Browse by UCL Departments and Centres
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Number of items: 72.
A
Alosert, Haneen;
(2024)
Big data analytics streamlining
therapeutic drug development from
micro-scale to bench-scale cell culture.
Doctoral thesis (Eng.D), UCL (University College London).
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Atanasova, Gergana G;
Klettner, Christian A;
Micheletti, Martina;
Ducci, Andrea;
(2024)
On the fluid dynamics of spin-over in a partially filled cylinder.
Physics of Fluids
, 36
(12)
, Article 124122. 10.1063/5.0239925.
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Atanasova, Gergana Georgieva;
(2024)
Fluid flow, mixing and suspension in an intermittently rotating cylinder bioreactor for CAR-T cell therapy manufacturing.
Doctoral thesis (Ph.D), UCL (University College London).
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Atanasova, GG;
Ducci, A;
Micheletti, M;
(2024)
Fluid dynamics and mixing in a novel intermittently rotating bioreactor for CAR-T cell therapy: Spin-down from incomplete spin-up.
Chemical Engineering Research and Design
, 205
pp. 486-497.
10.1016/j.cherd.2024.04.016.
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Ayrton, John-Paul;
Ho, Chapman;
Zhang, Haoran;
Chudasama, Vijay;
Frank, Stefanie;
Thomas, Michael R;
(2024)
Multivalent nanobody engineering for enhanced physisorption and functional display on gold nanoparticles.
Nanoscale
, 16
pp. 19881-19896.
10.1039/d4nr02762k.
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B
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Borgosz, L;
Dikicioglu, D;
(2024)
Industrial internet of things: What does it mean for the bioprocess industries?
Biochemical Engineering Journal
, 201
, Article 109122. 10.1016/j.bej.2023.109122.
(In press).
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C
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Chan, Choi Yee;
(2024)
3D Biomimetic Scaffolds for
In Vitro γδ T Cell Expansion.
Doctoral thesis (Ph.D), UCL (University College London).
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Charalambidou, Artemis-Danae;
Wyrobnik, Tom A;
Micheletti, Martina;
Ducci, Andrea;
(2024)
Investigation of the impact of probes and internals on power and flow in stirred tank reactors.
Chemical Engineering Science
, 286
, Article 119683. 10.1016/j.ces.2023.119683.
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Colao, Ivano Luigi;
Corteling, Randolph L;
Bracewell, Daniel G;
Wall, Ivan B;
(2024)
Neural stem cell-derived extracellular vesicles purified by monolith chromatography retain stimulatory effect on in vitro scratch assay.
Cytotherapy
10.1016/j.jcyt.2024.11.007.
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Csalane Besenyei, Greta;
(2024)
Engineering Phaeodactylum for vaccine production.
Doctoral thesis (Ph.D), UCL (University College London).
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D
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Davidson, Alexander James;
(2024)
Investigating the optimal expansion platform and bioprocessing parameters for the improved production of autologous chimeric antigen receptor T-cell immunotherapies.
Doctoral thesis (Eng.D), UCL (University College London).
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Delbridge, Jordan;
(2024)
A Comprehensive Characterisation of the Allegro™ Stirred Tank Bioreactor Towards Process Optimisation.
Doctoral thesis (Eng.D), UCL (University College London).
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Deuker, D;
Asilonu, E;
Bracewell, DG;
Frank, S;
(2024)
Adeno-Associated Virus 5 Protein Particles Produced by E. coli Cell-Free Protein Synthesis.
ACS Synthetic Biology
10.1021/acssynbio.4c00403.
(In press).
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Dorn, Marie;
Klottrup-Rees, Kerensa;
Lee, Ken;
Micheletti, Martina;
(2024)
Platform development for high-throughput optimization of perfusion processes: Part I: Implementation of cell bleeds in microwell plates.
Biotechnology and Bioengineering
10.1002/bit.28682.
(In press).
