Henderson, SR; Guiliano, D; Presneau, N; McLean, S; Frow, R; Vujovic, S; Anderson, J; ... Boshoff, C; + view all Henderson, SR; Guiliano, D; Presneau, N; McLean, S; Frow, R; Vujovic, S; Anderson, J; Sebire, N; Whelan, J; Athanasou, N; Flanagan, AM; Boshoff, C; - view fewer (2005) A molecular map of mesenchymal tumors. GENOME BIOL , 6 (9) , Article R76. 10.1186/gb-2005-6-9-r76.

Preview

PDF 6812.pdf Download (314kB)

Abstract

Background: Bone and soft tissue tumors represent a diverse group of neoplasms thought to derive from cells of the mesenchyme or neural crest. Histological diagnosis is challenging due to the poor or heterogenous differentiation of many tumors, resulting in uncertainty over prognosis and appropriate therapy.Results: We have undertaken a broad and comprehensive study of the gene expression profile of 96 tumors with representatives of all mesenchymal tissues, including several problem diagnostic groups. Using machine learning methods adapted to this problem we identify molecular fingerprints for most tumors, which are pathognomonic (decisive) and biologically revealing.Conclusion: We demonstrate the utility of gene expression profiles and machine learning for a complex clinical problem, and identify putative origins for certain mesenchymal tumors.

Download activity - last month

Export as CSVJSONXML

Download activity - last 12 months

Export as CSVJSONXML

Downloads by country - last 12 months

Export as CSVJSONXML

Archive Staff Only

View Item