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Neuroanatomical dissociation of encoding processes related to priming and explicit memory

Schott, B.H.; Richardson-Klavehn, A.; Henson, R.N.A.; Becker, C.; Heinze, H.-J.; Düzel, E.; (2006) Neuroanatomical dissociation of encoding processes related to priming and explicit memory. Journal of Neuroscience , 26 (3) pp. 792-800. 10.1523/JNEUROSCI.2402-05.2006. Green open access

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Abstract

Priming is a facilitation of cognitive processing with stimulus repetition that can occur without explicit memory. Whereas the functional neuroanatomy of perceptual priming at retrieval is established, encoding processes that initiate priming and explicit memory have not yet been anatomically separated, and we investigated them using event-related functional magnetic resonance imaging. Activations predicting later explicit memory occurred in the bilateral medial temporal lobe (MTL) and left prefrontal cortex (PFC). Activity predicting later priming did not occur in these areas, but rather in the bilateral extrastriate cortex, left fusiform gyrus, and bilateral inferior PFC, areas linked with stimulus identification. Surprisingly, these regions showed response reductions. Our results demonstrate that priming and explicit memory have distinct functional neuroanatomies at encoding, with MTL activations being specific for explicit memory, and suggest that priming is initiated by sharpness of neural responding in stimulus identification areas, consistent with recent electrophysiological evidence regarding priming-related neural oscillations at encoding. We tentatively suggest that this sharpened responding at encoding may set the stage for increased neural processing efficiency at retrieval, with these different neural mechanisms both leading to observed priming-related hemodynamic decreases, and argue that neural measurements at encoding, and not just at retrieval, will be critical in resolving the debate about the neural mechanisms of learning that underlie priming.

Type: Article
Title: Neuroanatomical dissociation of encoding processes related to priming and explicit memory
Open access status: An open access version is available from UCL Discovery
DOI: 10.1523/JNEUROSCI.2402-05.2006
Publisher version: http://dx.doi.org/10.1523/JNEUROSCI.2402-05.2006
Language: English
Additional information: Published by the Society of Neuroscience This work is licensed under the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. The license allows you to copy, distribute, and transmit the work, as well as adapting it. However, you must attribute the work to the author (but not in any way that suggests that they endorse you or your use of the work), and cannot use the work for commercial purposes without prior permission of the author. If you alter or build upon this work, you can distribute the resulting work only under the same or similar license to this one. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ or send a letter to Creative Commons, 444 Castro Street, Suite 900, Mountain View, California, 94041, USA.
Keywords: Priming, explicit memory, encoding, event-related fMRI, medial temporal lobe, extrastriate cortex, fusiform gyrus, prefrontal cortex
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Institute of Cognitive Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/7339
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