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T Cell Polarization at the Virological Synapse

Jolly, C; (2010) T Cell Polarization at the Virological Synapse. [Review]. Viruses , 2 (6) pp. 1261-1278. 10.3390/v2061261. Green open access

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Abstract

Cell-to-cell spread of HIV-1 between CD4+ T cells takes place at multimolecular structures called virological synapses. A defining feature of the virological synapse is polarization of viral assembly and budding at sites of T cell-T cell contact. Recent work is beginning to address how viral proteins are targeted to the virological synapse and the molecular mechanisms that regulate HIV-1 egress by cell-to-cell spread. This review discusses our current understanding of these processes and considers how T cell polarization during other forms of intercellular communication may provide insight into HIV-1 assembly and dissemination.

Type: Article
Title: T Cell Polarization at the Virological Synapse
Open access status: An open access version is available from UCL Discovery
DOI: 10.3390/v2061261
Publisher version: http://doi.org/10.3390/v2061261
Language: English
Additional information: Copyright © 2010 by the authors; licensee MDPI, Basel, Switzerland. This article is an Open Access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
Keywords: HIV; T cell; virological synapse; polarization; cytoskeleton; MTOC; secretion
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
URI: https://discovery.ucl.ac.uk/id/eprint/83615
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