Burtin, GE;
Madge, DJ;
Selwood, DL;
(2000)
New synthesis of KT5823 indolocarbazole aglycone.
Heterocycles
, 53
(10)
2119 -2122.
10.3987/COM-00-8992.
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Abstract
The indolo[2,3-a]pyrrolo[3,4-c]carbazole aglycone of the selective protein kinase G inhibitor KT5823 has been synthesised in four steps and 36% overall yield from 2,3-dichloro-N-methylmaleimide by utilising an efficient new two step reduction sequence for the key imide to amide transformation.
| Type: | Article |
|---|---|
| Title: | New synthesis of KT5823 indolocarbazole aglycone |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3987/COM-00-8992 |
| Publisher version: | https://doi.org/10.3987/COM-00-8992 |
| Language: | English |
| Additional information: | This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Wolfson Inst for Biomedical Research |
| URI: | https://discovery.ucl.ac.uk/id/eprint/73048 |
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