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The differential diagnosis of chorea

Wild, EJ; Tabrizi, SJ; (2007) The differential diagnosis of chorea. Practical Neurology , 7 (6) 360 - 373. 10.1136/pn.2007.134585. Green open access

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Abstract

Chorea is a hyperkinetic movement disorder characterised by excessive spontaneous movements that are irregularly timed, randomly distributed and abrupt. In this article, the authors discuss the causes of chorea, particularly Huntington's disease and the genetic syndromes that may resemble it, including HDL1-3, inherited prion disease, spinocerebellar ataxias 1, 3 and 17, neuroacanthocytosis, dentatorubro-pallidoluysian atrophy (DRPLA), brain iron accumulation disorders, Wilson's disease, benign hereditary chorea, Friedreich's ataxia and mitochondrial disease. Acquired causes of chorea include vascular disease, post-infective autoimmune central nervous system disorders (PANDAS), drugs, systemic lupus erythematosus, antiphospholipid syndrome, thyrotoxicosis, AIDS, chorea gravidarum, and polycythaemia rubra vera. The authors suggest an approach to the clinical assessment of chorea, the value of investigations, including genetic tests (for which they offer a structured framework highlighting the importance of prior counselling), and finally briefly discuss symptomatic drug treatment of chorea.

Type: Article
Title: The differential diagnosis of chorea
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1136/pn.2007.134585
Publisher version: http://dx.doi.org/10.1136/pn.2007.134585
Language: English
Keywords: Anti-Dyskinesia Agents, Autoimmune Diseases of the Nervous System, Basal Ganglia Diseases, Brain Diseases, Metabolic, Chorea, Diagnosis, Differential, Genetic Counseling, Genetic Predisposition to Disease, Humans, Huntington Disease, Neurologic Examination
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/80093
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