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Dorn, Marie;
Lucas, Ciara;
Klottrup-Rees, Kerensa;
Lee, Ken;
Micheletti, Martina;
(2024)
Platform development for high-throughput optimization of perfusion processes—Part II: Variation of perfusion rate strategies in microwell plates.
Biotechnology and Bioengineering
10.1002/bit.28685.
(In press).
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E
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Elia Venanzi, Niccolo Alberto;
Basciu, Andrea;
Vargiu, Attilio Vittorio;
Kiparissides, Alexandros;
Dalby, Paul A;
Dikicioglu, Duygu;
(2024)
Machine Learning Integrating Protein Structure, Sequence, and
Dynamics to Predict the Enzyme Activity of Bovine Enterokinase
Variants.
Journal of Chemical Information and Modeling
10.1021/acs.jcim.3c00999.
(In press).
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Escrich, A;
Jonguitud-Borrego, N;
Malci, K;
Sanchez-Muñoz, R;
Palazon, J;
Rios-Solis, L;
Moyano, E;
(2024)
A novel step towards the heterologous biosynthesis of paclitaxel: Characterization of T1βOH taxane hydroxylase.
Metabolic Engineering
, 85
pp. 201-212.
10.1016/j.ymben.2024.08.005.
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F
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Fanthom, Thomas Benjamin;
(2024)
Mechanisms of Therapeutic Protein Aggregation During Peristaltic Pumping.
Doctoral thesis (Eng.D), UCL (University College London).
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Frost, Sarah Chaney;
(2024)
Interchain disulfide bond reduction alters the structure and function of therapeutic monoclonal antibodies.
Doctoral thesis (Ph.D), UCL (University College London).
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G
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Galindo-Rodriguez, Giuseppe Rafael;
Sarwar, M Sulaiman;
Rios-Solis, Leonardo;
Dimartino, Simone;
(2024)
Development, characterization and application of 3D printed adsorbents for in situ recovery of taxadiene from microbial cultivations.
Journal of Chromatography A
, 1721
, Article 464815. 10.1016/j.chroma.2024.464815.
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Gkoutzioupa, Victoria;
(2024)
Integrated Experimental Investigation of Upstream and Primary Recovery Operations to Improve Mammalian Cell Based Process Performance.
Doctoral thesis (Ph.D), UCL (University College London).
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Gulec, Fatih;
Williams, Orla;
Samson, Abby;
Kostas, Emily T;
Stevens, Lee A;
Lester, Edward;
(2024)
Exploring the Utilisation of Natural Biosorbents for Effective Methylene Blue Removal.
Applied Sciences
, 14
(1)
, Article 81. 10.3390/app14010081.
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Gurgul, SJ;
Kollamaram, G;
Zhang, C;
Williams, GR;
(2024)
An investigation into the effect of polysorbate 80 grade in biotherapeutic formulations.
Journal of Excipients and Food Chemicals
, 1
(1)
pp. 25-55.
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H
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Hailes, Helen C;
Wang, Yu;
Li, Yiwen;
Ni, Yeke;
Bucar, Dejan-Kresimir;
Dalby, Paul A;
Ward, John M;
(2024)
A transaminase-mediated aldol reaction and applications in cascades to styryl pyridines.
Catalysis Science & Technology
10.1039/d3cy01370g.
(In press).
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Hood, T;
Slingsby, F;
Sandner, V;
Geis, W;
Schmidberger, T;
Bevan, N;
Vicard, Q;
... Rafiq, QA; + view all
(2024)
A quality-by-design approach to improve process understanding and optimise the production and quality of CAR-T cells in automated stirred-tank bioreactors.
Frontiers in Immunology
, 15
, Article 1335932. 10.3389/fimmu.2024.1335932.
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Howe, Geoffrey;
Bal, Mehtap;
Wasmuth, Matthew;
Massaro, G;
Rahim, Ahad;
Ali, Sadfer;
Rivera, Milena;
... Nesbeth, Darren; + view all
(2024)
An autonucleolytic suspension HEK293F host cell line for high-titre serum-free AAV5 and AAV9 production with reduced levels of DNA impurity.
