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Circulating humoral factors and endothelial progenitor cells in patients with differing coronary collateral support

Lambiase, PD; Edwards, RJ; Anthopoulos, P; Rahman, S; Meng, YG; Bucknall, CA; Redwood, SR; ... Marber, MS; + view all (2004) Circulating humoral factors and endothelial progenitor cells in patients with differing coronary collateral support. CIRCULATION , 109 (24) 2986 - 2992. 10.1161/01.CIR.0000130639.97284.EC. Green open access

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Abstract

Background - The mechanisms underlying the variation in collateral formation between patients, even with similar patterns of coronary artery disease, remain unclear. This study investigates whether circulating humoral or cellular factors can provide an insight into this variation.Methods and Results - Thirty patients with isolated left anterior descending coronary artery disease underwent percutaneous coronary intervention with collateral flow index (CFI) determined using a pressure wire. Patients with inadequate ( CFI < 0.25) compared with those with adequate ( CFI &GE; 0.25) collateral support had, or tended to have, lower concentrations of coronary sinus growth factors and plasma exerting a weaker effect on endothelial cell migration and angiogenesis in vitro. However, there was an inverse correlation between serum mitogenicity and CFI ( r = - 0.61, P < 0.01). No significant differences were detected between the 2 groups in plasma levels of total vascular endothelial growth factor, vascular endothelial growth factor(165), or placental growth factor. There was a strong positive correlation between numbers of CD34/CD133-positive circulating hemopoietic precursor cells and CFI ( r = 0.75, P < 0.001). In patients with inadequate, compared with those with adequate, CFI, the numbers of differentiated endothelial progenitor cells (EPCs) appearing in the circulation and in culture were significantly reduced by 75% ( P < 0.05) and 70% ( P < 0.05), respectively.Conclusions - In this study, inadequate coronary collateral development is associated with reduced numbers of circulating EPCs and impaired chemotactic and proangiogenic but not mitogenic activity. These findings are consistent with current efforts to enhance collateral formation by augmentation of circulating EPCs.

Type: Article
Title: Circulating humoral factors and endothelial progenitor cells in patients with differing coronary collateral support
Open access status: An open access version is available from UCL Discovery
DOI: 10.1161/01.CIR.0000130639.97284.EC
Keywords: collateral circulation, angiogenesis, coronary disease, ARTERY-DISEASE, BLOOD-FLOW, POSTNATAL NEOVASCULARIZATION, ANGIOGENESIS, GROWTH, TRANSPLANTATION, EXPRESSION, INCREASE, PATHWAYS, THERAPY
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Clinical Science
URI: https://discovery.ucl.ac.uk/id/eprint/7831
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