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Fragments of a larger whole: Retrieval cues constrain observed neural correlates of memory encoding

Otten, LJ; (2007) Fragments of a larger whole: Retrieval cues constrain observed neural correlates of memory encoding. CEREB CORTEX , 17 (9) 2030 - 2038. 10.1093/cercor/bhl111. Green open access

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Abstract

Laying down a new memory involves activity in a number of brain regions. Here, it is shown that the particular regions associated with successful encoding depend on the way in which memory is probed. Event-related functional magnetic resonance imaging signals were acquired while subjects performed an incidental encoding task on a series of visually presented words denoting objects. A recognition memory test using the Remember/Know procedure to separate responses based on recollection and familiarity followed 1 day later. Critically, half of the studied objects were cued with a corresponding spoken word, and half with a corresponding picture. Regardless of cue, activity in prefrontal and hippocampal regions predicted subsequent recollection of a word. Type of retrieval cue modulated activity in prefrontal, temporal, and parietal cortices. Words subsequently recognized on the basis of a sense of familiarity were at study also associated with differential activity in a number of brain regions, some of which were probe dependent. Thus, observed neural correlates of successful encoding are constrained by type of retrieval cue, and are only fragments of all encoding-related neural activity. Regions exhibiting cue-specific effects may be sites that support memory through the degree of overlap between the processes engaged during encoding and those engaged during retrieval.

Type: Article
Title: Fragments of a larger whole: Retrieval cues constrain observed neural correlates of memory encoding
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/cercor/bhl111
Keywords: encoding, episodic memory, fMRI, recognition, retrieval, transfer-appropriate processing, WORD FORM AREA, MEDIAL TEMPORAL-LOBE, EVENT-RELATED FMRI, EPISODIC MEMORY, SUBSEQUENT MEMORY, EXPLICIT MEMORY, FRONTAL-CORTEX, BRAIN ACTIVITY, RECOGNITION, LANGUAGE
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Institute of Cognitive Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/5854
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