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Three dimensional optical imaging of blood volume and oxygenation in the neonatal brain

Austin, T; Gibson, AP; Branco, G; Yusof, RM; Arridge, SR; Meek, JH; Wyatt, JS; ... Hebden, JC; + view all (2006) Three dimensional optical imaging of blood volume and oxygenation in the neonatal brain. Neuroimage , 31 (4) 1426 - 1433. 10.1016/j.neuroimage.2006.02.038. Green open access

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Abstract

Optical methods provide a means of monitoring cerebral oxygenation in newborn infants at risk of brain injury. A 32-channel optical imaging system has been developed with the aim of reconstructing three-dimensional images of regional blood volume and oxygenation. Full image data sets were acquired from 14 out of 24 infants studied; successful images have been reconstructed in 8 of these infants. Regional variations in cerebral blood volume and tissue oxygen saturation are present in healthy preterm infants. In an infant with a large unilateral intraventricular haemorrhage, a corresponding region of low oxygen saturation was detected. These results suggest that optical tomography may provide an appropriate technique for investigating regional cerebral haemodynamics and oxygenation at the cotside. (c) 2006 Elsevier Inc. All rights reserved.

Type: Article
Title: Three dimensional optical imaging of blood volume and oxygenation in the neonatal brain
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.neuroimage.2006.02.038
Publisher version: http://dx.doi.org/10.1016/j.neuroimage.2006.02.038
Language: English
Keywords: Premature-infant brain, tomography, hemorrhage, newborn, light, flow
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Neonatology
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/2995
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