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Impaired carotid viscoelastic properties in women with polycystic ovaries

Lakhani, K; Seifalian, AM; Hardiman, P; (2002) Impaired carotid viscoelastic properties in women with polycystic ovaries. CIRCULATION , 106 (1) 81 - 85. 10.1161/01.CIR.0000020681.19400.8A. Green open access

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Abstract

Background-The purpose of this study was to assess the elastic properties of the carotid arteries in women with polycystic ovarian syndrome, asymptomatic women with polycystic ovaries. and healthy controls.Methods and Results-We recruited the following 60 subjects: 20 symptomatic women with polycystic ovaries attending the reproductive endocrinology clinics, 20 asymptomatic women with polycystic ovaries attending the family planning clinic, and 20 staff volunteers as healthy controls with normal ovaries on transvaginal scan. Compliance and stiffness index were assessed in the common and internal carotid arteries using duplex ultrasound equipped with an echo-locked arterial wall-tracking system. Compliance was significantly lower in the common carotid artery in symptomatic and asymptomatic women with polycystic ovaries than in the controls (10.7, 14.1, and 19.2%mm Hg-1 x 10(-2), respectively). The arterial stiffness index was correspondingly increased (12.3, 10.2, and 6.7, respectively). Similar results were obtained in the internal carotid artery for compliance (10.1. 11.0, and 16.9 %mm Hg-1 x 10(-2), respectively) and stiffness index (14.8, 16.2, and 8.7, respectively).Conclusions-The results of this study provide additional evidence of vascular dysfunction in women with polycystic ovaries and are compatible with the hypothesis that they are at increased risk from coronary artery disease and stroke.

Type: Article
Title: Impaired carotid viscoelastic properties in women with polycystic ovaries
Open access status: An open access version is available from UCL Discovery
DOI: 10.1161/01.CIR.0000020681.19400.8A
Keywords: carotid arteries, cardiovascular disease, stroke, elasticity, hemodynamics, CORONARY-ARTERY-DISEASE, TERM-FOLLOW-UP, IN-VIVO, CARDIOVASCULAR RISK, VASCULAR-DISEASE, ATHEROSCLEROSIS, HYPERTENSION, AMENORRHEA, DIAGNOSIS, HISTORY
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Inst for Women's Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Inst for Women's Health > Reproductive Health
URI: https://discovery.ucl.ac.uk/id/eprint/8509
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