Molecular Therapy - Methods and Clinical Development
, Article 101317. 10.1016/j.omtm.2024.101317.
(In press).
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Howe, Geoffrey;
Wasmuth, matthew;
Emanuelle, Pamela;
Massaro, Giulia;
Rahim, Ahad;
Ali, sadfer;
Rivera, Milena;
... Nesbeth, Darren; + view all
(2024)
Engineering an autonucleolytic mammalian suspension host cell line to reduce DNA impurity levels in serum-free lentiviral process streams.
ACS Synthetic Biology
, 13
(2)
pp. 408-692.
10.1021/acssynbio.3c00682.
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Hu, Heng;
(2024)
Evaluation of the Performance of Immobilised Enzymes in Batch and Continuous Reactions.
Doctoral thesis (Ph.D), UCL (University College London).
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I
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Isimite, Joseph Ogochukwu;
(2024)
Development of a Biorefinery Training Simulator with Automatic Operating Procedure Adaptation.
Doctoral thesis (Ph.D), UCL (University College London).
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J
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Jiang, W;
Cai, Y;
Sun, S;
Wang, W;
Tišma, M;
Baganz, F;
Hao, J;
(2024)
Inactivation of hydrogenase-3 leads to enhancement of 1,3-propanediol and 2,3-butanediol production by Klebsiella pneumoniae.
Enzyme and Microbial Technology
, 177
, Article 110438. 10.1016/j.enzmictec.2024.110438.
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Jungbauer, Alois;
Satzer, Peter;
Duerauer, Astrid;
Azevedo, Ana;
Aires-Barros, Raquel;
Nilsson, Bernt;
Farid, Suzy;
... Marcelo Fernandez Lahore, Hector; + view all
(2024)
Continuous downstream processing.
Separation and Purification Technology
, 338
, Article 126439. 10.1016/j.seppur.2024.126439.
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K
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Kashif-Khan, Naail;
Savva, Renos;
Frank, Stefanie;
(2024)
Mining metagenomics data for novel bacterial nanocompartments.
NAR Genomics and Bioinformatics
, 6
(1)
, Article lqae025. 10.1093/nargab/lqae025.
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Khiawjan, Sansanee;
(2024)
Intensification of biocatalytic process for the conversion of lignin derivative ferulic acid to high value chemicals.
Doctoral thesis (Ph.D), UCL (University College London).
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L
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Liu, Shuchang;
(2024)
Assessment of CV-1 as a Production Cell Line for Large Scale Manufacturing of a Lister Strain Oncolytic Vaccinia Virus.
Doctoral thesis (Ph.D), UCL (University College London).
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Lyle, Annabel;
(2024)
Decisional Tools for Optimising Process Economics, Capacity Sourcing and Portfolio Management for Biotherapeutics.
Doctoral thesis (Eng.D), UCL (University College London).
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M
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Matchett, KP;
Wilson-Kanamori, JR;
Portman, JR;
Kapourani, CA;
Fercoq, F;
May, S;
Zajdel, E;
... Henderson, NC; + view all
(2024)
Multimodal decoding of human liver regeneration.
Nature
10.1038/s41586-024-07376-2.
(In press).
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Meng, Ke;
(2024)
Block copolymer-derived mesoporous membranes for bioprocessing.
Doctoral thesis (Ph.D), UCL (University College London).
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Mukhopadhyay, Arka;
Karu, Kersti;
Dalby, Paul A;
(2024)
Two-substrate enzyme engineering using small libraries that combine the substrate preferences from two different variant lineages.
Scientific Reports
, 14
, Article 1287. 10.1038/s41598-024-51831-z.
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N
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Neves, Catarina PG;
Coffman, Jonathan L;
Farid, Suzanne S;
(2024)
Evaluating end-to-end continuous antibody manufacture with column-free capture alternatives from economic, environmental, and robustness perspectives.
