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Serum amyloid P aids complement-mediated immunity to Streptococcus pneumoniae

Yuste, J.; Botto, M.; Bottoms, S.E.; Brown, J.S.; (2007) Serum amyloid P aids complement-mediated immunity to Streptococcus pneumoniae. PLoS Pathogens , 3 (9) , Article e120. 10.1371/journal.ppat.0030120. Green open access

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The physiological functions of the acute phase protein serum amyloid P (SAP) component are not well defined, although they are likely to be important, as no natural state of SAP deficiency has been reported. We have investigated the role of SAP for innate immunity to the important human pathogen Streptococcus pneumoniae. Using flow cytometry assays, we show that SAP binds to S. pneumoniae, increases classical pathway–dependent deposition of complement on the bacteria, and improves the efficiency of phagocytosis. As a consequence, in mouse models of infection, mice genetically engineered to be SAP-deficient had an impaired early inflammatory response to S. pneumoniae pneumonia and were unable to control bacterial replication, leading to the rapid development of fatal infection. Complement deposition, phagocytosis, and control of S. pneumoniae pneumonia were all improved by complementation with human SAP. These results demonstrate a novel and physiologically significant role for SAP for complement-mediated immunity against an important bacterial pathogen, and provide further evidence for the importance of the classical complement pathway for innate immunity.

Type: Article
Title: Serum amyloid P aids complement-mediated immunity to Streptococcus pneumoniae
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.ppat.0030120
Publisher version: http://dx.doi.org/10.1371/journal.ppat.0030120
Language: English
Additional information: © 2007 Yuste et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Nephrology
URI: https://discovery.ucl.ac.uk/id/eprint/8253
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