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Relationship between hippocampal structure and memory function in elderly humans

Schiltz, K; Szentkuti, A; Guderian, S; Kaufmann, J; Munte, TF; Heinze, HJ; Duzel, E; (2006) Relationship between hippocampal structure and memory function in elderly humans. J COGNITIVE NEUROSCI , 18 (6) 990 - 1003. Green open access

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Abstract

With progressing age, the ability to recollect personal events declines, whereas familiarity-based memory remains relatively intact. It has been hypothesized that age-related hippocampal atrophy may contribute to this pattern because of its critical role for recollection in younger humans and after acute injury. Here, we show that hippocampal volume loss in healthy older persons correlates with gray matter loss (estimated with voxel-based morphometry) of the entire limbic system and shows no correlation with an electrophysiological (event-related potential [ERP]) index of recollection. Instead, it covaries with more substantial and less specific electrophysiological changes of stimulus processing. Age-related changes in another complementary structural measure, hippocampal diffusion, on the other hand, seemed to be more regionally selective and showed the expected correlation with the ERP index of recollection. Thus, hippocampal atrophy in older persons accompanies limbic atrophy, and its functional impact on memory is more fundamental than merely affecting recollection.

Type: Article
Title: Relationship between hippocampal structure and memory function in elderly humans
Open access status: An open access version is available from UCL Discovery
Keywords: MILD COGNITIVE IMPAIRMENT, EVENT-RELATED POTENTIALS, VOXEL-BASED MORPHOMETRY, TEMPORAL-LOBE EPILEPSY, PARTIAL LEAST-SQUARES, AGE-RELATED-CHANGES, RECOGNITION MEMORY, ALZHEIMERS-DISEASE, PARAHIPPOCAMPAL CORTICES, SPATIOTEMPORAL ANALYSIS
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Institute of Cognitive Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/5989
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