Goldblatt, D;
Hussain, M;
Andrews, N;
Ashton, L;
Virta, C;
Melegaro, A;
Pebody, R;
... Miller, E; + view all
(2005)
Antibody responses to nasopharyngeal carriage of Streptococcus pneumoniae in adults: A longitudinal household study.
JOURNAL OF INFECTIOUS DISEASES
, 192
(3)
387 - 393.
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Abstract
Background. Natural immunity to Streptococcus pneumoniae is thought to be induced by exposure to S. pneumoniae or cross-reactive antigens. No longitudinal studies of carriage of and immune responses to S. pneumoniae have been conducted using sophisticated immunological laboratory techniques.Methods. We enrolled 121 families with young children into this study. Nasopharyngeal (NP) swabs were collected monthly for 10 months from all family members and were cultured in a standard fashion. Cultured S. pneumoniae isolates were serotyped. At the beginning (month 0) and end (month 10) of the study, venous blood was collected from family members 118 years old. Serotype-specific antipolysaccharide immunoglobulin G (IgG) and functional antibody and antibodies to pneumolysin, pneumococcal surface protein A (PspA), and pneumococcal surface antigen A (PsaA) were measured in paired serum samples.Results. Levels of anticapsular IgG increased significantly after carriage of serotypes 9V, 14, 18C, 19F, and 23F by an individual or family member. For serotype 14, a higher level of anticapsular IgG at the beginning of the study was associated with reduced odds of carriage (P = .0006). There was a small (similar to 20%) but significant increase in titers of antibodies to PsaA and pneumolysin but no change in titers of antibody to PspA.Conclusions. Adults respond to NP carriage by mounting anticapsular and weak antiprotein antibody responses, and naturally induced anticapsular IgG can prevent carriage.
| Type: | Article |
|---|---|
| Title: | Antibody responses to nasopharyngeal carriage of Streptococcus pneumoniae in adults: A longitudinal household study |
| Location: | Helsinki, FINLAND |
| Open access status: | An open access version is available from UCL Discovery |
| Keywords: | PNEUMOCOCCAL CAPSULAR POLYSACCHARIDES, LINKED-IMMUNOSORBENT-ASSAY, SURFACE PROTEIN-A, INDUCE SALIVARY ANTIBODIES, ACUTE OTITIS-MEDIA, CONJUGATE VACCINE, NATURAL DEVELOPMENT, ADHESIN-A, CHILDREN, COLONIZATION |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/7766 |
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