Malacarne, F;
Webster, GJM;
Reignat, S;
Gotto, J;
Behboudi, S;
Burroughs, AK;
Dusheiko, GM;
... Bertoletti, A; + view all
(2003)
Tracking the source of the hepatitis B virus-specific CD8 T cells during lamivudine treatment.
JOURNAL OF INFECTIOUS DISEASES
, 187
(4)
679 - 682.
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Abstract
Lamivudine treatment in chronic hepatitis B leads to the reconstitution of virus-specific T cells in the circulation, but it is not clear whether this is the preferential result of T cell efflux from the liver or lymph nodes. To address this question, the frequency and function of liver-, lymph node-, and blood-derived hepatitis B virus (HBV)-specific CD8 T cells were analyzed in patients treated with lamivudine and undergoing liver transplantation. HBV-specific CD8 T cells, identified in portal lymph nodes, were able to expand in vitro after antigen-specific stimulation and displayed a heterogeneous profile of cytokine production. These findings suggest that the peripherally reconstituted HBV-specific CD8 T cells can originate from precursor cells within lymph nodes.
| Type: | Article |
|---|---|
| Title: | Tracking the source of the hepatitis B virus-specific CD8 T cells during lamivudine treatment |
| Location: | PARIS, FRANCE |
| Open access status: | An open access version is available from UCL Discovery |
| Keywords: | INFECTION, THERAPY, RESPONSES |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine |
| URI: | https://discovery.ucl.ac.uk/id/eprint/8719 |
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