The preparation and characterisation of cells and their scaffolds suitable for tissue repair applications. Doctoral thesis , University of London.

Scarr, James Richard Hadley; (2008) Pharmaceutical development processes. Doctoral thesis , UCL (University College London).

2007

Dartnell, LR; Desorgher, L; Ward, JM; Coates, AJ; (2007) Modelling the surface and subsurface Martian radiation environment: Implications for astrobiology. Geophysical Research Letters , 34 (2) , Article L02207. 10.1029/2006GL027494.

Gerontas, S.; (2007) Bioreactor design for the controlled formation of engineered tissues. Doctoral thesis , University of London.

Hussain, W.; (2007) Characterisation and selection of room temperature ionic liquids as co-solvents for redox biocatalysis. Doctoral thesis , University of London.

Hutchinson, N.; (2007) New ultra scale-down principles for monoclonal antibody recovery and purifications. Doctoral thesis , University of London.

Kalia, P.; (2007) Enhancing the fixation of massive implants using bone marrow stromal cells. Doctoral thesis , University of London.

Kong, S.Y.; (2007) Plasmid DNA and bacterial artificial chromosomes processing for gene therapy and vaccination: studies on membrane sterile filtration. Doctoral thesis , University of London.

Lewis, W.J.K.; (2007) Novel llama antibody fusion proteins as deposition aids for particles containing encapsulated actives for use in industrial applications. Doctoral thesis , University of London.

Maskey, S.R.; (2007) An integrated hydrodynamic and adsorption model of expanded bed operation: Its development and application. Doctoral thesis , University of London.

Reid, E.C.T.Q.; (2007) A tool-kit for in-process determination and control of structural and conformational authenticity of complex biopharmaceuticals. Doctoral thesis , University of London.

2006

Al-Marzouqi, I.; (2006) Recovery and purification of plasmid DNA gene therapy vectors using aqueous two-phase systems in a J-type countercurrent chromatograph. Doctoral thesis , University of London.

Betts, JI; Baganz, F; (2006) Miniature bioreactors: current practices and future opportunities. [Review]. Microbial Cell Factories , 5 , Article 21. 10.1186/1475-2859-5-21.

Fish, S.; (2006) Enhancing the oxygen supply to whole-cell oxygenase bioconversions. Doctoral thesis , University of London.

Ingram, C.U.; (2006) Biocatalytic synthesis of amino-alcohols using a de novo designed transketolase-/beta-alanine: Pyruvate transaminase pathway in Escherichia coli. Doctoral thesis , University of London.

Joseph, J; Sinclair, A; Titchener-Hooker, NJ; Zhou, Y; (2006) A Framework for Assessing the Solutions in Chromatographic Process Design and Operation for Large Scale Manufacture. Journal of Chemical Technology and Biotechnology , 81 (6) pp. 1009-1020. 10.1002/jctb.1508.

Mannall, G.J.; (2006) Characterisation of the effect of process factors upon protein refolding yield. Doctoral thesis , University of London.

Nealon, A.J.; (2006) Microwell methods for fast process development. Doctoral thesis , University of London.

Salte, H.; (2006) Rapid evaluation of options for the primary recovery of antibody fragments expressed in high cell density cultures. Doctoral thesis , University of London.

Shorrock, V.J.; (2006) An NADH dependent reductase for isolated enzyme and whole cell catalysis. Doctoral thesis , University of London.

2005

Abu, M.; (2005) Kinetic study of human thymine DNA glycosylase and examination of its interaction with apurinic endonuclease 1 in base excision repair. Doctoral thesis , University of London.

Aucamp, JP; Cosme, AM; Lye, GJ; Dalby, PA; (2005) High-throughput measurement of protein stability in microtiter plates. BIOTECHNOL BIOENG , 89 (5) 599 - 607.

Bains, SRE; (2005) Physical computation and embodied artificial intelligence. Doctoral thesis , The Open University.

Christopher, M.; (2005) Studies to allow the consistent fabrication of many units of engineered tissue. Doctoral thesis , University of London.