Biotechnology Progress
, Article e3427. 10.1002/btpr.3427.
(In press).
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Nowrouzi, Behnaz;
Torres-Montero, Pablo;
Kerkhoven, Eduard J;
Martínez, José L;
Rios-Solis, Leonardo;
(2024)
Rewiring Saccharomyces cerevisiae metabolism for optimised Taxol® precursors production.
Metabolic Engineering Communications
, 18
, Article e00229. 10.1016/j.mec.2023.e00229.
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Nweke, Mauryn C;
(2024)
Evaluating Professional Skills Development Across the Engineering Undergraduate Degree Programme: An IEP Review.
In:
The Paris Conference on Education 2024: Official Conference Proceedings.
(pp. pp. 469-481).
The International Academic Forum (IAFOR)
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Nweke, Mauryn C;
Florez-Martin, Maria;
Ackerley, Samuel;
Truscott, Fiona;
(2024)
Teaching Scientific Writing in the Era of ChatGPT.
In:
The Paris Conference on Education 2024: Official Conference Proceedings.
(pp. pp. 483-496).
The International Academic Forum(IAFOR)
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O
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Ovari, Gyorgy;
Johnson, Thomas F;
Foroutan, Farzad;
Malmquist, Gunnar;
Townsend, Matthew;
Bracewell, Daniel G;
(2024)
Fabrication of electrospun ion exchanger adsorbents with morphologies designed for the separation of proteins and plasmid DNA.
Journal of Chromatography A
, 1734
, Article 465268. 10.1016/j.chroma.2024.465268.
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P
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Pandya, Akash;
Zhang, Cheng;
Barata, Teresa S;
Brocchini, Steve;
Howard, Mark J;
Zloh, Mire;
Dalby, Paul A;
(2024)
Molecular Dynamics Simulations Reveal How Competing Protein-Surface Interactions for Glycine, Citrate, and Water Modulate Stability in Antibody Fragment Formulations.
Molecular Pharmaceutics
10.1021/acs.molpharmaceut.4c00332.
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Parker, Brenda;
Cruz, Marcos;
(2024)
Augmented Polycultures: Scaling up Algal Ecosystems and Design of a Biofouling Aesthetic.
In: Hendlin, Yogi Hale and Weggelar, Johanna and Derossi, Natalia and Mugnai, Sergio, (eds.)
Being Algae: Transformations in Water, Plants.
(pp. 234-267).
Brill: Leiden, Netherlands.
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Prout, Luba;
Hailes, Helen C;
Ward, John M;
(2024)
Natural transaminase fusions for biocatalysis.
RSC Advances
, 14
(6)
pp. 4264-4273.
10.1039/d3ra07081f.
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R
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Ramin, Elham;
Cardillo, Antonio Gaetano;
Liebers, Reinhard;
Schmölder, Johannes;
Von Lieres, Eric;
Van Molle, Wim;
Niebel, Bastian;
... Gernaey, Krist V; + view all
(2024)
Accelerating vaccine manufacturing development through model-based approaches: current advances and future opportunities.
Current Opinion in Chemical Engineering
, 43
, Article 100998. 10.1016/j.coche.2023.100998.
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Ripoll Fiol, Carme;
(2024)
Development of a scalable and robust upstream process for the chemically-defined production of lentiviral vectors for gene-modified cellular immunotherapies.
Doctoral thesis (Eng.D), UCL (University College London).
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Rizzo, Andrea;
Aranda, Carmen;
Galman, James;
Alcasabas, Annette;
Pandya, Akash;
Bornadel, Amin;
Costa, Bruna;
... Dominguez, Beatriz; + view all
(2024)
Broadening The Substrate Scope of Aldolases Through Metagenomic Enzyme Discovery.
ChemBioChem
, Article e202400278. 10.1002/cbic.202400278.
(In press).
