Schappi, MG;
Smith, VV;
Milla, PJ;
Lindley, KJ;
(2003)
Eosinophilic myenteric ganglionitis is associated with functional intestinal obstruction.
Gut
, 52
(5)
pp. 752-755.
10.1136/gut.52.5.752.
![[thumbnail of 8235.pdf]](https://discovery.ucl.ac.uk/style/images/fileicons/application_pdf.png) Preview |
PDF
8235.pdf Download (201kB) |
Abstract
The diagnostic features and clinical course of three children (aged 1 month to 15 years) with severe functional intestinal obstruction and inflammation of the colonic lamina propria and myenteric plexus are described. The myenteric inflammatory infiltrate was eosinophil predominant with none of the immunological characteristics of lymphocytic ganglionitis. Neurones in the myenteric ganglia expressed the potent eosinophil chemoattractant interleukin 5. None responded to dietary exclusion but all three responded symptomatically to immunosuppression/anti-inflammatory treatments. Eosinophilic ganglionitis is associated with a pseudo-obstructive syndrome which is amenable to anti-inflammatory treatment
| Type: | Article |
|---|---|
| Title: | Eosinophilic myenteric ganglionitis is associated with functional intestinal obstruction |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1136/gut.52.5.752 |
| Additional information: | DA - 20030414 IS - 0017-5749 LA - eng PT - Case Reports PT - Journal Article SB - AIM SB - IM |
| Keywords: | adolescent, Aged, Autonomic Nervous System Diseases, Biopsy, case report, characteristics, Child, children, clinical, complications, dietary, Eosinophilia, etiology, EXCLUSION, FEATURES, Female, functional, Ganglia, Ganglia, Autonomic, Gastrointestinal Motility, IM, Infant, Newborn, Inflammation, intestinal, intestinal mucosa, Intestinal Obstruction, LA, LAMINA PROPRIA, Myenteric Plexus, Neurones, Obstruction, pathology, physiology, physiopathology, POTENT, report, Stomach Diseases, Syndrome, treatment |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/8235 |
Archive Staff Only
 |
View Item |
