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Dissociable human perirhinal, hippocampal, and parahippocampal roles during verbal encoding

Strange, B.A.; Otten, L.J.; Josephs, O.; Rugg, M.D.; Dolan, R.J.; (2002) Dissociable human perirhinal, hippocampal, and parahippocampal roles during verbal encoding. Journal of Neuroscience , 22 (2) 523 -528. Green open access

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Abstract

The precise contribution of perirhinal cortex to human episodic memory is uncertain. Human intracranial recordings highlight a role in successful episodic memory encoding, but encoding-related perirhinal activation has not been observed with functional imaging. By adapting functional magnetic resonance imaging scanning parameters to maximize sensitivity to medial temporal lobe activity, we demonstrate that left perirhinal and hippocampal responses during word list encoding are greater for subsequently recalled than forgotten words. Although perirhinal responses predict memory for all words, successful encoding of initial words in a list, demonstrating a primacy effect, is associated with parahippocampal and anterior hippocampal activation. We conclude that perirhinal cortex and hippocampus participate in successful memory encoding. Encoding-related parahippocampal and anterior hippocampal responses for initial, remembered words most likely reflects enhanced attentional orienting to these positionally distinctive items.

Type: Article
Title: Dissociable human perirhinal, hippocampal, and parahippocampal roles during verbal encoding
Open access status: An open access version is available from UCL Discovery
Publisher version: http://www.jneurosci.org/cgi/reprint/22/2/523.pdf
Language: English
Additional information: Copyright © 2002 Society for Neuroscience. This work is licensed under the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. The license allows you to copy, distribute, and transmit the work, as well as adapting it. However, you must attribute the work to the author (but not in any way that suggests that they endorse you or your use of the work), and cannot use the work for commercial purposes without prior permission of the author. If you alter or build upon this work, you can distribute the resulting work only under the same or similar license to this one. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ or send a letter to Creative Commons, 444 Castro Street, Suite 900, Mountain View, California, 94041, USA.
Keywords: perirhinal cortex, hippocampus, parahippocampal cortex, fMRI, episodic memory encoding, subsequent memory effect, primacy effect
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Institute of Cognitive Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/4040
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