Ness, AR and Reynolds, LA and Tansey, EM (Eds). (2002) Population-based Research in South Wales: The MRC Pneumoconiosis Research Unit and the MRC Epidemiology Unit, vol. 13. [Book]. Wellcome Witnesses to Twentieth Century Medicine: Vol.13. Wellcome Trust Centre for the History of Medicine at UCL: London.

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Abstract

Population-based research in south Wales developed from a postwar mass X-ray programme of miners for pneumoconiosis. Archie Cochrane, the renowned epidemiologist, and his clinical and environmental studies group at the Pneumoconiosis Research Unit at Llandough Hospital, Cardiff, conducted respiratory and blood pressure surveys of workers in the Welsh valleys. In 1960 the epidemiological studies were separated from pneumoconiosis research and detailed studies began in the new Epidemiological Research Unit (South Wales) in Cardiff on glaucoma, dust diseases in flax, asbestos, steel and slate workers, with later work on iron deficiency anaemia, environmental lead, migraine, asthma, and two high-profile trials showing the reduction of heart incidents with the regular use of aspirin and the positive effect of a healthy diet on heart conditions. Statisticians and field workers made important contributions to both randomized controlled trials and observational studies at the unit over five decades. Volume 13 includes reminiscences from interviews with former members of both units and a section on the impact on data analysis from steadily increasing computational capacity. Contributors include:Dr David Bainton, Dr Michael Burr, Professor Sir Richard Doll, Dr Peter Elwood, Dr Joan Faulkner, Dr Philip D’Arcy Hart, Dr Julian Tudor Hart, Dr Sheila Howarth, Mrs Janie Hughes, Dr Philip Hugh-Jones, Mrs Marion Jones, Professor Stewart Kilpatrick, Dr Bill Miall, Professor John Pemberton, Professor George Davey Smith, Dr Selwyn St Leger, Mr Peter Sweetnam, Mrs Mary Thomas, Dr David Tyrrell, Professor Owen Wade, Professor Estlin Waters, Dr Jean Weddell, Mrs Sheila Wright and Dr John Yarnell. Introduction by Professor George Davey Smith.

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