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Determining the neurotransmitter concentration profile at active synapses

Scimemi, A.; Beato, M.; (2009) Determining the neurotransmitter concentration profile at active synapses. Molecular Neurobiology , 40 (3) pp. 289-306. 10.1007/s12035-009-8087-7. Green open access

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Establishing the temporal and concentration profiles of neurotransmitters during synaptic release is an essential step towards understanding the basic properties of inter-neuronal communication in the central nervous system. A variety of ingenious attempts has been made to gain insights into this process, but the general inaccessibility of central synapses, intrinsic limitations of the techniques used, and natural variety of different synaptic environments have hindered a comprehensive description of this fundamental phenomenon. Here, we describe a number of experimental and theoretical findings that has been instrumental for advancing our knowledge of various features of neurotransmitter release, as well as newly developed tools that could overcome some limits of traditional pharmacological approaches and bring new impetus to the description of the complex mechanisms of synaptic transmission.

Type: Article
Title: Determining the neurotransmitter concentration profile at active synapses
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s12035-009-8087-7
Publisher version: http://dx.doi.org/10.1007/s12035-009-8087-7
Language: English
Additional information: © The Author(s) 2009. This article is published with open access at Springerlink.com The article is published under the Creative Commons Attribution Noncommercial License, which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited; please see http://creativecommons.org/licenses/by-nc/2.5
Keywords: Time course, diffusion, competitive low-affinity antagonist, neurotransmitter, synapse
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: https://discovery.ucl.ac.uk/id/eprint/20026
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