Cooke, J.R.; (2005) Intrinsic DNA abnormalities and their effect on plasmid processing. Doctoral thesis , University of London.

Garcia-Arrazola, R.; (2005) Evaluation of the effects and interactions of gas blending and feeding strategy on a Fab' fermentation process by Escherichia coli. Doctoral thesis , University of London.

Gardner, P.J.; (2005) The effect of operating parameters and matrix properties on the productivity of an expanded bed adsorption column. Doctoral thesis , University of London.

Hibbert, EG; Dalby, PA; (2005) Directed evolution strategies for improved enzymatic performance. Microbial Cell Factories , 4 , Article 29. 10.1186/1475-2859-4-29.

Hodgson, B.J.; (2005) Hybrid modelling of bioprocesses. Doctoral thesis , University of London.

Miller, O.J.; (2005) Directed evolution of transketolase, a carbon-carbon forming enzyme. Doctoral thesis , University of London.

Nabarro, S; Himoudi, N; Papanastasiou, A; Gilmour, K; Gibson, S; Sebire, N; Thrasher, A; ... Anderson, J; + view all Nabarro, S; Himoudi, N; Papanastasiou, A; Gilmour, K; Gibson, S; Sebire, N; Thrasher, A; Blundell, MP; Hubank, M; Canderan, G; Anderson, J; - view fewer (2005) Coordinated oncogenic transformation and inhibition of host immune responses by the PAX3-FKHR fusion oncoprotein. Journal of Experimental Medicine , 202 (10) pp. 1399-1410. 10.1084/jem.20050730.

Neal, G.E.; (2005) Integrated scale down of the primary downstream purification process and assessment of alternative process options for the production of an ovine polyclonal antibody based anti-venom. Doctoral thesis , University of London.

Reynolds, Tommy Sean; (2005) The accelerated study of bioprocess purification sequences for improved bioprocessing discovery. Doctoral thesis , UCL (University College London).

Roberts, Nicola Jean; (2005) Biocatalytic routes to the synthesis of chiral pharmaceutical intermediates in ionic liquids. Doctoral thesis , UCL (University College London).

Rock, Cassandra Fernanda; (2005) Characterisation and monitoring of plasmid DNA vectors of increasing size during processing for gene therapy and DNA vaccination applications. Doctoral thesis , UCL (University College London).

Sarkar, Supti; (2005) Biophysical characterisation of plasmid formulation. Doctoral thesis , UCL (University College London).

Shitu, Jennifer Olajumoke; (2005) The use of multiparameter flow cytometry to examine the state of Escherichia coli during a bioprocess. Doctoral thesis , UCL (University College London).

Siu, Sun Chau; (2005) New methods to evaluate the effects of fouling on process chromatography. Doctoral thesis , UCL (University College London).

Uzir, Mohamad Hekarl; (2005) Dynamic modelling and simulation of biocatalytic reactions. Doctoral thesis , UCL (University College London).

Zoro, Barnaby James Henry; (2005) Bioprocessing of mammalian cells for tissue engineering and cell therapies. Doctoral thesis , UCL (University College London).

2004

Bird, P.A.; (2004) Near infrared spectroscopic monitoring and control of a whole-cell biocatalytic process. Doctoral thesis , University of London.

Cody, J.T.; (2004) The design and application of a small-scale corn degerming process for the recovery of transgenic products from corn seeds. Doctoral thesis , University of London.

Dellar, S.; (2004) Comparison of the action of primary alcohols as inhibitors of a soluble and a membrane-bound cytochrome P450 hydroxylase. Doctoral thesis , University of London.

Kay, A.; (2004) Plasmid fermentation for gene therapy and vaccination. Doctoral thesis , University of London.

2002

Farid, Suzanne; (2002) A decision-support tool for simulating the process and business perspectives of biopharmaceutical manufacture. Doctoral thesis (Ph.D), UCL (University College London).

2000

Bracewell, DG; (2000) The use of optical biosensor for the real-time monitoring of product and product variants in biological process streams and application for control. University of London PhD thesis. UNSPECIFIED thesis , UNSPECIFIED.