UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Mechanical properties of collagen fibrils

Wenger, MPE; Bozec, L; Horton, MA; Mesquida, P; (2007) Mechanical properties of collagen fibrils. BIOPHYS J , 93 (4) 1255 - 1263. 10.1529/biophysj.106.103192. Green open access

[img]
Preview
PDF
9834.pdf

Download (337kB)

Abstract

The formation of collagen fibers from staggered subfibrils still lacks a universally accepted model. Determining the mechanical properties of single collagen fibrils ( diameter 50 - 200 nm) provides new insights into collagen structure. In this work, the reduced modulus of collagen was measured by nanoindentation using atomic force microscopy. For individual type 1 collagen fibrils from rat tail, the modulus was found to be in the range from 5 GPa to 11.5 GPa ( in air and at room temperature). The hypothesis that collagen anisotropy is due to the subfibrils being aligned along the fibril axis is supported by nonuniform surface imprints performed by high load nanoindentation.

Type: Article
Title: Mechanical properties of collagen fibrils
Open access status: An open access version is available from UCL Discovery
DOI: 10.1529/biophysj.106.103192
Publisher version: http://www.ncbi.nlm.nih.gov/pmc/ articles/PMC19290...
Keywords: ATOMIC-FORCE MICROSCOPE, BIOLOGICAL-MATERIALS, ELASTIC PROPERTIES, NATIVE COLLAGEN, SPRING CONSTANT, YOUNGS MODULUS, NANOINDENTATION, INDENTATION, CANTILEVERS, HYDRATION
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/9834
Downloads since deposit
1,015Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item