Nicolas, LB;
Fry, JP;
(2007)
The steroid sulfatase inhibitor COUMATE attenuates rather than enhances access of dehydroepiandrosterone sulfate to the brain in the mouse.
Brain Research
, 1174
92 - 96.
10.1016/j.brainres.2007.07.078.
Preview |
Text
Fry_Nicolas %26 Fry Brain Res submission 20July07 plus fig.pdf Download (194kB) | Preview |
Abstract
Intraperitoneal injection of adult male mice with the neuroactive steroid dehydroepiandrosterone sulfate (DHEAS) at 1 and 40 mg/kg caused dose-dependent increases in the concentration of both this compound and its corresponding free steroid DHEA in brain within 1 h of injection. Pretreatment of these animals for 24 h with the steroid sulfatase inhibitor COUMATE at a dose (10 mg/kg, p.o.) shown previously to cause almost complete inhibition of this enzyme in liver and brain was expected to increase the amount of the DHEAS dose reaching the brain. Surprisingly however, the increases in brain concentrations of DHEAS and DHEA after injection of DHEAS i.p. were attenuated by pretreatment with COUMATE. The results suggest that the arylsulfamate based steroid sulfatase inhibitors such as COUMATE interfere with the influx of the DHEAS anion into the brain.
| Type: | Article |
|---|---|
| Title: | The steroid sulfatase inhibitor COUMATE attenuates rather than enhances access of dehydroepiandrosterone sulfate to the brain in the mouse |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.brainres.2007.07.078 |
| Publisher version: | http://dx.doi.org/10.1016/j.brainres.2007.07.078 |
| Language: | English |
| Additional information: | Copyright © 2007. This manuscript version is published under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International licence (CC BY-NC-ND 4.0). This licence allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licences are available at http://creativecommons.org/licenses/by/4.0. |
| Keywords: | COUMATE, Dehydroepiandrosterone, DHEAS, mouse, neurosteroid, steroid sulfatase, efflux transport, in-vivo, mice, blood, neurosteroids, metabolism, receptors, behavior, barrier, tissue |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/54618 |
Archive Staff Only
 |
View Item |
