UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Novel IL10 gene family associations with systemic juvenile idiopathic arthritis

Fife, MS; Gutierrez, A; Ogilvie, EM; Stock, CJW; Samuel, JM; Thomson, W; Mack, LF; ... Woo, P; + view all (2006) Novel IL10 gene family associations with systemic juvenile idiopathic arthritis. ARTHRITIS RES THER , 8 (5) , Article R148. 10.1186/ar2041. Green open access

[thumbnail of 7172.pdf]
Preview
PDF
7172.pdf

Download (160kB)

Abstract

Juvenile idiopathic arthritis (JIA) is the most common cause of chronic childhood disability and encompasses a number of disease subgroups. In this study we have focused on systemic JIA (sJIA), which accounts for approximately 11% of UK JIA cases. This study reports the investigation of three members of the IL10 gene family as candidate susceptibility loci in children with sJIA. DNA from 473 unaffected controls and 172 patients with sJIA was genotyped for a single nucleotide polymorphism (SNP) in IL19 and IL20 and two SNPs in IL10. We examined evidence for association of the four SNPs by single marker and haplotype analysis. Significant differences in allele frequency were observed between cases and controls, for both IL10-1082 (p = 0.031) and IL20-468 (p = 0.028). Furthermore, examination of the haplotypes of IL10-1082 and IL20-468 revealed greater evidence for association (global p = 0.0006). This study demonstrates a significant increased prevalence of the low expressing IL10-1082 genotype in patients with sJIA. In addition, we show a separate association with an IL20 polymorphism, and the IL10-1082A/IL20-468T haplotype. The two marker 'A-T' haplotype confers an odds ratio of 2.24 for sJIA. This positive association suggests an important role for these cytokines in sJIA pathogenesis.

Type: Article
Title: Novel IL10 gene family associations with systemic juvenile idiopathic arthritis
Open access status: An open access version is available from UCL Discovery
DOI: 10.1186/ar2041
Keywords: SERUM INTERLEUKIN-6 LEVELS, RHEUMATOID-ARTHRITIS, T-CELLS, JOINT INVOLVEMENT, CYTOKINES IL-19, HAPLOTYPES, POLYMORPHISMS, RECEPTOR, IL-24, TRANSCRIPTION
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
URI: https://discovery.ucl.ac.uk/id/eprint/7172
Downloads since deposit
157Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item