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S
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Salinger, Matthew T;
Castellano Garrido, Daniel;
Lamming, Eleanor D;
Ward, John M;
Moody, Thomas S;
Jeffries, Jack WE;
Hailes, Helen C;
(2024)
An Alternative Cascade for the Selective Methylation of Catechols and Tetrahydroisoquinolines by O-Methyltransferases.
ChemCatChem
, 16
(7)
, Article e202400492. 10.1002/cctc.202400492.
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Sari, Yustika;
Sousa Rosa, Sara;
Jeffries, Jack;
Marques, Marco PC;
(2024)
Comprehensive evaluation of T7 promoter for enhanced yield and quality in mRNA production.
Scientific Reports
, 14
(1)
, Article 9655. 10.1038/s41598-024-59978-5.
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Sawadkar, Prasad;
Mandakhbayar, Nandin;
Patel, Kapil D;
Owji, Nazanin;
Rajasekar, Poojitha;
Sarama, Roudin;
Lee, Jung-Hwan;
... Garcia-Gareta, Elena; + view all
(2024)
3D Porous Binary Composites of Collagen, Elastin, and Fibrin Proteins Orchestrate Adipose Tissue Regeneration.
Macromolecular Bioscience
, Article 2400073. 10.1002/mabi.202400073.
(In press).
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Sharma, Paras;
Robbel, Lars;
Schmitt, Michael;
Dikicioglu, Duygu;
Bracewell, Daniel G;
(2024)
Integrated micro-scale protein a chromatography and Low pH viral inactivation unit operations on an automated platform.
Biotechnology Progress
, Article e3476. 10.1002/btpr.3476.
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Söderström, Ksheereja;
(2024)
Scale-down models for increased capacity in egg-based Influenza vaccines manufacturing.
Doctoral thesis (Ph.D), UCL (University College London).
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Sodhi, GK;
Kaur, G;
George, N;
Walia, HK;
Sillu, D;
Rath, SK;
Saxena, S;
... Dwibedi, V; + view all
(2024)
Waste to wealth: microbial-based valorization of grape pomace for nutraceutical, cosmetic, and therapeutic applications to promote circular economy.
Process Safety and Environmental Protection
, 188
pp. 1464-1478.
10.1016/j.psep.2024.06.059.
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Spiteri, Valentina A;
Doutch, James;
Rambo, Robert P;
Bhatt, Jayesh S;
Gor, Jayesh;
Dalby, Paul A;
Perkins, Stephen J;
(2024)
Using atomistic solution scattering modelling to elucidate the role of the Fc glycans in human IgG4.
PLoS One
, 19
(4)
, Article e0300964. 10.1371/journal..
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Stibbs, Dale J;
Silva Couto, Pedro;
Takeuchi, Yasuhiro;
Rafiq, Qasim A;
Jackson, Nigel B;
Rayat, Andrea CME;
(2024)
Continuous manufacturing of lentiviral vectors using a stable producer cell line in a fixed-bed bioreactor.
Molecular Therapy: Methods & Clinical Development
, 32
(1)
, Article 101209. 10.1016/j.omtm.2024.101209.
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Suarez Heredia, Ricardo;
(2024)
A combined in-vitro and in-silico investigation on the design and optimisation of nutrient supplementation strategies for mammalian cell cultures.
Doctoral thesis (Ph.D), UCL (University College London).
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T
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Talukdar, Avishek;
Kundu, Pritha;
Bhattacharya, Sayan;
Dutta, Nalok;
(2024)
Microplastic contamination in wastewater: Sources, distribution, detection and remediation through physical and chemical-biological methods.
Science of the Total Environment
, 916
, Article 170254. 10.1016/j.scitotenv.2024.170254.
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Torres-Acosta, Mario A;
Bozeat, Pierce;
Ceballos Rodriguez-Conde, Fatima;
Kent, Ross;
Leitão, Nuno;
Lye, Gary J;
Dikicioglu, Duygu;
(2024)
Practical considerations for the high-level automation of a biosciences research laboratory.
Biochemical Engineering Journal
, 201
, Article 109154. 10.1016/j.bej.2023.109154.
