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An appraisal of the histopathological assessment of liver fibrosis

Standish, R.A.; Cholongitas, E.; Dhillon, A.; Burroughs, A.K.; Dhillon, A.P.; (2006) An appraisal of the histopathological assessment of liver fibrosis. Gut , 55 (4) pp. 569-578. 10.1136/gut.2005.084475. Green open access

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Abstract

One of the most important aspects of the histopathological assessment of liver biopsies in the setting of chronic liver disease is determination of the degree of fibrosis and architectural change. Most of the work in this regard has been concerned with chronic viral hepatitis. This article attempts to assess critically our current and historical biopsy practice, from subjective fibrosis scoring systems to biopsy sample size; and the appropriate use of the data that scoring systems generate in the research and clinical setting. An understanding of the limitations of each of the components of the fibrosis assessment process can help to devise appropriate protocols to ensure that the information obtained is optimised, and its degree of reliability appreciated. It is only from this starting point that recently promulgated antifibrotic medications and "non-invasive" liver fibrosis assessment techniques can be evaluated properly.

Type: Article
Title: An appraisal of the histopathological assessment of liver fibrosis
Open access status: An open access version is available from UCL Discovery
DOI: 10.1136/gut.2005.084475
Publisher version: http://dx.doi.org/10.1136/gut.2005.084475
Language: English
Keywords: Liver, biopsy adequacy, fibrosis, computer assisted image analysis
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Nephrology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Pathology
URI: https://discovery.ucl.ac.uk/id/eprint/7391
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