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Treatment of head and neck cancer with photodynamic therapy: results after one year

Dilkes, MG; DeJode, ML; Gardiner, Q; Kenyon, GS; McKelvie, P; (1995) Treatment of head and neck cancer with photodynamic therapy: results after one year. Journal of Laryngology and Otology , 109 (11) 1072 - 1076. 10.1017/S0022215100132050. Green open access

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Abstract

Photodynamic therapy (PDT) is a new and promising treatment modality for the treatment of malignant disease. This paper reports the preliminary experience of our group in the use of this therapy for the treatment of tumours arising in the head and neck. The majority of treatments in these cases have used a second generation systemic photosensitizer, meta-tetrahydroxyphenylchlorin (m-THPC). Two other cases were treated with either Photofrin 2 (a first generation systemic sensitizer) or with the topical photosensitizer, delta-aminolaevulinic acid (delta-ALA).The initial results have been encouraging with good clinical responses evident in patients presenting with a variety of differing tumour types. We feel there is now sufficient evidence of the efficacy of this treatment to warrant a multicentre prospective study into the treatment of early head and neck cancer with PDT.

Type: Article
Title: Treatment of head and neck cancer with photodynamic therapy: results after one year
Open access status: An open access version is available from UCL Discovery
DOI: 10.1017/S0022215100132050
Publisher version: http://dx.doi.org/10.1017/S0022215100132050
Language: English
Additional information: Copyright Cambridge University Press 1995
Keywords: Head and neck neoplasms, Photochemotherapy, Carcinoma
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of the Built Environment
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of the Built Environment > Centre for Advanced Spatial Analysis
URI: https://discovery.ucl.ac.uk/id/eprint/68146
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