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Socioeconomic position in childhood and adult cardiovascular risk factors, vascular structure, and function: cardiovascular risk in Young Finns study

Kivimäki, M.; Davey Smith, G.; Juonala, M.; Ferrie, J.E.; Keltikangas-Järvinen, L.; Elovainio, M.; Pulkki-Råback, L.; ... Raitakari, O.T.; + view all (2005) Socioeconomic position in childhood and adult cardiovascular risk factors, vascular structure, and function: cardiovascular risk in Young Finns study. Heart , 92 (4) pp. 474-480. 10.1136/hrt.2005.067108. Green open access

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Abstract

Objective: To examine the association of childhood socioeconomic position (SEP) with adult cardiovascular risk factors, vascular structure, and vascular function in a contemporary population of young adults. Design: Population based prospective cohort study with baseline assessment in 1980. Setting: Finland. Participants: 856 men and 1066 women whose childhood SEP was determined by parental occupational status (manual, lower non-manual, upper non-manual) at age 3–18 years. Main outcome measures: Cardiovascular risk factors, carotid artery intima–media thickness, and brachial artery flow mediated vasodilatation, assessed at age 24–39 years. Results: After adjustment for age and adult SEP, systolic pressure was 2.3 mm Hg higher (p = 0.0002), high density lipoprotein (HDL) cholesterol 0.03 mmol/l lower (p = 0.02), and insulin resistance score (homeostasis model assessment index) 0.12 units greater (p = 0.05) among men; and systolic pressure was 1.3 mm Hg higher (p = 0.02), diastolic pressure 1.1 mm Hg higher (p = 0.01), and height 1.1 cm lower (p < 0.0001) among women for each step down the childhood SEP hierarchy. Lower childhood SEP was associated with a 20% increase in the odds of having a waist circumference > 102 cm in men and > 88 cm in women (overall p = 0.05). Childhood SEP was not associated with intima–media thickness, flow mediated vasodilatation, the metabolic syndrome, low density lipoprotein cholesterol, triglycerides, body mass index, alcohol consumption, or smoking. Conclusions: Among adults under 40, low childhood SEP predicted higher blood pressure and central obesity and, among men, unfavourable HDL cholesterol and insulin resistance, independent of current SEP. No independent effects were found on adult vascular structure, vascular function, or health related behaviours at this life stage.

Type: Article
Title: Socioeconomic position in childhood and adult cardiovascular risk factors, vascular structure, and function: cardiovascular risk in Young Finns study
Open access status: An open access version is available from UCL Discovery
DOI: 10.1136/hrt.2005.067108
Publisher version: http://dx.doi.org/10.1136/hrt.2005.067108
Language: English
Keywords: Socioeconomic status, cardiovascular diseases, atherosclerosis, endothelial function, risk factors
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health
URI: https://discovery.ucl.ac.uk/id/eprint/5484
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