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Total plasma carotenoids and mortality in the elderly: results of the Epidemiology of Vascular Ageing (EVA) study

Akbaraly, TN; Favier, A; Berr, C; (2009) Total plasma carotenoids and mortality in the elderly: results of the Epidemiology of Vascular Ageing (EVA) study. BRIT J NUTR , 101 (1) 86 - 92. 10.1017/S0007114508998445. Green open access

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Abstract

Carotenoids are pigments found in fruits and vegetables. While high intakes of fruits and vegetables have been found to be associated with lower mortality, our objective is to investigate if total plasma carotenoids, via their antioxidant properties. are associated with mortality risk in a free-living elderly population. The 'Epidemiology of Vascular Ageing' (EVA) study (n 1389 59-71 years) is a 9-year longitudinal study with six waves of follow-up. The association between baseline total plasma carotenoids and mortality was determined by Cox proportional hazards regression analyses. Low total plasma carotenoid level was significantly associated with all-cause mortality in men but not in women. After controlling for potential confounding factors, mortality risk increased significantly in men (P=0.03) with plasma carotenoids in the lowest quintile compared with men with plasma carotenoids in the highest (relative risk 2.94 (95 % CI 1.21, 7.17)). A significant association between mortality by cancer and low plasma carotenoid level variable was also found in men (unit = 1 mu mol/l; relative risk 1.72 (95 % CI 1.02, 2.86); P=0.01). Associations between total plasma carotenoids and mortality risk remained statistically significant after taking into account: (1) plasma Se level, which previously was found associated with mortality in this population and (2) thiobarbituric acid-reactive substances level considered as an indicator of oxidative stress. By showing, prospectively, in a general healthy elderly population, that total plasma carotenoid levels were independently associated with mortality risk in men, the present study suggests that total plasma carotenoid levels could be a health indicator in elderly populations.

Type: Article
Title: Total plasma carotenoids and mortality in the elderly: results of the Epidemiology of Vascular Ageing (EVA) study
Open access status: An open access version is available from UCL Discovery
DOI: 10.1017/S0007114508998445
Publisher version: http://dx.doi.org/10.1017/S0007114508998445
Language: English
Additional information: © The Authors 2009
Keywords: Total plasma carotenoids, Mortality, Elderly, Longitudinal studies, CORONARY-HEART-DISEASE, ALL-CAUSE MORTALITY, BETA-CAROTENE, ALPHA-TOCOPHEROL, VEGETABLE CONSUMPTION, OXIDATIVE STRESS, POOLED ANALYSIS, LUNG-CANCER, ANTIOXIDANT VITAMINS, SERUM CONCENTRATIONS
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Behavioural Science and Health
URI: https://discovery.ucl.ac.uk/id/eprint/87264
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