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Association of drusen deposition with choroidal intercapillary pillars in the aging human eye

Lengyel, I; Tufail, A; Al Hosaini, H; Luthert, P; Bird, AC; Jeffery, G; (2004) Association of drusen deposition with choroidal intercapillary pillars in the aging human eye. INVEST OPHTH VIS SCI , 45 (9) 2886 - 2892. 10.1167/iovs.03-1083. Green open access

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Abstract

PURPOSE. To determine the pattern of drusen accumulation with age and to investigate the initial sites of deposition and their relationship to choroidal capillaries in human donor eyes from the eye bank of Moorfields Eye Hospital.METHODS. Wholemounted, hydrated preparations of the choriocapillaris and Bruch's membrane from donor eyes ranging from 42 to 95 years, with or without retinal pigment epithelium (RPE), were examined by conventional and confocal microscopy. Drusen were visualized by their autofluorescence.RESULTS. In all age groups studied autofluorescent drusen were present at the equator but were not found centrally where the vascular architecture is different, being tubular rather than a honeycomb pattern. Autofluorescing drusen were strongly associated with the lateral walls of the choriocapillaris (an area commonly known as the intercapillary pillars of the choriocapillaris (P = 0.028; Wilcoxon signed ranks test). Nonfluorescing drusen were occasionally seen centrally, but were not easily identified, and because of their large size, their localization with respect to capillary walls was not possible.CONCLUSIONS. These results strongly support the notion that autofluorescent drusen are not randomly distributed and have a specific spatial relationship to choroidal vessel walls. That equatorial drusen fluoresce, whereas central drusen do not, suggests that they may have different chemical compositions at the two sites and possibly different significance in age-related macular disease.

Type: Article
Title: Association of drusen deposition with choroidal intercapillary pillars in the aging human eye
Open access status: An open access version is available from UCL Discovery
DOI: 10.1167/iovs.03-1083
Keywords: RETINAL-PIGMENT EPITHELIUM, AGE-RELATED MACULOPATHY, SCANNING ELECTRON-MICROSCOPY, MACULAR DEGENERATION, BRUCHS MEMBRANE, COMPLEMENT ACTIVATION, POSTMORTEM EYES, VITRONECTIN GENE, OCULAR DRUSEN, RISK-FACTORS
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/8034
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