Cinquin, O;
Page, KM;
(2007)
Generalized, switch-like competitive heterodimerization networks.
B MATH BIOL
, 69
(2)
483 - 494.
10.1007/s11538-006-9114-8.
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Abstract
High-dimensional switches have been proposed as a way to model cellular differentiation, particularly in the context of basic Helix-Loop-Helix (bHLH) competitive heterodimerization networks. A previous study derived a simple rule showing how many elements can be co-expressed, depending on the rate of competition within the network. A limitation to that rule, however, is that many biochemical parameters were considered to be identical. Here, we derive a generalized rule. This in turns allows one to study more ways in which these networks could be regulated, linking intrinsic cellular differentiation determinants to extra-cellular cues.
| Type: | Article |
|---|---|
| Title: | Generalized, switch-like competitive heterodimerization networks |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/s11538-006-9114-8 |
| Keywords: | signaling networks, network motifs, cellular differentiation, bHLH dimerization, competitive heterodimerization, inhibitors of differentiation (Id), LOOP-HELIX PROTEINS, TRANSCRIPTION FACTORS, PHOSPHORYLATION, DIFFERENTIATION, GENE, MYOD, AUTOREGULATION, EXPRESSION, DROSOPHILA, COMPLEX |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Mathematics |
| URI: | https://discovery.ucl.ac.uk/id/eprint/2649 |
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