Strange, BA;
Dolan, RJ;
(2007)
Beta-adrenergic modulation of oddball responses in humans.
Behavioral and Brain Functions
, 3
, Article 29. 10.1186/1744-9081-3-29.
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Abstract
Detection of salient or motivationally significant stimuli is of adaptive importance. The neurophysiological correlates of this detection have been extensively studied in 'oddball' paradigms. Much theoretical data supports the role of noradrenergic systems in generating oddball responses. We combine psychopharmacology and functional neuroimaging to demonstrate modulation of neuronal responses to oddball nouns by the beta-adrenergic antagonist propranolol. Critically, responses in regions implicated in oddball detection, namely right ventrolateral prefrontal cortex and temporoparietal junction (TPJ), were abolished by propranolol. Thus, oddball responses depend on modulatory adrenergic inputs, mediated via beta-adrenergic receptors.
| Type: | Article |
|---|---|
| Title: | Beta-adrenergic modulation of oddball responses in humans |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1186/1744-9081-3-29 |
| Publisher version: | http://dx.doi.org/10.1186/1744-9081-3-29 |
| Language: | English |
| Additional information: | © 2007 Strange and Dolan; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Locus-coeruleus neurons, Potentials, Stimuli, Cortex, Brain, P3 |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience |
| URI: | https://discovery.ucl.ac.uk/id/eprint/74623 |
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