Jolly, C;
(2010)
T Cell Polarization at the Virological Synapse.
[Review].
Viruses
, 2
(6)
pp. 1261-1278.
10.3390/v2061261.
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Abstract
Cell-to-cell spread of HIV-1 between CD4+ T cells takes place at multimolecular structures called virological synapses. A defining feature of the virological synapse is polarization of viral assembly and budding at sites of T cell-T cell contact. Recent work is beginning to address how viral proteins are targeted to the virological synapse and the molecular mechanisms that regulate HIV-1 egress by cell-to-cell spread. This review discusses our current understanding of these processes and considers how T cell polarization during other forms of intercellular communication may provide insight into HIV-1 assembly and dissemination.
| Type: | Article |
|---|---|
| Title: | T Cell Polarization at the Virological Synapse |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3390/v2061261 |
| Publisher version: | http://doi.org/10.3390/v2061261 |
| Language: | English |
| Additional information: | Copyright © 2010 by the authors; licensee MDPI, Basel, Switzerland. This article is an Open Access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
| Keywords: | HIV; T cell; virological synapse; polarization; cytoskeleton; MTOC; secretion |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/83615 |
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