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New synthesis of KT5823 indolocarbazole aglycone

Burtin, GE; Madge, DJ; Selwood, DL; (2000) New synthesis of KT5823 indolocarbazole aglycone. Heterocycles , 53 (10) 2119 -2122. 10.3987/COM-00-8992. Green open access

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Abstract

The indolo[2,3-a]pyrrolo[3,4-c]carbazole aglycone of the selective protein kinase G inhibitor KT5823 has been synthesised in four steps and 36% overall yield from 2,3-dichloro-N-methylmaleimide by utilising an efficient new two step reduction sequence for the key imide to amide transformation.

Type: Article
Title: New synthesis of KT5823 indolocarbazole aglycone
Open access status: An open access version is available from UCL Discovery
DOI: 10.3987/COM-00-8992
Publisher version: https://doi.org/10.3987/COM-00-8992
Language: English
Additional information: This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Wolfson Inst for Biomedical Research
URI: https://discovery.ucl.ac.uk/id/eprint/73048
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