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Eosinophilic myenteric ganglionitis is associated with functional intestinal obstruction

Schappi, MG; Smith, VV; Milla, PJ; Lindley, KJ; (2003) Eosinophilic myenteric ganglionitis is associated with functional intestinal obstruction. Gut , 52 (5) pp. 752-755. 10.1136/gut.52.5.752. Green open access

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Abstract

The diagnostic features and clinical course of three children (aged 1 month to 15 years) with severe functional intestinal obstruction and inflammation of the colonic lamina propria and myenteric plexus are described. The myenteric inflammatory infiltrate was eosinophil predominant with none of the immunological characteristics of lymphocytic ganglionitis. Neurones in the myenteric ganglia expressed the potent eosinophil chemoattractant interleukin 5. None responded to dietary exclusion but all three responded symptomatically to immunosuppression/anti-inflammatory treatments. Eosinophilic ganglionitis is associated with a pseudo-obstructive syndrome which is amenable to anti-inflammatory treatment

Type: Article
Title: Eosinophilic myenteric ganglionitis is associated with functional intestinal obstruction
Open access status: An open access version is available from UCL Discovery
DOI: 10.1136/gut.52.5.752
Additional information: DA - 20030414 IS - 0017-5749 LA - eng PT - Case Reports PT - Journal Article SB - AIM SB - IM
Keywords: adolescent, Aged, Autonomic Nervous System Diseases, Biopsy, case report, characteristics, Child, children, clinical, complications, dietary, Eosinophilia, etiology, EXCLUSION, FEATURES, Female, functional, Ganglia, Ganglia, Autonomic, Gastrointestinal Motility, IM, Infant, Newborn, Inflammation, intestinal, intestinal mucosa, Intestinal Obstruction, LA, LAMINA PROPRIA, Myenteric Plexus, Neurones, Obstruction, pathology, physiology, physiopathology, POTENT, report, Stomach Diseases, Syndrome, treatment
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept
URI: https://discovery.ucl.ac.uk/id/eprint/8235
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