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The boundary cap: a source of neural crest stem cells that generate multiple sensory neuron subtypes

Hjerling-Leffler, J; Marmigere, F; Heglind, M; Cederberg, A; Koltzenburg, M; Enerback, S; Ernfors, P; (2005) The boundary cap: a source of neural crest stem cells that generate multiple sensory neuron subtypes. DEVELOPMENT , 132 (11) 2623 - 2632. 10.1242/dev.01852. Green open access

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Abstract

The boundary cap (BC) is a transient neural crest-derived group of cells located at the dorsal root entry zone (DREZ) that have been shown to differentiate into sensory neurons and glia in vivo. We find that when placed in culture, BC cells self-renew, show multipotency in clonal cultures and express neural crest stem cell (NCSCs) markers. Unlike sciatic nerve NCSCs, the BC-NCSC (bNCSCs) generates sensory neurons upon differentiation. The bNCSCs constitute a common source of cells for functionally diverse types of neurons, as a single bNCSC can give rise to several types of nociceptive and thermoreceptive sensory neurons. Our data suggests that BC cells comprise a source of multipotent sensory specified stem cells that persist throughout embryogenesis.

Type: Article
Title: The boundary cap: a source of neural crest stem cells that generate multiple sensory neuron subtypes
Open access status: An open access version is available from UCL Discovery
DOI: 10.1242/dev.01852
Keywords: mouse, peripheral nervous system, migration, Fkh3, Foxs1, PERIPHERAL NERVOUS-SYSTEM, DORSAL-ROOT-GANGLIA, SPINAL-CORD, DEVELOPMENTAL-CHANGES, EXPRESSION PATTERN, PROGENITOR CELLS, MOTOR-NEURONS, MOUSE EMBRYO, EXIT POINTS, ENTRY ZONE
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: https://discovery.ucl.ac.uk/id/eprint/8531
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