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Ketoconazole in the treatment of cryptococcosis of the central nervous system.

Trevisol-Bittencourt, PC; Sander, JW; Silvado, CS; Wittig, EO; (1991) Ketoconazole in the treatment of cryptococcosis of the central nervous system. Arquivos de neuro-psiquiatria , 49 (2) 208 - 210. 10.1590/S0004-282X1991000200016. Green open access

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Abstract

Two patients with cryptococcosis of the CNS were treated with ketoconazole (KTZ), an imidazole derivative with fungistatic properties; they had either failed standard therapy (Amphotericin-B + 5-Flurocytosine) or suffred intolerable side-effects to it. Both patients were administered KTZ 800 mg/day as monotherapy for six months without interruption and both responded. One month after KTZ therapy was withdrawn, however, a relapse of the infection was seen in one case. Side-effects were minimal during the trial of treatment. KTZ could be a useful drug in some cases of neurocryptococcosis.

Type: Article
Title: Ketoconazole in the treatment of cryptococcosis of the central nervous system.
Open access status: An open access version is available from UCL Discovery
DOI: 10.1590/S0004-282X1991000200016
Publisher version: http://dx.doi.org/10.1590/S0004-282X1991000200016
Language: English
Additional information: All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy
URI: https://discovery.ucl.ac.uk/id/eprint/81149
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