Vamathevan, JJ;
Hasan, S;
Emes, RD;
Amrine-Madsen, H;
Rajagopalan, D;
Topp, SD;
Kumar, V;
... Holbrook, JD; + view all
(2008)
The role of positive selection in determining the molecular cause of species differences in disease.
BMC Evolutionary Biology
, 8
(Octobe)
, Article 273. 10.1186/1471-2148-8-273.
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Abstract
Related species, such as humans and chimpanzees, often experience the same disease with varying degrees of pathology, as seen in the cases of Alzheimer's disease, or differing symptomatology as in AIDS. Furthermore, certain diseases such as schizophrenia, epithelial cancers and autoimmune disorders are far more frequent in humans than in other species for reasons not associated with lifestyle. Genes that have undergone positive selection during species evolution are indicative of functional adaptations that drive species differences. Thus we investigate whether biomedical disease differences between species can be attributed to positively selected genes.
| Type: | Article |
|---|---|
| Title: | The role of positive selection in determining the molecular cause of species differences in disease |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1186/1471-2148-8-273 |
| Publisher version: | http://dx.doi.org/10.1186/1471-2148-8-273 |
| Language: | English |
| Additional information: | PMCID: PMC2576240 © 2008 Vamathevan et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Algorithms, Animals, Base Sequence, Cluster Analysis, Computational Biology, Disease, Dogs, Evolution, Molecular, Genetic Variation, Humans, Mice, Pan troglodytes, Rats, Selection, Genetic, Sequence Alignment, Species Specificity |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment |
| URI: | https://discovery.ucl.ac.uk/id/eprint/99933 |
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