Trevisol-Bittencourt, PC;
Sander, JW;
Silvado, CS;
Wittig, EO;
(1991)
Ketoconazole in the treatment of cryptococcosis of the central nervous system.
Arquivos de neuro-psiquiatria
, 49
(2)
208 - 210.
10.1590/S0004-282X1991000200016.
![[thumbnail of 16.pdf]](https://discovery.ucl.ac.uk/style/images/fileicons/application_pdf.png) Preview |
PDF
16.pdf Available under License : See the attached licence file. Download (34kB) |
Abstract
Two patients with cryptococcosis of the CNS were treated with ketoconazole (KTZ), an imidazole derivative with fungistatic properties; they had either failed standard therapy (Amphotericin-B + 5-Flurocytosine) or suffred intolerable side-effects to it. Both patients were administered KTZ 800 mg/day as monotherapy for six months without interruption and both responded. One month after KTZ therapy was withdrawn, however, a relapse of the infection was seen in one case. Side-effects were minimal during the trial of treatment. KTZ could be a useful drug in some cases of neurocryptococcosis.
Archive Staff Only
 |
View Item |
