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Risk factors for drug resistant tuberculosis in Leicestershire - poor adherence to treatment remains an important cause of resistance

Pritchard, AJ; Hayward, AC; Monk, PN; Neal, KR; (2003) Risk factors for drug resistant tuberculosis in Leicestershire - poor adherence to treatment remains an important cause of resistance. EPIDEMIOL INFECT , 130 (3) 481 - 483. 10.1017/S0950268803008367. Green open access

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Abstract

In the light of rising numbers of tuberculosis (TB) cases in the United Kingdom, the problem of anti-tubercular drug resistance remains a significant concern. Drug resistant TB cases are more difficult and costly to treat, and require appropriate treatment and control mechanisms. This matched case control study aimed to investigate risk factors for resistance in Leicestershire, using data for laboratory isolates of Mycobacterium tuberculosis identified from 1993 to 1998. Each case, defined as culture positive laboratory isolates resistant to at least one first-line drug, was matched to four fully sensitive controls on age, sex and ethnic group. Twenty-three cases and 81 controls were included in the analysis. Drug resistance in Leicestershire was found to be associated with poor adherence to treatment (OR 4(.)8, 95% CI 1(.)6-14(.)4, P=0(.)005) and with previous TB (OR 3(.)7, 95% CI 1(.)2-11(.)8, P=0(.)022). These findings emphasize the need to provide support to patients taking treatment in order to maximize adherence.

Type: Article
Title: Risk factors for drug resistant tuberculosis in Leicestershire - poor adherence to treatment remains an important cause of resistance
Open access status: An open access version is available from UCL Discovery
DOI: 10.1017/S0950268803008367
Publisher version: http://dx.doi.org/10.1017/S0950268803008367
Language: English
Additional information: © 2003 Cambridge University Press
Keywords: adherence, DRUG, factors, Resistance, Risk, RISK FACTOR, Risk Factors, RISK-FACTORS, treatment, tuberculosis, Infection
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health
URI: https://discovery.ucl.ac.uk/id/eprint/56622
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