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The genetic architecture of Alzheimer's disease: beyond APP, PSENs and APOE.

Guerreiro, RJ; Gustafson, DR; Hardy, J; (2012) The genetic architecture of Alzheimer's disease: beyond APP, PSENs and APOE. Neurobiology of Disease , 33 (3) 437 - 456. 10.1016/j.neurobiolaging.2010.03.025. Green open access

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Abstract

Alzheimer's disease (AD) is a complex disorder with a clear genetic component. Three genes have been identified as the cause of early onset familial AD (EOAD). The most common form of the disease, late onset Alzheimer's disease (LOAD), is, however, a sporadic one presenting itself in later stages of life. The genetic component of this late onset form of AD has been the target of a large number of studies, because only one genetic risk factor (APOE4) has been consistently associated with the disease. However, technological advances allow new approaches in the study of complex disorders. In this review, we discuss the new results produced by genome wide association studies, in light of the current knowledge of the complexity of AD genetics.

Type: Article
Title: The genetic architecture of Alzheimer's disease: beyond APP, PSENs and APOE.
Location: US
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.neurobiolaging.2010.03.025
Publisher version: http://dx.doi.org/10.1016/j.neurobiolaging.2010.03...
Language: English
Additional information: This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. PMCID: PMC2980860
Keywords: Alzheimer Disease, Amyloid beta-Protein Precursor, Animals, Apolipoproteins E, Humans, Presenilin-1, Presenilin-2
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/741327
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