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Dementia in Older Adults With Intellectual Disabilities—Epidemiology, Presentation, and Diagnosis

Strydom, A; Shooshtari, S; Lee, L; Raykar, V; Torr, J; Tsiouris, J; Jokinen, N; ... Maaskant, M; + view all (2010) Dementia in Older Adults With Intellectual Disabilities—Epidemiology, Presentation, and Diagnosis. Journal of Policy and Practice in Intellectual Disabilities , 7 (2) 96 - 110. 10.1111/j.1741-1130.2010.00253.x. Green open access

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Abstract

As life expectancy of people with intellectual disabilities (ID) extends into older age, dementia is an increasing cause of morbidity and mortality. To update and summarize current knowledge on dementia in older adults with ID, the authors conducted a comprehensive review of the published literature from 1997-2008 with a specific focus on: (1) epidemiology of dementia in ID in general as well as in specific genetic syndromes; (2) presentation; and (3) diagnostic criteria for dementia. The review drew upon a combination of searches in electronic databases Medline, EMBASE, and PsycINFO for original research papers in English, Dutch, or German. The authors report that varied methodologies and inherent challenges in diagnosis yield a wide range of reported prevalence rates of dementia. Rates of dementia in the population with intellectual disability not because of Down syndrome (DS) are comparable with or higher than the general population. Alzheimer's disease onset in DS appears earlier and the prevalence increases from under 10% in the 40s to more than 30% in the 50s, with varying prevalence reported for those 60 and older. Incidence rates increase with age. Few studies of dementia in other genetic syndromes were identified. Presentation differs in the ID population compared with the general population; those with DS present with prominent behavioral changes believed to be because of frontal lobe deficits. Authors recommend large-scale collaborative studies of high quality to further knowledge on the epidemiology and clinical presentation of dementia in this population.

Type: Article
Title: Dementia in Older Adults With Intellectual Disabilities—Epidemiology, Presentation, and Diagnosis
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/j.1741-1130.2010.00253.x
Publisher version: http://dx.doi.org/10.1111/j.1741-1130.2010.00253.x
Language: English
Additional information: This is the peer reviewed version of the following article: Strydom, A; Shooshtari, S; Lee, L; Raykar, V; Torr, J; Tsiouris, J; Jokinen, N; (2010) Dementia in Older Adults With Intellectual Disabilities—Epidemiology, Presentation, and Diagnosis. Journal of Policy and Practice in Intellectual Disabilities, 7 (2) 96 - 110, which has been published in final form at: http://dx.doi.org/10.1111/j.1741-1130.2010.00253.x. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving (http://olabout.wiley.com/WileyCDA/Section/id-828039.html#terms).
Keywords: aging, Alzheimer's disease, comprehensive review, dementia, Down syndrome, intellectual disabilities, Prader-Willi syndrome, Downs syndrome, Alzheimers disease, Rett syndrome, follow-up, mental retardation, natural history, sudden death, learning disabilities, Klinefelter syndrome
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
URI: https://discovery.ucl.ac.uk/id/eprint/408026
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