UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Allergic skin rash with lamotrigine and concomitant valproate therapy - Evidence for an increased risk

Li, LM; Russo, M; ODonoghue, MF; Duncan, JS; Sander, JWAS; (1996) Allergic skin rash with lamotrigine and concomitant valproate therapy - Evidence for an increased risk. ARQ NEURO-PSIQUIAT , 54 (1) 47 - 49. 10.1590/S0004-282X1996000100008. Green open access

[thumbnail of 08.pdf]
Preview
PDF
08.pdf

Download (284kB)

Abstract

Cutaneous rash is one of the commonest adverse events associated with lamotrigine. We assessed whether the risk is increased in patients receiving concomitant valproate therapy in a population of 103 adult patients with intractable epilepsy, who had lamotrigine added to their treatment. Of the 33 patients taking valproate, 10 (30%) developed a rash, whilst of the 70 not taking valproate, only 6 (8%) developed a rash. This suggests a significantly higher risk of cutaneous rash when starting lamotrigine in patients already taking valproate (p<0.02).

Type: Article
Title: Allergic skin rash with lamotrigine and concomitant valproate therapy - Evidence for an increased risk
Open access status: An open access version is available from UCL Discovery
DOI: 10.1590/S0004-282X1996000100008
Publisher version: http://dx.doi.org/10.1590/S0004-282X1996000100008
Language: English
Additional information: All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License.
Keywords: allergic skin rash, antiepileptic drugs, lamotrigine, valproate
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy
URI: https://discovery.ucl.ac.uk/id/eprint/81207
Downloads since deposit
201Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item