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Torres-Acosta, Mario A;
Olivares-Molina, Alex;
Kent, Ross;
Leitão, Nuno;
Gershater, Markus;
Parker, Brenda;
Lye, Gary J;
(2024)
Practical Deployment of Automation to Expedite Aqueous Two-Phase Extraction.
Journal of Biotechnology
, 387
pp. 32-43.
10.1016/j.jbiotec.2024.03.013.
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V
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Van de Steen, Alexander;
Wilkinson, Henry C;
Dalby, Paul A;
Frank, Stefanie;
(2024)
Encapsulation of Transketolase into In Vitro-Assembled Protein Nanocompartments Improves Thermal Stability.
ACS Applied Biomaterials
, 7
(6)
pp. 3660-3674.
10.1021/acsabm.3c01153.
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Venanzi, Niccolò Alberto Elia;
(2024)
Machine Learning for Protein Engineering Using Molecular Dynamics Simulation Data.
Doctoral thesis (Ph.D), UCL (University College London).
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W
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Wang, Q;
Jiang, W;
Cai, Y;
Tišma, M;
Baganz, F;
Shi, J;
Lye, GJ;
... Hao, J; + view all
(2024)
2-Hydroxyisovalerate production by Klebsiella pneumoniae.
Enzyme and Microbial Technology
, 172
, Article 110330. 10.1016/j.enzmictec.2023.110330.
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Wanika, Linda;
Egan, Joseph R;
Swaminathan, Nivedhitha;
Duran-Villalobos, Carlos A;
Branke, Juergen;
Goldrick, Stephen;
Chappell, Mike;
(2024)
Structural and practical identifiability analysis in bioengineering: a beginner’s guide.
Journal of Biological Engineering
, 18
, Article 20. 10.1186/s13036-024-00410-x.
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Williams-Fegredo, Thomas Edward;
(2024)
Developing strategies to enhance transfection efficiency and mitigate auto-transduction in transient lentiviral vector bioprocessing.
Doctoral thesis (Ph.D), UCL (University College London).
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Wood, Victoria E;
Kellerman, Mark-Adam;
Groves, Kate;
Quaglia, Milena;
Topp, Elizabeth M;
Matejtschuk, Paul;
Dalby, Paul A;
(2024)
Investigation of the Solid-State Interactions in Lyophilized Human G-CSF Using Hydrogen-Deuterium Exchange Mass Spectrometry.
Molecular Pharmaceutics
, 21
(4)
pp. 1965-1976.
10.1021/acs.molpharmaceut.3c01211.
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Worsham, Robert D;
(2024)
Continuous Manufacturing of Liposomal Drug Products.
Doctoral thesis (Ph.D), UCL (University College London).
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Wyrobnik, Tom A;
Oh, Steve;
Micheletti, Martina;
Ducci, Andrea;
(2024)
Insights into the fluid dynamics of the Bach impeller.
Chemical Engineering Research and Design
, 206
pp. 511-523.
10.1016/j.cherd.2024.05.026.
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Y
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Yamanie, Almir;
(2024)
Towards Upstream Process Development Using Mixed Induction Strategy and Continuous System in Cultivation of Komagataella phaffii.
Doctoral thesis (Ph.D), UCL (University College London).
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Yoon, John K;
Schindler, Jeffrey W;
Loperfido, Mariana;
Baricordi, Cristina;
DeAndrade, Mark P;
Jacobs, Mary E;
Treleaven, Christopher;
... van Til, Niek P; + view all
(2024)
Preclinical lentiviral vector-mediated hematopoietic stem and progenitor cell gene therapy corrects Pompe disease-related muscle and neurological manifestations.
Molecular Therapy
10.1016/j.ymthe.2024.09.024.
(In press).
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Youngthong, Chalermkiart;
(2024)
Establishing yeast Komagataella phaffii as an expression
platform for prokaryotic nanocompartments and its
potential application for antigen display.
Doctoral thesis (Ph.D), UCL (University College London).
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