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High resolution MRI of the brain at 4.7 Tesla using fast spin echo imaging

De Vita, E.; Thomas, D.L.; Roberts, S.; Parkes, H.G.; Turner, R.; Kinchesh, P.; Shmueli, K.; ... Ordidge, R.J.; + view all (2003) High resolution MRI of the brain at 4.7 Tesla using fast spin echo imaging. British Journal of Radiology , 76 (909) pp. 631-637. 10.1259/bjr/69317841. Green open access

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Abstract

Over recent years, high field MR scanners (3 T and above) have become increasingly widespread due to potential advantages such as higher signal-to-noise ratio. However, few examples of high resolution images covering the whole brain in reasonable acquisition times have been published to date and none have used fast spin echo (FSE), a sequence commonly employed for the acquisition of T2 weighted images at 1.5 T. This is mostly due to the increased technical challenges associated with uniform signal generation and the increasingly restrictive constraints of current safety guidelines at high field. We investigated 10 volunteers using an FSE sequence optimized to the 4.7 T environment. This sequence allows the acquisition of 17- and 34-slice data sets with an in-plane resolution of approximately 500 µm x 500 µm and a slice thickness of 2 mm, in 5 min 40 s and 11 min 20 s, respectively. The images appear T2 weighted, although the contrast is due to the combined effects of chosen echo time, magnetization transfer, direct radio frequency saturation and diffusion as well as the T1 and T2 relaxation times of the tissue. The result is an excellent detailed visualization of anatomical structures, demonstrating the great potential of 4.7 T MRI for clinical applications. This paper shows that, with careful optimization of sequence parameters, FSE imaging can be used at high field to generate images with high spatial resolution and uniform contrast across the whole brain within the prescribed power deposition limits.

Type: Article
Title: High resolution MRI of the brain at 4.7 Tesla using fast spin echo imaging
Open access status: An open access version is available from UCL Discovery
DOI: 10.1259/bjr/69317841
Publisher version: http://dx.doi.org/10.1259/bjr/69317841
Language: English
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neuroinflammation
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Institute of Cognitive Neuroscience
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation
URI: https://discovery.ucl.ac.uk/id/eprint/7683
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