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Integrating chemotaxis and contact-inhibition during collective cell migration: small GTPases at work

Theveneau, E; Mayor, R; (2010) Integrating chemotaxis and contact-inhibition during collective cell migration: small GTPases at work. Small GTPases , 1 (2) 113 - 117. 10.4161/sgtp.1.2.13673. Green open access

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Abstract

For directional cell migration to occur cells must interpret guiding cues present in their environment. Chemotaxis based on negative or positive signals has been long thought as the main driving force of guided cell migration. However during collective cell migration cells do receive information from external signals but also upon interactions with their direct neighbours. These multiple inputs must be translated into intracellular reorganisation in order to promote efficient directional migration. Small GTPases, being involved in establishing cell polarity and regulating protrusive activity, are likely to play a central role in signal integration. Indeed, recent findings from our laboratory indicate that Contact-Inhibition of Locomotion controlled by N-Cadherin and chemotaxis dependent on Sdf1/Cxcr4 signalling converge towards regulation of the localized activity of RhoA and Rac1. All together they establish cell polarity and select well-oriented cell protrusions to ensure directional cell migration.

Type: Article
Title: Integrating chemotaxis and contact-inhibition during collective cell migration: small GTPases at work
Open access status: An open access version is available from UCL Discovery
DOI: 10.4161/sgtp.1.2.13673
Publisher version: http://dx.doi.org/10.4161/sgtp.1.2.13673
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: https://discovery.ucl.ac.uk/id/eprint/401928
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