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Management and prevention of chronic obstructive pulmonary disease exacerbations: a state of the art review

Hurst, JR; Wedzicha, JA; (2009) Management and prevention of chronic obstructive pulmonary disease exacerbations: a state of the art review. BMC Medicine , 7 , Article 40. 10.1186/1741-7015-7-40. Green open access

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Abstract

Exacerbations of chronic obstructive pulmonary disease (COPD) are important events in the natural history of this prevalent and devastating condition. This review provides a concise, state of the art summary on prevention and management of exacerbations. Considerable new data underpins evidence in support of many preventative interventions, pharmacological and non-pharmacological, that are now available. Challenges remain in developing new approaches, and delivering those that already exist to the right patient at the right time. Management of an exacerbation remains stepwise according to clinical severity, but there is now additional focus on addressing comorbidities and taking the opportunity at acute events to optimise preventative strategies for the future. Ultimately, exacerbations are heterogeneous events in a heterogeneous disease, and an individualised approach is paramount.

Type: Article
Title: Management and prevention of chronic obstructive pulmonary disease exacerbations: a state of the art review
Open access status: An open access version is available from UCL Discovery
DOI: 10.1186/1741-7015-7-40
Publisher version: http://dx.doi.org/10.1186/1741-7015-7-40
Language: English
Additional information: © 2009 Hurst and Wedzicha; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: randomized controlled-trial, antibiotic-treatment, chronic-bronchitis, risk-factors, COPD, therapy, rehabilitation, metaanalysis, tiotropium, ventilation
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Internal Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/62666
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