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The NMDA agonist D-cycloserine facilitates fear memory consolidation in humans

Kalisch, R.; Holt, B.; Petrovic, P.; De Martino, B.; Klöppel, S.; Büchel, C.; Dolan, R.J.; (2009) The NMDA agonist D-cycloserine facilitates fear memory consolidation in humans. Cerebral Cortex , 19 (1) pp. 187-196. 10.1093/cercor/bhn076. Green open access

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Abstract

Animal research suggests that the consolidation of fear and extinction memories depends on N-methyl D-aspartate (NMDA)- type glutamate receptors. Using a fear conditioning and extinction paradigm in healthy normal volunteers, we show that postlearning administration of the NMDA partial agonist D-cycloserine (DCS) facilitates fear memory consolidation, evidenced behaviorally by enhanced skin conductance responses, relative to placebo, for presentations of a conditioned stimulus (CS) at a memory test performed 72 h later. DCS also enhanced CS-evoked neural responses in a posterior hippocampus/collateral sulcus region and in the medial prefrontal cortex at test. Our data suggest a role for NMDA receptors in regulating fear memory consolidation in humans.

Type: Article
Title: The NMDA agonist D-cycloserine facilitates fear memory consolidation in humans
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/cercor/bhn076
Publisher version: http://dx.doi.org/10.1093/cercor/bhn076
Language: English
Additional information: © 2008 The Authors. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Anxiety, conditioning, emotion, fMRI, hippocampus, MPFC
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/20082
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