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Executive "brake failure" following deactivation of human frontal lobe

Chambers, C.D.; Bellgrove, M.A.; Stokes, M.G.; Henderson, T.R.; Garavan, H.; Robertson, I.H.; Morris, A.P.; (2006) Executive "brake failure" following deactivation of human frontal lobe. Journal of Cognitive Neuroscience , 18 (3) 444 - 445. 10.1162/089892906775990606. Green open access

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Abstract

In the course of daily living, humans frequently encounter situations in which a motor activity, once initiated, becomes unnecessary or inappropriate. Under such circumstances, the ability to inhibit motor responses can be of vital importance. Although the nature of response inhibition has been studied in psychology for several decades, its neural basis remains unclear. Using transcranial magnetic stimulation, we found that temporary deactivation of the pars opercularis in the right inferior frontal gyrus selectively impairs the ability to stop an initiated action. Critically, deactivation of the same region did not affect the ability to execute responses, nor did it influence physiological arousal. These findings confirm and extend recent reports that the inferior frontal gyrus is vital for mediating response inhibition.

Type: Article
Title: Executive "brake failure" following deactivation of human frontal lobe
Open access status: An open access version is available from UCL Discovery
DOI: 10.1162/089892906775990606
Publisher version: http://dx.doi.org/10.1162/089892906775990606
Language: English
Additional information: © 2006 Massachusetts Institute of Technology
Keywords: Design, human factors, theory
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Institute of Cognitive Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/2757
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