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A molecular map of mesenchymal tumors

Henderson, SR; Guiliano, D; Presneau, N; McLean, S; Frow, R; Vujovic, S; Anderson, J; ... Boshoff, C; + view all (2005) A molecular map of mesenchymal tumors. GENOME BIOL , 6 (9) , Article R76. 10.1186/gb-2005-6-9-r76. Green open access

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Abstract

Background: Bone and soft tissue tumors represent a diverse group of neoplasms thought to derive from cells of the mesenchyme or neural crest. Histological diagnosis is challenging due to the poor or heterogenous differentiation of many tumors, resulting in uncertainty over prognosis and appropriate therapy.Results: We have undertaken a broad and comprehensive study of the gene expression profile of 96 tumors with representatives of all mesenchymal tissues, including several problem diagnostic groups. Using machine learning methods adapted to this problem we identify molecular fingerprints for most tumors, which are pathognomonic (decisive) and biologically revealing.Conclusion: We demonstrate the utility of gene expression profiles and machine learning for a complex clinical problem, and identify putative origins for certain mesenchymal tumors.

Type: Article
Title: A molecular map of mesenchymal tumors
Open access status: An open access version is available from UCL Discovery
DOI: 10.1186/gb-2005-6-9-r76
Publisher version: http://www.ncbi.nlm.nih.gov/pmc/ articles/PMC12422...
Keywords: GENE-EXPRESSION PROFILES, SOFT-TISSUE SARCOMAS, NERVE SHEATH TUMORS, EWINGS-SARCOMA, SYNOVIAL SARCOMA, HUMAN OSTEOSARCOMA, CDNA MICROARRAYS, COPY NUMBER, CELL-LINES, TRANSLOCATION
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Cancer Bio
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Pathology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Population, Policy and Practice Dept
URI: https://discovery.ucl.ac.uk/id/eprint/6812
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