Kalisch, R.;
Holt, B.;
Petrovic, P.;
De Martino, B.;
Klöppel, S.;
Büchel, C.;
Dolan, R.J.;
(2009)
The NMDA agonist D-cycloserine facilitates fear memory consolidation in humans.
Cerebral Cortex
, 19
(1)
pp. 187-196.
10.1093/cercor/bhn076.
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Abstract
Animal research suggests that the consolidation of fear and extinction memories depends on N-methyl D-aspartate (NMDA)- type glutamate receptors. Using a fear conditioning and extinction paradigm in healthy normal volunteers, we show that postlearning administration of the NMDA partial agonist D-cycloserine (DCS) facilitates fear memory consolidation, evidenced behaviorally by enhanced skin conductance responses, relative to placebo, for presentations of a conditioned stimulus (CS) at a memory test performed 72 h later. DCS also enhanced CS-evoked neural responses in a posterior hippocampus/collateral sulcus region and in the medial prefrontal cortex at test. Our data suggest a role for NMDA receptors in regulating fear memory consolidation in humans.
| Type: | Article |
|---|---|
| Title: | The NMDA agonist D-cycloserine facilitates fear memory consolidation in humans |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/cercor/bhn076 |
| Publisher version: | http://dx.doi.org/10.1093/cercor/bhn076 |
| Language: | English |
| Additional information: | © 2008 The Authors. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Anxiety, conditioning, emotion, fMRI, hippocampus, MPFC |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience |
| URI: | https://discovery.ucl.ac.uk/id/eprint/20082 |
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