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Temperature Entrainment of Drosophila's Circadian Clock Involves the Gene nocte and Signaling from Peripheral Sensory Tissues to the Brain

Sehadova, H; Glaser, FT; Gentile, C; Simoni, A; Giesecke, A; Albert, JT; Stanewsky, R; (2009) Temperature Entrainment of Drosophila's Circadian Clock Involves the Gene nocte and Signaling from Peripheral Sensory Tissues to the Brain. Neuron , 64 (2) 251 - 266. 10.1016/j.neuron.2009.08.026. Green open access

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Abstract

Circadian clocks are synchronized by the natural day/night and temperature cycles. Our previous work demonstrated that synchronization by temperature is a tissue autonomous process, similar to synchronization by light. We show here that this is indeed the case, with the important exception of the brain. Using luciferase imaging we demonstrate that brain clock neurons depend on signals from peripheral tissues in order to be synchronized by temperature. Reducing the function of the gene nocte in chordotonal organs changes their structure and function and dramatically interferes with temperature synchronization of behavioral activity. Other mutants known to affect the function of these sensory organs also interfere with temperature synchronization, demonstrating the importance of nocte in this process and identifying the chordotonal organs as relevant sensory structures. Our work reveals surprising and important mechanistic differences between light- and temperature-synchronization and advances our understanding of how clock resetting is accomplished in nature.

Type: Article
Title: Temperature Entrainment of Drosophila's Circadian Clock Involves the Gene nocte and Signaling from Peripheral Sensory Tissues to the Brain
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.neuron.2009.08.026
Publisher version: http://dx.doi.org/10.1016/j.neuron.2009.08.026
Language: English
Additional information: Published under an Elsevier user license. This version is the version of record [delete as appropriate]. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Locomotor Rhythms, Constant Light, Compound Eyes, Neurons, Synchronization, Transcription, Cryptochrome, Transduction, Melanogaster, Oscillator
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > The Ear Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/84456
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