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Patterns of regional brain hypometabolism associated with knowledge of semantic features and categories in Alzheimer's disease

Zahn, R.; Garrard, P.; Talazko, J.; Gondan, M.; Bubrowski, P.; Juengling, F.; Slawik, S.; ... Hull, M.; + view all (2006) Patterns of regional brain hypometabolism associated with knowledge of semantic features and categories in Alzheimer's disease. Journal of Cognitive Neuroscience , 18 (12) pp. 2138-2151. 10.1162/jocn.2006.18.12.2138. Green open access

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Abstract

The study of semantic memory in patients with Alzheimer's disease (AD) has raised important questions about the representation of conceptual knowledge in the human brain. It is still unknown whether semantic memory impairments are caused by localized damage to specialized regions or by diffuse damage to distributed representations within nonspecialized brain areas. To our knowledge, there have been no direct correlations of neuroimaging of in vivo brain function in AD with performance on tasks differentially addressing visual and functional knowledge of living and nonliving concepts. We used a semantic verification task and resting 18-fluorodeoxyglucose positron emission tomography in a group of mild to moderate AD patients to investigate this issue. The four task conditions required semantic knowledge of (1) visual, (2) functional properties of living objects, and (3) visual or (4) functional properties of nonliving objects. Visual property verification of living objects was significantly correlated with left posterior fusiform gyrus metabolism (Brodmann's area [BA] 37/19). Effects of visual and functional property verification for non-living objects largely overlapped in the left anterior temporal (BA 38/20) and bilateral premotor areas (BA 6), with the visual condition extending more into left lateral precentral areas. There were no associations with functional property verification for living concepts. Our results provide strong support for anatomically separable representations of living and nonliving concepts, as well as visual feature knowledge of living objects, and against distributed accounts of semantic memory that view visual and functional features of living and nonliving objects as distributed across a common set of brain areas.

Type: Article
Title: Patterns of regional brain hypometabolism associated with knowledge of semantic features and categories in Alzheimer's disease
Open access status: An open access version is available from UCL Discovery
DOI: 10.1162/jocn.2006.18.12.2138
Publisher version: http://dx.doi.org/10.1162/jocn.2006.18.12.2138
Language: English
Additional information: © 2006 Massachusetts Institute of Technology
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Institute of Cognitive Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/6036
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