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Delusions in frontotemporal lobar degeneration

Omar, R.; Sampson, E.L.; Loy, C.T.; Mummery, C.J.; Fox, N.C.; Rossor, M.N.; Warren, J.D.; (2009) Delusions in frontotemporal lobar degeneration. Journal of Neurology , 256 (4) pp. 600-607. 10.1007/s00415-009-0128-7. Green open access

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We assessed the significance and nature of delusions in frontotemporal lobar degeneration (FTLD), an important cause of young-onset dementia with prominent neuropsychiatric features that remain incompletely characterised. The case notes of all patients meeting diagnostic criteria for FTLD attending a tertiary level cognitive disorders clinic over a three year period were retrospectively reviewed and eight patients with a history of delusions were identified. All patients underwent detailed clinical and neuropsychological evaluation and brain MRI. The diagnosis was confirmed pathologically in two cases. The estimated prevalence of delusions was 14 %. Delusions were an early, prominent and persistent feature. They were phenomenologically diverse; however paranoid and somatic delusions were prominent. Behavioural variant FTLD was the most frequently associated clinical subtype and cerebral atrophy was bilateral or predominantly right-sided in most cases. We conclude that delusions may be a clinical issue in FTLD, and this should be explored further in future work.

Type: Article
Title: Delusions in frontotemporal lobar degeneration
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s00415-009-0128-7
Publisher version: http://dx.doi.org/10.1007/s00415-009-0128-7
Language: English
Additional information: © Steinkopff-Verlag 2009. This article is published with open access at Springerlink.com The article is reproduced here under the terms of the Creative Commons Attribution Noncommercial License, which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited, please see http://creativecommons.org/licenses/by-nc/2.5
Keywords: Delusions, frontotemporal lobar degeneration, Pick’s disease, dementia
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/20154
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