Wenger, MPE;
Bozec, L;
Horton, MA;
Mesquida, P;
(2007)
Mechanical properties of collagen fibrils.
BIOPHYS J
, 93
(4)
1255 - 1263.
10.1529/biophysj.106.103192.
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Abstract
The formation of collagen fibers from staggered subfibrils still lacks a universally accepted model. Determining the mechanical properties of single collagen fibrils ( diameter 50 - 200 nm) provides new insights into collagen structure. In this work, the reduced modulus of collagen was measured by nanoindentation using atomic force microscopy. For individual type 1 collagen fibrils from rat tail, the modulus was found to be in the range from 5 GPa to 11.5 GPa ( in air and at room temperature). The hypothesis that collagen anisotropy is due to the subfibrils being aligned along the fibril axis is supported by nonuniform surface imprints performed by high load nanoindentation.
| Type: | Article |
|---|---|
| Title: | Mechanical properties of collagen fibrils |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1529/biophysj.106.103192 |
| Publisher version: | http://www.ncbi.nlm.nih.gov/pmc/ articles/PMC19290... |
| Keywords: | ATOMIC-FORCE MICROSCOPE, BIOLOGICAL-MATERIALS, ELASTIC PROPERTIES, NATIVE COLLAGEN, SPRING CONSTANT, YOUNGS MODULUS, NANOINDENTATION, INDENTATION, CANTILEVERS, HYDRATION |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/9834 |
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